Ganciclovir (BW 759)

Catalog No.S1878 Synonyms: RS-21592, 2'-Nor-2'-deoxyguanosine

For research use only.

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

Ganciclovir (BW 759) Chemical Structure

CAS No. 82410-32-0

Selleck's Ganciclovir (BW 759) has been cited by 13 publications

Purity & Quality Control

Choose Selective CMV Inhibitors

Biological Activity

Description Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro

Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. [1] Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. [2] Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. [3] Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. [4] Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. [5] Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines M{j0[2Z2dmO2aX;uJIF{e2G7 NUD2N4lGTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1{IDjIV3YuOiliaX7keYNm\CCleYTvdIF1cGmlaYT5JIJ6KDVyJTDpckBGPlOPIHPlcIwhdGmwZYOsJGVEPTB;MT6yJI5O M1jHd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEm1OVg3Lz5zMUS5OVU5PjxxYU6=
OST TK- cells M1rBd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWrEeoU1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFusJGlEPTB;MD6wNFE6|ryPLh?= MmLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
HEL M{\JSWFvfGm4aYLhcEBie3OjeR?= NI[3O2NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yME[0{txONg>? NHK4e4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
HEL Mn64RY51cX[rcnHsJIF{e2G7 NY\h[ZBESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlAy|ryPLh?= M4TzdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkOyPFI5Lz5{MUKzNlgzQDxxYU6=
HEL NH;MUFJCdnSrdnnyZYwh[XO|YYm= NVrBb5JtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUKgS{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFHPxE1w M1L6[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{m1NlM5Lz5{M{e5OVI{QDxxYU6=
HEL MmnQRY51cX[rcnHsJIF{e2G7 NYLLWmlvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtNWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xOc7:TT6= NXraPWM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVUzOzhpPkKzO|k2OjN6PD;hQi=>
HEL MV7BcpRqfmm{YXygZZN{[Xl? M1LDNlMh\GG7cx?= M4fySmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIH3leIhw\CxiRVO1NF0xNjBzzszNMi=> NUi0WJpERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFY6PTJpPkOwNlg3QTV{PD;hQi=>
HEL MojnRY51cX[rcnHsJIF{e2G7 NH7WVmY{KGSjeYO= M2fmbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgcYV1cG:mLDDFR|UxRTBwMEJOwG0v NXXh[mxqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFY6PTJpPkOwNlg3QTV{PD;hQi=>
HEL MXTBcpRqfmm{YXygZZN{[Xl? NVr5TWZISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wNVPPxE1w NXHsfIg5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPVkxQTdpPkKzNFk6ODl5PD;hQi=>
HEL M2XUSmFvfGm4aYLhcEBie3OjeR?= M3\abWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wNVXPxE1w Ml7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
OST TK- cells NHTkU21EgXSxdH;4bYNqfHliYYPzZZk> NIm2bo9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB{LkWgeW0hOS2dNj2oeJJqeGinbonscYV1cG:6eTno[Zh6dF22aIntbY5mNCCLQ{WwQVAvODF6zszNMi=> MmnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
HEL M{jM[2FvfGm4aYLhcEBie3OjeR?= NGjzb41CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC5yMUpOwG0v M3X5UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HEL MWXBcpRqfmm{YXygZZN{[Xl? Mki1NkB1dyB|IHThfZM> MorSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBt[XG3ZTDmc5Ju[XSrb36gcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fCCrbn\lZ5Rqd25uIFXDOVA:OC5yMUpOwG0v MnHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
HEL M{HoOGFvfGm4aYLhcEBie3OjeR?= NF7GXFBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkCy{txONg>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL NVTGVpRISW62aY\pdoFtKGG|c3H5 NYjpUJdwPCCmYYnz NGTtcHhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IESg[IF6eyxiRVO1NF0xNjB{zszNMi=> MlLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUm4O|YoRjJ{NEW5PFc3RC:jPh?=
HEL NUfzXHFJSW62aY\pdoFtKGG|c3H5 MkT2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMENOwG0v NITKfFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HEL NYDJSIg{SW62aY\pdoFtKGG|c3H5 M{TTOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{zszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6MEK1NUc,Ojl6OECyOVE9N2F-
HEL NXXDOllTSW62aY\pdoFtKGG|c3H5 MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuNFLPxE1w NHHnXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
Vero M1nhN2FvfGm4aYLhcEBie3OjeR?= MYi3NkBpenN? NUHwXG01SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFfGVEBmgHC{ZYPzbY9vKGGodHXyJFczKGi{czDifUBITlBvYnHz[YQh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuNFI2|ryPLh?= M1i4T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUCzOFc3Lz5|MUWwN|Q4PjxxYU6=
HEL NES3XolCdnSrdnnyZYwh[XO|YYm= MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJGchcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOjgQvF2u NXvGbWRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HEL NXT3WIgySW62aY\pdoFtKGG|c3H5 MnXZRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGK7II\pdoFtKEOSRTDhd5NigSxiRVO1NF0xNjB{N988UU4> NYL2O5ZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OVgzOjJpPkKyPFU5OjJ{PD;hQi=>
HEL Mn3rRY51cX[rcnHsJIF{e2G7 NID5XmhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGK7II\pdoFtKEOSRTDhd5NigSxiRVO1NF0xNjB{Od88UU4> MlnpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL M{LTWGFvfGm4aYLhcEBie3OjeR?= NFjScmUzKHSxIEOg[IF6ew>? MlPqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZNmdnOrdHn2[UBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEROwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB|NEexNUc,OjByM{S3NVE9N2F-
HEL M4LVc2FvfGm4aYLhcEBie3OjeR?= M1XC[VIhfG9iMzDkZZl{ NFX4RmlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEROwG0v NX62[oh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwN|Q4OTFpPkKwNFM1PzFzPD;hQi=>
HEL NH\adJJCdnSrdnnyZYwh[XO|YYm= NHv4PVUzKHSxIEOg[IF6ew>? NXv5UlRTSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIZzd21idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCyJJRwKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:OC5yM988UU4> NIP4PVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECzOFcyOSd-MkCwN|Q4OTF:L3G+
HEL M3v3d2FvfGm4aYLhcEBie3OjeR?= MX60JIRigXN? MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> NEDpTFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[5Olk3Oyd-MkG2PVY6PjN:L3G+
HEL MlnCRY51cX[rcnHsJIF{e2G7 NHf6NJhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkCz{txONg>? M{nPTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL NUXGfXFUSW62aY\pdoFtKGG|c3H5 NUPaNXRIPCCmYYnz M4HnZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> NIDETYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[5Olk3Oyd-MkG2PVY6PjN:L3G+
HEL M1\mS2FvfGm4aYLhcEBie3OjeR?= NFXZc2c1KGSjeYO= NWH5VHRnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNDDkZZl{NCCHQ{WwQVAvODQQvF2u NIS2NVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL MmDYRY51cX[rcnHsJIF{e2G7 M2O5UGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= NH;pZpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL MVnBcpRqfmm{YXygZZN{[Xl? NUHmN2N3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNvMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMEROwG0v NYH4R|UyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HEL M4rqN2FvfGm4aYLhcEBie3OjeR?= MojjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> MkXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NEX5NWZCdnSrdnnyZYwh[XO|YYm= NXj5V5dbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;MD6wN:69VS5? MknBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlgoRjJ5NkO5N|Y5RC:jPh?=
HELF M{XuRWFvfGm4aYLhcEBie3OjeR?= NILJV49CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDzeJJicW5iaX7m[YN1\WRiaX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> NWrTSZBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HELF MmHVRY51cX[rcnHsJIF{e2G7 MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJGche3S{YXnuJIlv\mWldHXkJIlvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFPPxE1w MnHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi0PFEoRjNyMEm4OFgyRC:jPh?=
HEL M4fVcWFvfGm4aYLhcEBie3OjeR?= NVGyXYl7SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCz{txONg>? Ml3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6Mkm5NVMoRjJ6OEK5PVE{RC:jPh?=
HEL NF[0bFNCdnSrdnnyZYwh[XO|YYm= M4fud2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEROwG0v MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
HEL M{m4[GFvfGm4aYLhcEBie3OjeR?= MmfxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCrbjDISWwh[2WubIOsJGVEPTB;MD6wN|LPxE1w M2XCeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HEL M2jac2FvfGm4aYLhcEBie3OjeR?= Ml3BRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yM{NOwG0v MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ5MkS0OUc,OTd4N{K0OFU9N2F-
HEL NGfMdXNCdnSrdnnyZYwh[XO|YYm= NEn0coFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wN|LPxE1w NH33eoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
OST TK- cells M3u5eWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjEfZJuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiNTD1UUAyNVt4LTj0dolxcGWweXzt[ZRpd3i7KXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xOzQQvF2u NUTXc205RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
fibroblast cells MlLORY51cX[rcnHsJIF{e2G7 Ml;zRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKGi3bXHuJIZwemW|a3nuJIZq[nKxYnzhd5Qh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvODUQvF2u NHm5fHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5O|I4OSd-MUmzPVczPzF:L3G+
HEL Ml7qRY51cX[rcnHsJIF{e2G7 MlrKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|MkiyPEc,OjF{M{K4Nlg9N2F-
HFF MlnyRY51cX[rcnHsJIF{e2G7 MkHoNUBpeg>? MlfWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KCi|dILhbY4hSURzNkmpJIlv\mWldHXkJIlvKDFiaIKgdJJmfHKnYYTl[EBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtNWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nlibnX1eJJidCC{ZXSgeZB1[WunIHHzd4F6NCCHQ{WwQVAvODUQvF2u NYi2d5NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO|Y1OjlpPkKxN|c3PDJ7PD;hQi=>
HEL NV3UbYN7SW62aY\pdoFtKGG|c3H5 NHnzWlhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB2zszNMi=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL NY\kXI8{SW62aY\pdoFtKGG|c3H5 M3vBWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFTPxE1w NVrVcpMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
Vero NYL5Ro97SW62aY\pdoFtKGG|c3H5 MmD3N|YhcHK| MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YhOSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBxdGGzdXWg[o9zdWG2aX;uJIlv[3WkYYTl[EBnd3JiM{[gbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKGKjc3XkJIF{e2G7LDDFR|UxRTBwMEVOwG0v NYjDOHdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
OST TK- cells MULDfZRwfG:6aXPpeJkh[XO|YYm= M4[5[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDFyIIXNJFEuYzZvKITybZBp\W67bH3leIhwgHlraHX4fYxefGi7bXnu[UwhUUN3ME2wMlA1Oc7:TT6= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL MlKzRY51cX[rcnHsJIF{e2G7 NGP1VlEzKHSxIEOg[IF6ew>? NX;IPFBiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCvZXHzeZJm\CCjZoTldkAzKHSxIEOg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2wMlA1Pc7:TT6= NV[zeoQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
OST TK- cells NI\Ue5REgXSxdH;4bYNqfHliYYPzZZk> Mn\0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xPc7:TT6= NV\t[ldYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
human Mo\XRY51cX[rcnHsJIF{e2G7 MWq3JIRigXN? MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEeg[IF6eyxiRVO1NF0xNjB3zszNMi=> NFvPSlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HEL MlTxRY51cX[rcnHsJIF{e2G7 NUTzTZlTOiC2bzCzJIRigXN? NF7NepVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB{IITvJFMh\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF0xNjB3Md88UU4> NVezS|RwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL MnnERY51cX[rcnHsJIF{e2G7 MnzKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB3Nd88UU4> M1r6UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
HEL MlfKRY51cX[rcnHsJIF{e2G7 NHvSTWQzKHSxIEOg[IF6ew>? MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IH3lZZN2emWmIHHmeIVzKDJidH:gN{Bl[Xm|IIDvd5QucW6oZXP0bY9vNCCHQ{WwQVAvODV5zszNMi=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
HEL NYHFZnpiTnWwY4Tpc44h[XO|YYm= NFqw[YFEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqNX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFqRzmgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvODcQvF2u NWG3V3dpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2OFM{OjhpPkG0OlQ{OzJ6PD;hQi=>
Hel NWXGbJZuTnWwY4Tpc44h[XO|YYm= M3jBNmVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZTCxJGtweyC|dILhbY4hcW6mdXPl[EBkgXSxcHH0bIlkcXS7IHnuJGhmdCClZXzsd{whTUN3ME2wMlA3|ryPLh?= NUf6cnJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2OVg5PThpPkG1OlU5QDV6PD;hQi=>
HEL MU\BcpRqfmm{YXygZZN{[Xl? MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= NGPBUXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO5Nlc6OSd-MU[zPVI4QTF:L3G+
HEL NUTrR5RuSW62aY\pdoFtKGG|c3H5 M3f5UGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= M3PxeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{myO|kyLz5zNkO5Nlc6OTxxYU6=
HEL MV3BcpRqfmm{YXygZZN{[Xl? MVKzJIRigXN? NUPFXmNoSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOiC|dILhbY4hTyCrbn\lZ5Rm\CCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:OC5yN988UU4> NIXQcIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi:FaFXNRmwoRkOqRV3CUFww[T5?
HEL NYrk[293SW62aY\pdoFtKGG|c3H5 NUe4eoZqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEhOwG0v NVO0eoQ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|g3PTNpPkOwO|M5PjV|PD;hQi=>
HELF MkDjRY51cX[rcnHsJIF{e2G7 MYm3JIRigXN? M17MPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVEZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yN988UU4> M4jqR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HEL NInI[VJCdnSrdnnyZYwh[XO|YYm= MUm3JIRigXN? NEnGU4NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPyCmYYnzMEBGSzVyPUCuNFjPxE1w M2T1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUK4OlY3Lz5{MUGyPFY3PjxxYU6=
HEL MVLBcpRqfmm{YXygZZN{[Xl? NFPq[Gk{KGSjeYO= NILoW4tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKHO2cnHpckBIKGmwZnXjeIVlKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1yLkC4{txONg>? MkDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL NELlPHBCdnSrdnnyZYwh[XO|YYm= M1;kN|Mh\GG7cx?= Mn3GRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA5|ryPLh?= NYTm[m9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
OST TK- cells M4nKO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kA2KHWPIEGtX|YuYzFuMT2o[IlxcGWweXypMVEuMDRvcInybYR6dCmvZYToc5h6ZWineInsYZRpgW2rbnWsJGlEPTB;MD6wPFHPxE1w M3:ybVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HEL MWrBcpRqfmm{YXygZZN{[Xl? MlTpN{Bl[Xm| MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJJN1emGrbjDLU3MhcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODoQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HEL MUTBcpRqfmm{YXygZZN{[Xl? MX\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEpOwG0v NIKye|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QCd-Mke2N|k{Pjh:L3G+
E6SM NGHYVJRCdnSrdnnyZYwh[XO|YYm= NFXDSoVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlvKEV4U12gZ4VtdHNuIF3JR|0xNjB7Nt88UU4> Mn\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOUK3NlgoRjF5MEmyO|I5RC:jPh?=
E6SM NG\tenRCdnSrdnnyZYwh[XO|YYm= NF;GUmRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFetbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpckBGPlOPIHPlcIx{NCCPSVO9NE4xQTcQvF2u Mlu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOUK3NlgoRjF5MEmyO|I5RC:jPh?=
HEL MWLBcpRqfmm{YXygZZN{[Xl? M1zjSmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFkgWOub4\pdk1z\XOrc4ThcpQhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlHPxE1w MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|MkiyPEc,OjF{M{K4Nlg9N2F-
HEL M{PIdWFvfGm4aYLhcEBie3OjeR?= MmfYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgRWNXNXKnc3nzeIFvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvOc7:TT6= NVvCcG1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
OST TK- cells M33MbmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NVtzLEGtLIRqeGinbonsLU0yNSh2LYD5dollgWxrbXX0bI95gV2qZYj5cH11cHmvaX7lMEBKSzVyPUCuNVHPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HFF NYPYdmNXSW62aY\pdoFtKGG|c3H5 NVLm[21uOTBiZHH5dy=> NGrSe41CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwZnXjeIVlKGmwIFjGSkBk\WyuczDpcoN2[mG2ZXSg[o9zKDFyIHThfZMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlE1|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSyNEc,OjF6MUK0NlA9N2F-
HFF M4fzVmZ2dmO2aX;uJIF{e2G7 NILzcXZKdmirYnn0bY9vKG:oIFjDUXYhSURzNkmgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JIN6fG:yYYTobYMh\W[oZXP0JIF{e2G7LDDFR|UxRTBwMUZOwG0v Mnj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MCA-TK M1jV[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nnemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2FQT3UT{Bk\WyuczygTWM2OD1yLkG1{txONg>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4MEmyOkc,OTd7NkC5NlY9N2F-
vero NGP6WpFCdnSrdnnyZYwh[XO|YYm= Mnr1RY51cX[rcnHsJIFkfGm4aYT5JJdieyCmZYTldo1qdmWmIHnuJJBt[XG3ZTDy[YR2[3Srb36gZZN{[XliaX6geoVzdyClZXzsd{Bi\2GrboP0JGhUXi1zIF[gd5Rz[WmwLDDJSFUxRTBwMt88UU4> NEPQ[oM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|OEexPFYxLz5|OEexPFYxRC:jPh?=
Vero MXnBcpRqfmm{YXygZZN{[Xl? MWnJckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImge4F{KG2nYYP1doVlKGGpYXnud5QhUFOYLUGoSkkhcW5iVnXyc{Bk\WyuczygTWQ2OD1yLkNOwG0v MmHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUixNUc,OzByOUixNVww[T5?
Vero MUTBcpRqfmm{YXygZZN{[Xl? NHKyZ2NCdnSrdnnyZYwh[WO2aY\peJkh\GW2ZYLtbY5m\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJR6eGViMTCoSkB{fHKjaX6pJIJ6KHCuYYH1[UBz\WS3Y4Tpc44hcW5iVnXyc{Bk\WyuczygTWQ2OD1yLkNOwG0v NHvtNpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG2NlY{Lz5|MEG2NlY{RC:jPh?=
HEL MmXYRY51cX[rcnHsJIF{e2G7 NHvXNmxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5{zszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL NYn1dW11SW62aY\pdoFtKGG|c3H5 NEi3Umw{KGSjeYO= MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JHRMNWSnZnXjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEOg[IF6eyCkeTDtbYNzd3Olb4DpZ{Bu\XSqb3SsJGVEPTB;MD6y{txONg>? Mn[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
fibroblast cells MnjiSpVv[3Srb36gZZN{[Xl? NF20VIxKdmirYnn0bY9vKG:oII\pdoFtKGO7dH;wZZRpcWNiZX\m[YN1KGmwIHnu[oVkfGWmIHj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscEBqdiCvb37vcIF6\XK|IH;mJGhUXi1{IFHEJHZmem9iY3XscJMh[nliNUClMEBGSzVyPUCuNlPPxE1w NUexbXBsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG1PFU1PTdpPkGxOVg2PDV5PD;hQi=>
HEL NUPNSnlvSW62aY\pdoFtKGG|c3H5 NHm0V|lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQyPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzMEBGSzVyPUCuNlXPxE1w MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG3PEc,OjdzMkixO|g9N2F-
vero NWDjd|hMSW62aY\pdoFtKGG|c3H5 Ml3YTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJZqenW|IFjTWk0yKCiIIIP0doFqdiliaX6geoVzdyClZXzsd{B1cXO|dXWgZ5VtfHW{ZTygTWQ2OD1yLkROwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTl|NkG1K|4zQTl|NkG1QE9iRg>?
HELF NXLtNG5ZSW62aY\pdoFtKGG|c3H5 NVHwR2xCPyCmYYnz MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMlPPxE1w MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HS27 MlqzRY51cX[rcnHsJIF{e2G7 NXHXO|V2PyCmYYnz M{X2TGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKU{K3JINmdGy|IHHmeIVzKDdiZHH5d{BjgSCJRmCtZoF{\WRiZnz1c5Jme2OnboSgdoVlfWO2aX;uJIF{e2G7LDDFR|UxRTBwM{NOwG0v NHeyRng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC0O|kyOSd-MkCwOFc6OTF:L3G+
HEL MVrBcpRqfmm{YXygZZN{[Xl? M4\STGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;MD6zPO69VS5? MnH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MUG4OVYoRjJ|OUGxPFU3RC:jPh?=
HEL MkL1RY51cX[rcnHsJIF{e2G7 NV3Qe3hySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IEC3M|EhcW6oZXP0[YQhcW5iSFXMJINmdGy|LDDFR|UxRTBwNN88UU4> NHX0W|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE4QCd-MkexNlgyPzh:L3G+
HEL NIO5cYVCdnSrdnnyZYwh[XO|YYm= NEPrVmhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvPM7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HEL NXLNSVJvSW62aY\pdoFtKGG|c3H5 NHu5TlhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC52ON88UU4> NXjLdmh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjJpPkG3NVgyOTZ{PD;hQi=>
HFF MonCSpVv[3Srb36gZZN{[Xl? NHj1Oo1KdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gc4YhfGinIHTyeYch[WejaX7zeEB1cGViY4n0c5BifGirYzDl[oZm[3RiZn;yJGFFOTZ7IIP0doFqdiCxZjDldJN1\WmwIHLhdpIhfmm{dYOtNkApUEOPVjmgbY4hcHWvYX6gTGZHKGOnbHzzMEBGSzVyPUCuOe69VS5? M2HWPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh|OUS5N|MoRjh|OUS5N|M9N2F-
HEL M4fFbWZ2dmO2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGNOXiCGTlGgd5lvfGinc3nzJIlvKEOPVj3pcoZm[3SnZDDISWwh[2WubIOsJGlEPTB;MD61{txONg>? NX\ZSGtLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{e1NlIxPSd-N{e1NlIxPTxxYU6=
HEL M{Xve2FvfGm4aYLhcEBie3OjeR?= NHr6eJdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlXPxE1w NVji[lU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFE{PDRpPkK2NFAyOzR2PD;hQi=>
HELF MXLBcpRqfmm{YXygZZN{[Xl? M2fwfmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JIFkgWOub4\pdk1z\XOrc4ThcpQhUHWvYX6gbIVzeGW|dnnyeZMhOSCNT2Ogd5Rz[WmwIHnu[oVkfGWmIHnuJGhGVEZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwNd88UU4> NGX5NYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
Vero M2PtdmFvfGm4aYLhcEBie3OjeR?= MUKzOkBpenN? M2XoT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXiB{IHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44hcW6ldXLheIVlKG[xcjCzOkBpenNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGVEPTB;MD61PO69VS5? MojjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzJzOUG0OVYoRjN{MUmxOFU3RC:jPh?=
HEL MWjBcpRqfmm{YXygZZN{[Xl? M1\iS|Uh\GG7cx?= MoLTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWoFzcWOnbHzhJJpwe3SncjD2bZJ2eyCRS1GgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEWg[IF6eyxiRVO1NF0xNjV7zszNMi=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HEL MoPpRY51cX[rcnHsJIF{e2G7 M{Cwd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLk[2{txONg>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
HEL NGXkPJBCdnSrdnnyZYwh[XO|YYm= NVTTcmRJSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDFiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuOlnPxE1w M4DjelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL NF\NWG9CdnSrdnnyZYwh[XO|YYm= M2fG[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkhOwG0v MmHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
Vero NYnpO21ESW62aY\pdoFtKGG|c3H5 MWOzOkB1dyB2ODDodpM> NVqye4J2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDGJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMheGyjcYXlJJJm\HWldHnvckBi\nSncjCzOkB1dyB2ODDodpMtKEWFNUC9NE44|ryPLh?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC2NUc,OTd2M{iwOlE9N2F-
HFF M2XZfGFvfGm4aYLhcEBie3OjeR?= NEizdJY5KHSxIEGwJIRigXN? NYHh[3ZySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDURlQxKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckB1emWjdHXkJJdqfGhiY3;tdI92dmRiZn;scI94cW6pII\pdoFtKGmwZnXjeIlwdiCjbnSgbY5kfWKjdHXkJIZweiB6IITvJFExKGSjeYOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZoF{\WRiYYPzZZktKEWFNUC9NE44Os7:TT6= NXrqRm43RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
fibroblast cells MnjBRY51cX[rcnHsJIF{e2G7 M{\LfFEhcG:3ch?= MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSWRzNkmgLHdVMSCybHHxeYUh\m:{bXnu[{B2dmm2IHfyc5dvKG:wIFj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscJMhfXCxbjDpcoN2[mG2aX;uJIZweiBzIHjveZIh[XRiM{eg[IVoemWnczDDJJdqfGhiY3;tdI92dmRiZHnzd49tfmWmIHnuJGROW09uIFnDOVA:OC56zszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjF|NEm0Okc,OTZzM{S5OFY9N2F-
fibroblast cells M1HVXGFvfGm4aYLhcEBie3OjeR?= MnnWNUBpd3W{ MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSWRzNkmgLHY5OjODKTDwcIFyfWViZn;ycYlv\yC3bnn0JIdzd3ewIH;uJGh2dWGwIH\vdoV{c2mwIH\pZpJw[myjc4SgZ4VtdHNidYDvckBqdmO3YnH0bY9vKG[xcjCxJIhwfXJiYYSgN|ch\GWpcnXld{BEKHerdHigZ49ueG:3bnSg[Il{e2:udnXkJIlvKESPU1:sJGlEPTB;MD64{txONg>? NI\vPYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkGzOFk1Pid-MU[xN|Q6PDZ:L3G+
E6SM NG\0UnRCdnSrdnnyZYwh[XO|YYm= NWf3RWRlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDUT{0hU0:VIFHDWk1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlvKEV4U12gZ4VtdHNuIF3JR|0xNjkQvF2u NH7PeGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C5NlczQCd-MUewPVI4Ojh:L3G+
HEL MULBcpRqfmm{YXygZZN{[Xl? MUC0JIRigXN? M3PQdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzMVEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TT6= MnLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4OU[5OlMoRjJzNkm2PVY{RC:jPh?=
HEL M1zJSGFvfGm4aYLhcEBie3OjeR?= NHPUfGJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLklOwG0v NYD2ZVNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL NHPvXpNCdnSrdnnyZYwh[XO|YYm= NVHXbYNuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[W6mIHHjbYNtd3[rcjDy[ZNqe3SjboSgbIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TT6= M3HpOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{O4OlU{Lz5|MEezPFY2OzxxYU6=
HELF NEjvdXZCdnSrdnnyZYwh[XO|YYm= NEKwcow4KGSjeYO= MmT3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCWSz3LU3MuSUOYIHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE45|ryPLh?= MlzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HEL M2rOWGFvfGm4aYLhcEBie3OjeR?= MX3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuPe69VS5? M4DuSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU3Lz5{M{mxNVg2PjxxYU6=
CRFK MomwRY51cX[rcnHsJIF{e2G7 M{XxN2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDI[ZJx\XNidnnyeZMhcW6oZXP0[YQhcW5iY3H0JGNTTktiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlnPxE1w MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
Vero MWLBcpRqfmm{YXygZZN{[Xl? NYDI[nB4OyCmYYnz MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKHO2cnHpckBHKF[ULUezN{Bqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;MD65{txONg>? NWXZW2tGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlA5QDNpPkK2OFYxQDh|PD;hQi=>
MRC5 MVvBcpRqfmm{YXygZZN{[Xl? NF;PTZdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIHnuJG1TSzViY3XscJMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlky|ryPLh?= NYHJOJpmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyN|k2QTRpPkG3NlM6PTl2PD;hQi=>
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HEL M370PWFvfGm4aYLhcEBie3OjeR?= NFvpelNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBCS1ZvcnXzbZN1[W62IGTLMYRm\mmlaXXueEBJW1ZvMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2x{txONg>? M{jtPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{m1NlM5Lz5{M{e5OVI{QDxxYU6=
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HEL NFXOS5NCdnSrdnnyZYwh[XO|YYm= NGri[5FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJWE2SQT3y[ZNqe3SjboSgTGNOXiCDREG2PUBkdG:wZTCyJI12fGGwdDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NU4z|ryPLh?= M4H4T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
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HFF MnTGSpVv[3Srb36gZZN{[Xl? MXfDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCWb4fu[UB{fHKjaX6gc4YhUEOPVjDpckBiKHmrZXzkJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDPVA:OS54zszNMi=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HFF MVnGeY5kfGmxbjDhd5NigQ>? NInaXWZEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIJ6KHmrZXzkJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDPVA:OS54zszNMi=> NXzLTHZORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzVpPkGwPFgzOzd3PD;hQi=>
HFF MYLBcpRqfmm{YXygZZN{[Xl? MoLkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeI94dmVic4TyZYlvKEiFTW[ge4F{KGSndHXycYlv\WRiYomgfYlmdGRicnXkeYN1cW:wIHHzd4F6KGmwIHT1dIxq[2G2ZTD3[YxteyC3c3nu[{BJTkZiY3XscJMtKEmFOUC9NU43|ryPLh?= NGDCTWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4OCd-MUC4PFI{PzB:L3G+
HFF MXrBcpRqfmm{YXygZZN{[Xl? MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKHejczDk[ZRmem2rbnXkJIJ6KHmrZXzkJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDPVA:OS54zszNMi=> MmrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|IoRjFyOEiyN|czRC:jPh?=
MRC5 NEfmfI1CdnSrdnnyZYwh[XO|YYm= MVS3JIRigXN? NUS2SFdvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IHnu[oVkfGWmIHnuJIh2dWGwIF3SR|Uh[2WubIOgZYZ1\XJiNzDkZZl{KGK7IFfGVE1j[XOnZDDmcJVwemW|Y3XueEBz\WS3Y4Tpc44h[XO|YYmsJGVEPTB;MT62Oe69VS5? NIjVeXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC0O|kyOSd-MkCwOFc6OTF:L3G+
HEL MlH3RY51cX[rcnHsJIF{e2G7 NYH5NYN4PCCmYYnz M1\JTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSE0yPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNicHzhdZVmKG[xcn3heIlwdiCjZoTldkA1KGSjeYOsJGVEPTB;MT62Oe69VS5? M{DQTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL M2nkdWFvfGm4aYLhcEBie3OjeR?= MnvFOEBl[Xm| MlvqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNDDkZZl{NCCHQ{WwQVEvPjYQvF2u M4DQT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HFF NWnFVWJCTnWwY4Tpc44h[XO|YYm= Ml3ETY5pcWKrdHnvckBw\iCKQ13WJJRwf26nIILldIxq[2G2aX;uJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVEvQM7:TT6= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzByNEeyOkc,OTdyMES3NlY9N2F-
HFF NV7sRWtOSW62aY\pdoFtKGG|c3H5 MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gRWQyPjliaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD1zLkpOwG0v NETOW5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
HEL MomxRY51cX[rcnHsJIF{e2G7 MkfCO{Bl[Xm| NV;5Om5{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5Rqdm[nY4Tpc44tKEWFNUC9Nu69VS5? M1y2bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF M{nzfmZ2dmO2aX;uJIF{e2G7 MoXHTY5pcWKrdHnvckBw\iCKQ13WJHRwf26nIILldIxq[2G2aX;uJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvOc7:TT6= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
HFF NVy4RZVVSW62aY\pdoFtKGG|c3H5 MnrOPEBl[Xm| NXLSSpBSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpcoZm[3SnZDDpckBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDhiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUKuNe69VS5? MmTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4MEe4PFMoRjJ{NkC3PFg{RC:jPh?=
HEL NUf2emJbSW62aY\pdoFtKGG|c3H5 MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1{LkJOwG0v NWPWPYlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
HFF NGC3UlFCdnSrdnnyZYwh[XO|YYm= MXy4JJRwKDFyIHThfZM> M{XZZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVH;3coUhcW6oZXP0[YQhcW5iaIXtZY4hUE[IIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBxdGGzdXWg[o9zdWG2aX;uJJRz\WG2ZXSge4l1cCClb33wc5Vv\CCob3zsc5dqdmdidnnyZYwhcW6oZXP0bY9vKGGwZDDpcoN2[mG2ZXSg[o9zKDhidH:gNVAh\GG7czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhTUN3ME2yMlHPxE1w NVnDSGtoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
Vero NW\2SGFESW62aY\pdoFtKGG|c3H5 M3n3NFMh\GG7cx?= MYnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgWnIuQDB5IHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0zNjF2zszNMi=> M3;1XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[wPFg{Lz5{NkS2NFg5OzxxYU6=
HFF NULHcIV[TnWwY4Tpc44h[XO|YYm= NGLiSlFKdmirYnn0bY9vKG:oIFjDUXYhSURzNkmgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JGNRTSCrbnjpZol1cW:wIHHzd4F6NCCHQ{WwQVIvOs7:TT6= NGHobI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[xOVU1PSd-MUW2NVU2PDV:L3G+
HEL NI\SWYJCdnSrdnnyZYwh[XO|YYm= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVIvOjoQvF2u M2foO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEiwNlUyLz5{OUi4NFI2OTxxYU6=
HEL MoLRRY51cX[rcnHsJIF{e2G7 NHTRZ3Y2KGSjeYO= MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDUT{shXlqYIGnTJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjDh[pRmeiB3IHThfZMtKEWFNUC9Nk4{|ryPLh?= NWLYU29qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NlIyOjhpPkG3OlIzOTJ6PD;hQi=>
HELF MUHBcpRqfmm{YXygZZN{[Xl? M1zwelch\GG7cx?= M334R2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlv[3WkYYTl[EBnd3JiNzDkZZl{KGK7IFfp[Y1{[SC|dHHpcolv\yCkYYPl[EBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0zNjQQvF2u NWC0NHFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HEL299 NEfLZYJCdnSrdnnyZYwh[XO|YYm= NIjyNJI4KGSjeYO= NF\MXWJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gTGVNOjl7IHPlcIx{KGGodHXyJFch\GG7czDifUBITlBvYnHz[YQh\my3b4Lld4NmdnRicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvOzoQvF2u MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB2N{mxNUc,OjByNEe5NVE9N2F-
HFF M13L[WZ2dmO2aX;uJIF{e2G7 MWDJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIFO0JJN1emGrbjCoWWw2PiBtIGXMPFkhdXW2YX70JIdmdmVrIHX4dJJme3OnZDDpckBJTkZiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1{LkZOwG0v NFmwNHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
HFF M1;FXmFvfGm4aYLhcEBie3OjeR?= M1zY[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF0zNjYQvF2u MmW3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEK0NVAoRjF6MEiyOFExRC:jPh?=
HEL MUjBcpRqfmm{YXygZZN{[Xl? NHKxXGQ4KGSjeYO= M2niTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5QhcW6oZXP0bY9vNCCHQ{WwQVIvPc7:TT6= NEXRfG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL NH7JdXFCdnSrdnnyZYwh[XO|YYm= MoPuOUBl[Xm| NHfYcIZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJIRm\mmlaXXueEBX[XKrY3XscIEhgm:|dHXyJJZqenW|IEC3M|EhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyJFUh\GG7czygSWM2OD1{LkZOwG0v MlvPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|M{mwPFIoRjF7M{O5NFgzRC:jPh?=
HFF NFS5foRHfW6ldHnvckBie3OjeR?= M1XQbWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{Bz\XCuaXPheIlwdiCrbjDISmYh[2WubIOge4F{KGSndHXycYlv\WRiYomgZ5l1d3CjdHjpZ{Bm\m[nY4SgbY5pcWKrdHnvckBie3OjeTygTWM2OD1{LkdOwG0v MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDN6MEG3K|46PDN6MEG3QE9iRg>?
HEL NVXFNlNlSW62aY\pdoFtKGG|c3H5 MkHrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[o9{[2G{bnX0MZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJGMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTJwNt88UU4> M3vJUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF NFPONYZCdnSrdnnyZYwh[XO|YYm= NXnLV21iSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkSxO{B4cXSqIIDvcEBCQDB7VjDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2yMlbPxE1w NFLSTYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL M4e5XmFvfGm4aYLhcEBie3OjeR?= MVq3JIRigXN? MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhTGG4aYOgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF0zNjcQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ5MkS0OUc,OTd4N{K0OFU9N2F-
CRFK NUHkRpBySW62aY\pdoFtKGG|c3H5 NVXObGlUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTmWuaX7lJIhmenCnc4\pdpV{KGmwZnXjeIVlKGmwIHPheEBEWk[NIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36g[pJwdSC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIJ6KE2WVDDhd5NigSxiRVO1NF0zNjcQvF2u MnzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HFF MVXBcpRqfmm{YXygZZN{[Xl? M2D0W2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ3NEKge4l1cCCyb3ygWFgyO1NibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mj63{txONg>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL NHLEW2VCdnSrdnnyZYwh[XO|YYm= NWnYXJZISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDEZZZqeyCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9Nk44Pc7:TT6= M3nOTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL NV\hNVR3SW62aY\pdoFtKGG|c3H5 M3e1[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUKuPVbPxE1w MlvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
BSC-1 MUjBcpRqfmm{YXygZZN{[Xl? MWPBcpRqfmm{YXygZYN1cX[rdImgc4YhfGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh[WejaX7zeEB1cGViSHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIHnuJGJUSy1zIHPlcIx{NCCLQ{WwQVPPxE1w M4W5NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOzNFAoRjJ7MUOzNFA9N2F-
MRC5 NH6xWJpHfW6ldHnvckBie3OjeR?= Mln3TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiQVSxOlkhe3S{YXnuJI9nKEiFTW[gbY4hVVKFNTDj[YxteyxiSVO1NF0{|ryPLh?= NGHGeGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUS1OFQ3PSd-MUG0OVQ1PjV:L3G+
HFF NG\xcINCdnSrdnnyZYwh[XO|YYm= MonrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCWb4fu[UBqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0{|ryPLh?= NFLpVXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G2NVk1Pid-MUexOlE6PDZ:L3G+
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HEL M1\QSGFvfGm4aYLhcEBie3OjeR?= M1fPdlch\GG7cx?= M37wW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhUFOYMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDdiZHH5d{whTUN3ME2z{txONg>? MlO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HFF MYnBcpRqfmm{YXygZZN{[Xl? MVKxNEBl[Xm| M2PSPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgNVAh\GG7czygTWM2OD1|zszNMi=> M1Oz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkSxNlE5Lz5{MU[0NVIyQDxxYU6=
HEL M3vu[mFvfGm4aYLhcEBie3OjeR?= NHTWdZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2zMlHPxE1w NI[wNHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxNVg2Pid-MkO5NVE5PTZ:L3G+
HEL MkHURY51cX[rcnHsJIF{e2G7 M4HP[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUOuNe69VS5? M3rrVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HELF NEHlSJJCdnSrdnnyZYwh[XO|YYm= NGnqR3Q4KGSjeYO= MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpcoN2[mG2ZXSg[o9zKDdiZHH5d{BjgSCJaXXtd4Ehe3SjaX7pcoch[mG|ZXSgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9N{4yPc7:TT6= NYXvUY06RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HFF NULTXWp4SW62aY\pdoFtKGG|c3H5 NIjVRnhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBo[W6laXPsc5Zqei2|ZX7zbZRqfmViSFPNWlEhcXOxbHH0[UBz\XCuaXPheIlwdiCrbjDISmYh[2WubIOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1|LkKy{txONg>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzME[4OEc,OTlyMUC2PFQ9N2F-
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HEL NGjidVhCdnSrdnnyZYwh[XO|YYm= M3XjeFYhfG9iNzDkZZl{ NHHiO5FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2LXnu[oVkfGmxbjygSWM2OD1|LkOx{txONg>? NXXtb5hVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
MEF NI[5fmVHfW6ldHnvckBie3OjeR?= MYrJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCvdYLpcoUh[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIF3FSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVMvPM7:TT6= M2S5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl2M{iwNVcoRjl2M{iwNVc9N2F-
BSC-1 MUDBcpRqfmm{YXygZZN{[Xl? NHfBZm5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTCobIVzeGW|IIPpcZBt\XhidnnyeZMqNCCmZYTldo1qdmWmIHL5JGVNUVODIHnuJJF2[WS{dYDsbYNifGVid3XscJMhfXOrbnegRnNENTFiY3XscJMtKEmFNUC9N{42|ryPLh?= MojzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|AoRjFyOEiyN|cxRC:jPh?=
BSC-1 MnnxSpVv[3Srb36gZZN{[Xl? MUfFUGlUSSCjc4PhfUB4[XNicHXy[o9zdWWmIIXzbY5oKEKVQz2xJINmdGy|IITvJIRmfGW{bXnu[UBi[3Srdnn0fUBi\2GrboP0JGhUXi1zLDDJR|UxRTNwNd88UU4> M33UPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|czLz5zMEi4NlM4OjxxYU6=
BSC-1 M1rkbWFvfGm4aYLhcEBie3OjeR?= MlPtTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFidnnyeZMhcW5iQmPDMVEhMG2xbnvlfUBscWSwZYmpJINmdGy|LDDJR|UxRTNwNd88UU4> NVLIemRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3PSd-OUC1O|g3PTxxYU6=
HEL MXnBcpRqfmm{YXygZZN{[Xl? NF3SR49CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBRVUWGQWCtdoV{cXO2YX70JGhEVVZiQVSxOlkh[2yxbnWgOEBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:Oy53zszNMi=> M3rsNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF NFfBbJhCdnSrdnnyZYwh[XO|YYm= Mof3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjR{MDD3bZRpKHCxbDDHPFQySSCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1|LkZOwG0v NXnUN4FORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
BSC-1 M2rW[WZ2dmO2aX;uJIF{e2G7 MYTJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB3cXK3czD0fZBmNTFiKFjTWk0yMSCneIDy[ZN{\WRiaX6gRnNENTFiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkhTUyLU1GgZZN{[XluIFnDOVA:Oy53zszNMi=> MmixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|QoRjF3NUC5NVc1RC:jPh?=
BSC-1 MUDGeY5kfGmxbjDhd5NigQ>? NWrsNnV4UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJEhJW1ZvMTmg[ZhxemW|c3XkJIlvKEKVQz2xJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IFXMTXNCKGG|c3H5MEBKSzVyPUOuOe69VS5? MoWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|UoRjF3NUC5NVc2RC:jPh?=
BSC-1 NHy1dlJHfW6ldHnvckBie3OjeR?= NYLiOoZMUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJEhJW1ZvMTmg[ZhxemW|c3XkJIlvKEKVQz2xJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IFXMTXNCKGG|c3H5MEBKSzVyPUOuOe69VS5? MmLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|YoRjF3NUC5NVc3RC:jPh?=
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HEL M4HkUGFvfGm4aYLhcEBie3OjeR?= NHL3fWM4KGSjeYO= MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1|LkdOwG0v Mli5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HFF NHW2b3hCdnSrdnnyZYwh[XO|YYm= NVfr[ZRjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkK1PEB4cXSqIGXMPVchSzV7MlegcZV1[W62IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{46|ryPLh?= MkG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL M1j0b2FvfGm4aYLhcEBie3OjeR?= NFKyeFIzKHSxIEOg[IF6ew>? NWTRbVI6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[U1l\W[rY3nlcpQhSUOYLYLld4l{fGGwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uJI1m[XO3cnXkJIFnfGW{IEKgeI8hOyCmYYnzJJBwe3RiaX7m[YN1cW:wLDDFR|UxRTNwOUJOwG0v NIrjc3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
MRC-5 M3zQR2FvfGmqZYLw[ZN3cXK3czDhd5NigQ>? NF3nPY9KdiC4aYTyc{BidnSraHXydIV{fmm{dYOgZYN1cX[rdImgZYdicW6|dDDNVmMuPSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjDUXYhMEGGLUG2PUB{fHKjaX6pMEBKSzVyPUVOwG0v M3q5OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF|MkO2O|goRjF|MkO2O|g9N2F-
HEL NYTZdItISW62aY\pdoFtKGG|c3H5 NEnTbppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBkcWSxZn;2bZIhUEOPVjDBSFE3QSClbH;u[UA2KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF01|ryPLh?= MmnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HEL M1SyUmFvfGm4aYLhcEBie3OjeR?= M4jN[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY4njcI93cXJvcnXzbZN1[W62IFjTWlEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:PM7:TT6= M{D1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEm5NFk4Lz5{M{C5PVA6PzxxYU6=
HEL M3jX[2FvfGm4aYLhcEBie3OjeR?= M2Da[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHRMNW6nZ3H0bZZmKEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> MnnyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
HEL NVHQUmtMSW62aY\pdoFtKGG|c3H5 MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> NGXGTWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HEL M3XYbWFvfGm4aYLhcEBie3OjeR?= NG\GXlJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME20MlA2|ryPLh?= NG\LUnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k6OCd-Mkm0NFc6QTB:L3G+
HFF NXLFPVE5TnWwY4Tpc44h[XO|YYm= Ml61R49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3RiQz20JHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND6x{txONg>? MkXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HFF MVHBcpRqfmm{YXygZZN{[Xl? M1[3RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVOjJ7MTDpckBJTkZiY3XscJMh[nliUGLBMEBKSzVyPUSuNe69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
CRFK NFHvfFVCdnSrdnnyZYwh[XO|YYm= NGizPFc1KGSjeYO= M{TQUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:PC5zzszNMi=> NVmwOZJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
CRFK NXzn[JloSW62aY\pdoFtKGG|c3H5 NXPJdo1tSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\mWuaX7lJIhmenCnc4\pdpV{KGmwZnXjeIVlKGmwIHPheEBEWk[NIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JG1VWyCjc4PhfUwhTUN3ME20MlHPxE1w NYnJRVdGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HEL MnjjRY51cX[rcnHsJIF{e2G7 MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDnZY5kcWOub4\pdk1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UA1KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD12LkROwG0v MkTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HEL M1PNdGFvfGm4aYLhcEBie3OjeR?= MmPWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWNXNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUSuN:69VS5? NVj3WFBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
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HEL Mon1RY51cX[rcnHsJIF{e2G7 NWD0SoRxPyCmYYnz NWf5PYhGSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:PC55Mt88UU4> Mn34QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUGwN|goRjJ4MkmxNFM5RC:jPh?=
HEL MXzBcpRqfmm{YXygZZN{[Xl? NE\VO4o4KGSjeYO= MojwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGyjcYXlJIZwem2jdHnvckBi\nSncjC3JIRigXNuIFXDOVA:PC56zszNMi=> NYrmfHJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1N|k3OjJpPkG3OVM6PjJ{PD;hQi=>
HEL NYC3boxJSW62aY\pdoFtKGG|c3H5 MYCzJIRigXN? NE[4ZVFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:PC56zszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4MUi1NUc,OTd7NkG4OVE9N2F-
HEL M2DZT2FvfGm4aYLhcEBie3OjeR?= MV[2JJRwKDdiZHH5dy=> M{LwOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKG2nYYP1doVlKGGodHXyJFYhfG9iNzDkZZl{KHCxc4SgbY5n\WO2aX;uMEBGSzVyPUSuPFPPxE1w NX;sV2pxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC5 NH:1[lZCdnSrdnnyZYwh[XO|YYm= NX3MOVU5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFSxd37lJIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVQvQc7:TT6= Mn[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
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CEM M3TFfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHTBZ5REgXSxdH;4bYNqfHliYXfhbY5{fCCFRV2gZ4VtdHNuIFPDOVA:Pc7:TT6= MlrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1OFUoRjF3NkG1OVQ2RC:jPh?=
HFF M3r5VmFvfGm4aYLhcEBie3OjeR?= NXjmZ5JHPSC2bzC3JIRigXN? M2[0TWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiaX7m[YN1\WRiSF\GJINmdGy|IHHmeIVzKDVidH:gO{Bl[Xm|IHL5JJZqemGuIInp[YxlKGG|c3H5MEBGSzl7Lkm9Oe69VS5? M{TNZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{K5NVA{Lz5zN{OyPVExOzxxYU6=
HEL MnjuRY51cX[rcnHsJIF{e2G7 NGPpN5E4KGSjeYO= M37zXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IEeg[IF6eyxiRVO1NF02NjIQvF2u NFe1XWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
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HEL M{nuXmFvfGm4aYLhcEBie3OjeR?= NVPEVFNMSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OU43O87:TT6= NIDSXGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k6OCd-Mkm0NFc6QTB:L3G+
NIH 3T3 M3zSVGFvfGm4aYLhcEBie3OjeR?= NXLhVpVwPCC2bzC1JIRigXN? Mnq0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIHP5eI9u\WejbH;2bZJ2eyC|dILhbY4hW22rdHigbY5n\WO2ZXSgbY4hdW:3c3WgUmlJKDOWMzDj[YxteyCjZoTldkA1KHSxIEWg[IF6eyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVUvP87:TT6= M1HzRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEW4NVI1Lz5zOES1PFEzPDxxYU6=
RG2TK+ NYjSeIo1S3m2b4TvfIlkcXS7IHHzd4F6 MX23NkBpenN? NYLI[pJxS3m2b4TvfIlkcXS7IHHnZYlve3RiSGPWNU11cyCpZX7lJI93\XKneIDy[ZN{cW6pIGLHNnRMMyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUWuPFbPxE1w NFvw[3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiwNFc3PCd-MUi4NFA4PjR:L3G+
MRC-5 MmPmSpVv[3Srb36gZZN{[Xl? NYfQWYVjS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3Wgeolz[WxicHzhdZVmKG[xcn3heIlwdiCkeTDIeY1idiCFeYTvcYVo[WyxdnnyeZMhMEiFTW[pJEh{fHKjaX6gRWQuOTZ7KTDpckBOWkNvNTDj[YxteyxiSVO1NF02NjoQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODl4Nke0NEc,OTB7Nk[3OFA9N2F-
HEL MYPBcpRqfmm{YXygZZN{[Xl? NFLPemdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;NT65{txONg>? M33VbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
HEL NIPhZmpCdnSrdnnyZYwh[XO|YYm= NGDVe5hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgSIF3cXNiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCybHHxeYUh\m:{bXH0bY9vNCCHQ{WwQVUvQTkQvF2u NVThVndORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HCMV AD 169 NFnxc5BCdnSrdnnyZYwh[XO|YYm= NFL2SYJKdiC4aYTyc{BidnSrdnnyZYwh[W6mIHHueIlk\WyudXzhdkBi[3Srdnn0fUB4[XNiZY\hcJVifGWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YIFHEJFE3QSliaX6gLGhEVVZiQVSgNVY6MSClZXzsd{whUUR3ME22{txONg>? MnixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{[xOUc,Ojl7M{[xOVww[T5?
HEL NWW0bIhbSW62aY\pdoFtKGG|c3H5 MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Nt88UU4> NFzWNJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HEL NVXPdJFVSW62aY\pdoFtKGG|c3H5 MVGzJIRigXN? MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JHRMNWSnZnnjbYVvfCCKZYDy[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9Ou69VS5? Mny2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HFF M3eyZWFvfGm4aYLhcEBie3OjeR?= NWfWPGNqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMke4OEB4cXSqIIDvcEBCQDB7VjDVUFk4KEN3OULHJIRwfWKuZTDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME22MlHPxE1w MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL MVjBcpRqfmm{YXygZZN{[Xl? M4juVlch\GG7cx?= NWfJ[HZYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:Pi5zMt88UU4> M2jKdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkmxNFM5Lz5{NkK5NVA{QDxxYU6=
MRC-5 NVv1bVdyTnWwY4Tpc44h[XO|YYm= MVrJcohq[mm2b4L5JINwdmOnboTyZZRqd25iZn;yJIFvfGlvSFPNWkBi[3Srdnn0fUBi\2GrboP0JGFFNTF4OTDzeJJicW5iaX6gUXJENTViY3XscJMtKEmFNUC9Ok4{|ryPLh?= NGDYT|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEO2OlE{Lz57OEO2OlE{RC:jPh?=
HEL NHH6VZJCdnSrdnnyZYwh[XO|YYm= MVnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5JIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD14LkROwG0v M3\xXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL NW\RblZESW62aY\pdoFtKGG|c3H5 NHjkWXVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF03NjQQvF2u M{Wwe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL MmHqRY51cX[rcnHsJIF{e2G7 M2jOSVYhfG9iNzDkZZl{ MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD14LkS2{txONg>? NHLvTow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
HEL M4nCcGFvfGm4aYLhcEBie3OjeR?= MUG3JIRigXN? MnX1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR21XKEGGMU[5JIlvKGi3bXHuJGhGVCClZXzsd{Bi\nSncjC3JIRigXNuIFXDOVA:Pi53zszNMi=> NUTYTpYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2O|I1PDVpPkG3OlczPDR3PD;hQi=>
HEL MWPBcpRqfmm{YXygZZN{[Xl? NWLiVo5uSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNicHzhdZVmKG[xcn3heIlwdixiRVO1NF03NjYQvF2u NXfMZ|FORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
HELF MnzPRY51cX[rcnHsJIF{e2G7 MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgd5Rz[WmwIHnu[oVkfGWmIHnuJGhGVEZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTZwNUNOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OES4NUc,OzByOUi0PFE9N2F-
HEL NU[xRVJySW62aY\pdoFtKGG|c3H5 MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Nj61OO69VS5? NELNZ3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HFF MkXvRY51cX[rcnHsJIF{e2G7 M3fkTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ5OUige4l1cCCyb3ygWFgyO1NiVVy5O{BEPTl{RzDkc5VjdGVibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Nj62{txONg>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL M1X5XGFvfGm4aYLhcEBie3OjeR?= M2rMTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPU[uO|nPxE1w NXzLSmJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
HEL NILMVoFHfW6ldHnvckBie3OjeR?= NWG4em5uUW6qaXLpeIlwdiCjZ3HpcpN1KESQQTDv[kB2dmmwZnXjeIVlKEiHTDDj[YxteyCkeTDpcoNwenCxcnH0bY9vKG:oIGuzTH1V\FJuIFnDOVA:P87:TT6= M2DQPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd5NUKyNFUoRjd5NUKyNFU9N2F-
HFF M{LxemFvfGm4aYLhcEBie3OjeR?= MmfuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjlzIHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTdwMd88UU4> NHvJbZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
HEL MVPBcpRqfmm{YXygZZN{[Xl? NUW5UWpVSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTdwMd88UU4> NYXwZ2lwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HEL NVHqbYhKSW62aY\pdoFtKGG|c3H5 NYPjZY9KSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjIQvF2u MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
CRFK MWrBcpRqfmm{YXygZZN{[Xl? NH7SWmM{KGSjeYO= NHK4R5hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrZDDo[ZJx\XO4aYL1d{AyKGmwZnXjeIVlKGOjdDDDVmZMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVcvO87:TT6= M3:wNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
HEL NXPUfZRRSW62aY\pdoFtKGG|c3H5 NX[4[2NmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nz6z{txONg>? NFfvbms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HFF NFXORpVCdnSrdnnyZYwh[XO|YYm= NGe3UGZKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIDjUc5dv\SC|dILhbY4qKGmwIFjGSkApcHWvYX6g[oljem:kbHHzeEkh[2WubIOsJGlEPTB;Nz60{txONg>? MlHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB3N{i2OUc,QTB3N{i2OVww[T5?
HFF NIOwZ3dHfW6ldHnvckBie3OjeR?= MlrMTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIFjGSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVcvPM7:TT6= Mnn6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
HFF M3KzfGZ2dmO2aX;uJIF{e2G7 MVHDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCWb4fu[UB{fHKjaX6gc4YhUEOPVjDpckBiKHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> M4PMWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HFF M3:3eGZ2dmO2aX;uJIF{e2G7 M{HhUmNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjmgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDOVA:Py52zszNMi=> NEK3ZZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PSd-MUC4PFI{PzV:L3G+
HFF NIXFbYNCdnSrdnnyZYwh[XO|YYm= MlvaRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeI94dmVic4TyZYlvKEiFTW[ge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSCrbjDkeZBtcWOjdHWge4VtdHNidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= M{S2SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|cxLz5zMEi4NlM4ODxxYU6=
HFF MXjBcpRqfmm{YXygZZN{[Xl? Mn7zRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v NUe5[4lIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzJpPkGwPFgzOzd{PD;hQi=>
HFF M2TCdGZ2dmO2aX;uJIF{e2G7 MWXJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHX4dJJme3OnZDDpckBJTkZiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD15LkVOwG0v NVnaPY1kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzRpPkG1OVA6OTd2PD;hQi=>
HFF NXi4co84TnWwY4Tpc44h[XO|YYm= M1PlTmlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjmg[ZhxemW|c3XkJIlvKEiIRjDj[YxteyC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUeuOO69VS5? MnqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|UoRjF3NUC5NVc2RC:jPh?=
HFF MmjhSpVv[3Srb36gZZN{[Xl? NXeyUW9xUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBmgHC{ZYPz[YQhcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= M1TBcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HEL NXvWVlY{SW62aY\pdoFtKGG|c3H5 MkDURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGLUG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTdwNN88UU4> NFPnV3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HEL MnPJRY51cX[rcnHsJIF{e2G7 NXrzeZVlPiC2bzC3JIRigXN? MlHERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiNjD0c{A4KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:Py52Md88UU4> NVriNHAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL MYrBcpRqfmm{YXygZZN{[Xl? NXriXXJiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTdwNd88UU4> NWXVTIFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HFF MXjBcpRqfmm{YXygZZN{[Xl? MXXBcpRqfmm{YXygZYN1cX[rdImge4F{KGSndHXycYlv\WRiYomgeIhmKEiFTW[gdIxieXWnIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlfPxE1w M{XiTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyNUe4OlYoRjlyNUe4OlY9N2F-
HEL NGLNOXFCdnSrdnnyZYwh[XO|YYm= NVvLclViSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwheGyjcYXlJIZwem2jdHnvckwhTUN3ME23MljPxE1w NHm4[4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS0N|U2OCd-Mk[0OFM2PTB:L3G+
HEL NXvXcVV6SW62aY\pdoFtKGG|c3H5 NYHnW5lGSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFNTF4OTDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25uIFXDOVA:Py56N988UU4> MmizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
CRFK M{mzSGFvfGm4aYLhcEBie3OjeR?= MkHDRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcW6nIHjldpBme3[rcoXzJIlv\mWldHXkJIlvKEOURlugZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBi\2GrboP0JJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME24MlHPxE1w NVzHdolRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HEL NIPrZZBCdnSrdnnyZYwh[XO|YYm= M{DYOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHliYX\0[ZItKEWFNUC9PE4z|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1OEc,OjN7MUG4OVQ9N2F-
HFF NWHVOlRxTnWwY4Tpc44h[XO|YYm= MV\JckB3cXS{bzDpcohq[mm2aX;uJI9nKGi3bXHuJIN6fG:vZXfhcI93cXK3czDpckBJTkZiY3XscJMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME24MlTPxE1w MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HFF Mnj5RY51cX[rcnHsJIF{e2G7 M2DycWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhOjhzNzD3bZRpKHCxbDDHPFQySSCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD16LkVOwG0v MmP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL NVT1Rmx2SW62aY\pdoFtKGG|c3H5 M4fXeFch\GG7cx?= NEfubZFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckBi\nSncjC3JIRigXNuIFXDOVA:QC55zszNMi=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ{MkGyPEc,OTd4MkKxNlg9N2F-
HEL MmfkRY51cX[rcnHsJIF{e2G7 NV3rcFZWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9PE44|ryPLh?= M2i0eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkiyNFY4Lz5{OE[4NlA3PzxxYU6=
HEL NUfNSWpKSW62aY\pdoFtKGG|c3H5 MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhcoQh[WO7Y3zveolzKHKnc3nzeIFvfCCKU2[xJGtQWyCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBi\2GrboP0JJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME25{txONg>? MoT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEGyNlUoRjF7MkixNlI2RC:jPh?=
HEL M1XZfGFvfGm4aYLhcEBie3OjeR?= MkjZRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYomgeolz[WxiQ2DFJIF{e2G7LDDFR|UxRTlwMd88UU4> M{XDeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
MRC-5 NX;ZO|ZSTnWwY4Tpc44h[XO|YYm= NHXVVmxKdmirYnn0c5J6KGGldHn2bZR6KG:oIHPvcZBwfW6mIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDpckBOWkNvNTDj[YxteyxiRVO1NF06NjUQvF2u M3\yT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{KzPVUyLz5zMkeyN|k2OTxxYU6=
Vero M{P4fWFvfGm4aYLhcEBie3OjeR?= NGnwPWZKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHnZYlve3RiSGPWMVEhMEZiZHXseIEhOzB3KTDpckBX\XKxIHPlcIx{NCCLREWwQVEx|ryPLh?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEGxK|4{ODB7OEGxQE9iRg>?
HFF NV;TNWFbSW62aY\pdoFtKGG|c3H5 MmXJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjl|IHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;MUFOwG0v Mn3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
Vero MnTURY51cX[rcnHsJIF{e2G7 M1X2eVMh\GG7cx?= M1:xcmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZiemmlZXzsZU17d3O2ZYKgeolzfXNiRXzs[Y4hXlJvMUO2O{Bqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;MUGuNe69VS5? NF3ReYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
HEL MmnHRY51cX[rcnHsJIF{e2G7 NVLTV5dUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1zMT60N:69VS5? NEKzZ2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
HELF NVzMfoVbSW62aY\pdoFtKGG|c3H5 M13CfGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUB{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MUGuO|XPxE1w NIX5W5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HFF MUjBcpRqfmm{YXygZZN{[Xl? MlzIRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOzFzIHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;MUKuOO69VS5? NHjoRmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
HEL MYnBcpRqfmm{YXygZZN{[Xl? MVq3JIRigXN? MWLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2xNk43|ryPLh?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HEL NWj2[VVGSW62aY\pdoFtKGG|c3H5 MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTF|LkpOwG0v MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR2M{W1NEc,OjZ2NEO1OVA9N2F-
Vero NEOxbm1CdnSrdnnyZYwh[XO|YYm= MYizOkB1dyB2ODDodpM> MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNiQjD2bZJ2eyB{NEGwOUBqdm[nY4Tl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KHCuYYH1[UBz\WS3Y4Tpc44h[W[2ZYKgN|YhfG9iNEigbJJ{NCCHQ{WwQVE1NjYQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC2NUc,OTd2M{iwOlE9N2F-
HEL NUfiVGxzSW62aY\pdoFtKGG|c3H5 MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIH7l[4F1cX[nIHHu[EBCS1ZicnXzbZN1[W62IFjTWlEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{BjgSC4aYLhcEBEWEViYYPzZZktKEWFNUC9NVQvP87:TT6= NGi1[ms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFIzOid-MkK4OVgzOjJ:L3G+
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Assay
Methods Test Index PMID
Growth inhibition assay Cell viability 29845211
In vivo Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response[7].

Protocol (from reference)

Cell Research:

[7]

  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    To assess cell proliferation by thymidine incorporation, a total of 2 × 10<sup>4</sup> BV-2 cells were seeded in a 96-well plate for a maximum of 12 h in 10% FBS containing DMEM and then serum starved for an additional 12 h before the addition of varying concentrations of GCV for a total of 24 h. Cultures were pulsed for the final 8 h with 1 µCi/well [3H]thymidine before incorporated radioactivity was measured using a β plate scintillation counter.

Animal Research:

[7]

  • Animal Models: C57BL/6 mice
  • Dosages: 100 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

2mg/mL

Chemical Information

Molecular Weight 255.23
Formula

C9H13N5O4

CAS No. 82410-32-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04478474 Not yet recruiting Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme Corp. September 15 2020 --
NCT03698435 Unknown status Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4
NCT02152358 Unknown status Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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