RAAS

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Isoform-selective Inhibitors

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Catalog No. Product Name Information Product Use Citations Product Validations
S1506 Perindopril Erbumine Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.
Neurotherapeutics, 2018, 15(2):500-510
S1657 Enalaprilat Dihydrate Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
J Transl Med, 2021, 19(1):91
Proteomics, 2019, 19(4):e1800288
Drug Metab Dispos, 2017, 45(11):1149-1155
S1793 Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S1941 Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
Molecules, 2022, 27(4)1417
ACS Omega, 2021, 6(29):18610-18622
S2051 Captopril Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Front Pharmacol, 2021, 12:765951
Exp Ther Med, 2020, 20(2):818-829
Drug Metab Dispos, 2020, 48(8):613-621
S2076 Lisinopril dihydrate Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2079 Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
J Cell Biochem, 2022, 10.1002/jcb.30213
S2095 Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S2099 Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S2100 Temocapril Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109 Imidapril HCl Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S2199 Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Kidney Int, 2018, 94(4):689-700
J Physiol, 2018, 596(15):3217-3232
S2488 VTP-27999 TFA VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S2581 Quinapril HCl Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S5712 Zofenopril calcium Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S5728 Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5767 Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity.
Angiogenesis, 2017, 20(1):175-181
Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Front Pharmacol, 2021, 12:740529
S6468 Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S7382 Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
S9820New Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
S1284 Benazepril HCl Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
Mol Pharm, 2015, 12(9):3399-407
S1506 Perindopril Erbumine Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.
Neurotherapeutics, 2018, 15(2):500-510
S1657 Enalaprilat Dihydrate Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
J Transl Med, 2021, 19(1):91
Proteomics, 2019, 19(4):e1800288
Drug Metab Dispos, 2017, 45(11):1149-1155
S1793 Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S1941 Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
Molecules, 2022, 27(4)1417
ACS Omega, 2021, 6(29):18610-18622
S2051 Captopril Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Front Pharmacol, 2021, 12:765951
Exp Ther Med, 2020, 20(2):818-829
Drug Metab Dispos, 2020, 48(8):613-621
S2076 Lisinopril dihydrate Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2079 Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
J Cell Biochem, 2022, 10.1002/jcb.30213
S2095 Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S2099 Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S2100 Temocapril Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109 Imidapril HCl Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S2199 Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Kidney Int, 2018, 94(4):689-700
J Physiol, 2018, 596(15):3217-3232
S2488 VTP-27999 TFA VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S2581 Quinapril HCl Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S5712 Zofenopril calcium Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S5728 Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5767 Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity.
Angiogenesis, 2017, 20(1):175-181
Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Front Pharmacol, 2021, 12:740529
S6468 Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S7382 Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
S9820New Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
S1284 Benazepril HCl Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
Mol Pharm, 2015, 12(9):3399-407
S9820New Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
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