Resmetirom (MGL-3196)

Synonyms: VIA-3196

Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.

Resmetirom (MGL-3196) Chemical Structure

Resmetirom (MGL-3196) Chemical Structure

CAS: 920509-32-6

Selleck's Resmetirom (MGL-3196) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.81%
99.81

Resmetirom (MGL-3196) Related Products

Choose Selective THR Inhibitors

Biological Activity

Description Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.
Targets
THR-β [1]
(Cell-free assay)
0.21μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04951219 Recruiting
Non-Alcoholic Fatty Liver Disease
Madrigal Pharmaceuticals Inc.
July 9 2021 Phase 3
NCT04197479 Completed
Non-Alcoholic Fatty Liver Disease
Madrigal Pharmaceuticals Inc.
December 16 2019 Phase 3
NCT04671069 Completed
Healthy
Madrigal Pharmaceuticals Inc.
July 26 2019 Phase 1
NCT03900429 Active not recruiting
NASH - Nonalcoholic Steatohepatitis
Madrigal Pharmaceuticals Inc.
March 28 2019 Phase 3
NCT04671056 Completed
Healthy
Madrigal Pharmaceuticals Inc.
November 9 2018 Phase 1
NCT03220165 Completed
Healthy
Madrigal Pharmaceuticals Inc.|Worldwide Clinical Trials
August 6 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 435.22 Formula

C17H12Cl2N6O4

CAS No. 920509-32-6 SDF --
Smiles CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 87 mg/mL ( (199.89 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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