Resmetirom (MGL-3196)

Catalog No.S6663 Synonyms: VIA-3196

For research use only.

Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.

Resmetirom (MGL-3196) Chemical Structure

CAS No. 920509-32-6

Selleck's Resmetirom (MGL-3196) has been cited by 1 Publication

Purity & Quality Control

Choose Selective THR Inhibitors

Biological Activity

Description Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.
Targets
THR-β [1]
(Cell-free assay)
0.21μM(EC50)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 435.22
Formula

C17H12Cl2N6O4

CAS No. 920509-32-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04951219 Recruiting Drug: Resmetirom Non-Alcoholic Fatty Liver Disease Madrigal Pharmaceuticals Inc. July 9 2021 Phase 3
NCT04197479 Unknown status Drug: Placebo|Drug: Resmetirom Non-Alcoholic Fatty Liver Disease Madrigal Pharmaceuticals Inc. December 16 2019 Phase 3
NCT04671069 Completed Drug: MGL-3196|Drug: Clopidogrel Healthy Madrigal Pharmaceuticals Inc. July 26 2019 Phase 1
NCT03900429 Recruiting Drug: MGL-3196|Drug: Placebo NASH - Nonalcoholic Steatohepatitis Madrigal Pharmaceuticals Inc. March 28 2019 Phase 3
NCT04671056 Completed Drug: MGL-3196|Drug: Pioglitazone 15mg Healthy Madrigal Pharmaceuticals Inc. November 9 2018 Phase 1
NCT03220165 Completed Drug: MGL-3196 Healthy Madrigal Pharmaceuticals Inc.|Worldwide Clinical Trials August 6 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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