Ganciclovir (BW 759)

For research use only.

Catalog No.S1878 Synonyms: RS-21592, 2'-Nor-2'-deoxyguanosine

9 publications

Ganciclovir (BW 759) Chemical Structure

CAS No. 82410-32-0

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

Selleck's Ganciclovir (BW 759) has been cited by 9 publications

1 Customer Review

  • Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.

    Sci Rep, 2017, 7: 43349. Ganciclovir (BW 759) purchased from Selleck.

Purity & Quality Control

Choose Selective CMV Inhibitors

Biological Activity

Description Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro

Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. [1] Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. [2] Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. [3] Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. [4] Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. [5] Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines MV;GeY5kfGmxbjDhd5NigQ>? MXXF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IFjldpBmeyC|aX3wcIV5KH[rcoXzMVIhMEiVVj2yLUBqdmS3Y3XkJIN6fG:yYYTobYNqfHliYomgOVAmKGmwIFW2V20h[2WubDDsbY5meyxiRVO1NF0yNjJibl2= Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2OUW1PFYoRjFzNEm1OVg3RC:jPh?=
OST TK- cells NFHYSIVEgXSxdH;4bYNqfHliYYPzZZk> MkD1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtuIFnDOVA:OC5yMEG5{txONg>? NIDuNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL MVXBcpRqfmm{YXygZZN{[Xl? NY\pcYFXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygUWlERTBwMEC2OO69VS5? MoDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL NF3sXFhCdnSrdnnyZYwh[XO|YYm= NVnid4tNSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlAy|ryPLh?= NUSyZpVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL M3rwWmFvfGm4aYLhcEBie3OjeR?= NIGwXWZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wNe69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7NUKzPEc,OjN5OUWyN|g9N2F-
HEL NIjjbHVCdnSrdnnyZYwh[XO|YYm= NETr[JBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlAy|ryPLh?= MnnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUWyN|goRjJ|N{m1NlM5RC:jPh?=
HEL NFfs[YxCdnSrdnnyZYwh[XO|YYm= NVizc4ZiOyCmYYnz MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCvZYToc4QtKEWFNUC9NE4xOc7:TT6= MnTkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
HEL MmK2RY51cX[rcnHsJIF{e2G7 M2X6d|Mh\GG7cx?= M1n3c2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgcYV1cG:mLDDFR|UxRTBwMEJOwG0v NFK4U|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK4Olk2Oid-M{CyPFY6PTJ:L3G+
HEL M{O5cmFvfGm4aYLhcEBie3OjeR?= M4e4UWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEGz{txONg>? NWrDPHZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPVkxQTdpPkKzNFk6ODl5PD;hQi=>
HEL NUHoXIdiSW62aY\pdoFtKGG|c3H5 NUm5V2dNSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlAyPc7:TT6= M3r4PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEm5NFk4Lz5{M{C5PVA6PzxxYU6=
OST TK- cells M3nZPWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml32R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvKITybZBp\W67bH3leIhwgHlraHX4fYxefGi7bXnu[UwhUUN3ME2wMlAyQM7:TT6= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL M{DNfmFvfGm4aYLhcEBie3OjeR?= NVfwfJhiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iSFXMJINmdGy|LDDFR|UxRTBwMEG5{txONg>? Ml7oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlIoRjF5MUixNVYzRC:jPh?=
HEL M{HwTmFvfGm4aYLhcEBie3OjeR?= M33IcVIhfG9iMzDkZZl{ MmHYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBt[XG3ZTDmc5Ju[XSrb36gcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fCCrbn\lZ5Rqd25uIFXDOVA:OC5yMUpOwG0v M{HxTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
HEL MWPBcpRqfmm{YXygZZN{[Xl? NHXOTW9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkCy{txONg>? NYXBc45xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFEzOjVpPkG5NlgyOjJ3PD;hQi=>
HEL Ml7zRY51cX[rcnHsJIF{e2G7 Ml61OEBl[Xm| MnS3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDh[pRmeiB2IHThfZMtKEWFNUC9NE4xOs7:TT6= NXraSllYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HEL M4nWOGFvfGm4aYLhcEBie3OjeR?= MkXJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMENOwG0v MmizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL MX7BcpRqfmm{YXygZZN{[Xl? NYj5T3d5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwMENOwG0v NFfhbWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
HEL NIXjUWhCdnSrdnnyZYwh[XO|YYm= M3zqUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOs7:TT6= NEHLXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
Vero MVHBcpRqfmm{YXygZZN{[Xl? MWC3NkBpenN? MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YuOSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhT0[SIHX4dJJme3Orb36gZYZ1\XJiN{KgbJJ{KGK7IFfGVE1j[XOnZDDmcJVwemW|Y3XuZ4UhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yMkZOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTVyM{S3Okc,OzF3MEO0O|Y9N2F-
HEL MYHBcpRqfmm{YXygZZN{[Xl? M4LpbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhTyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{N988UU4> M3r6UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL MYPBcpRqfmm{YXygZZN{[Xl? NH\MT25CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYomgeolz[WxiQ2DFJIF{e2G7LDDFR|UxRTBwMEK3{txONg>? NF\XSWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFIzOid-MkK4OVgzOjJ:L3G+
HEL M1XDZWFvfGm4aYLhcEBie3OjeR?= NUDncoozSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OC5yMkpOwG0v M1\PRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
HEL NFfSU49CdnSrdnnyZYwh[XO|YYm= MUeyJJRwKDNiZHH5dy=> MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtd4Vve2m2aY\lJGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIZzd21idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCyJJRwKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:OC5yM988UU4> MnL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HEL MlThRY51cX[rcnHsJIF{e2G7 MYWyJJRwKDNiZHH5dy=> NH3FcXpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEROwG0v MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB|NEexNUc,OjByM{S3NVE9N2F-
HEL Ml;ERY51cX[rcnHsJIF{e2G7 NW\pbpl2OiC2bzCzJIRigXN? NF\MZ2xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36g[pJwdSC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEKgeI8hOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0xNjB|zszNMi=> NYnWXZp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwN|Q4OTFpPkKwNFM1PzFzPD;hQi=>
HEL NF\XWFdCdnSrdnnyZYwh[XO|YYm= NIK4[IQ1KGSjeYO= M2TSZWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEROwG0v M{PMU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL NGToPXBCdnSrdnnyZYwh[XO|YYm= NIX4dGZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLkCz{txONg>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL MYHBcpRqfmm{YXygZZN{[Xl? NHfHR4c1KGSjeYO= MnvRRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMuOiCJIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvODQQvF2u Ml;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4OU[5OlMoRjJzNkm2PVY{RC:jPh?=
HEL M2D3NmFvfGm4aYLhcEBie3OjeR?= NIfzXlc1KGSjeYO= MnSwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPCCmYYnzMEBGSzVyPUCuNFPPxE1w M33WTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL Mk\zRY51cX[rcnHsJIF{e2G7 NITmTo1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u NHHueWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL M1jveWFvfGm4aYLhcEBie3OjeR?= NFjLe4lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1zIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HEL MX;BcpRqfmm{YXygZZN{[Xl? MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u M2LPPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL NFG1cI5CdnSrdnnyZYwh[XO|YYm= MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNicHzhdZVmKG[xcn3heIlwdixiRVO1NF0xNjB|zszNMi=> NYPscoFDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
HELF NYPPSHgySW62aY\pdoFtKGG|c3H5 MkL3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUBMV1Nic4TyZYlvKGmwZnXjeIVlKGmwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u MlTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi0PFEoRjNyMEm4OFgyRC:jPh?=
HELF MkLIRY51cX[rcnHsJIF{e2G7 M3\I[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhTyC|dILhbY4hcW6oZXP0[YQhcW5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= NV;JV4FCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HEL NYKyNXFCSW62aY\pdoFtKGG|c3H5 M1;6WmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yM988UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL NEnBS4NCdnSrdnnyZYwh[XO|YYm= NE\zWZNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCz{txONg>? M4DEflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
HEL MnzDRY51cX[rcnHsJIF{e2G7 MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKGmwIFjFUEBk\WyuczygSWM2OD1yLkCzNu69VS5? NYnmO2xnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjJpPkG3NVgyOTZ{PD;hQi=>
HEL NW\yfFhCSW62aY\pdoFtKGG|c3H5 NHHnT2xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJG1KSz1yLkCzNu69VS5? NFToWWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
HEL NWi3dYRPSW62aY\pdoFtKGG|c3H5 NFLKfmNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wN|LPxE1w NXjIR|ZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
OST TK- cells M3;XT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIjXdllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB3IIXNJFEuYzZvKITybZBp\W67bH3leIhwgHlraHX4fYxefGi7bXnu[UwhUUN3ME2wMlA{O87:TT6= NED5NFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
fibroblast cells MYnBcpRqfmm{YXygZZN{[Xl? NG\2NmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4h\m:{ZYPrbY4h\mmkcn;icIF{fCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> Mn\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUeyO|EoRjF7M{m3NlcyRC:jPh?=
HEL M4PFXmFvfGm4aYLhcEBie3OjeR?= M3rwTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEVOwG0v NGK0eFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzNlgzQCd-MkGyN|I5Ojh:L3G+
HFF NIrHO4ZCdnSrdnnyZYwh[XO|YYm= NWfKPVM{OSCqch?= M1fwTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyBqc4TyZYlvKEGGMU[5LUBqdm[nY4Tl[EBqdiBzIHjyJJBz\XS{ZXH0[YQhcHWvYX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidC2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGK7IH7leZRz[WxicnXkJJVxfGGtZTDhd5NigSxiRVO1NF0xNjB2zszNMi=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkSyPUc,OjF|N{[0Nlk9N2F-
HEL NX7kR|FKSW62aY\pdoFtKGG|c3H5 MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlA1|ryPLh?= NV[0NGE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
HEL M37hemFvfGm4aYLhcEBie3OjeR?= NV61TYZzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= M4nTeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
Vero NYHhdop4SW62aY\pdoFtKGG|c3H5 M{HId|M3KGi{cx?= NV3lO2RlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYIEGgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5icHzhdZVmKG[xcn3heIlwdiCrbnP1ZoF1\WRiZn;yJFM3KGi{czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhTUN3ME2wMlA1|ryPLh?= M2O1XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
OST TK- cells MofGR5l1d3SxeHnjbZR6KGG|c3H5 M{LzeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDFyIIXNJFEuYzZvKITybZBp\W67bH3leIhwgHlraHX4fYxefGi7bXnu[UwhUUN3ME2wMlA1Oc7:TT6= Ml7uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
HEL NFL6N|dCdnSrdnnyZYwh[XO|YYm= NUHY[YZtOiC2bzCzJIRigXN? NFn3eVhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKG2nYYP1doVlKGGodHXyJFIhfG9iMzDkZZl{KHCxc4SgbY5n\WO2aX;uMEBGSzVyPUCuNFQ2|ryPLh?= NYDmRWhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
OST TK- cells NXXx[lA4S3m2b4TvfIlkcXS7IHHzd4F6 NFfYXnVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB{LkWgeW0hOS2dNj3bNUwyNSimaYDo[Y56dClvMT2oOE1xgXKrZInsLY1mfGixeIndbIV5gWyfdHj5cYlv\SxiSVO1NF0xNjB3zszNMi=> MknxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
human M{i1cWFvfGm4aYLhcEBie3OjeR?= M4DIZ|ch\GG7cx?= M1rJcGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTBwMEZOwG0v NUL0cXNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlg3PjZpPkKxNVI5PjZ4PD;hQi=>
HEL MXLBcpRqfmm{YXygZZN{[Xl? NVzrUJF{OiC2bzCzJIRigXN? NWm5emVESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:OC5yNUJOwG0v MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
HEL NUf3[21xSW62aY\pdoFtKGG|c3H5 M1flO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yNUZOwG0v NGDlS|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HEL MXPBcpRqfmm{YXygZZN{[Xl? M{KxTFIhfG9iMzDkZZl{ NF;me4dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JI1m[XO3cnXkJIFnfGW{IEKgeI8hOyCmYYnzJJBwe3RvaX7m[YN1cW:wLDDFR|UxRTBwMEW3{txONg>? MkPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
HEL Ml7MSpVv[3Srb36gZZN{[Xl? MVnDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpMZZqemGuIHHjeIl3cXS7IHHnZYlve3RiSGPWMVEpTyliaX6gTGVNKGOnbHzzMEBGSzVyPUCuNFbPxE1w M3W3UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NkSzN|I5Lz5zNE[0N|MzQDxxYU6=
Hel MYHGeY5kfGmxbjDhd5NigQ>? NXi2VpRlTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBp\XKyZYOgd4lueGyneDD2bZJ2eyC2eYDlJFEhU2:|IIP0doFqdiCrbnT1Z4VlKGO7dH;wZZRpcWOrdImgbY4hUGWuIHPlcIx{NCCHQ{WwQVAvODcQvF2u M2nkWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkW4PFU5Lz5zNU[1PFg2QDxxYU6=
HEL M2LKNWFvfGm4aYLhcEBie3OjeR?= MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= MljNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ|OUK3PVEoRjF4M{myO|kyRC:jPh?=
HEL NIHpN4pCdnSrdnnyZYwh[XO|YYm= M4Gw[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= NIDNXmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO5Nlc6OSd-MU[zPVI4QTF:L3G+
HEL MX;BcpRqfmm{YXygZZN{[Xl? M1LRZlMh\GG7cx?= MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJJN1emGrbjDHJIlv\mWldHXkJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCzJIRigXNiYomgZ49td3KrbXX0dolkKG[xcn3hfoFvNWKjc3XkJG1VWyCjc4PhfUwhTUN3ME2wMlA4|ryPLh?= MoXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL NYHiU2h7SW62aY\pdoFtKGG|c3H5 MmP3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvODgQvF2u MlfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5M{i2OVMoRjNyN{O4OlU{RC:jPh?=
HELF NUf1fpVUSW62aY\pdoFtKGG|c3H5 M1vOSVch\GG7cx?= MmnTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> NXG2R5V2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HEL NVjVXGt1SW62aY\pdoFtKGG|c3H5 NVi4[|JKPyCmYYnz MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTBwMElOwG0v NFj5eVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HEL MkLzRY51cX[rcnHsJIF{e2G7 NXK5fVRmOyCmYYnz MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCyJJN1emGrbjDHJIlv\mWldHXkJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0xNjB6zszNMi=> MlXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL MWPBcpRqfmm{YXygZZN{[Xl? M16yUVMh\GG7cx?= M4ThTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFEhe3S{YXnuJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9NE4xQM7:TT6= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
OST TK- cells NX\3SXQ4S3m2b4TvfIlkcXS7IHHzd4F6 NIHJbINEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB3IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xQDIQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL MmDERY51cX[rcnHsJIF{e2G7 Mny5N{Bl[Xm| NV\ScJN7SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOSC|dILhbY4hU0:VIHnu[oVkfGWmIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nliY3;sc5JqdWW2cnnjJIZwem2jenHuMYJie2WmIF3UV{Bie3OjeTygSWM2OD1yLkC5{txONg>? MlHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL MkfhRY51cX[rcnHsJIF{e2G7 NITmWW9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUCuNFnPxE1w Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlgoRjJ5NkO5N|Y5RC:jPh?=
E6SM MWHBcpRqfmm{YXygZZN{[Xl? MoPLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpckBGPlOPIHPlcIx{NCCPSVO9NE4xQTcQvF2u NYjiT|hsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewPVI4OjhpPkG3NFkzPzJ6PD;hQi=>
E6SM NHLsXm9CdnSrdnnyZYwh[XO|YYm= NXPoXJhmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY4hTT[VTTDj[YxteyxiTVnDQVAvODl4zszNMi=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB7MkeyPEc,OTdyOUK3Nlg9N2F-
HEL M2jpUmFvfGm4aYLhcEBie3OjeR?= MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6x{txONg>? NWHUbHhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL NUjVNJdwSW62aY\pdoFtKGG|c3H5 MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDBR3YuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4y|ryPLh?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
OST TK- cells M2nodmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIDLdllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iBzMDD1UUAyNVt4LWuxMFEuMGSrcHjlcpltMS1zLTi0MZB6emmmeXypcYV1cG:6eW3o[Zh6dF22aIntbY5mNCCLQ{WwQVAvOTIQvF2u M1\kclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HFF M1TxVmFvfGm4aYLhcEBie3OjeR?= MkfTNVAh\GG7cx?= NHPuNZRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwZnXjeIVlKGmwIFjGSkBk\WyuczDpcoN2[mG2ZXSg[o9zKDFyIHThfZMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlE1|ryPLh?= NUHmO4RzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NVI1OjBpPkKxPFEzPDJyPD;hQi=>
HFF M4G1[mZ2dmO2aX;uJIF{e2G7 NH\uWVVKdmirYnn0bY9vKG:oIFjDUXYhSURzNkmgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JIN6fG:yYYTobYMh\W[oZXP0JIF{e2G7LDDFR|UxRTBwMUZOwG0v MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzByNEeyOkc,OTdyMES3NlY9N2F-
MCA-TK M4TvZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBOS0FvVFugZ4VtdHNuIFnDOVA:OC5zNd88UU4> NI\rb4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2NFkzPid-MUe5OlA6OjZ:L3G+
vero MkfJRY51cX[rcnHsJIF{e2G7 NYTU[49MSW62aY\pdoFtKGGldHn2bZR6KHejczDk[ZRmem2rbnXkJIlvKHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgbY4hfmW{bzDj[YxteyCjZ3HpcpN1KEiVVj2xJGYhe3S{YXnuMEBKTDVyPUCuNu69VS5? NIrKcIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|OEexPFYxLz5|OEexPFYxRC:jPh?=
Vero NYXJXo9NSW62aY\pdoFtKGG|c3H5 M37ofWlvKH[rdILvJIFvfGm4aYLhcEBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYXfhbY5{fCCKU2[tNUhHMSCrbjDW[ZJwKGOnbHzzMEBKTDVyPUCuNu69VS5? M3:1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4NVEoRjNyMEm4NVE9N2F-
Vero MWnBcpRqfmm{YXygZZN{[Xl? MUfBcpRqfmm{YXygZYN1cX[rdImg[IV1\XKvaX7l[EBi\2GrboP0JIhmenCnczDzbY1xdGW6IIT5dIUhOSBqRjDzeJJicW5rIHL5JJBt[XG3ZTDy[YR2[3Srb36gbY4hXmW{bzDj[YxteyxiSVS1NF0xNjMQvF2u M2jmXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMU[yOlMoRjNyMU[yOlM9N2F-
HEL M3O4TmFvfGm4aYLhcEBie3OjeR?= M{T1W2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjMQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL NX[yVHdWSW62aY\pdoFtKGG|c3H5 M3vrdFMh\GG7cx?= M{joWWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXm[YNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKG2ndHjv[EwhTUN3ME2wMlLPxE1w MnLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
fibroblast cells M4DhPGZ2dmO2aX;uJIF{e2G7 NWD1Tmh2UW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhcW5ibX;uc4xigWW{czDv[kBJW1ZvMjDBSEBX\XKxIHPlcIx{KGK7IEWwKUwhTUN3ME2wMlI{|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTV6NUS1O{c,OTF3OEW0OVc9N2F-
HEL NUHQN5NCSW62aY\pdoFtKGG|c3H5 MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|LDDFR|UxRTBwMkZOwG0v MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG3PEc,OjdzMkixO|g9N2F-
vero NYDWOXZLSW62aY\pdoFtKGG|c3H5 MX;JckB3cXS{bzDhcpRqfmm{YXygZY5lKGGwdHnj[YxtfWyjcjDhZ5Rqfmm2eTD3ZZMh\X[jbIXheIVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeolzfXNiSGPWMVEhMEZic4TyZYlvMSCrbjD2[ZJwKGOnbHzzJJRqe3O3ZTDjeYx1fXKnLDDJSFUxRTBwM988UU4> NEL4[XQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOlE2Lz5{OUmzOlE2RC:jPh?=
HELF MVTBcpRqfmm{YXygZZN{[Xl? NYHuSoVWPyCmYYnz MlnvRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE4{|ryPLh?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HS27 Mn3mRY51cX[rcnHsJIF{e2G7 Mn3QO{Bl[Xm| NYLpeotnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IHnu[oVkfGWmIHnuJIh2dWGwIFjTNlch[2WubIOgZYZ1\XJiNzDkZZl{KGK7IFfGVE1j[XOnZDDmcJVwemW|Y3XueEBz\WS3Y4Tpc44h[XO|YYmsJGVEPTB;MD6zNu69VS5? MnXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNEe5NVEoRjJyMES3PVEyRC:jPh?=
HEL M2rtfWFvfGm4aYLhcEBie3OjeR?= MmT2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1yLkO4{txONg>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
HEL NWHzSoZVSW62aY\pdoFtKGG|c3H5 Mki1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KDB5L{GgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvPM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG3PEc,OjdzMkixO|g9N2F-
HEL Mm\uRY51cX[rcnHsJIF{e2G7 MnXVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMlTPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HEL Mny5RY51cX[rcnHsJIF{e2G7 NYPvcnlzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iSFXMJINmdGy|LDDFR|UxRTBwNElOwG0v MlHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlIoRjF5MUixNVYzRC:jPh?=
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HEL M4\XPWZ2dmO2aX;uJIF{e2G7 NYLKboZLUW6qaXLpeIlwdiCxZjDoeY1idiCFTW[gSG5CKHO7boTo[ZNqeyCrbjDDUXYucW6oZXP0[YQhUEWOIHPlcIx{NCCLQ{WwQVAvPc7:TT6= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HEL NGGyNo5CdnSrdnnyZYwh[XO|YYm= Mo\ZRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgZYN6[2yxdnnyMZJme2m|dHHueEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD61{txONg>? NHTXcXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HELF M{\yVGFvfGm4aYLhcEBie3OjeR?= MVvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGh2dWGwIHjldpBme3[rcoXzJFEhU0:VIIP0doFqdiCrbn\lZ5Rm\CCrbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjYQvF2u NVrFdGxKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
Vero NUPRZmZbSW62aY\pdoFtKGG|c3H5 M1;R[lM3KGi{cx?= Mmr0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXKDJiaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckBqdmO3YnH0[YQh\m:{IEO2JIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yCkYYPl[EBie3OjeTygSWM2OD1yLkW4{txONg>? NWrrTZpbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
HEL NXu0bmI1SW62aY\pdoFtKGG|c3H5 MlXQOUBl[Xm| NF;qWJFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[XKrY3XscIEhgm:|dHXyJJZqenW|IF;LRUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgOUBl[Xm|LDDFR|UxRTBwNUpOwG0v MljRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|M{mwPFIoRjF7M{O5NFgzRC:jPh?=
HEL NE\Xd5dCdnSrdnnyZYwh[XO|YYm= MV\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC54Nt88UU4> M1\PU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL NWTuZW86SW62aY\pdoFtKGG|c3H5 Ml3rRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJFEhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwNkpOwG0v NH\tOXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL NH;qTWtCdnSrdnnyZYwh[XO|YYm= MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC55zszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
Vero MkDuRY51cX[rcnHsJIF{e2G7 MYmzOkB1dyB2ODDodpM> NIH2WHJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIF[gbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BxdGGzdXWgdoVlfWO2aX;uJIFnfGW{IEO2JJRwKDR6IHjyd{whTUN3ME2wMlfPxE1w M1fzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFYyLz5zN{SzPFA3OTxxYU6=
HFF NYnMOVBVSW62aY\pdoFtKGG|c3H5 NW\0PIRTQCC2bzCxNEBl[Xm| NWPLdZJYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDURlQxKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckB1emWjdHXkJJdqfGhiY3;tdI92dmRiZn;scI94cW6pII\pdoFtKGmwZnXjeIlwdiCjbnSgbY5kfWKjdHXkJIZweiB6IITvJFExKGSjeYOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZoF{\WRiYYPzZZktKEWFNUC9NE44Os7:TT6= M2D3OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
fibroblast cells NH62VnhCdnSrdnnyZYwh[XO|YYm= MojjNUBpd3W{ NELUdItCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQXSxOlkhMFeWKTDwcIFyfWViZn;ycYlv\yC3bnn0JIdzd3ewIH;uJGh2dWGwIH\vdoV{c2mwIH\pZpJw[myjc4SgZ4VtdHNidYDvckBqdmO3YnH0bY9vKG[xcjCxJIhwfXJiYYSgN|ch\GWpcnXld{BEKHerdHigZ49ueG:3bnSg[Il{e2:udnXkJIlvKESPU1:sJGlEPTB;MD64{txONg>? MoHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzM{S5OFYoRjF4MUO0PVQ3RC:jPh?=
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HEL MW\BcpRqfmm{YXygZZN{[Xl? NY\xNohQPCCmYYnz NIT5cohCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KFSNLXTl[olkcWWwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0yKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjkQvF2u NFLE[JU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[5Olk3Oyd-MkG2PVY6PjN:L3G+
HEL NWe1cHV2SW62aY\pdoFtKGG|c3H5 NH\QUXlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLklOwG0v NWm5e|Q4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL MX;BcpRqfmm{YXygZZN{[Xl? MoDFRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZY5lKGGlaXPsc5ZqeiC{ZYPpd5RidnRiaHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuPO69VS5? NIXDcI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEezPFY2Oyd-M{C3N|g3PTN:L3G+
HELF NXG0R202SW62aY\pdoFtKGG|c3H5 M324RVch\GG7cx?= NF7XdpRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIGTLMWtQWy2DQ2[gbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjkQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
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HFF M1rvR2FvfGm4aYLhcEBie3OjeR?= MmjpOUBl[Xm| NVnrU2IySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpcoZm[3SnZDDISmYh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IHTveEBjdG:2IHHzd4F6NCCLQ{WwQVHPxE1w M3XQclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{K5NVA{Lz5zN{OyPVExOzxxYU6=
HEL MorURY51cX[rcnHsJIF{e2G7 M{jxZWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGFEXi2{ZYPpd5RidnRiVFut[IVncWOrZX70JGhUXi1zIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUJOwG0v MlzLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUWyN|goRjJ|N{m1NlM5RC:jPh?=
HFF NVG2cWwxSW62aY\pdoFtKGG|c3H5 MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzOjFzIHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NU4y|ryPLh?= NHvMS4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL Mnm5RY51cX[rcnHsJIF{e2G7 NXLtVI9YPSCmYYnz NWjlfGRvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmG{aXPlcIxiKHqxc4TldkB3cXK3czDZV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgOUBl[Xm|LDDFR|UxRTFwMd88UU4> Mn;xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|M{mwPFIoRjF7M{O5NFgzRC:jPh?=
CRFK NXLIW3BtSW62aY\pdoFtKGG|c3H5 MoTVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcW6nIHjldpBme3[rcoXzJIlv\mWldHXkJIlvKEOURlugZ4VtdHNiYomgeolz[WxiQ2DFJIF{e2G7LDDFR|UxRTFwMUZOwG0v MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
HEL NYHSbYt3SW62aY\pdoFtKGG|c3H5 M17xVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhRVVCDLYLld4l{fGGwdDDIR21XKEGGMU[5JINtd26nIEKgcZV1[W62IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME2xMlLPxE1w NW\uXoJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
fibroblast cells MV7BcpRqfmm{YXygZZN{[Xl? MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhXG:5bnWgbY5n\WO2ZXSgbY4hcHWvYX6g[o9z\XOtaX6g[oljem:kbHHzeEBk\WyuczDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDFR|UxRTFwMt88UU4> MljMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUeyO|EoRjF7M{m3NlcyRC:jPh?=
HFF NFzmN3JHfW6ldHnvckBie3OjeR?= M{XvV2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjmge4lt\CC2eYDlJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2xMlLPxE1w NIHGSmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
HFF MW\GeY5kfGmxbjDhd5NigQ>? NEDxenBKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJGQyOCC|dILhbY4hMFWOOEmgcZV1[W62IHflcoUqKGW6cILld5Nm\CCrbjDISmYh[2WubIOge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0yNjMQvF2u M4noWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HFF NEPjW25HfW6ldHnvckBie3OjeR?= NWflR4loUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBzPTZic4TyZYlvKCiXTEW2JI12fGGwdDDn[Y5mMSCneIDy[ZN{\WRiaX6gTGZHKGOnbHzzJJdieyCmZYTldo1qdmWmIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:OS5{zszNMi=> NHHwUVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
FRCK NUPJ[XpSSW62aY\pdoFtKGG|c3H5 MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDG[YxqdmViaHXydIV{fmm{dYOgbY4h\mWuaX7lJGZTS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NU4z|ryPLh?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
CRFK NIrhd2ZCdnSrdnnyZYwh[XO|YYm= M1r4eFMh\GG7cx?= MlLaRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcW6nIHjldpBme3[rcoXzJIlv\mWldHXkJIlvKEOURlugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHliYX\0[ZIhOyCmYYnzMEBGSzVyPUGuNu69VS5? NHrQb4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C0O|IzQSd-MkOwOFczOjl:L3G+
vero MUjBcpRqfmm{YXygZZN{[Xl? M4jpeGlvKH[rdILvJIFvfGm4aYLhcEBidmRiYX70bYNmdGy3bHHyJIFkfGm4aYT5JJdieyCndnHseYF1\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB3cXK3czDIV3YuOiBqRzDzeJJicW5rIHnuJJZmem9iY3XscJMtKEmGNUC9NU4{|ryPLh?= MoS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{[xOUc,Ojl7M{[xOVww[T5?
fibroblast cells NUDLelZqSW62aY\pdoFtKGG|c3H5 NF:wZZJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiKFTheol{KHO2cnHpckkh\3Kxd36gc44hcHWvYX6g[o9z\XOtaX6g[oljem:kbHHzeEBk\WyuczDk[ZRmem2rbnXkJIJ6KHKnZIXjeIlwdiCrbjDwcIFyfWViZn;ycYF1cW:wIIXwc44hcW6ldXLheIlwdiCjdDCzO{Bl\We{ZXXzJGMhf2m2aDD0bIUh[2:vcH;1coQh\Gm|c3;seoVlKGmwIFTNV28tKEmFNUC9NU4{|ryPLh?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjF|NEm0Okc,OTZzM{S5OFY9N2F-
HFF MVnBcpRqfmm{YXygZZN{[Xl? MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzOTFiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:OS5|zszNMi=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL MWjBcpRqfmm{YXygZZN{[Xl? NV74TW1RP2SjeYO= NEHVNJJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGGodHXyJFdl[Xm|LDDFR|UxRTFwM988UU4> NVTaPXRYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1N|k3OjJpPkG3OVM6PjJ{PD;hQi=>
HFF NIKxb2xCdnSrdnnyZYwh[XO|YYm= M3HERmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:OS5|zszNMi=> NV\VN45HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|Q{ODRpPkG3OFM1OzB2PD;hQi=>
HEL MkTmRY51cX[rcnHsJIF{e2G7 NFzVXoE{KGSjeYO= MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDh[pRmeiB|IHThfZMtKEWFNUC9NU4{|ryPLh?= NGq0fmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2NVg2OSd-MUe5OlE5PTF:L3G+
HFF MYDBcpRqfmm{YXygZZN{[Xl? NWDYZYpsSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUGuN:69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF4N{S4PEc,OjBzNke0PFg9N2F-
HFF M3;TeGZ2dmO2aX;uJIF{e2G7 M2C5[GlvcGmkaYTpc44hd2ZiSFPNWkBFVkFicH;sfY1memG|ZTDpcoZm[3SnZDDpckBJTkZiY3XscJMtKEmFNUC9NU4{|ryPLh?= NG\EZms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwN|Y6Pid-MkC0NFM3QTZ:L3G+
MRC5 NV\xZ4NXTnWwY4Tpc44h[XO|YYm= NUXrXmpMUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgSIF3cXNic4TyZYlvKG:oIFjDUXYhcW5iTWLDOUBk\WyuczygTWM2OD1zLkVOwG0v MmD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2NUS0OlUoRjFzNEW0OFY2RC:jPh?=
HFF MXTBcpRqfmm{YXygZZN{[Xl? MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzPDFiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:OS52zszNMi=> M37Gc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HFF NWW1XI0xSW62aY\pdoFtKGG|c3H5 NYPMVYNvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{MkOzJIlvKEiIRjDj[YxteyCkeTDTSWFRKGG|c3H5MEBKSzVyPUGuOO69VS5? MlLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
Vero MWnBcpRqfmm{YXygZZN{[Xl? NIflTmk{KGSjeYO= Ml7LRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiC|dILhbY4hVVNiVmKtOVQxKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2xMlTPxE1w M{\O[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[wPFg{Lz5{NkS2NFg5OzxxYU6=
MRC5 MV3GeY5kfGmxbjDhd5NigQ>? NU[xU5ZFUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgWI94dmVic4TyZYlvKG:oIFjDUXYhcW5iTWLDOUBk\WyuczygTWM2OD1zLkZOwG0v NFHPfmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUS1OFQ3PSd-MUG0OVQ1PjV:L3G+
CCL81 NX3Yc|RtSW62aY\pdoFtKGG|c3H5 MkLXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCrbjDDR2w5OSClZXzsd{whTUN3ME2xMlXPxE1w M3G0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUi4OFAzLz5zN{G4PFQxOjxxYU6=
CCL81 MVjBcpRqfmm{YXygZZN{[Xl? MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKGmwIFPDUFgyKGOnbHzzMEBGSzVyPUGuOe69VS5? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6OESwNkc,OTdzOEi0NFI9N2F-
MRC5 NHvJfodHfW6ldHnvckBie3OjeR?= NEDWPHZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDCyOVk6WiC|dILhbY4hd2ZiSFPNWkBqdiCPUlO1JINmdGy|LDDJR|UxRTFwNt88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR3NES2OUc,OTF2NUS0OlU9N2F-
Vero MnfmRY51cX[rcnHsJIF{e2G7 MXPJckB3cXS{bzDhcpRqfmm{YXygZYN1cX[rdImge4F{KG2nYYP1doVlKGGpYXnud5QhUFOYLUKoS{khcW5iVnXyc{Bk\WyuczygTWQ2OD1zLkdOwG0v M2fLSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4NVEoRjNyMEm4NVE9N2F-
HFF NXnPdIxHTnWwY4Tpc44h[XO|YYm= MmfNTY4hfmm2cn:gdoVlfWO2aX;uJIlvKHmrZXzkJI9nKFSxd37lJJN1emGrbjDv[kBJS02YIHnuJGhHTiBqaIXtZY4h\mmkcn;icIF{fCliY3XscJMtKEmFOUC9NU43|ryPLh?= MoOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB3N{i2OUc,QTB3N{i2OVww[T5?
HFF MlKySpVv[3Srb36gZZN{[Xl? MXTJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IInp[YxlKHKnZIXjeIlwdiCjc4PhfUwhUUN7ME2xMlbPxE1w MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDN6MEG3K|46PDN6MEG3QE9iRg>?
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HFF NGDIOWRHfW6ldHnvckBie3OjeR?= MWjDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHL5JJlq\WymIILl[JVkfGmxbjDhd5NigSC3c3nu[{BJTkZiY3XscJMtKEmFOUC9NU43|ryPLh?= NGnmb4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PSd-MUC4PFI{PzV:L3G+
HFF NGfmdFZCdnSrdnnyZYwh[XO|YYm= MkPQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeI94dmVic4TyZYlvKEiFTW[ge4F{KGSndHXycYlv\WRiYomgfYlmdGRicnXkeYN1cW:wIHHzd4F6KGmwIHT1dIxq[2G2ZTD3[YxteyC3c3nu[{BJTkZiY3XscJMtKEmFOUC9NU43|ryPLh?= NE[x[Xc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4OCd-MUC4PFI{PzB:L3G+
HFF NXLEcWdISW62aY\pdoFtKGG|c3H5 NXHN[o9[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjD3ZZMh\GW2ZYLtbY5m\CCkeTD5bYVt\CC{ZXT1Z5Rqd25iYYPzZZkhfXOrbnegTGZHKGOnbHzzMEBKSzlyPUGuOu69VS5? MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|IoRjFyOEiyN|czRC:jPh?=
MRC5 Mo\oRY51cX[rcnHsJIF{e2G7 MonBO{Bl[Xm| MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hVVKFNTDj[YxteyCjZoTldkA4KGSjeYOgZpkhT0[SLXLhd4VlKG[udX;y[ZNk\W62IILl[JVkfGmxbjDhd5NigSxiRVO1NF0yNjZ3zszNMi=> M{TuSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMES3PVEyLz5{MEC0O|kyOTxxYU6=
HEL MVnBcpRqfmm{YXygZZN{[Xl? MmPzOEBl[Xm| NIP3cWJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IIDsZZF2\SCob4LtZZRqd25iYX\0[ZIhPCCmYYnzMEBGSzVyPUGuOlXPxE1w M4rvSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL MlfPRY51cX[rcnHsJIF{e2G7 M1TWXFQh\GG7cx?= MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjDh[pRmeiB2IHThfZMtKEWFNUC9NU43Pc7:TT6= MnO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUm4O|YoRjJ{NEW5PFc3RC:jPh?=
HFF M1z3e2Z2dmO2aX;uJIF{e2G7 NIHUSmJKdmirYnn0bY9vKG:oIFjDUXYhfG:5bnWgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFXDOVA:OS56zszNMi=> NVL2SmZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewNFQ4OjZpPkG3NFA1PzJ4PD;hQi=>
HFF M{f1fmFvfGm4aYLhcEBie3OjeR?= M3XVc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBCTDF4OTDpckBJTkZiY3XscJMh[nliUGLBMEBKSzVyPUGuPe69VS5? MoDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
HEL M3vOcGFvfGm4aYLhcEBie3OjeR?= NX74ZpE4PyCmYYnz NWfafYxISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5Rqdm[nY4Tpc44tKEWFNUC9Nu69VS5? M3T1R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF MUTGeY5kfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKEiFTW[gWI94dmVicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9Nk4y|ryPLh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
HFF MXfBcpRqfmm{YXygZZN{[Xl? NXPnUW0{QCCmYYnz NWnmcmRSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpcoZm[3SnZDDpckBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDhiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUKuNe69VS5? NF\sO3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[wO|g5Oyd-MkK2NFc5QDN:L3G+
HEL NIXlRoRCdnSrdnnyZYwh[XO|YYm= M1rhV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUKuNe69VS5? M1XXelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HFF MnLXRY51cX[rcnHsJIF{e2G7 NIHad|Q5KHSxIEGwJIRigXN? NIKxNZFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckB1emWjdHXkJJdqfGhiY3;tdI92dmRiZn;scI94cW6pII\pdoFtKGmwZnXjeIlwdiCjbnSgbY5kfWKjdHXkJIZweiB6IITvJFExKGSjeYOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZoF{\WRiYYPzZZktKEWFNUC9Nk4y|ryPLh?= NW\ONIZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
Vero M{\6ZWFvfGm4aYLhcEBie3OjeR?= NVq2NnJOOyCmYYnz NUG1Ro5ZSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KF[ULUiwO{Bqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;Mj6xOO69VS5? MnXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkC4PFMoRjJ4NE[wPFg{RC:jPh?=
HFF NG\TUJJHfW6ldHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKEiFTW[gRWQyPjlicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IFPQSUBqdmirYnn0bY9vKGG|c3H5MEBGSzVyPUKuNu69VS5? M3fpblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkG1OVQ2Lz5zNU[xOVU1PTxxYU6=
HEL MoXWRY51cX[rcnHsJIF{e2G7 MnrTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0zNjJ7zszNMi=> NGC1bnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
HEL NGnvOFRCdnSrdnnyZYwh[XO|YYm= NETqc5Q2KGSjeYO= NWrjWJlWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXEttIG\aWkB[WyCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgOUBl[Xm|LDDFR|UxRTJwM988UU4> MonDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MkKxNlgoRjF5NkKyNVI5RC:jPh?=
HELF MoPhRY51cX[rcnHsJIF{e2G7 M2jqNFch\GG7cx?= Mke5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY5kfWKjdHXkJIZweiB5IHThfZMh[nliR3nlcZNiKHO2YXnubY5oKGKjc3XkJI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVIvO87:TT6= NF\JU3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUW4Olg{Oid-M{G1PFY5OzJ:L3G+
HEL299 MlrSRY51cX[rcnHsJIF{e2G7 Ml\nO{Bl[Xm| M3\KSGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCrbn\lZ5Rm\CCrbjDISWwzQTliY3XscJMh[W[2ZYKgO{Bl[Xm|IHL5JGdHWC2kYYPl[EBndHWxcnXzZ4VvfCC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9Nk4{Qc7:TT6= MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNEe5NVEoRjJyMES3PVEyRC:jPh?=
HFF MoSySpVv[3Srb36gZZN{[Xl? MmrJTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDDOEB{fHKjaX6gLHVNPTZiKzDVUFg6KG23dHHueEBo\W6nKTDlfJBz\XO|ZXSgbY4hUE[IIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Mj61{txONg>? M1rsXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HFF M{nu[GFvfGm4aYLhcEBie3OjeR?= NF3LNphCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiVH;3coUhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFXDOVA:Oi53zszNMi=> M13LZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEiyOFExLz5zOEC4NlQyODxxYU6=
HEL NYLCblZuSW62aY\pdoFtKGG|c3H5 NH\GfJE4KGSjeYO= M1HvRmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5QhcW6oZXP0bY9vNCCHQ{WwQVIvPc7:TT6= M3v4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{O5NFgzLz5zOUOzPVA5OjxxYU6=
HEL NHjDWmtCdnSrdnnyZYwh[XO|YYm= MkHoOUBl[Xm| MnH3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgWoFzcWOnbHzhJJpwe3SncjD2bZJ2eyByNz:xJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC1JIRigXNuIFXDOVA:Oi53zszNMi=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HFF NEDWc5NHfW6ldHnvckBie3OjeR?= NVKz[lNlUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KHKncHzpZ4F1cW:wIHnuJGhHTiClZXzsd{B4[XNiZHX0[ZJucW6nZDDifUBkgXSxcHH0bIlkKGWoZnXjeEBqdmirYnn0bY9vKGG|c3H5MEBKSzVyPUKuOu69VS5? NI\Tc3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97NEO4NFE4Lz57NEO4NFE4RC:jPh?=
HEL MV7BcpRqfmm{YXygZZN{[Xl? NF\MSGRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBnd3OlYYLu[ZQuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhSyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Mj62{txONg>? NYKxPFNTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HFF NF\XTFVCdnSrdnnyZYwh[XO|YYm= MkTpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjRzNzD3bZRpKHCxbDDBPFA6XiCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{LkdOwG0v NXTHN2tpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NIjrSYpCdnSrdnnyZYwh[XO|YYm= Mk[1O{Bl[Xm| MWPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhTGG4aYOgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF0zNjcQvF2u MnPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
CRFK MVjBcpRqfmm{YXygZZN{[Xl? M4C1[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIH\yc40hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDifUBOXFRiYYPzZZktKEWFNUC9Nk43|ryPLh?= NGLZOXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECzOFcyOSd-MkCwN|Q4OTF:L3G+
HFF NEOwU5ZCdnSrdnnyZYwh[XO|YYm= NEPNdotCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKFR{NUSyJJdqfGhicH;sJHQ5OTOVIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUKuO:69VS5? NGS4RY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL NF\MOnpCdnSrdnnyZYwh[XO|YYm= MoH0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mj63Oe69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVzOES1PUc,OTd3MUi0OVk9N2F-
HEL NW[z[mtlSW62aY\pdoFtKGG|c3H5 NF\nUWtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2yMlk3|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
BSC-1 NGPZRoRCdnSrdnnyZYwh[XO|YYm= NYTVOG4zSW62aY\pdoFtKGGldHn2bZR6KG:oIITo[UBkd22yb4Xu[EB4[XNiZY\hcJVifGWmIHHnZYlve3RidHjlJGhmenCnczDzbY1xdGW6II\pdpV{KHS7cHWtNUBqdiCEU1OtNUBk\WyuczygTWM2OD1|zszNMi=> Mn;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzM{OwNEc,OjlzM{OwNFww[T5?
MRC5 MYjGeY5kfGmxbjDhd5NigQ>? M{fMTWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IFHENVY6KHO2cnHpckBw\iCKQ13WJIlvKE2UQ{WgZ4VtdHNuIFnDOVA:O87:TT6= M3j5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEW0OFY2Lz5zMUS1OFQ3PTxxYU6=
HFF NUnuR|hwSW62aY\pdoFtKGG|c3H5 MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSxd37lJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwQVPPxE1w NUPBNFFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOlE6PDZpPkG3NVYyQTR4PD;hQi=>
hhTERT-BJ1 NXewNVQ2SW62aY\pdoFtKGG|c3H5 MlLGNkBl[Xm| MoHjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KFSxd37lJIlv\mWldHXkJIlvKGi3bXHuJIhpXEWUVD3CTlEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyCvZXTpZZRm\CCGTlGgd5lvfGinc3nzJIFnfGW{IEKg[IF6eyxiRVO1NF0{|ryPLh?= MnPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NUixNlQoRjF6NEW4NVI1RC:jPh?=
HEL M2jLdmFvfGm4aYLhcEBie3OjeR?= M1Li[lch\GG7cx?= NX6xV3BuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKU2[xJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNzDkZZl{NCCHQ{WwQVPPxE1w MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF{OE[2Okc,OjFzMki2OlY9N2F-
HFF MUjBcpRqfmm{YXygZZN{[Xl? Mmr0NVAh\GG7cx?= MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhXG:5bnWgbY5n\WO2ZXSgbY4hUE[IIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IEGwJIRigXNuIFnDOVA:O87:TT6= M2Swd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkSxNlE5Lz5{MU[0NVIyQDxxYU6=
HEL NVrTWZZ5SW62aY\pdoFtKGG|c3H5 Mn;KRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mz6x{txONg>? NVjtXYt2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVE5PTZpPkKzPVEyQDV4PD;hQi=>
HEL NGXQfXFCdnSrdnnyZYwh[XO|YYm= NFTvXopCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2zMlHPxE1w MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PEc,Ojd4M{mzOlg9N2F-
HELF NXXKdnV1SW62aY\pdoFtKGG|c3H5 MUm3JIRigXN? NVizZmdISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFOTZ7IHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgS4lmdXOjIIP0ZYlvcW6pIHLhd4VlKG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTNwMUZOwG0v NYC0TGVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HFF M3GxZmFvfGm4aYLhcEBie3OjeR?= MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDnZY5kcWOub4\pdk1{\W6|aYTpeoUhUEOPVkGgbZNwdGG2ZTDy[ZBtcWOjdHnvckBqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0{NjJ{zszNMi=> NFPqVVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCxNFY5PCd-MUmwNVA3QDR:L3G+
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HEL M2HOTmFvfGm4aYLhcEBie3OjeR?= MUO2JJRwKDdiZHH5dy=> MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB4IITvJFch\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF0{NjNzzszNMi=> M1vFPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkewO|A2Lz5{OU[3NFcxPTxxYU6=
MEF M1PFRWZ2dmO2aX;uJIF{e2G7 NHf6ZZZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDteZJqdmViY4n0c41m\2Gub4\pdpV{KHKncHzpZ4F1cW:wIHnuJG1GTiClZXzsd{B4[XNiZHX0[ZJucW6nZDDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDJR|UxRTNwNN88UU4> MkfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
BSC-1 MX\BcpRqfmm{YXygZZN{[Xl? MXzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YuOSBqaHXydIV{KHOrbYDs[Zghfmm{dYOpMEBl\XSncn3pcoVlKGK7IFXMTXNCKGmwIIH1ZYRzfXCuaXPheIUhf2WubIOgeZNqdmdiQmPDMVEh[2WubIOsJGlEPTB;Mz61{txONg>? MoPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|AoRjFyOEiyN|cxRC:jPh?=
BSC-1 MVfGeY5kfGmxbjDhd5NigQ>? NVvrTYlvTUyLU1GgZZN{[Xlid3HzJJBmem[xcn3l[EB2e2mwZzDCV2MuOSClZXzsd{B1dyCmZYTldo1qdmViYXP0bZZqfHliYXfhbY5{fCCKU2[tNUwhUUN3ME2zMlXPxE1w NHqxdIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4Oid-MUC4PFI{PzJ:L3G+
BSC-1 MVzBcpRqfmm{YXygZZN{[Xl? NUHkdW9TUW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgeolzfXNiaX6gRnNENTFiKH3vcotmgSCtaXTu[ZkqKGOnbHzzMEBKSzVyPUOuOe69VS5? M1[3NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyNUe4OlUoRjlyNUe4OlU9N2F-
HEL MmjhRY51cX[rcnHsJIF{e2G7 NEjFTmhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBRVUWGQWCtdoV{cXO2YX70JGhEVVZiQVSxOlkh[2yxbnWgOEBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:Oy53zszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
HFF NHfU[2pCdnSrdnnyZYwh[XO|YYm= MnLxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjR{MDD3bZRpKHCxbDDHPFQySSCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1|LkZOwG0v M3[xS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
BSC-1 MYLGeY5kfGmxbjDhd5NigQ>? MoPsTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIDjIV3YuOSliZYjwdoV{e2WmIHnuJGJUSy1zIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KEWOSWPBJIF{e2G7LDDJR|UxRTNwNd88UU4> MkTYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|QoRjF3NUC5NVc1RC:jPh?=
BSC-1 MX7GeY5kfGmxbjDhd5NigQ>? NGXjdWpKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? NEfNbHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4PSd-MUW1NFkyPzV:L3G+
BSC-1 MkjGSpVv[3Srb36gZZN{[Xl? MWLJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB3cXK3czD0fZBmNTFiKFjTWk0yMSCneIDy[ZN{\WRiaX6gRnNENTFiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkhTUyLU1GgZZN{[XluIFnDOVA:Oy53zszNMi=> M1[wZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HFF M{iwTmZ2dmO2aX;uJIF{e2G7 NE[xdm5Ed22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCyPVE3KEGGMU[5JJN1emGrbjDv[kBJS02YIHnuJJlq\WymIILl[JVkfGmxbjDhd5NigSC3c3nu[{BJTkZiY3XscJMtKEmFOUC9N{43|ryPLh?= M3HOclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HEL MoPYRY51cX[rcnHsJIF{e2G7 MknyO{Bl[Xm| M4XzOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUOuOu69VS5? NUjyfYN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HFF MXfBcpRqfmm{YXygZZN{[Xl? NYDjb|RSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkK1PEB4cXSqIGXMPVchSzV7MlegcZV1[W62IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{46|ryPLh?= NVTZbIZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NVnS[XB1SW62aY\pdoFtKGG|c3H5 M2G5eFIhfG9iMzDkZZl{ MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDBR3YuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9N{46Oc7:TT6= NHrqNWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
MRC-5 MVnBcpRqcGW{cHXzeolzfXNiYYPzZZk> MVrJckB3cXS{bzDhcpRqcGW{cHXzeolzfXNiYXP0bZZqfHliYXfhbY5{fCCPUlOtOUBk\WyuczDpcoZm[3SnZDD3bZRpKEiFTW[gLGFFNTF4OTDzeJJicW5rLDDJR|UxRTUQvF2u M3HGTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF|MkO2O|goRjF|MkO2O|g9N2F-
HEL M3LGfmFvfGm4aYLhcEBie3OjeR?= MmXpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZ4lld2[xdnnyJGhEVVZiQVSxOlkh[2yxbnWgOUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9OO69VS5? NGrlV5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL M2iyfGFvfGm4aYLhcEBie3OjeR?= Mm\sRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZY5lKGGleXPsc5Zqei2{ZYPpd5RidnRiSGPWNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF01|ryPLh?= NVnJbZpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPVkxQTdpPkKzNFk6ODl5PD;hQi=>
HEL MoL0RY51cX[rcnHsJIF{e2G7 NGX5bItCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBVUy2wZXfheIl3\SCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;NN88UU4> NV;we2FIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HEL NInrRY9CdnSrdnnyZYwh[XO|YYm= MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> NHnoXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HEL NXPaPXpTSW62aY\pdoFtKGG|c3H5 MVvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD12LkC1{txONg>? MmPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5PVAoRjJ7NEC3PVkxRC:jPh?=
HFF MnzKSpVv[3Srb36gZZN{[Xl? NV3uN3I2S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR{01KFSxd37lJJN1emGrbjDv[kBJS02YIHnuJJlq\WymIILl[JVkfGmxbjDhd5NigSC3c3nu[{BJTkZiY3XscJMtKEmFNUC9OE4y|ryPLh?= Mn;EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HFF NE[zXI9CdnSrdnnyZYwh[XO|YYm= NIrBTINCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUGgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME20MlHPxE1w MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
CRFK NVK2NZY{SW62aY\pdoFtKGG|c3H5 M3nEfVQh\GG7cx?= M2DNcGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:PC5zzszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3OUi3Okc,OjJ2NUm4O|Y9N2F-
CRFK NUfubVlFSW62aY\pdoFtKGG|c3H5 NGixZpRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBn\WyrbnWgbIVzeGW|dnnyeZMhcW6oZXP0[YQhcW5iY3H0JGNTTktiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYomgUXRUKGG|c3H5MEBGSzVyPUSuNe69VS5? Mk[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
HEL MnnERY51cX[rcnHsJIF{e2G7 M1jRUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIdidmOrY3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDRiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUSuN:69VS5? M{m3eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL MX7BcpRqfmm{YXygZZN{[Xl? MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDBR3YuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;ND6z{txONg>? M2XVdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HFF M3ToOmZ2dmO2aX;uJIF{e2G7 NV3xWoJ1S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\C22eYDlJHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND61{txONg>? Mkn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HEL M1HCVGFvfGm4aYLhcEBie3OjeR?= M1TscFch\GG7cx?= MoLiRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIV5eHKnc4Pl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44hcW6ldXLheIVlKG[xcjC3JIRigXNiYomgS4lmdXOjIIP0ZYlvKGKjc3XkJI1q[3Kxc3PvdJktKEWFNUC9OE44Os7:TT6= NWjLT4RURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
HEL Mn3GRY51cX[rcnHsJIF{e2G7 MoLtO{Bl[Xm| NITqbppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGGodHXyJFch\GG7czygSWM2OD12LklOwG0v NEm4V|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WzPVYzOid-MUe1N|k3OjJ:L3G+
HEL MU\BcpRqfmm{YXygZZN{[Xl? MoGzN{Bl[Xm| NHvpW45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:PC56zszNMi=> NH3kWpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2NVg2OSd-MUe5OlE5PTF:L3G+
HEL Mm\zRY51cX[rcnHsJIF{e2G7 M{XhPVYhfG9iNzDkZZl{ M3vlbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKG2nYYP1doVlKGGodHXyJFYhfG9iNzDkZZl{KHCxc4SgbY5n\WO2aX;uMEBGSzVyPUSuPFPPxE1w M1LoUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
MRC5 Mn[0RY51cX[rcnHsJIF{e2G7 NXLVcWt[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFSxd37lJIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVQvQc7:TT6= NHzVd209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
MRC5 M{nKcWFvfGm4aYLhcEBie3OjeR?= NFK1d4hKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHnZYlve3RiSFPNWkhCTC1zNkmpJIlvKE2UQ{WgZ4VtdHNuIFnEOVA:Pc7:TT6= M1TURlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4NVEoRjNyMEm4NVE9N2F-
H-1 MUPGeY5kfGmxbjDhd5NigQ>? MlLrSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDFdJN1\WmwLXLhdpIhfmm{dYOgdoVxdGmlYYTpc44hcW5iSD2xJINmdGy|IHnuJGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ|NECwN{c,OTV4M{SwNFM9N2F-
H1 M3jxVWZ2dmO2aX;uJIF{e2G7 M4\nb2lvcGmkaYTpc44hd2ZiRVLWJJJmeGyrY3H0bY9vKGmwIFixJINmdGy|IHL5JGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u MnrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
H1 MX;GeY5kfGmxbjDhd5NigQ>? NGLoWolKdmirYnn0bY9vKG:oIFXCWkBz\XCuaXPheIlwdiCrbjDINUBk\WyuczDifUBFVkFiaInidollcXqjdHnvckBie3OjeTygSWM2OD13zszNMi=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
CEM Mo\VR5l1d3SxeHnjbZR6KGG|c3H5 MlnMR5l1d3SxeHnjbZR6KGGpYXnud5QhS0WPIHPlcIx{NCCFQ{WwQVXPxE1w MniwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1OFUoRjF3NkG1OVQ2RC:jPh?=
HFF NX7sVoxQSW62aY\pdoFtKGG|c3H5 NGC4NmI2KHSxIEeg[IF6ew>? MoO1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCrbn\lZ5Rm\CCKRl[gZ4VtdHNiYX\0[ZIhPSC2bzC3JIRigXNiYomgeolz[WxieXnlcIQh[XO|YYmsJGVEQTlwOU21{txONg>? Ml7jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MkmxNFMoRjF5M{K5NVA{RC:jPh?=
HEL NYfaWZh2SW62aY\pdoFtKGG|c3H5 NXraWodGPyCmYYnz MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5JIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjDh[pRmeiB5IHThfZMtKEWFNUC9OU4y|ryPLh?= NHS4eW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
HEL M2i5SmFvfGm4aYLhcEBie3OjeR?= MmnnO{Bl[Xm| MlTrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PU9F[X[rczDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTVwMt88UU4> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF{OE[2Okc,OjFzMki2OlY9N2F-
AKATA MV3BcpRqfmm{YXygZZN{[Xl? Ml\KOFghcHK| NF7HZoxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBGSlZiaX7m[YN1\WRiaX6gbJVu[W5iQVvBWGEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFnnS{1qdmS3Y3XkJIx6fGmlII\pdpV{KHKncHzpZ4F1cW:wIH3lZZN2emWmIHH0JFQ5KGi{czDwc5N1NWy7dHnjJIlv\HWldHnvckBjgSCzUmStVGNTKGGwYXz5d4l{NCCHQ{WwQVUvOs7:TT6= NHe4fXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
MRC5 MonIRY51cX[rcnHsJIF{e2G7 NUC1c|U3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{Mkm2JIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVUvPM7:TT6= NFn6TZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
fibroblast cells Mon0RY51cX[rcnHsJIF{e2G7 M1XmR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gcY92e2ViZX3idplwdmmlIH\pZpJw[myjc4SgZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjYQvF2u NFqxW289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5O|I4OSd-MUmzPVczPzF:L3G+
HFF NWDkbJliSW62aY\pdoFtKGG|c3H5 NHTESZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUOgbY4hUE[IIHPlcIx{KGK7IGPFRXAh[XO|YYmsJGlEPTB;NT62{txONg>? M1njNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL M{T5d2FvfGm4aYLhcEBie3OjeR?= M3q0NmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUWuOlPPxE1w M{[zflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVkxLz5{OUSwO|k6ODxxYU6=
NIH 3T3 MXLBcpRqfmm{YXygZZN{[Xl? MkT2OEB1dyB3IHThfZM> M1;vbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNic4TyZYlvKFOvaYToJIlv\mWldHXkJIlvKG2xdYPlJG5KUCB|VEOgZ4VtdHNiYX\0[ZIhPCC2bzC1JIRigXNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjgQvF2u NW\od3A3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OVgyOjRpPkG4OFU5OTJ2PD;hQi=>
RG2TK+ MnL0R5l1d3SxeHnjbZR6KGG|c3H5 NFqxOIk4OiCqcoO= Mn\jR5l1d3SxeHnjbZR6KGGpYXnud5QhUFOYMT30b{Bo\W6nIH;2[ZJmgHC{ZYPzbY5oKFKJMmTLL{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTVwOEdOwG0v MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDhyMEe2OEc,OTh6MEC3OlQ9N2F-
MRC-5 NFfkXVBHfW6ldHnvckBie3OjeR?= MWTDc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SC4aYLhcEBxdGGzdXWg[o9zdWG2aX;uJIJ6KEi3bXHuJGN6fG:vZXfhcI93cXK3czCoTGNOXiliKIP0doFqdiCDRD2xOlkqKGmwIF3SR{02KGOnbHzzMEBKSzVyPUWuPe69VS5? NITRV|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm2Olc1OCd-MUC5OlY4PDB:L3G+
HEL MljORY51cX[rcnHsJIF{e2G7 NGrvcllCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;NT65{txONg>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
HEL NWrnVG9ZSW62aY\pdoFtKGG|c3H5 NXPmPVRKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZicHzhdZVmKG[xcn3heIlwdixiRVO1NF02Njl6zszNMi=> NFfUOJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HCMV AD 169 NWDYXnoxSW62aY\pdoFtKGG|c3H5 NXLPUoJiUW5idnn0do8h[W62aY\pdoFtKGGwZDDhcpRq[2WubIXsZZIh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjDBSEAyPjlrIHnuJEhJS02YIFHEJFE3QSliY3XscJMtKEmGNUC9Ou69VS5? M{fIfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUO2NVUoRjJ7OUO2NVU9N2F-
HEL NVzxXmFTSW62aY\pdoFtKGG|c3H5 NXnDZYFrSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVbPxE1w MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL NV;GVWdnSW62aY\pdoFtKGG|c3H5 NXu2T|BrOyCmYYnz MnvBRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZJme2m|dHHueEBVUy2mZX\pZ4lmdnRiSHXwdoV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVbPxE1w MkfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HFF MmC1RY51cX[rcnHsJIF{e2G7 M{D3SmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ5OESge4l1cCCyb3ygRVgxQVZiVVy5O{BEPTl{RzDkc5VjdGVibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Nj6x{txONg>? NEPY[nU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL NGP4ZWRCdnSrdnnyZYwh[XO|YYm= MUO3JIRigXN? NXHLR4t1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:Pi5zMt88UU4> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ7MUCzPEc,OjZ{OUGwN|g9N2F-
MRC-5 NFjlbZJHfW6ldHnvckBie3OjeR?= Mlj1TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIH\vdkBidnSrLVjDUXYh[WO2aY\peJkh[WejaX7zeEBCTC1zNkmgd5Rz[WmwIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVYvO87:TT6= NGfwfoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEO2OlE{Lz57OEO2OlE{RC:jPh?=
HEL NVvVVpVLSW62aY\pdoFtKGG|c3H5 MkD4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Nj6z{txONg>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVzOES1PUc,OTd3MUi0OVk9N2F-
HEL NGPOcIxCdnSrdnnyZYwh[XO|YYm= MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME22MlPPxE1w Mn;lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL M1ywSWFvfGm4aYLhcEBie3OjeR?= NUfrZlZmPiC2bzC3JIRigXN? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD14LkS2{txONg>? NXT4WYM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
HEL NX3JcnBiSW62aY\pdoFtKGG|c3H5 M{fXb|ch\GG7cx?= MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhSURzNkmgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF03NjYQvF2u Ml3sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL MYHBcpRqfmm{YXygZZN{[Xl? NXnmSXFtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNicHzhdZVmKG[xcn3heIlwdixiRVO1NF03NjYQvF2u MkHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
HELF MWPBcpRqfmm{YXygZZN{[Xl? MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgd5Rz[WmwIHnu[oVkfGWmIHnuJGhGVEZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTZwNUNOwG0v NUHIZYYyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HEL M3TCTmFvfGm4aYLhcEBie3OjeR?= NV;sRpl3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVYvPTUQvF2u M2TVNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HFF MkHVRY51cX[rcnHsJIF{e2G7 NEiyemRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKFR{N{m4JJdqfGhicH;sJHQ5OTOVIGXMPVchSzV7Mleg[I92[mynIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPU[uOu69VS5? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL MVvBcpRqfmm{YXygZZN{[Xl? NHzxZWFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME22Mlc6|ryPLh?= Mnz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
HEL MnfoSpVv[3Srb36gZZN{[Xl? M4S3[GlvcGmkaYTpc44h[WejaX7zeEBFVkFib3[geY5qdm[nY4Tl[EBJTUxiY3XscJMh[nliaX7jc5Jxd3KjdHnvckBw\iCdM1jdWIRTNCCLQ{WwQVfPxE1w MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HFF MYnBcpRqfmm{YXygZZN{[Xl? NEDmTGRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUGgbY4hUE[IIHPlcIx{KGK7IGPFRXAh[XO|YYmsJGlEPTB;Nz6x{txONg>? NETYOIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
HEL NFrBOphCdnSrdnnyZYwh[XO|YYm= NFG2ZlFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:Py5zzszNMi=> NGfFNoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW3PFc5Oyd-MkK1O|g4QDN:L3G+
HEL MknDRY51cX[rcnHsJIF{e2G7 M1TpPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9O{4y|ryPLh?= MoOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
CRFK MUPBcpRqfmm{YXygZZN{[Xl? MoryN{Bl[Xm| MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDG[Yxq\CCqZYLw[ZN3cXK3czCxJIlv\mWldHXkJINifCCFUl\LJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEOg[IF6eyCkeTDjc4xwemmvZYTybYMh\m:{bXH6ZY4u[mG|ZXSgUXRUKGG|c3H5MEBGSzVyPUeuN:69VS5? M2\6bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
HEL NFvoUodCdnSrdnnyZYwh[XO|YYm= NXy3SFV5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nz6z{txONg>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HFF MV3BcpRqfmm{YXygZZN{[Xl? NFj1fFFKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIDjUc5dv\SC|dILhbY4qKGmwIFjGSkApcHWvYX6g[oljem:kbHHzeEkh[2WubIOsJGlEPTB;Nz60{txONg>? MlXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB3N{i2OUc,QTB3N{i2OVww[T5?
HFF NHmzcJZHfW6ldHnvckBie3OjeR?= M2rQdGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{Bz\XCuaXPheIlwdiCrbjDISmYh[2WubIOge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF04NjUQvF2u MnXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
HFF NW\ENYRZTnWwY4Tpc44h[XO|YYm= NF\IRm9Ed22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDUc5dv\SC|dILhbY4hd2ZiSFPNWkBqdiCjIIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZkhfXOrbnegTGZHKGOnbHzzMEBKSzVyPUeuOO69VS5? NYjxd4tGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HFF NX7nOoxqTnWwY4Tpc44h[XO|YYm= MYLDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XlidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= Mo\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|UoRjFyOEiyN|c2RC:jPh?=
HFF NYfSUYN7SW62aY\pdoFtKGG|c3H5 NYC1XGgySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfG:5bnWgd5Rz[WmwIFjDUXYhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTDpckBlfXCuaXPheIUhf2WubIOgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> M4nx[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|cxLz5zMEi4NlM4ODxxYU6=
HFF MnTFRY51cX[rcnHsJIF{e2G7 MnLsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v NHnQTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4Oid-MUC4PFI{PzJ:L3G+
HFF M1nCfmZ2dmO2aX;uJIF{e2G7 MV\Jcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHX4dJJme3OnZDDpckBJTkZiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD15LkVOwG0v NYL3NFRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzRpPkG1OVA6OTd2PD;hQi=>
HFF MoPOSpVv[3Srb36gZZN{[Xl? NFHvZWZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME23MlTPxE1w MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OUc,OTV3MEmxO|U9N2F-
HFF NYrifVBzTnWwY4Tpc44h[XO|YYm= MojaTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDlfJBz\XO|ZXSgbY4hUE[IIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Nz60{txONg>? NInVfVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
HEL MXXBcpRqfmm{YXygZZN{[Xl? NELjN4xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nz60{txONg>? NWixSWhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4Nlk6OTNpPkK4PFI6QTF|PD;hQi=>
HEL MmC0RY51cX[rcnHsJIF{e2G7 M3TEblYhfG9iNzDkZZl{ M{TpfGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JI1m[XO3cnXkJIFnfGW{IE[geI8hPyCmYYnzJJBwe3RvaX7m[YN1cW:wLDDFR|UxRTdwNEJOwG0v NHfFfVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NFcxPSd-Mkm2O|A4ODV:L3G+
HEL MkjQRY51cX[rcnHsJIF{e2G7 NYPYXWU2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTdwNd88UU4> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV5OEe4N{c,OjJ3N{i3PFM9N2F-
HFF M{TtZmFvfGm4aYLhcEBie3OjeR?= Mo\4RY51cX[rcnHsJIFkfGm4aYT5JJdieyCmZYTldo1qdmWmIHL5JJRp\SCKQ13WJJBt[XG3ZTDhd5NigSC3c3nu[{BJTkZiY3XscJMtKEmFNUC9O{44|ryPLh?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODV5OE[2K|46ODV5OE[2QE9iRg>?
HEL NEOwbVJCdnSrdnnyZYwh[XO|YYm= MmW5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD15LklOwG0v MkSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NEO1OVAoRjJ4NESzOVUxRC:jPh?=
HEL NEe1OpJCdnSrdnnyZYwh[XO|YYm= NXPPeVBjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFNTF4OTDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25uIFXDOVA:Py56N988UU4> MlrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
CRFK NWO0bWdRSW62aY\pdoFtKGG|c3H5 M13mSWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiCFUl\LJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9PE4y|ryPLh?= MlzMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL MkjDRY51cX[rcnHsJIF{e2G7 MmDyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSCjZoTldkwhTUN3ME24MlLPxE1w M{f1NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU1Lz5{M{mxNVg2PDxxYU6=
HFF NW[xVHRnTnWwY4Tpc44h[XO|YYm= Mn;QTY4hfmm2cn:gbY5pcWKrdHnvckBw\iCqdX3hckBkgXSxbXXnZYxwfmm{dYOgbY4hUE[IIHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9PE41|ryPLh?= MkHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HFF NHvMb4FCdnSrdnnyZYwh[XO|YYm= NWi2OphYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiB{OEG3JJdqfGhicH;sJGc5PDGDIGXMPVchSzV7Mleg[I92[mynIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUiuOO69VS5? M4myelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
HEL NYrxWFV6SW62aY\pdoFtKGG|c3H5 MXy3JIRigXN? MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjDh[pRmeiB5IHThfZMtKEWFNUC9PE44|ryPLh?= NUTzN3JrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NlIyOjhpPkG3OlIzOTJ6PD;hQi=>
HEL MmfyRY51cX[rcnHsJIF{e2G7 NIHpSFVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME24MlfPxE1w Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEKwOlcoRjJ6NkiyNFY4RC:jPh?=
HEL MnfHRY51cX[rcnHsJIF{e2G7 MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhcoQh[WO7Y3zveolzKHKnc3nzeIFvfCCKU2[xJGtQWyCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBi\2GrboP0JJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME25{txONg>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL MXfBcpRqfmm{YXygZZN{[Xl? MV\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:QS5zzszNMi=> M2\QRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
MRC-5 MVzGeY5kfGmxbjDhd5NigQ>? NFLWcJVKdmirYnn0c5J6KGGldHn2bZR6KG:oIHPvcZBwfW6mIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDpckBOWkNvNTDj[YxteyxiRVO1NF06NjUQvF2u M3[xS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{KzPVUyLz5zMkeyN|k2OTxxYU6=
Vero Mk\lRY51cX[rcnHsJIF{e2G7 Mke5TY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiVVj2xJEhHKGSnbIThJFMxPSliaX6gWoVzdyClZXzsd{whUUR3ME2xNO69VS5? Ml3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUixNUc,OzByOUixNVww[T5?
HFF M3TDb2FvfGm4aYLhcEBie3OjeR?= MlfsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjl|IHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;MUFOwG0v NXvIXmJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
Vero NVS4VndCSW62aY\pdoFtKGG|c3H5 NEDvdY8{KGSjeYO= M13LdWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZiemmlZXzsZU17d3O2ZYKgeolzfXNiRXzs[Y4hXlJvMUO2O{Bqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;MUGuNe69VS5? NWXRSJU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlA5QDNpPkK2OFYxQDh|PD;hQi=>
HEL NIfPOHNCdnSrdnnyZYwh[XO|YYm= NU\COIp{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1zMT60N:69VS5? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6MEK1NUc,Ojl6OECyOVE9N2F-
HELF NHHOfVFCdnSrdnnyZYwh[XO|YYm= M2fjbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUB{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MUGuO|XPxE1w NHf5WIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HFF M2i0e2FvfGm4aYLhcEBie3OjeR?= MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFI{OTFiaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD1zMj60{txONg>? Mln0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
HEL NWC2[|kySW62aY\pdoFtKGG|c3H5 NEDPWJM4KGSjeYO= MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2xNk43|ryPLh?= M1rRNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{O5NFgzLz5zOUOzPVA5OjxxYU6=
HEL Mk\1RY51cX[rcnHsJIF{e2G7 NITQWG5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUGzMlnPxE1w NGixSmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS0N|U2OCd-Mk[0OFM2PTB:L3G+
Vero NWTkZXJpSW62aY\pdoFtKGG|c3H5 Mn7HN|YhfG9iNEigbJJ{ NVXmNIhWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJGIhfmm{dYOgNlQyODViaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDwcIFyfWVicnXkeYN1cW:wIHHmeIVzKDN4IITvJFQ5KGi{czygSWM2OD1zND61{txONg>? Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOlEoRjF5NEO4NFYyRC:jPh?=
HEL NEHTeppCdnSrdnnyZYwh[XO|YYm= NGm4[pFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJI5m\2G2aY\lJIFv\CCDQ2[gdoV{cXO2YX70JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OTRwN988UU4> NGLkOJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFIzOid-MkK4OVgzOjJ:L3G+
HEL NWPz[HFOSW62aY\pdoFtKGG|c3H5 M{Tnd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{KHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9NVQvQc7:TT6= MkHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxOVQoRjJ5N{WwNVU1RC:jPh?=
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 29845211     


(A) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml respectively. After 24 h post-transfection, cell viability was measured by MTT assay. (B) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml, respectively for 48 h. Cell viability was also measured by MTT assay.

29845211
In vivo Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response[7].

Protocol

Cell Research:

[7]

- Collapse
  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    To assess cell proliferation by thymidine incorporation, a total of 2 × 10<sup>4</sup> BV-2 cells were seeded in a 96-well plate for a maximum of 12 h in 10% FBS containing DMEM and then serum starved for an additional 12 h before the addition of varying concentrations of GCV for a total of 24 h. Cultures were pulsed for the final 8 h with 1 µCi/well [3H]thymidine before incorporated radioactivity was measured using a β plate scintillation counter.


    (Only for Reference)
Animal Research:

[7]

- Collapse
  • Animal Models: C57BL/6 mice
  • Dosages: 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 27 mg/mL warmed (105.78 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 255.23
Formula

C9H13N5O4

CAS No. 82410-32-0
Storage powder
in solvent
Synonyms RS-21592, 2'-Nor-2'-deoxyguanosine
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04478474 Not yet recruiting Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme Corp. September 15 2020 --
NCT03698435 Recruiting Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4
NCT02152358 Unknown status Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID