FDL169

Catalog No.S8795

For research use only.

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

FDL169 Chemical Structure

CAS No. 1628416-28-3

Selleck's FDL169 has been cited by 2 Publications

Purity & Quality Control

Choose Selective CFTR Inhibitors

Other CFTR Products

Biological Activity

Description FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
Targets
CFTR [1]
()
In vitro

FDL169 has been shown to increase Phe508del CFTR cell-surface abundance[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 33 mg/mL
(67.83 mM)
Ethanol 8 mg/mL
(16.44 mM)
Water Insoluble

Chemical Information

Molecular Weight 486.49
Formula
C27H23FN4O4
 
CAS No. 1628416-28-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC1=CC2=C(C=C1)C(=NN(C2=O)CC(=O)N(C)C3=CC4=C(C=C3)N=C(O4)C)C5=CC(=CC=C5)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03527095 Completed Drug: FDL169 Cystic Fibrosis Flatley Discovery Lab LLC April 5 2018 Phase 1
NCT02767297 Completed Drug: FDL169 Cystic Fibrosis Flatley Discovery Lab LLC April 2016 Phase 1|Phase 2
NCT02680418 Completed Drug: FDL169 Cystic Fibrosis Flatley Discovery Lab LLC December 2015 Phase 1
NCT02359357 Completed Drug: FDL169|Drug: Placebo Cystic Fibrosis Flatley Discovery Lab LLC January 2015 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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