Ganciclovir

For research use only.

Catalog No.S1878 Synonyms: RS-21592, 2'-Nor-2'-deoxyguanosine

7 publications

Ganciclovir Chemical Structure

CAS No. 82410-32-0

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

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Selleck's Ganciclovir has been cited by 7 publications

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  • Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.

    Sci Rep, 2017, 7: 43349. Ganciclovir (BW 759) purchased from Selleck.

Purity & Quality Control

Choose Selective CMV Inhibitors

Biological Activity

Description Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro

Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. [1] Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. [2] Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. [3] Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. [4] Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. [5] Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines NFS2Z|dHfW6ldHnvckBie3OjeR?= NGLXfmNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiKFjTWk0zMSCrbnT1Z4VlKGO7dH;wZZRpcWOrdImgZpkhPTBnIHnuJGU3W01iY3XscEBtcW6nczygSWM2OD1zLkKgcm0> NGrV[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUS5OVU5Pid-MUG0PVU2QDZ:L3G+
OST TK- cells NGi4WmdEgXSxdH;4bYNqfHliYYPzZZk> NUDxUJRzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFusJGlEPTB;MD6wNFE6|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL M3q3VWFvfGm4aYLhcEBie3OjeR?= NEfwUohCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yME[0{txONg>? M2DmZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkeyOFQ2Lz5zN{[3NlQ1PTxxYU6=
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HEL M4jqcWFvfGm4aYLhcEBie3OjeR?= MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjBzM988UU4> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB7OUC5O{c,OjNyOUmwPVc9N2F-
HEL NHX0bnBCdnSrdnnyZYwh[XO|YYm= NIHVVplCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFE2|ryPLh?= Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
OST TK- cells NXL6UolwS3m2b4TvfIlkcXS7IHHzd4F6 NF7Zb2NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB{LkWgeW0hOS2dNj2oeJJqeGinbonscYV1cG:6eTno[Zh6dF22aIntbY5mNCCLQ{WwQVAvODF6zszNMi=> NX\0T2Z1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL NXz1Z3NGSW62aY\pdoFtKGG|c3H5 NV\JcFZqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iSFXMJINmdGy|LDDFR|UxRTBwMEG5{txONg>? NI\nVJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3Oid-MUexPFEyPjJ:L3G+
HEL Mkj6RY51cX[rcnHsJIF{e2G7 M{jrZlIhfG9iMzDkZZl{ NULZ[oozSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNkB1dyB|IHThfZMheG:|dDDpcoZm[3Srb36sJGVEPTB;MD6wNVnPxE1w M2XpU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
HEL M37wZWFvfGm4aYLhcEBie3OjeR?= MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{zszNMi=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL MXXBcpRqfmm{YXygZZN{[Xl? NHrzSoc1KGSjeYO= NGX4boZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IESg[IF6eyxiRVO1NF0xNjB{zszNMi=> NYTXVFRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HEL NWrtc254SW62aY\pdoFtKGG|c3H5 MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yMt88UU4> M{PuXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL MmXZRY51cX[rcnHsJIF{e2G7 MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOs7:TT6= NVXrUHoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL NI[5Z|BCdnSrdnnyZYwh[XO|YYm= NGfwTXZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvODMQvF2u NYnxSoJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
Vero M3zhZmFvfGm4aYLhcEBie3OjeR?= NI\pUlE4OiCqcoO= NUPDXpM1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFfGVEBmgHC{ZYPzbY9vKGGodHXyJFczKGi{czDifUBITlBvYnHz[YQh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuNFI2|ryPLh?= MoHnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MEO0O|YoRjNzNUCzOFc3RC:jPh?=
HEL NEfNb2JCdnSrdnnyZYwh[XO|YYm= NEmybo9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yMkhOwG0v NYrKOnlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HEL NHLlVFlCdnSrdnnyZYwh[XO|YYm= NVfD[o9OSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHL5JJZqemGuIFPQSUBie3OjeTygSWM2OD1yLkCyO:69VS5? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
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HEL NYfSRWxnSW62aY\pdoFtKGG|c3H5 NUXoZ254PCCmYYnz M{fHdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEROwG0v Ml\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4OU[5OlMoRjJzNkm2PVY{RC:jPh?=
HEL Ml;PRY51cX[rcnHsJIF{e2G7 NUH6NJhYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD6wN:69VS5? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL NHLU[ZBCdnSrdnnyZYwh[XO|YYm= MXG0JIRigXN? M3m4N2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> NV\MRZJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2PVY6PjNpPkKxOlk3QTZ|PD;hQi=>
HEL MoLLRY51cX[rcnHsJIF{e2G7 Ml;xOEBl[Xm| M2jI[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDRiZHH5d{whTUN3ME2wMlA{|ryPLh?= M4qwcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
HEL MmSxRY51cX[rcnHsJIF{e2G7 M4\oeWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NE4xO87:TT6= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HEL MXTBcpRqfmm{YXygZZN{[Xl? M1nNPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> Mn70QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
HEL MmHSRY51cX[rcnHsJIF{e2G7 NYi1OW1YSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD1yLkCz{txONg>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
HEL M{PnNGFvfGm4aYLhcEBie3OjeR?= M2LuUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEROwG0v NX;lRpc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
HELF NH7rcpVCdnSrdnnyZYwh[XO|YYm= M{XoR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFEhU0:VIIP0doFqdiCrbn\lZ5Rm\CCrbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> M1nufVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HELF M{W4[mFvfGm4aYLhcEBie3OjeR?= Ml;WRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNkBIKHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlA{|ryPLh?= NVPudZdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HEL MYDBcpRqfmm{YXygZZN{[Xl? MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvODQQvF2u NEn3WI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HEL MmHlRY51cX[rcnHsJIF{e2G7 NFfoZlVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCz{txONg>? Mk\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
HEL MYjBcpRqfmm{YXygZZN{[Xl? NWDvSo1KSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDpckBJTUxiY3XscJMtKEWFNUC9NE4xOzMQvF2u M1znXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HEL MlXsRY51cX[rcnHsJIF{e2G7 NEHmcIZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJG1KSz1yLkCzNu69VS5? Mo\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL NU\UNJVFSW62aY\pdoFtKGG|c3H5 NVLBd2tnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFMz|ryPLh?= M3X2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
OST TK- cells NV3Q[HhmS3m2b4TvfIlkcXS7IHHzd4F6 M4fuOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDVidV2gNU1cPi1qdILpdIhmdnmubXX0bI95gSmqZYj5cH11cHmvaX7lMEBKSzVyPUCuNFM{|ryPLh?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
fibroblast cells MV3BcpRqfmm{YXygZZN{[Xl? NXizfXhkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEVOwG0v M4GzXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3NlcyLz5zOUO5O|I4OTxxYU6=
HEL MmGzRY51cX[rcnHsJIF{e2G7 MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB2zszNMi=> NUPmTVBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HFF M1jadmFvfGm4aYLhcEBie3OjeR?= M4iyOVEhcHJ? M2LtcmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyBqc4TyZYlvKEGGMU[5LUBqdm[nY4Tl[EBqdiBzIHjyJJBz\XS{ZXH0[YQhcHWvYX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidC2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGK7IH7leZRz[WxicnXkJJVxfGGtZTDhd5NigSxiRVO1NF0xNjB2zszNMi=> NFXrUIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3OlQzQSd-MkGzO|Y1Ojl:L3G+
HEL M{[0[WFvfGm4aYLhcEBie3OjeR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlA1|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL MULBcpRqfmm{YXygZZN{[Xl? Mln0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wOO69VS5? M17NdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
Vero MoXqRY51cX[rcnHsJIF{e2G7 NUXFNGx2OzZiaILz NHPWOlFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZiMTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgN|YhcHK|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuNFTPxE1w MnPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzJzOUG0OVYoRjN{MUmxOFU3RC:jPh?=
OST TK- cells NEXTTXFEgXSxdH;4bYNqfHliYYPzZZk> MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NSi2cnnwbIVvgWyvZYToc5h6MWineInsYZRpgW2rbnWsJGlEPTB;MD6wOFHPxE1w M3PDZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HEL NXLnVZJzSW62aY\pdoFtKGG|c3H5 MVKyJJRwKDNiZHH5dy=> MnHQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjCyJJRwKDNiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD1yLkC0Oe69VS5? M3TlPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
OST TK- cells M1jCUWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{LGSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9UXCCWSz2gZ4VtdHNiZYjwdoV{e2mwZzDIV3YyKFSNIHnuJJBz\XOnbnPlJI9nKDJwNTD1UUAyNVt4LWuxMFEuMGSrcHjlcpltMS1zLTi0MZB6emmmeXypcYV1cG:6eW3o[Zh6dF22aIntbY5mNCCLQ{WwQVAvODYQvF2u M{LNSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
human NXzOSW9HSW62aY\pdoFtKGG|c3H5 Mn\OO{Bl[Xm| MmfVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjC3JIRigXNuIFXDOVA:OC5yNd88UU4> Mn64QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HEL M3zLXGFvfGm4aYLhcEBie3OjeR?= NXTjNYNLOiC2bzCzJIRigXN? MoflRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNicH;zeE1qdm[nY4Tpc44tKEWFNUC9NE4xPTIQvF2u Mki3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
HEL NHWzeWZCdnSrdnnyZYwh[XO|YYm= M33nXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yNUZOwG0v MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
HEL NEHj[YRCdnSrdnnyZYwh[XO|YYm= MVeyJJRwKDNiZHH5dy=> MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IH3lZZN2emWmIHHmeIVzKDJidH:gN{Bl[Xm|IIDvd5QucW6oZXP0bY9vNCCHQ{WwQVAvODV5zszNMi=> NVjmNVVWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL MX\GeY5kfGmxbjDhd5NigQ>? NFH1dlNEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqNX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFqRzmgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvODcQvF2u M2SzV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NkSzN|I5Lz5zNE[0N|MzQDxxYU6=
Hel NXm0N|F7TnWwY4Tpc44h[XO|YYm= NEnxPIpG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JIhmenCnczDzbY1xdGW6II\pdpV{KHS7cHWgNUBMd3Nic4TyZYlvKGmwZIXj[YQh[3m2b4DheIhq[2m2eTDpckBJ\WxiY3XscJMtKEWFNUC9NE4xPs7:TT6= NFH3VZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[1PFg2QCd-MUW2OVg5PTh:L3G+
HEL NWLEXWRySW62aY\pdoFtKGG|c3H5 NEP4b45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNuIFXDOVA:OC5yNt88UU4> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN7Mke5NUc,OTZ|OUK3PVE9N2F-
HEL NInLR5hCdnSrdnnyZYwh[XO|YYm= MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX6gTGVNKGOnbHzzMEBGSzVyPUCuNFbPxE1w NVyzTolIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zPVI4QTFpPkG2N|kzPzlzPD;hQi=>
HEL NHzEUZZCdnSrdnnyZYwh[XO|YYm= MXGzJIRigXN? M{C3PWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODgQvF2u MlH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL MmLMRY51cX[rcnHsJIF{e2G7 MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE4xP87:TT6= M{PpW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{O4OlU{Lz5|MEezPFY2OzxxYU6=
HELF NXX2TmpwSW62aY\pdoFtKGG|c3H5 NF;hVY44KGSjeYO= MnnQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> NF;JbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUW4Olg{Oid-M{G1PFY5OzJ:L3G+
HEL M1ryemFvfGm4aYLhcEBie3OjeR?= MX23JIRigXN? NVfVclI1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDdiZHH5d{whTUN3ME2wMlA5|ryPLh?= NFexUpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HEL NY[5OItvSW62aY\pdoFtKGG|c3H5 MU[zJIRigXN? NYH3R|ZbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhOiC|dILhbY4hTyCrbn\lZ5Rm\CCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGVEPTB;MD6wPO69VS5? NVLMV4pYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL NX\5N2czSW62aY\pdoFtKGG|c3H5 NHjQPWw{KGSjeYO= Ml[zRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA5|ryPLh?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
OST TK- cells NGjzSXZEgXSxdH;4bYNqfHliYYPzZZk> MorNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhPSC3TTCxMXs3NVtzLEGtLIRqeGinbonsLU0yNSh2LYD5dollgWxrbXX0bI95gV2qZYj5cH11cHmvaX7lMEBKSzVyPUCuNFgy|ryPLh?= NVjpSZdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL MlSxRY51cX[rcnHsJIF{e2G7 MVSzJIRigXN? NIj5dI9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AyKHO2cnHpckBMV1NiaX7m[YN1\WRiaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDNiZHH5d{BjgSClb3zvdolu\XS{aXOg[o9zdWG8YX6tZoF{\WRiTWTTJIF{e2G7LDDFR|UxRTBwMEpOwG0v MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HEL MWPBcpRqfmm{YXygZZN{[Xl? NX71NFBSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2wMlA6|ryPLh?= M3\LTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
E6SM NVnsR5gzSW62aY\pdoFtKGG|c3H5 M4DDbGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY4hTT[VTTDj[YxteyxiTVnDQVAvODl4zszNMi=> M3fnd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
E6SM MYHBcpRqfmm{YXygZZN{[Xl? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbjDFOnNOKGOnbHzzMEBOUUN;MD6wPVbPxE1w M2nUPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
HEL MoXJRY51cX[rcnHsJIF{e2G7 NYDHNGdmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[WO7Y3zveolzNXKnc3nzeIFvfCCKU2[xJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvOc7:TT6= NWD1bnE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL NH;5[VhCdnSrdnnyZYwh[XO|YYm= M2TLemFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JGFEXi2{ZYPpd5RidnRiSHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjIQvF2u NYDnV4ZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
OST TK- cells NFjJcVVEgXSxdH;4bYNqfHliYYPzZZk> MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NVtzLEGtLIRqeGinbonsLU0yNSh2LYD5dollgWxrbXX0bI95gV2qZYj5cH11cHmvaX7lMEBKSzVyPUCuNVHPxE1w NYjHXndqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HFF Ml[zRY51cX[rcnHsJIF{e2G7 M4PiSFExKGSjeYO= MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSxd37lJIlv\mWldHXkJIlvKEiIRjDj[YxteyCrbnP1ZoF1\WRiZn;yJFExKGSjeYOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1yLkG0{txONg>? M1i3[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEGyOFIxLz5{MUixNlQzODxxYU6=
HFF M2XOSmZ2dmO2aX;uJIF{e2G7 NF;EfVJKdmirYnn0bY9vKG:oIFjDUXYhSURzNkmgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JIN6fG:yYYTobYMh\W[oZXP0JIF{e2G7LDDFR|UxRTBwMUZOwG0v MoWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MCA-TK MkH4R5l1d3SxeHnjbZR6KGG|c3H5 NVi3S2lKS3m2b4TvfIlkcXS7IHHnZYlve3RiTVPBMXRMKGOnbHzzMEBKSzVyPUCuNVXPxE1w NYSxXmZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OlA6OjZpPkG3PVYxQTJ4PD;hQi=>
vero NGrUN3hCdnSrdnnyZYwh[XO|YYm= NIi0d2VCdnSrdnnyZYwh[WO2aY\peJkhf2G|IHTleIVzdWmwZXSgbY4heGyjcYXlJJJm\HWldHnvckBie3OjeTDpckB3\XKxIHPlcIx{KGGpYXnud5QhUFOYLUGgSkB{fHKjaX6sJGlFPTB;MD6y{txONg>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{QDdzOE[wK|4{QDdzOE[wQE9iRg>?
Vero NHn5e2NCdnSrdnnyZYwh[XO|YYm= NV3IcY1JUW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KHejczDt[YF{fXKnZDDh[4FqdnO2IFjTWk0yMEZrIHnuJHZmem9iY3XscJMtKEmGNUC9NE4z|ryPLh?= NWLWNIlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVgyOSd-M{CwPVgyOTxxYU6=
Vero MX3BcpRqfmm{YXygZZN{[Xl? NULHN5A3SW62aY\pdoFtKGGldHn2bZR6KGSndHXycYlv\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB1gXCnIEGgLGYhe3S{YXnuLUBjgSCybHHxeYUhemWmdXP0bY9vKGmwIG\ldo8h[2WubIOsJGlFPTB;MD6y{txONg>? M1r1SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMU[yOlMoRjNyMU[yOlM9N2F-
HEL MWPBcpRqfmm{YXygZZN{[Xl? NHnI[JVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5{zszNMi=> M3X0e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkixNlI2Lz5zOUK4NVIzPTxxYU6=
HEL MmHWRY51cX[rcnHsJIF{e2G7 NH\v[|k{KGSjeYO= M3iyUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXm[YNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKG2ndHjv[EwhTUN3ME2wMlLPxE1w NGLM[Y89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK4Olk2Oid-M{CyPFY6PTJ:L3G+
fibroblast cells NGPJZY1HfW6ldHnvckBie3OjeR?= M2fCbmlvcGmkaYTpc44hd2ZidnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QhcW5iaX7m[YN1\WRiaIXtZY4h\m:{ZYPrbY4h\mmkcn;icIF{fCClZXzsJIlvKG2xbn;sZZlmenNib3[gTHNXNTJiQVSgWoVzdyClZXzsd{BjgSB3MDWsJGVEPTB;MD6yN:69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTV6NUS1O{c,OTF3OEW0OVc9N2F-
HEL NEDZOGRCdnSrdnnyZYwh[XO|YYm= Mmn5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczygSWM2OD1yLkK1{txONg>? MoS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixO|goRjJ5MUK4NVc5RC:jPh?=
vero MmTmRY51cX[rcnHsJIF{e2G7 MYTJckB3cXS{bzDhcpRqfmm{YXygZY5lKGGwdHnj[YxtfWyjcjDhZ5Rqfmm2eTD3ZZMh\X[jbIXheIVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeolzfXNiSGPWMVEhMEZic4TyZYlvMSCrbjD2[ZJwKGOnbHzzJJRqe3O3ZTDjeYx1fXKnLDDJSFUxRTBwM988UU4> M4CzUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUO2NVUoRjJ7OUO2NVU9N2F-
HELF Mn7HRY51cX[rcnHsJIF{e2G7 MYe3JIRigXN? MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMlPPxE1w M3mzelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
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HEL MnnORY51cX[rcnHsJIF{e2G7 NWr1c4RvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjUQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HEL NXfi[FNwSW62aY\pdoFtKGG|c3H5 NXO4N3AySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iSFXMJINmdGy|LDDFR|UxRTBwNElOwG0v MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2Nkc,OTdzOEGxOlI9N2F-
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HEL M2S1d2FvfGm4aYLhcEBie3OjeR?= M4DnOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JIFkgWOub4\pdk1z\XOrc4ThcpQhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuOe69VS5? M4nmZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
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HEL Mn7rRY51cX[rcnHsJIF{e2G7 M4i5R2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLk[2{txONg>? NVvTWHpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL MYTBcpRqfmm{YXygZZN{[Xl? NVjvOopISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDFiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuOlnPxE1w NW\oVFZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL MkSwRY51cX[rcnHsJIF{e2G7 MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC55zszNMi=> M1TyOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
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HEL MmexRY51cX[rcnHsJIF{e2G7 NImzU4tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTJwMkpOwG0v MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6MEK1NUc,Ojl6OECyOVE9N2F-
HEL NYrrbXkzSW62aY\pdoFtKGG|c3H5 MXy1JIRigXN? MlTMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWGssKF[cVjDZV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNTDkZZl{NCCHQ{WwQVIvO87:TT6= NFnDZ2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
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HEL299 MkHJRY51cX[rcnHsJIF{e2G7 MkTCO{Bl[Xm| MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhcW6oZXP0[YQhcW5iSFXMNlk6KGOnbHzzJIFnfGW{IEeg[IF6eyCkeTDHSnAu[mG|ZXSg[ox2d3Knc3PlcpQhemWmdXP0bY9vKGG|c3H5MEBGSzVyPUKuN|nPxE1w Mm\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNEe5NVEoRjJyMES3PVEyRC:jPh?=
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HEL NES2SoxCdnSrdnnyZYwh[XO|YYm= M2C5cFch\GG7cx?= M1G0WGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5QhcW6oZXP0bY9vNCCHQ{WwQVIvPc7:TT6= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HEL MUnBcpRqfmm{YXygZZN{[Xl? NWrlTYRjPSCmYYnz NI\idnRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJIRm\mmlaXXueEBX[XKrY3XscIEhgm:|dHXyJJZqenW|IEC3M|EhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyJFUh\GG7czygSWM2OD1{LkZOwG0v M4Pqe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{O5NFgzLz5zOUOzPVA5OjxxYU6=
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HEL M{G5dmFvfGm4aYLhcEBie3OjeR?= NHPI[I5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBnd3OlYYLu[ZQuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhSyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Mj62{txONg>? NWPMVZVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
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HEL M1q1U2FvfGm4aYLhcEBie3OjeR?= NWnwNYw3PyCmYYnz NHLBZXJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEVVZiRHH2bZMhcW5iaIXtZY4hUEWOIHPlcIx{KGGodHXyJFch\GG7czygSWM2OD1{LkdOwG0v NH7IXoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
CRFK MXzBcpRqfmm{YXygZZN{[Xl? NF:1co9CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrbnWgbIVzeGW|dnnyeZMhcW6oZXP0[YQhcW5iY3H0JGNTTktiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDmdo9uKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZpkhVVSWIHHzd4F6NCCHQ{WwQVIvPs7:TT6= NYTPRoFlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwN|Q4OTFpPkKwNFM1PzFzPD;hQi=>
HFF NGDIZVJCdnSrdnnyZYwh[XO|YYm= NVu0PG1PSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkW0NkB4cXSqIIDvcEBVQDF|UzDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2yMlfPxE1w NXrCbnNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NVvlOWJISW62aY\pdoFtKGG|c3H5 NYHGb4tvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDEZZZqeyCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9Nk44Pc7:TT6= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVzOES1PUc,OTd3MUi0OVk9N2F-
HEL MUPBcpRqfmm{YXygZZN{[Xl? MkjsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Mj65Ou69VS5? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
BSC-1 MnfjRY51cX[rcnHsJIF{e2G7 NF20UWRCdnSrdnnyZYwh[WO2aY\peJkhd2ZidHjlJINwdXCxdX7kJJdieyCndnHseYF1\WRiYXfhbY5{fCC2aHWgTIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJIlvKEKVQz2xJINmdGy|LDDJR|UxRTQQvF2u MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|M{CwK|4zQTF|M{CwQE9iRg>?
MRC5 NVPJU4RkTnWwY4Tpc44h[XO|YYm= NV7WT4hvUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgRWQyPjlic4TyZYlvKG:oIFjDUXYhcW5iTWLDOUBk\WyuczygTWM2OD1|zszNMi=> MkDhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2NUS0OlUoRjFzNEW0OFY2RC:jPh?=
HFF NFvJbHdCdnSrdnnyZYwh[XO|YYm= NGTvO4pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwIFjGSkBk\WyuczDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDJR|UxRTQQvF2u MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF4MUm0Okc,OTdzNkG5OFY9N2F-
hhTERT-BJ1 NVjoZWZlSW62aY\pdoFtKGG|c3H5 M{HWWFIh\GG7cx?= M2Xue2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCqdX3hckBpcFSHUmStRmoyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNibXXkbYF1\WRiRF7BJJN6dnSqZYPpd{Bi\nSncjCyJIRigXNuIFXDOVA:O87:TT6= MmPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NUixNlQoRjF6NEW4NVI1RC:jPh?=
HEL MoPkRY51cX[rcnHsJIF{e2G7 MoHaO{Bl[Xm| NVK5Rok5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKU2[xJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNzDkZZl{NCCHQ{WwQVPPxE1w NGXmWWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
HFF MoD1RY51cX[rcnHsJIF{e2G7 Mln6NVAh\GG7cx?= NXjXT4g4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IGTve45mKGmwZnXjeIVlKGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5icHzhdZVmKG[xcn3heIlwdiCjZoTldkAyOCCmYYnzMEBKSzVyPUROwG0v Mn;pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NEGyNVgoRjJzNkSxNlE5RC:jPh?=
HEL MXHBcpRqfmm{YXygZZN{[Xl? MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1|LkJOwG0v MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
HEL MXnBcpRqfmm{YXygZZN{[Xl? M{\PWmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUOuNe69VS5? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PEc,Ojd4M{mzOlg9N2F-
HELF NWrpWFNrSW62aY\pdoFtKGG|c3H5 M2nVWlch\GG7cx?= MkS1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY5kfWKjdHXkJIZweiB5IHThfZMh[nliR3nlcZNiKHO2YXnubY5oKGKjc3XkJI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVMvOTYQvF2u M2jCbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HFF MmTqRY51cX[rcnHsJIF{e2G7 NYrwNGF5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\2GwY3njcI93cXJvc3Xud4l1cX[nIFjDUXYyKGm|b3zheIUhemWybHnjZZRqd25iaX6gTGZHKGOnbHzzJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Mz6yNu69VS5? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzME[4OEc,OTlyMUC2PFQ9N2F-
HFF NGjKcItHfW6ldHnvckBie3OjeR?= M13sPGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IIfpcIQufHmyZTDBSFE3QSC|dILhbY4hd2ZiSFPNWkBqdiC7aXXs[EBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|kxRTNwM988UU4> NIO4WZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PCd-MUC4PFI{PzR:L3G+
HEL NGniT5NCdnSrdnnyZYwh[XO|YYm= MmryOkB1dyB5IHThfZM> NHvRVppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2LXnu[oVkfGmxbjygSWM2OD1|LkOx{txONg>? MmjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
MEF MmDFSpVv[3Srb36gZZN{[Xl? M2G0U2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IH31dolv\SCleYTvcYVo[WyxdnnyeZMhemWybHnjZZRqd25iaX6gUWVHKGOnbHzzJJdieyCmZYTldo1qdmWmIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Oy52zszNMi=> MnrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
BSC-1 NEDjZW5CdnSrdnnyZYwh[XO|YYm= M3Tx[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zIDjo[ZJx\XNic3ntdIxmgCC4aYL1d{ktKGSndHXycYlv\WRiYomgSWxKW0FiaX6gdZVi\HK3cHzpZ4F1\SC5ZXzsd{B2e2mwZzDCV2MuOSClZXzsd{whUUN3ME2zMlXPxE1w NWDUTY5XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzBpPkGwPFgzOzdyPD;hQi=>
BSC-1 NX;MUHlbTnWwY4Tpc44h[XO|YYm= M{TtOGVNUVODIHHzd4F6KHejczDw[ZJnd3KvZXSgeZNqdmdiQmPDMVEh[2WubIOgeI8h\GW2ZYLtbY5mKGGldHn2bZR6KGGpYXnud5QhUFOYLUGsJGlEPTB;Mz61{txONg>? NX72Tm1nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzJpPkGwPFgzOzd{PD;hQi=>
BSC-1 NWq0fmdGSW62aY\pdoFtKGG|c3H5 Ml;ITY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFidnnyeZMhcW5iQmPDMVEhMG2xbnvlfUBscWSwZYmpJINmdGy|LDDJR|UxRTNwNd88UU4> NYHw[ZlGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3PSd-OUC1O|g3PTxxYU6=
HEL NWXob4FuSW62aY\pdoFtKGG|c3H5 MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDQUWVFSVBvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9N{42|ryPLh?= NHzB[HM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HFF NFLIeo1CdnSrdnnyZYwh[XO|YYm= NFfSRnlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKFR{NEKwJJdqfGhicH;sJGc5PDGDIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUOuOe69VS5? NX35[oJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
BSC-1 NXHDfpN1TnWwY4Tpc44h[XO|YYm= Mnj3TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIDjIV3YuOSliZYjwdoV{e2WmIHnuJGJUSy1zIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KEWOSWPBJIF{e2G7LDDJR|UxRTNwNd88UU4> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OEc,OTV3MEmxO|Q9N2F-
BSC-1 NIPDWFRHfW6ldHnvckBie3OjeR?= M1vi[GlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDDh[4FqdnO2IHjldpBmeyC|aX3wcIV5KH[rcoXzJJR6eGVvMTCoTHNXNTFrIHX4dJJme3OnZDDpckBDW0NvMTDj[YxteyC5YYOg[IV1\XKvaX7l[EBjgSCHTFnTRUBie3OjeTygTWM2OD1|LkZOwG0v NWDhWnR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzVpPkG1OVA6OTd3PD;hQi=>
BSC-1 MoHpSpVv[3Srb36gZZN{[Xl? NXTOPIFmUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJEhJW1ZvMTmg[ZhxemW|c3XkJIlvKEKVQz2xJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IFXMTXNCKGG|c3H5MEBKSzVyPUOuOe69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3Okc,OTV3MEmxO|Y9N2F-
HFF NIrH[oVHfW6ldHnvckBie3OjeR?= M2DsWmNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IEK5NVYhSURzNkmgd5Rz[WmwIH;mJGhEVVZiaX6gfYlmdGRicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN7ME2zMlbPxE1w NXmxRpk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HEL MlHrRY51cX[rcnHsJIF{e2G7 NWnLTpdyPyCmYYnz NEnoOnRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2zMlbPxE1w NH\rXJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HFF NFn2PXhCdnSrdnnyZYwh[XO|YYm= NW\nT2p2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkK1PEB4cXSqIGXMPVchSzV7MlegcZV1[W62IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{46|ryPLh?= NIDNTYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL MY\BcpRqfmm{YXygZZN{[Xl? NFTqNmEzKHSxIEOg[IF6ew>? NH\mV3ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBCS1ZvcnXzbZN1[W62IFjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBt[XG3ZTDmc5Ju[XSrb36gcYVie3W{ZXSgZYZ1\XJiMjD0c{A{KGSjeYOgdI9{fCCrbn\lZ5Rqd25uIFXDOVA:Oy57Md88UU4> NXS3R5pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC-5 MYTBcpRqcGW{cHXzeolzfXNiYYPzZZk> M3XUeWlvKH[rdILvJIFvfGmqZYLw[ZN3cXK3czDhZ5Rqfmm2eTDh[4FqdnO2IF3SR{02KGOnbHzzJIlv\mWldHXkJJdqfGhiSFPNWkApSURvMU[5JJN1emGrbjmsJGlEPTB;NN88UU4> NIn2[4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{KzOlc5Lz5zM{KzOlc5RC:jPh?=
HEL NHrWeppCdnSrdnnyZYwh[XO|YYm= Mn61RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZ4lld2[xdnnyJGhEVVZiQVSxOlkh[2yxbnWgOUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9OO69VS5? NXTRcG14RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL MW\BcpRqfmm{YXygZZN{[Xl? M3LxVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY4njcI93cXJvcnXzbZN1[W62IFjTWlEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:PM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB7OUC5O{c,OjNyOUmwPVc9N2F-
HEL MYPBcpRqfmm{YXygZZN{[Xl? NF;kfFJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBVUy2wZXfheIl3\SCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;NN88UU4> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HEL NXPVRYtvSW62aY\pdoFtKGG|c3H5 NFezOIlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME20{txONg>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
HEL M4nRUGFvfGm4aYLhcEBie3OjeR?= NFvzZ5pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME20MlA2|ryPLh?= NVzWUW1tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6QTBpPkK5OFA4QTlyPD;hQi=>
HFF NIPme|hHfW6ldHnvckBie3OjeR?= MoHTR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3RiQz20JHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND6x{txONg>? M2TEflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|c1Lz5zMEi4NlM4PDxxYU6=
HFF M1jQbGFvfGm4aYLhcEBie3OjeR?= NHvyRZFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUGgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME20MlHPxE1w NFLXcI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
CRFK NWfyXXJlSW62aY\pdoFtKGG|c3H5 M4GyTFQh\GG7cx?= M4nzU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:PC5zzszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3OUi3Okc,OjJ2NUm4O|Y9N2F-
CRFK MXvBcpRqfmm{YXygZZN{[Xl? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDm[YxqdmViaHXydIV{fmm{dYOgbY5n\WO2ZXSgbY4h[2G2IFPSSmsh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[nliTWTTJIF{e2G7LDDFR|UxRTRwMd88UU4> MmLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
HEL NF7jN4ZCdnSrdnnyZYwh[XO|YYm= MkKwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhPCCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;ND6z{txONg>? M{HjOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL NX:0Xmt{SW62aY\pdoFtKGG|c3H5 M{f3SGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGFEXi2{ZYPpd5RidnRidHj5cYllcW6nIHvpcoF{\SCmZX\pZ4lmdnRiSHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME20MlPPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HFF M3HsT2Z2dmO2aX;uJIF{e2G7 M37uVGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IIfpcIQufHmyZTDUc5dv\SC|dILhbY4hd2ZiSFPNWkBqdiC7aXXs[EBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTRwNd88UU4> MmSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HEL Mk[wRY51cX[rcnHsJIF{e2G7 NVvJVYpPPyCmYYnz M4HTXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{BmgHC{ZYPz[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JGdq\W2|YTDzeIFqdiCkYYPl[EBucWO{b4Pjc5B6NCCHQ{WwQVQvPzMQvF2u MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUGwN|goRjJ4MkmxNFM5RC:jPh?=
HEL MYLBcpRqfmm{YXygZZN{[Xl? NUSwZpRzPyCmYYnz M3Lw[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTRwON88UU4> NYj4OnRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1N|k3OjJpPkG3OVM6PjJ{PD;hQi=>
HEL M4[0VmFvfGm4aYLhcEBie3OjeR?= MkDuN{Bl[Xm| M2fHcGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF01NjkQvF2u NH7w[oQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2NVg2OSd-MUe5OlE5PTF:L3G+
HEL NWH5OXJISW62aY\pdoFtKGG|c3H5 MX:2JJRwKDdiZHH5dy=> NV;iV|dWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPiC2bzC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9OE45O87:TT6= MorrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
MRC5 MVHBcpRqfmm{YXygZZN{[Xl? MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWI94dmViaX6gUXJEPSClZXzsd{BjgSCSUlGsJGlEPTB;ND65{txONg>? M3vUTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
MRC5 NHK0TmdCdnSrdnnyZYwh[XO|YYm= NHHnWZZKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHnZYlve3RiSFPNWkhCTC1zNkmpJIlvKE2UQ{WgZ4VtdHNuIFnEOVA:Pc7:TT6= NYXIO4hpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVgyOSd-M{CwPVgyOTxxYU6=
H-1 MYnGeY5kfGmxbjDhd5NigQ>? Mo\USYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDFdJN1\WmwLXLhdpIhfmm{dYOgdoVxdGmlYYTpc44hcW5iSD2xJINmdGy|IHnuJGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u M1rMXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkO0NFA{Lz5zNU[zOFAxOzxxYU6=
H1 NXnseJh7TnWwY4Tpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKEWEVjDy[ZBtcWOjdHnvckBqdiCKMTDj[YxteyCkeTDEUmEhcHmkcnnkbZpifGmxbjDhd5NigSxiRVO1NF02|ryPLh?= NUKyXHg3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewNFQ4OjZpPkG3NFA1PzJ4PD;hQi=>
H1 NUPtdFVHTnWwY4Tpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKEWEVjDy[ZBtcWOjdHnvckBqdiCKMTDj[YxteyCkeTDEUmEhcHmkcnnkbZpifGmxbjDhd5NigSxiRVO1NF02|ryPLh?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
CEM MYPDfZRwfG:6aXPpeJkh[XO|YYm= NIn6d2hEgXSxdH;4bYNqfHliYXfhbY5{fCCFRV2gZ4VtdHNuIFPDOVA:Pc7:TT6= NWT4dHBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2NVU2PDVpPkG1OlE2PTR3PD;hQi=>
HFF NUHQW3ZsSW62aY\pdoFtKGG|c3H5 MlnJOUB1dyB5IHThfZM> M3vZZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiaX7m[YN1\WRiSF\GJINmdGy|IHHmeIVzKDVidH:gO{Bl[Xm|IHL5JJZqemGuIInp[YxlKGG|c3H5MEBGSzl7Lkm9Oe69VS5? MknwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MkmxNFMoRjF5M{K5NVA{RC:jPh?=
HEL MYXBcpRqfmm{YXygZZN{[Xl? M1XwUVch\GG7cx?= NGnD[nVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckBi\nSncjC3JIRigXNuIFXDOVA:PS5zzszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ{MkGyPEc,OTd4MkKxNlg9N2F-
HEL NUnUNHdFSW62aY\pdoFtKGG|c3H5 NYj3[XNvPyCmYYnz MormRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PU9F[X[rczDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTVwMt88UU4> NFPLT|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
AKATA M2\zNmFvfGm4aYLhcEBie3OjeR?= NVvzdHl{PDhiaILz MmjlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSWJXKGmwZnXjeIVlKGmwIHj1cYFvKEGNQWTBJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCLZ1etbY5lfWOnZDDsfZRq[yC4aYL1d{Bz\XCuaXPheIlwdiCvZXHzeZJm\CCjdDC0PEBpenNicH;zeE1tgXSrYzDpcoR2[3Srb36gZpkheVKWLWDDVkBidmGueYPpd{whTUN3ME21MlLPxE1w M4[5W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
MRC5 NELLS3lCdnSrdnnyZYwh[XO|YYm= MWnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTZiaX6gUXJEPSClZXzsd{BjgSCSUlGsJGlEPTB;NT60{txONg>? NUH3S3VZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
fibroblast cells NVy3UIlpSW62aY\pdoFtKGG|c3H5 NU\6PWM5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhVXW{aX7lJIN6fG:vZXfhcI93cXK3czDpcoZm[3SnZDDpckBud3W|ZTDlcYJzgW:waXOg[oljem:kbHHzeEBk\WyuczDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDFR|UxRTVwNd88UU4> MmTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUeyO|EoRjF7M{m3NlcyRC:jPh?=
HFF M{Xa[2FvfGm4aYLhcEBie3OjeR?= Mm\iRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjl|IHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTVwNt88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL NXexdpd5SW62aY\pdoFtKGG|c3H5 Mn\lRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;NT62N:69VS5? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m5NEc,Ojl2MEe5PVA9N2F-
NIH 3T3 MUTBcpRqfmm{YXygZZN{[Xl? M1XH[FQhfG9iNTDkZZl{ M1rufmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNic4TyZYlvKFOvaYToJIlv\mWldHXkJIlvKG2xdYPlJG5KUCB|VEOgZ4VtdHNiYX\0[ZIhPCC2bzC1JIRigXNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjgQvF2u NGXnOmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES1PFEzPCd-MUi0OVgyOjR:L3G+
RG2TK+ NUHuUFk5S3m2b4TvfIlkcXS7IHHzd4F6 NITJfZA4OiCqcoO= MnHtR5l1d3SxeHnjbZR6KGGpYXnud5QhUFOYMT30b{Bo\W6nIH;2[ZJmgHC{ZYPzbY5oKFKJMmTLL{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTVwOEdOwG0v MnPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlQoRjF6OECwO|Y1RC:jPh?=
MRC-5 MlPUSpVv[3Srb36gZZN{[Xl? NWK3VWRHS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3Wgeolz[WxicHzhdZVmKG[xcn3heIlwdiCkeTDIeY1idiCFeYTvcYVo[WyxdnnyeZMhMEiFTW[pJEh{fHKjaX6gRWQuOTZ7KTDpckBOWkNvNTDj[YxteyxiSVO1NF02NjoQvF2u MnO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB7Nk[3OFAoRjFyOU[2O|QxRC:jPh?=
HEL NWfNdINzSW62aY\pdoFtKGG|c3H5 NXPsWJhKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDEZZZqeyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZpkhfmm{YXygR3BGKGG|c3H5MEBGSzVyPUWuPe69VS5? NEjHdVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFIzOid-MkK4OVgzOjJ:L3G+
HEL M{PEPWFvfGm4aYLhcEBie3OjeR?= Mof6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGyjcYXlJIZwem2jdHnvckwhTUN3ME21Mlk5|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HCMV AD 169 M3yweGFvfGm4aYLhcEBie3OjeR?= MnqwTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGi3bXHuJIN6fG:vZXfhcI93cXK3czCoTGNOXiCDRDCxOlkqKGmwIDjIR21XKEGGIEG2PUkh[2WubIOsJGlFPTB;Nt88UU4> NUnJU|BURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5N|YyPSd-Mkm5N|YyPTxxYU6=
HEL M1yzWmFvfGm4aYLhcEBie3OjeR?= NXXoWJJKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVbPxE1w NHm2fHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HEL NIXE[mZCdnSrdnnyZYwh[XO|YYm= M1H5XlMh\GG7cx?= MlTrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZJme2m|dHHueEBVUy2mZX\pZ4lmdnRiSHXwdoV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVbPxE1w NVrSe5RbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HFF NGXLRZRCdnSrdnnyZYwh[XO|YYm= NWLUU2txSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMke4OEB4cXSqIIDvcEBCQDB7VjDVUFk4KEN3OULHJIRwfWKuZTDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME22MlHPxE1w NYXofZVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL MoriRY51cX[rcnHsJIF{e2G7 MlfpO{Bl[Xm| MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmg[ZhxemW|c3XkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGyjcYXlJIZwem2jdHnvckBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDHbYVue2Fic4ThbY4h[mG|ZXSgcYlkem:|Y3;wfUwhTUN3ME22MlEz|ryPLh?= NWm2Zm81RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
MRC-5 NVHRTIhbTnWwY4Tpc44h[XO|YYm= NYe2fnVMUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIZweiCjboTpMWhEVVZiYXP0bZZqfHliYXfhbY5{fCCDRD2xOlkhe3S{YXnuJIlvKE2UQz21JINmdGy|LDDJR|UxRTZwM988UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDN4NkGzK|46QDN4NkGzQE9iRg>?
HEL MVzBcpRqfmm{YXygZZN{[Xl? M37VSWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPU[uN:69VS5? MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3MUi0OVkoRjF5NUG4OFU6RC:jPh?=
HEL M1j3TmFvfGm4aYLhcEBie3OjeR?= M33SfWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSE0yPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVYvO87:TT6= NIj4PWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HEL MXLBcpRqfmm{YXygZZN{[Xl? NEDyb|U3KHSxIEeg[IF6ew>? MlTqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOkB1dyB5IHThfZMheG:|dDDpcoZm[3Srb36sJGVEPTB;Nj60Ou69VS5? MlvBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
HEL NWP3bmhTSW62aY\pdoFtKGG|c3H5 M3nEbVch\GG7cx?= NF\xdmVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEVVZiQVSxOlkhcW5iaIXtZY4hUEWOIHPlcIx{KGGodHXyJFch\GG7czygSWM2OD14LkZOwG0v MnvOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL MlPkRY51cX[rcnHsJIF{e2G7 M4PURWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{KHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9Ok42|ryPLh?= NHrseVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HELF NH\J[opCdnSrdnnyZYwh[XO|YYm= M3j0WWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{B{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Nj61Nu69VS5? NYHSVpNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HEL M121VWFvfGm4aYLhcEBie3OjeR?= MlW4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIFo[Wmwc4SgeolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPU[uOVTPxE1w NEXoZXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HFF Mle3RY51cX[rcnHsJIF{e2G7 MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPzl6IIfpeIgheG:uIGS4NVNUKFWOOUegR|U6OkdiZH;1ZoxmKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTZwNt88UU4> M13CRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
HEL M1rRfGFvfGm4aYLhcEBie3OjeR?= MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD14Lke5{txONg>? MkDlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
HEL MkPrSpVv[3Srb36gZZN{[Xl? NULq[3VFUW6qaXLpeIlwdiCjZ3HpcpN1KESQQTDv[kB2dmmwZnXjeIVlKEiHTDDj[YxteyCkeTDpcoNwenCxcnH0bY9vKG:oIGuzTH1V\FJuIFnDOVA:P87:TT6= M3:5VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd5NUKyNFUoRjd5NUKyNFU9N2F-
HFF NV\ac5o6SW62aY\pdoFtKGG|c3H5 Moi2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjlzIHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTdwMd88UU4> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL MXvBcpRqfmm{YXygZZN{[Xl? M{DQUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF04NjIQvF2u NVX5TYo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HEL MVHBcpRqfmm{YXygZZN{[Xl? NV3QV|FkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjIQvF2u NGDnd4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
CRFK M4fPfGFvfGm4aYLhcEBie3OjeR?= NGLXVnQ{KGSjeYO= MmnvRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcWRiaHXydIV{fmm{dYOgNUBqdm[nY4Tl[EBk[XRiQ2LGT{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCzJIRigXNiYomgZ49td3KrbXX0dolkKG[xcn3hfoFvNWKjc3XkJG1VWyCjc4PhfUwhTUN3ME23MlPPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek9EcEWPQlynQmNpTU2ETEyvZV4>
HEL NHfBT2xCdnSrdnnyZYwh[XO|YYm= MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF04NjQQvF2u MnzYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6Mkm5NVMoRjJ6OEK5PVE{RC:jPh?=
HFF MV\BcpRqfmm{YXygZZN{[Xl? NHroOmxKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIDjUc5dv\SC|dILhbY4qKGmwIFjGSkApcHWvYX6g[oljem:kbHHzeEkh[2WubIOsJGlEPTB;Nz60{txONg>? NV7vSYlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3PSd-OUC1O|g3PTxxYU6=
HFF MmDQSpVv[3Srb36gZZN{[Xl? MUHJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= NHT2PIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97NEO4NFE4Lz57NEO4NFE4RC:jPh?=
HFF MlO0SpVv[3Srb36gZZN{[Xl? MVLDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCWb4fu[UB{fHKjaX6gc4YhUEOPVjDpckBiKHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> MlriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HFF MojWSpVv[3Srb36gZZN{[Xl? MVXDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XlidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= MlPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|UoRjFyOEiyN|c2RC:jPh?=
HFF NEH6TmdCdnSrdnnyZYwh[XO|YYm= NEDmOWxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1d3ewZTDzeJJicW5iSFPNWkB4[XNiZHX0[ZJucW6nZDDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7IHnuJIR2eGyrY3H0[UB4\WyuczD1d4lv\yCKRl[gZ4VtdHNuIFnDOVA:Py52zszNMi=> NFLrdVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4OCd-MUC4PFI{PzB:L3G+
HFF NYfXVVBqSW62aY\pdoFtKGG|c3H5 MmHORY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v M3T2d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|czLz5zMEi4NlM4OjxxYU6=
HFF NVn1eGJJTnWwY4Tpc44h[XO|YYm= NV\NW5hwUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBmgHC{ZYPz[YQhcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= M4fHdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc1Lz5zNUWwPVE4PDxxYU6=
HFF MXfGeY5kfGmxbjDhd5NigQ>? MnrjTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDlfJBz\XO|ZXSgbY4hUE[IIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Nz60{txONg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OUc,OTV3MEmxO|U9N2F-
HFF NED0PGFHfW6ldHnvckBie3OjeR?= M1TFe2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDDh[4FqdnO2IHj1cYFvKGO7dH;t[YdidG:4aYL1d{ApUEOPVjmg[ZhxemW|c3XkJIlvKEiIRjDj[YxteyC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUeuOO69VS5? MontQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|YoRjF3NUC5NVc3RC:jPh?=
HEL M37CVGFvfGm4aYLhcEBie3OjeR?= NWmw[ZJuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUeuOO69VS5? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL M4TsdmFvfGm4aYLhcEBie3OjeR?= NXq2UXpSPiC2bzC3JIRigXN? NX[zR3J1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QhdWWjc4Xy[YQh[W[2ZYKgOkB1dyB5IHThfZMheG:|dD3pcoZm[3Srb36sJGVEPTB;Nz60Ne69VS5? NIjOcGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NFcxPSd-Mkm2O|A4ODV:L3G+
HEL NXTtOWd5SW62aY\pdoFtKGG|c3H5 M3r0S2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF04NjYQvF2u MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV5OEe4N{c,OjJ3N{i3PFM9N2F-
HFF MY\BcpRqfmm{YXygZZN{[Xl? MXvBcpRqfmm{YXygZYN1cX[rdImge4F{KGSndHXycYlv\WRiYomgeIhmKEiFTW[gdIxieXWnIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlfPxE1w NEPVeo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MEW3PFY3Lz57MEW3PFY3RC:jPh?=
HEL NEXQTYRCdnSrdnnyZYwh[XO|YYm= NI\LR5RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUeuPO69VS5? M3fxXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NESzOVUxLz5{NkS0N|U2ODxxYU6=
HEL NF\EWYVCdnSrdnnyZYwh[XO|YYm= MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGyjcYXlJIZwem2jdHnvckwhTUN3ME23Mlg4|ryPLh?= NVK2dHVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
CRFK NGX0fHdCdnSrdnnyZYwh[XO|YYm= NXjtdFZsSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTmWuaX7lJIhmenCnc4\pdpV{KGmwZnXjeIVlKGmwIFPSSmsh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF05NjIQvF2u MmDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL NXvWW|BvSW62aY\pdoFtKGG|c3H5 MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCFeYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyMEBGSzVyPUiuNu69VS5? MmjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MUG4OVQoRjJ|OUGxPFU1RC:jPh?=
HFF MVfGeY5kfGmxbjDhd5NigQ>? NH\iNlVKdiC4aYTyc{BqdmirYnn0bY9vKG:oIHj1cYFvKGO7dH;t[YdidG:4aYL1d{BqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF05NjUQvF2u M37LVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
HFF MmL1RY51cX[rcnHsJIF{e2G7 M4fkV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhOjhzNzD3bZRpKHCxbDDHPFQySSCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD16LkVOwG0v MmfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL MWXBcpRqfmm{YXygZZN{[Xl? NXLTblh6PyCmYYnz NXr4SHZ6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDEZZZqeyCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRThwN988UU4> NILuXoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
HEL Mm\nRY51cX[rcnHsJIF{e2G7 Ml\xRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;OD63{txONg>? NVv2TIdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFIxPjdpPkK4OlgzODZ5PD;hQi=>
HEL MULBcpRqfmm{YXygZZN{[Xl? Mn3PRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZY5lKGGleXPsc5ZqeiC{ZYPpd5RidnRiSGPWNUBMV1NiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9Pe69VS5? NFvsUHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK4NVIzPSd-MUmyPFEzOjV:L3G+
HEL NFu3V4lCdnSrdnnyZYwh[XO|YYm= M{C4cmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHL5JJZqemGuIFPQSUBie3OjeTygSWM2OD17LkJOwG0v MmXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
MRC-5 M1XWT2Z2dmO2aX;uJIF{e2G7 NInTcWlKdmirYnn0c5J6KGGldHn2bZR6KG:oIHPvcZBwfW6mIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDpckBOWkNvNTDj[YxteyxiRVO1NF06NjUQvF2u MkTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ5MkO5OVEoRjF{N{KzPVUyRC:jPh?=
Vero MXLBcpRqfmm{YXygZZN{[Xl? MmnLTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiVVj2xJEhHKGSnbIThJFMxPSliaX6gWoVzdyClZXzsd{whUUR3ME2xNO69VS5? NHrrSJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFEyLz5|MEC5PFEyRC:jPh?=
HFF NVe3RnptSW62aY\pdoFtKGG|c3H5 MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTNiaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD1zMN88UU4> Moi4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
Vero Mnv4RY51cX[rcnHsJIF{e2G7 NX\ydIpuOyCmYYnz Mn3aRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWoFzcWOnbHzhMZpwe3SncjD2bZJ2eyCHbHzlckBXWi1zM{[3JIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1zMT6x{txONg>? NHfjeXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
HEL MWHBcpRqfmm{YXygZZN{[Xl? MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVEyNjR|zszNMi=> Ml;zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
HELF MlfFRY51cX[rcnHsJIF{e2G7 MlzwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JJN1emGrbjDpcoZm[3SnZDDpckBJTUyIIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD1zMT63Oe69VS5? NVv5coxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HFF NYP2bJVwSW62aY\pdoFtKGG|c3H5 NGe0N2FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ|MUGgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xNk41|ryPLh?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL MoLJRY51cX[rcnHsJIF{e2G7 NXjxe5hIPyCmYYnz MlLYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9NVIvPs7:TT6= M3yzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{O5NFgzLz5zOUOzPVA5OjxxYU6=
HEL MVLBcpRqfmm{YXygZZN{[Xl? M{P6dWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;MUOuPe69VS5? NYDFPHp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFM2PTBpPkK2OFQ{PTVyPD;hQi=>
Vero NFHzWYtCdnSrdnnyZYwh[XO|YYm= MVqzOkB1dyB2ODDodpM> M{DsUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDCJJZqenW|IEK0NVA2KGmwZnXjeIVlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNicHzhdZVmKHKnZIXjeIlwdiCjZoTldkA{PiC2bzC0PEBpenNuIFXDOVA:OTRwNd88UU4> Mk\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOlEoRjF5NEO4NFYyRC:jPh?=
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BT-37 NYfqXWhVeUiWUzDhd5NigQ>? NHHCO3dyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStN|ch[2WubIO= MlLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Saos-2 MWHxTHRUKGG|c3H5 MWnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy| NH;vR4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
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OHS-50 MlLEdWhVWyCjc4PhfS=> NWjZW25GeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=> NGnZO5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
MG 63 (6-TG R) NIS1fJNyUFSVIHHzd4F6 NXnKXXJQeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF3HJFY{KCh4LWTHJHIqKGOnbHzz M3KzT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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Vero M3H0S2Z2dmO2aX;uJIF{e2G7 NVrZZmtOOTBidV2= M13QWWlvcGmkaYTpc44hd2ZiVVy0NkBo\W6nIITyZY5{[3KrcITpc44hcW5iSGPWMVEhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{BifCBzMDD1UUBjgSCzUmStVGNTKGGwYXz5d4l{ NW\RcW9KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NFM1PzZpPkOxOVA{PDd4PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 29845211     


(A) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml respectively. After 24 h post-transfection, cell viability was measured by MTT assay. (B) HSV-TK-positive (HSV-TK: pLenO-GTP-HSV-TK) or negative (CON: pLenO-GTP) HXO-RB44 cells were treated with GCV at 0, 10, 20 or 40 µg/ml, respectively for 48 h. Cell viability was also measured by MTT assay.

29845211
In vivo Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response[7].

Protocol

Cell Research:

[7]

- Collapse
  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    To assess cell proliferation by thymidine incorporation, a total of 2 × 10<sup>4</sup> BV-2 cells were seeded in a 96-well plate for a maximum of 12 h in 10% FBS containing DMEM and then serum starved for an additional 12 h before the addition of varying concentrations of GCV for a total of 24 h. Cultures were pulsed for the final 8 h with 1 µCi/well [3H]thymidine before incorporated radioactivity was measured using a β plate scintillation counter.


    (Only for Reference)
Animal Research:

[7]

- Collapse
  • Animal Models: C57BL/6 mice
  • Dosages: 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 27 mg/mL warmed (105.78 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 255.23
Formula

C9H13N5O4

CAS No. 82410-32-0
Storage powder
in solvent
Synonyms RS-21592, 2'-Nor-2'-deoxyguanosine
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04478474 Not yet recruiting Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme Corp. September 15 2020 --
NCT03698435 Recruiting Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4
NCT02152358 Active not recruiting Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID