Catalog No.S8094

For research use only.

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

GlyH-101 Chemical Structure

CAS No. 328541-79-3

Selleck's GlyH-101 has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.
CFTR [1]
4.3 μM(Ki)
In vitro

GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]

In vivo In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

Protocol (from reference)

Animal Research:


  • Animal Models: CD1 mice
  • Dosages: 10 μM
  • Administration: Topical treatment

Solubility (25°C)

In vitro

DMSO 98 mg/mL
(198.72 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 493.15


CAS No. 328541-79-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C=C(C=CC2=C1)NCC(=O)NN=CC3=CC(=C(C(=C3O)Br)O)Br

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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