Liraglutide

Synonyms: NN2211, Liraglutida, Liraglutidum

Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.

Liraglutide Chemical Structure

Liraglutide Chemical Structure

CAS: 204656-20-2

Selleck's Liraglutide has been cited by 19 publications

Purity & Quality Control

Batch: Purity: 99.84%
99.84

Products often used together with Liraglutide

Metformin


Liraglutide With Metformin therapy ameliorates hepatic steatosis and liver Injury in mouse model.

Chiu HY, et al. In Vivo. 2023 May-Jun;37(3):1037-1046.

Insulin Degludec


Insulin degludec/Liraglutide (IDegLira) achieves glycemic control superior to that of Insulin degludec.

Buse JB, et al. Diabetes Care. 2014 Nov;37(11):2926-33.

Empagliflozin


Liraglutide induces greater changes in glycated hemoglobin and albumin than empagliflozin in patients with inadequately controlled type 2 diabetes.

Nakaguchi H, et al. J Diabetes Investig. 2020 Nov; 11(6): 1542–1550.

Insulin (human)


Liraglutide and Insulin continuous subcutaneous infusion improves glycemic control and variability and decreases oxidative stress markers in patients with newly diagnosed type 2 diabetes mellitus (T2DM).

Li LQ, et al. Endocr J. 2019 Oct 28;66(10):871-880.

Sitagliptin


Liraglutide and Sitagliptin in combination with a sulfonylurea reduce HbA1c levels in patients with inadequate glycemic control despite using antidiabetic drugs.

Yokoyama H, et al. Jpn Clin Med. 2014 Sep 17;5:33-41.

Liraglutide Related Products

Choose Selective Glucagon Receptor Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 Proliferation assay 0, 1, 10, 100, and 1000 nmol/L 48 h IC50~100 nM 31081108
MiaPaca-2 Cell viability assay 0, 10, 100, 1000 nM 48 h The inhibitory effects on cell viability and cell number were statistically significant only at the concentration of 1,000 nmol/L for liraglutide 29897998
H9c2 Function assay 100 nM 1 h Liraglutide reversed the downregulation of SIRT1 induced by TNF-α and hypoxia 29571736
MC3T3-E1 Apoptosis assay 0, 10, 100, or 1000 nM 48 h liraglutide suppressed the apoptosis of MC3T3-E1 cells 29463067
MCF-7 Proliferation assay 10, 100, 1,000 and 10,000 nM 48 h Liraglutide inhibits the proliferation and promotes apoptosis in the MCF-7 breast cancer cell line 29393459
SH-SY5Y Function assay 100 nM 16 h Liraglutide resolves UPR in the neuroblastoma SH-SY5Y cell line. 29170452
HEK293 Function assay up to 30 mins Agonist activity at human GLP1 receptor expressed in HEK293 cells harboring mCerulean and mCitrine fused Epac protein assessed as increase in cAMP level up to 30 mins by fluorescence assay, EC50 = 0.000067 μM. 28771355
HEK293 Function assay 30 mins Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by HTRF method, EC50 = 0.0074 μM. ChEMBL
Click to View More Cell Line Experimental Data

Biological Activity

Description Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.
Targets
GLP-1 receptor [1]
In vitro
In vitro

Liraglutide attenuates induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression in human vascular endothelial cells (hVECs) in vitro and may afford protection against endothelial cell dysfunction (ECD), an early abnormality in diabetic vascular disease. In vitro studies demonstrates GLP-1R-dependent liraglutide-mediated inhibition of stimulated PAI-1 and VAM expression[3].

Cell Research Cell lines human umbilical vein endothelial cell line C11-STH20
Concentrations 100 nM
Incubation Time 16 h
Method

C11-STH cells are cultured to confluence at 37°C in gelatin-coated Nunclon cell culture dishes in Media-199 supplemented with penicillin/streptomycin, 20% FCS, 20 µg/ml endothelial cell growth factor and 20 µg/ml heparin. C11-STH cells are incubated under serum free conditions with liraglutide (100 nM) or the GLP-1 receptor antagonist exendin (9-39) (100 nM) alone or with 10 ng/ml TNFα for 16 h alone or in combination with liraglutide and/or exendin (9-39). ELISA assays for VCAM-1 and ICAM-1 are performed using conditioned medium from C11-STH cells to determine protein expression levels.

Experimental Result Images Methods Biomarkers Images PMID
Western blot p-ERK / p-JNK / p-p38 / p-AKT / IκB-α 24217090
In Vivo
In vivo

In vivo studies of vascular reactivity and immunohistochemical analysis are performed in the ApoE-/- mouse model. They demonstrate significant improvement in endothelial function in liraglutide treated mice, a GLP-1R dependent effect. Liraglutide treatment also increases endothelial nitric oxide synthase (eNOS) and reduces intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium, an effect again dependent on the GLP-1R[3]. Liraglutide reduces hyperglycemia in T2D mouse models by increasing pancreatic b cell mass through enhanced proliferation[2].

Animal Research Animal Models Athymic nude mice
Dosages 300 μg/kg/day
Administration s.c.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05268237 Recruiting
Diabete Type 2
Biolingus|Chinese University of Hong Kong
April 25 2023 Phase 1|Phase 2
NCT05419856 Completed
Knee Osteoarthritis
4Moving Biotech|4P-Pharma
August 9 2022 Phase 1
NCT05467514 Completed
Diabetes Mellitus Type 1
David Sanchez Garcia|Instituto Mexicano del Seguro Social
July 1 2022 Phase 3
NCT04763564 Completed
Pouchitis|Irritable Pouch Syndrome
University of North Carolina Chapel Hill|Novo Nordisk A/S
March 22 2022 Phase 2

Chemical Information & Solubility

Molecular Weight 3751.25 Formula

C172H265N43O51

CAS No. 204656-20-2 SDF Download Liraglutide SDF Download Liraglutide SDF
Smiles CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC6=CN=CN6)N)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (26.65 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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