Lisinopril dihydrate

For research use only.

Catalog No.S2076

Lisinopril dihydrate Chemical Structure

CAS No. 83915-83-7

Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

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Description Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
ACE [1]
In vitro

Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2]

In vivo Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6]


Solubility (25°C)

In vitro Water 20 mg/mL (45.29 mM)
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 441.52


CAS No. 83915-83-7
Storage powder
in solvent
Synonyms N/A
Smiles C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03599466 Not yet recruiting Drug: BF-Lisinopril Tablets 20mg|Drug: Zestril Tab 20mg Healthy Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong October 2019 Phase 1
NCT01835418 Unknown status Drug: Amlodipine Hypertension Allina Health System April 2013 Not Applicable
NCT01491919 Completed Drug: Lisinopril Hypertension Uptal Patel|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The Emmes Company LLC|University of Rochester|OpAns LLC|Duke University June 2012 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID