For research use only.

Catalog No.S8094

1 publication

GlyH-101 Chemical Structure

CAS No. 328541-79-3

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

Selleck's GlyH-101 has been cited by 1 publication

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Biological Activity

Description GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.
CFTR [1]
4.3 μM(Ki)
In vitro

GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]

In vivo In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]


Animal Research:


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  • Animal Models: CD1 mice
  • Dosages: 10 μM
  • Administration: Topical treatment
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 98 mg/mL (198.72 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 493.15


CAS No. 328541-79-3
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC=C2C=C(C=CC2=C1)NCC(=O)NN=CC3=CC(=C(C(=C3O)Br)O)Br

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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CFTR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID