GlyH-101

Catalog No.S8094

GlyH-101 Chemical Structure

Molecular Weight(MW): 493.15

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

Size Price Stock Quantity  
USD 117 In stock
USD 447 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective CFTR Inhibitors

Biological Activity

Description GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.
Targets
CFTR [1]
4.3 μM(Ki)
In vitro

GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]

In vivo In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: CD1 mice
  • Formulation: --
  • Dosages: 10 μM
  • Administration: Topical treatment
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 98 mg/mL (198.72 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 493.15
Formula

C19H15Br2N3O3

CAS No. 328541-79-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

CFTR Signaling Pathway Map

Related CFTR Products

Tags: buy GlyH-101 | GlyH-101 supplier | purchase GlyH-101 | GlyH-101 cost | GlyH-101 manufacturer | order GlyH-101 | GlyH-101 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID