RAAS

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

RAAS Products

Catalog No. Information Product Use Citations Product Validations
S2199

Aliskiren Hemifumarate

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

S1657

Enalaprilat Dihydrate

Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

S1506

Perindopril Erbumine

Perindopril Erbumine (S9490-3) is a potent ACE inhibitor with IC50 of 1.05 nM.

S1793

Ramipril

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

S2488New

VTP-27999 TFA

VTP-27999 is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.

S1941

Enalapril Maleate

Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.

S2051

Captopril

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

S2076

Lisinopril dihydrate

Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

S2079

Moexipril HCl

Moexipril HCl is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.

S2581

Quinapril HCl

Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

S2099

Temocapril HCl

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2100

Temocapril

Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2109

Imidapril HCl

Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

S3981

Sinapinic Acid

Sinapinic acid (Sinapic acid), or sinapic acid is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM, and also inhibits ACE-I activity.

S7382

Phosphoramidon Disodium Salt

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.

S5767

Aliskiren

Aliskiren is a renin inhibitor with antihypertensive activity.

S5728

Delapril Hydrochloride

Delapril Hydrochloride is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

S5712

Zofenopril calcium

Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.

S5938

Benazepril

Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

S7678

Sacubitril/valsartan (LCZ696)

Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

S6468

Trandolapril

Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.

S2095

Fosinopril Sodium

Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

S1284

Benazepril HCl

Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.

Catalog No. Information Product Use Citations Product Validations
S2199

Aliskiren Hemifumarate

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

S1657

Enalaprilat Dihydrate

Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

S1506

Perindopril Erbumine

Perindopril Erbumine (S9490-3) is a potent ACE inhibitor with IC50 of 1.05 nM.

S1793

Ramipril

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

S2488New

VTP-27999 TFA

VTP-27999 is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.

S1941

Enalapril Maleate

Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.

S2051

Captopril

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

S2076

Lisinopril dihydrate

Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

S2079

Moexipril HCl

Moexipril HCl is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.

S2581

Quinapril HCl

Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

S2099

Temocapril HCl

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2100

Temocapril

Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2109

Imidapril HCl

Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

S3981

Sinapinic Acid

Sinapinic acid (Sinapic acid), or sinapic acid is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM, and also inhibits ACE-I activity.

S7382

Phosphoramidon Disodium Salt

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.

S5767

Aliskiren

Aliskiren is a renin inhibitor with antihypertensive activity.

S5728

Delapril Hydrochloride

Delapril Hydrochloride is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

S5712

Zofenopril calcium

Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.

S5938

Benazepril

Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

S7678

Sacubitril/valsartan (LCZ696)

Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

S6468

Trandolapril

Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.

S2095

Fosinopril Sodium

Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Catalog No. Information Product Use Citations Product Validations
S1284

Benazepril HCl

Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.