Tezacaftor (VX-661)

For research use only.

Catalog No.S7059

27 publications

Tezacaftor (VX-661) Chemical Structure

CAS No. 1152311-62-0

Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 550 In stock
EUR 265 In stock
EUR 953 In stock
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Selleck's Tezacaftor (VX-661) has been cited by 27 publications

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Biological Activity

Description Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
Targets
F508del-CFTR [1]
(Cell-free assay)
In vitro

VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (192.12 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 520.5
Formula

C26H27F3N2O6

CAS No. 1152311-62-0
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02412111 Completed Drug: Ivacaftor|Drug: Tezacaftor/Ivacaftor Cystic Fibrosis Vertex Pharmaceuticals Incorporated June 2015 Phase 3
NCT02015507 Completed Drug: ivacaftor|Drug: VX-661|Drug: ciprofloxacin Cystic Fibrosis Vertex Pharmaceuticals Incorporated January 2014 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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CFTR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID