NK1R Selective Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S0772 L-732138

L-732138 (L-732,138) is a selective, potent and competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibits the binding of 125I-SP to the human NK-1 receptor stably expressed in CHO cells with IC50 of 2.3 nM.

Selective NK-1 receptor, IC50: 2.3 nM
S3038 Fosaprepitant dimeglumine salt

Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

Selective