Triiodothyronine

Catalog No.S5726 Synonyms: T3, Liothyronine, 3,3',5-Triiodo-L-thyronine

For research use only.

Triiodothyronine (T3, Liothyronine, 3,3',5-Triiodo-L-thyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution.

Triiodothyronine Chemical Structure

CAS No. 6893-02-3

Selleck's Triiodothyronine has been cited by 3 Publications

Purity & Quality Control

Choose Selective THR Inhibitors

Biological Activity

Description Triiodothyronine (T3, Liothyronine, 3,3',5-Triiodo-L-thyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution.
In vitro

Triiodothyronine is one ingredient supplemented in the medium for inducing brown adipocytes differentiation.[1]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Brown preadipocytes
  • Concentrations: 2 nM
  • Incubation Time: 2 days
  • Method:

    Brown preadipocytes were isolated from perirenal adipose tissues of Chuanzhong black goats (1 day after birth). The cells were cultured in DMEM/F12 containing 10% fetal bovine serum and 2% penicillin/streptomycin and placed in an incubator (5% CO2, 37°C). Until 100% confluence, DMEM/F12 was supplemented with 2% FBS containing 5 μg/ml of insulin, 1 μM dexamethasone, 0.5 mM IBMX, 1 μM Rosiglitazone, and 2 nM triiodothyronine to induce brown adipocytes differentiation. Two days later, the induced medium was changed to a maintenance medium (DMEM/F12 supplemented with 2% FBS, 5 μg/ml of insulin, and 2 nM triiodothyronine). Cells were harvested 8 days after differentiation. L-carnitine was added to the medium throughout the differentiation process and supplemented at 600 μΜ. SiAMPKα (GAAGAGAAATTCAGAACCT)15 were transfected by Lipofectamine 3000. Lipid droplets were stained using Oil Red O solution. After staining, 1 ml isopropanol was used to dissolve the oil red O dye, and the absorbance at 510 nm was detected.

    (Data sourced from selleck products)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 650.97
Formula

C15H12I3NO4

CAS No. 6893-02-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05333432 Not yet recruiting Procedure: Multiparameric MRI with injection Prostate Cancer Assistance Publique - Hôpitaux de Paris|National Cancer Institute France October 1 2022 Not Applicable
NCT05435014 Not yet recruiting Drug: T-ACE Oil|Drug: Lipiodol Hepatocellular Carcinoma T-ACE Medical Co. Ltd July 8 2022 Phase 1|Phase 2
NCT05460689 Not yet recruiting Other: M-HEALTH APP|Other: Standard Care TONSILLECTOMY IRCCS Burlo Garofolo July 30 2022 Not Applicable
NCT05404412 Recruiting Procedure: Epidural Steroid Injection Lumbar Radiculopathy|Lumbar Spinal Stenosis|Cervical Radiculopathy|Cervical Stenosis Marmara University June 2022 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Triiodothyronine | Triiodothyronine supplier | purchase Triiodothyronine | Triiodothyronine cost | Triiodothyronine manufacturer | order Triiodothyronine | Triiodothyronine distributor