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Relacorilant (CORT125134) Glucocorticoid Receptor antagonist

Name: Relacorilant (CORT125134)
Brand: Selleck Chemicals
SKU: E1091
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.E1091

Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.

Chemical Structure

Molecular Weight: 586.56

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Quality Control

Batch: Purity: 99.37%

99.37

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor ACE RAAS Progesterone Receptor Opioid Receptor THR PGES
Other Glucocorticoid Receptor Inhibitors	Corticosterone AL082D06 (20S)-Protopanaxatriol Cortodoxone

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (170.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (8.52mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.830mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 16.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	586.56	Formula	C₂₇H₂₂F₄N₆O₃S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1496510-51-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	glucocorticoid receptor (in HepG2 TAT assay) 7.2 nM(Ki) Rat glucocorticoid receptor (in cell-based assay) 12 nM(Ki) Human glucocorticoid receptor (in cell-based assay) 81.2 nM(Ki) Monkey glucocorticoid receptor (in cell-based assay) 210 nM(Ki)
References	[1] https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00162

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-13)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07763496	NOT_YET_RECRUITING	Recurrent or Metastatic Cervical Cancer	ARCAGY/ GINECO GROUP	2026-10	PHASE2
NCT05726292	RECRUITING	Prostate Cancer; Prostate Adenocarcinoma	University of Chicago	2025-01-06	PHASE2
NCT07259317	RECRUITING	Adenocarcinoma; Carcinoma, Pancreatic Ductal	Corcept Therapeutics	2026-01-27	PHASE2
NCT03604198	ACTIVE_NOT_RECRUITING	Cushing Syndrome	Corcept Therapeutics	2018-05-07	PHASE2
NCT06906341	RECRUITING	Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Neoplasms; Endometrial Cancer	Corcept Therapeutics	2025-04-11	PHASE2
NCT05257408	ACTIVE_NOT_RECRUITING	Ovarian Neoplasm; Fallopian Tube Neoplasms; Peritoneal Neoplasms	Corcept Therapeutics	2022-06-29	PHASE3

Tech Support

Handling Instructions

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