Resmetirom (MGL-3196)

For research use only.

Catalog No.S6663 Synonyms: VIA-3196

Resmetirom (MGL-3196) Chemical Structure

CAS No. 920509-32-6

Resmetirom is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.

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Biological Activity

Description Resmetirom is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.
Targets
THR-β [1]
(Cell-free assay)
0.21μM(EC50)

Protocol

Solubility (25°C)

In vitro DMSO 87 mg/mL (199.89 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 435.22
Formula

C17H12Cl2N6O4

CAS No. 920509-32-6
Storage powder
in solvent
Synonyms VIA-3196
Smiles CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04197479 Recruiting Drug: Placebo|Drug: Resmetirom Non-Alcoholic Fatty Liver Disease Madrigal Pharmaceuticals Inc. December 16 2019 Phase 3
NCT03900429 Recruiting Drug: MGL-3196|Drug: Placebo NASH - Nonalcoholic Steatohepatitis Madrigal Pharmaceuticals Inc. March 28 2019 Phase 3
NCT03220165 Completed Drug: MGL-3196 Healthy Madrigal Pharmaceuticals Inc.|Worldwide Clinical Trials August 6 2017 Phase 1
NCT03038022 Completed Drug: MGL-3196|Drug: Placebo Heterozygous Familial Hypercholesterolemia Madrigal Pharmaceuticals Inc. February 9 2017 Phase 2
NCT02912260 Unknown status Drug: MGL-3196|Drug: Placebo Non-alcoholic Steatohepatitis Madrigal Pharmaceuticals Inc. September 2016 Phase 2
NCT02749578 Completed Drug: Atorvastatin|Drug: MGL-3196 Healthy Madrigal Pharmaceuticals Inc.|Celerion April 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID