Ganciclovir (BW 759)

Catalog No.S1878 Synonyms: RS-21592, 2'-Nor-2'-deoxyguanosine

For research use only.

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

Ganciclovir (BW 759) Chemical Structure

CAS No. 82410-32-0

Selleck's Ganciclovir (BW 759) has been cited by 11 Publications

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Purity & Quality Control

Choose Selective CMV Inhibitors

Biological Activity

Description Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro

Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. [1] Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. [2] Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. [3] Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. [4] Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. [5] Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines M2jOeWZ2dmO2aX;uJIF{e2G7 M{DqS2Vn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgTIVzeGW|IIPpcZBt\XhidnnyeZMuOiBqSGPWMVIqKGmwZIXj[YQh[3m2b4DheIhq[2m2eTDifUA2OCViaX6gSVZUVSClZXzsJIxqdmW|LDDFR|UxRTFwMjDuUS=> M{n5VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEm1OVg3Lz5zMUS5OVU5PjxxYU6=
OST TK- cells MkLsR5l1d3SxeHnjbZR6KGG|c3H5 NXzRcpB[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFusJGlEPTB;MD6wNFE6|ryPLh?= NYroXmNHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL NEnNcXpCdnSrdnnyZYwh[XO|YYm= NIPIWnVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yME[0{txONg>? MmXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL M2[yc2FvfGm4aYLhcEBie3OjeR?= NVnCZYd{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlAy|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|MkiyPEc,OjF{M{K4Nlg9N2F-
HEL Mo\sRY51cX[rcnHsJIF{e2G7 NULSd|M6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUKgS{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFHPxE1w M4S5NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{m1NlM5Lz5{M{e5OVI{QDxxYU6=
HEL Mk\GRY51cX[rcnHsJIF{e2G7 M4LUb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFHPxE1w MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7NUKzPEc,OjN5OUWyN|g9N2F-
HEL MWrBcpRqfmm{YXygZZN{[Xl? M3j6[VMh\GG7cx?= MWfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCvZYToc4QtKEWFNUC9NE4xOc7:TT6= MoS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
HEL MXPBcpRqfmm{YXygZZN{[Xl? M2XRdlMh\GG7cx?= M4PR[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgcYV1cG:mLDDFR|UxRTBwMEJOwG0v M3PrSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMki2PVUzLz5|MEK4Olk2OjxxYU6=
HEL MVjBcpRqfmm{YXygZZN{[Xl? M1r2b2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEGz{txONg>? NHrsPHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C5PVA6Pyd-MkOwPVkxQTd:L3G+
HEL MUDBcpRqfmm{YXygZZN{[Xl? NFrl[ZNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFE2|ryPLh?= Mnq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
OST TK- cells M1myR2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVXSOGdiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiMj61JJVOKDFvW{[tLJRzcXCqZX75cI1mfGixeImpbIV5gWyfdHj5cYlv\SxiSVO1NF0xNjBzON88UU4> NIjNSXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL NFjC[HhCdnSrdnnyZYwh[XO|YYm= M2XoTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlvKEiHTDDj[YxteyxiRVO1NF0xNjBzOd88UU4> NX2zeXNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjJpPkG3NVgyOTZ{PD;hQi=>
HEL MUPBcpRqfmm{YXygZZN{[Xl? MX[yJJRwKDNiZHH5dy=> NEjQNmZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjCyJJRwKDNiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD1yLkCxPe69VS5? NFrhU4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
HEL NFrP[mpCdnSrdnnyZYwh[XO|YYm= NV;hZVd{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD6wNu69VS5? MonKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEGyNlUoRjF7MkixNlI2RC:jPh?=
HEL M3KzUmFvfGm4aYLhcEBie3OjeR?= M{W0TlQh\GG7cx?= NWH2dHpUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjC0JIRigXNuIFXDOVA:OC5yMt88UU4> NFTxelc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL MUHBcpRqfmm{YXygZZN{[Xl? MlXlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMENOwG0v NFq5Z2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
HEL M4fZO2FvfGm4aYLhcEBie3OjeR?= Mnj6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvODMQvF2u MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6MEK1NUc,Ojl6OECyOVE9N2F-
HEL M33G[GFvfGm4aYLhcEBie3OjeR?= NFW2OJBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvODMQvF2u NGnWVGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi4NFI2OSd-Mkm4PFAzPTF:L3G+
Vero M2qxN2FvfGm4aYLhcEBie3OjeR?= NILDfHU4OiCqcoO= M13OOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zIHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCJRmCg[ZhxemW|c3nvckBi\nSncjC3NkBpenNiYomgS2ZRNWKjc3XkJIZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3CrYzDhcoFtgXOrczygSWM2OD1yLkCyOe69VS5? NUjGWHlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NFM1PzZpPkOxOVA{PDd4PD;hQi=>
HEL NUHHdmpJSW62aY\pdoFtKGG|c3H5 M3LoW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhTyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{N988UU4> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL MVvBcpRqfmm{YXygZZN{[Xl? MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[nlidnnyZYwhS1CHIHHzd4F6NCCHQ{WwQVAvODJ5zszNMi=> MkDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL MVLBcpRqfmm{YXygZZN{[Xl? NGS0clBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGK7II\pdoFtKEOSRTDhd5NigSxiRVO1NF0xNjB{Od88UU4> MlrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
HEL MnTDRY51cX[rcnHsJIF{e2G7 NGDGOoszKHSxIEOg[IF6ew>? M4rWc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1{\W6|aYTpeoUhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h\nKxbTD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGGodHXyJFIhfG9iMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1yLkCz{txONg>? M{\nTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL MVfBcpRqfmm{YXygZZN{[Xl? NH;uT2UzKHSxIEOg[IF6ew>? NX;3bVRmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h\nKxbTD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGGodHXyJFIhfG9iMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1yLkCz{txONg>? MnjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HEL M1;ncWFvfGm4aYLhcEBie3OjeR?= NGjaPHMzKHSxIEOg[IF6ew>? MVvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iZoLvcUB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDJidH:gN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA{|ryPLh?= M4ftOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL NFfyfJZCdnSrdnnyZYwh[XO|YYm= MX:0JIRigXN? MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> M{HsRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL MnvKRY51cX[rcnHsJIF{e2G7 MmnQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yM988UU4> MkXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL M4rITWFvfGm4aYLhcEBie3OjeR?= NH;wO|g1KGSjeYO= NEL1[|NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA1KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yM988UU4> NX3FbFVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2PVY6PjNpPkKxOlk3QTZ|PD;hQi=>
HEL MX3BcpRqfmm{YXygZZN{[Xl? NYWwU5RUPCCmYYnz MofrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPCCmYYnzMEBGSzVyPUCuNFPPxE1w NH;vemM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL NEGwbJpCdnSrdnnyZYwh[XO|YYm= MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFPPxE1w MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HEL MUPBcpRqfmm{YXygZZN{[Xl? M1LvT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{NTFiS1;TJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HEL NG\t[nlCdnSrdnnyZYwh[XO|YYm= M4WxcGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> M3XJd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MECxN|Q1Lz5{NkCwNVM1PDxxYU6=
HEL M3rSO2FvfGm4aYLhcEBie3OjeR?= M{XiZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEROwG0v NEj1Spk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QCd-Mke2N|k{Pjh:L3G+
HELF MmP2RY51cX[rcnHsJIF{e2G7 MlHkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUBMV1Nic4TyZYlvKGmwZnXjeIVlKGmwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u Mmf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi0PFEoRjNyMEm4OFgyRC:jPh?=
HELF M1\mWmFvfGm4aYLhcEBie3OjeR?= MonXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNkBIKHO2cnHpckBqdm[nY4Tl[EBqdiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlA{|ryPLh?= NVH0UWV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HEL MWXBcpRqfmm{YXygZZN{[Xl? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvODQQvF2u M{\mZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HEL NH[5fVdCdnSrdnnyZYwh[XO|YYm= NYfXRW41SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6wN:69VS5? NWXEcI15RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
HEL MXLBcpRqfmm{YXygZZN{[Xl? M{PIdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiaX6gTGVNKGOnbHzzMEBGSzVyPUCuNFMz|ryPLh?= M3LoeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HEL M3vwOmFvfGm4aYLhcEBie3OjeR?= MnfDRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yM{NOwG0v MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ5MkS0OUc,OTd4N{K0OFU9N2F-
HEL NVS2ToE5SW62aY\pdoFtKGG|c3H5 MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM{NOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
OST TK- cells NX\VS|l7S3m2b4TvfIlkcXS7IHHzd4F6 MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kA2KHWPIEGtX|YuMHS{aYDo[Y56dG2ndHjvfJkqcGW6eXzdeIh6dWmwZTygTWM2OD1yLkCzN:69VS5? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
fibroblast cells M2jNfGFvfGm4aYLhcEBie3OjeR?= MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6g[o9z\XOtaX6g[oljem:kbHHzeEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= M2XaN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3NlcyLz5zOUO5O|I4OTxxYU6=
HEL Mk\pRY51cX[rcnHsJIF{e2G7 M4nFeGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMEVOwG0v NYD1SG5ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HFF M17zeGFvfGm4aYLhcEBie3OjeR?= NUnreppTOSCqch?= MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhMHO2cnHpckBCTDF4OTmgbY5n\WO2ZXSgbY4hOSCqcjDwdoV1emWjdHXkJIh2dWGwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSCwZYX0doFtKHKnZDD1dJRic2ViYYPzZZktKEWFNUC9NE4xPM7:TT6= M{XCdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{e2OFI6Lz5{MUO3OlQzQTxxYU6=
HEL MYLBcpRqfmm{YXygZZN{[Xl? NXzOcWNiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> NHnIeWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HEL MmKyRY51cX[rcnHsJIF{e2G7 MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkC0{txONg>? M2f5[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
Vero MnviRY51cX[rcnHsJIF{e2G7 NGrjOnI{PiCqcoO= MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YhOSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBxdGGzdXWg[o9zdWG2aX;uJIlv[3WkYYTl[EBnd3JiM{[gbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKGKjc3XkJIF{e2G7LDDFR|UxRTBwMEVOwG0v M3T1RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
OST TK- cells MUTDfZRwfG:6aXPpeJkh[XO|YYm= Mo\OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOTBidV2gNU1cPi1qdILpdIhmdnmubXX0bI95gSmqZYj5cH11cHmvaX7lMEBKSzVyPUCuNFQy|ryPLh?= NX3CTHFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL NXz3UI9{SW62aY\pdoFtKGG|c3H5 NEPLbVgzKHSxIEOg[IF6ew>? MlnsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjCyJJRwKDNiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD1yLkC0Oe69VS5? NFHkR3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1NFc{PCd-Mkm1OVA4OzR:L3G+
OST TK- cells NH;ET5dEgXSxdH;4bYNqfHliYYPzZZk> MkX6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xPc7:TT6= Mk\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
human M{PsW2FvfGm4aYLhcEBie3OjeR?= MVG3JIRigXN? NWP6PJV{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA4KGSjeYOsJGVEPTB;MD6wOe69VS5? MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HEL NY\vXWxWSW62aY\pdoFtKGG|c3H5 MnH0NkB1dyB|IHThfZM> NITGZohCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB{IITvJFMh\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF0xNjB3Md88UU4> Mni5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
HEL MVPBcpRqfmm{YXygZZN{[Xl? NG[2WnhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMEW1{txONg>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
HEL M{P4b2FvfGm4aYLhcEBie3OjeR?= NHXlNIgzKHSxIEOg[IF6ew>? NX7vdI4xSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG|dYLl[EBi\nSncjCyJJRwKDNiZHH5d{Bxd3O2LXnu[oVkfGmxbjygSWM2OD1yLkC1O:69VS5? MoP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{C3NFUoRjJ7NkewO|A2RC:jPh?=
HEL NX;ST2x3TnWwY4Tpc44h[XO|YYm= NXf6e|hWS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFepJIlvKEiHTDDj[YxteyxiRVO1NF0xNjB4zszNMi=> NEC0N5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[0N|MzQCd-MUS2OFM{Ojh:L3G+
Hel M{jT[GZ2dmO2aX;uJIF{e2G7 NX3mdZZ6TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBp\XKyZYOgd4lueGyneDD2bZJ2eyC2eYDlJFEhU2:|IIP0doFqdiCrbnT1Z4VlKGO7dH;wZZRpcWOrdImgbY4hUGWuIHPlcIx{NCCHQ{WwQVAvODcQvF2u MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi1PEc,OTV4NUi4OVg9N2F-
HEL M4LGbWFvfGm4aYLhcEBie3OjeR?= MkfsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvODcQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN7Mke5NUc,OTZ|OUK3PVE9N2F-
HEL MoHNRY51cX[rcnHsJIF{e2G7 M3TvZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= MorrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ|OUK3PVEoRjF4M{myO|kyRC:jPh?=
HEL Ml61RY51cX[rcnHsJIF{e2G7 MojXN{Bl[Xm| NGDGd2xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKHO2cnHpckBIKGmwZnXjeIVlKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkh[2:ub4LpcYV1emmlIH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NF0xNjB5zszNMi=> NUjkN401RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL MWjBcpRqfmm{YXygZZN{[Xl? NH\3OVFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yN988UU4> NXX2PFlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|g3PTNpPkOwO|M5PjV|PD;hQi=>
HELF MVXBcpRqfmm{YXygZZN{[Xl? MXG3JIRigXN? MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvODgQvF2u M3P6TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HEL NXjWRoNJSW62aY\pdoFtKGG|c3H5 MnvWO{Bl[Xm| MnPVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGGodHXyJFch\GG7czygSWM2OD1yLkC4{txONg>? MoDLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMki2OlYoRjJzMUK4OlY3RC:jPh?=
HEL NUX4fI9NSW62aY\pdoFtKGG|c3H5 M3H5e|Mh\GG7cx?= M4O3UWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMElOwG0v NETwNmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi:FaFXNRmwoRkOqRV3CUFww[T5?
HEL NF3wZohCdnSrdnnyZYwh[XO|YYm= M1vuXlMh\GG7cx?= MoHlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA5|ryPLh?= M1zFWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
OST TK- cells MYLDfZRwfG:6aXPpeJkh[XO|YYm= NYTwOVhxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiNTD1UUAyNVt4LWuxMFEuMGSrcHjlcpltMS1zLTi0MZB6emmmeXypcYV1cG:6eW3o[Zh6dF22aIntbY5mNCCLQ{WwQVAvODhzzszNMi=> NUSzboZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HEL M1TZNmFvfGm4aYLhcEBie3OjeR?= M3vD[VMh\GG7cx?= MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJJN1emGrbjDLU3MhcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODoQvF2u M1HJSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
HEL M1rLSGFvfGm4aYLhcEBie3OjeR?= MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTBwMEpOwG0v NWniTnZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
E6SM Ml7URY51cX[rcnHsJIF{e2G7 NEjmfYZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlvKEV4U12gZ4VtdHNuIF3JR|0xNjB7Nt88UU4> M1yz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
E6SM Mnz1RY51cX[rcnHsJIF{e2G7 Mn6yRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJLXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliaX6gSVZUVSClZXzsd{whVUmFPUCuNFk3|ryPLh?= NYj4OlZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewPVI4OjhpPkG3NFkzPzJ6PD;hQi=>
HEL NYfsTIhJSW62aY\pdoFtKGG|c3H5 NX7NU|VZSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQh[WO7Y3zveolzNXKnc3nzeIFvfCCKU2[xJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1NCCHQ{WwQVAvOc7:TT6= NVWwUnNMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|I5OjhpPkKxNlMzQDJ6PD;hQi=>
HEL NHzWU5BCdnSrdnnyZYwh[XO|YYm= NFnyOmVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBCS1ZvcnXzbZN1[W62IFjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5zzszNMi=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
OST TK- cells NUTte|ZUS3m2b4TvfIlkcXS7IHHzd4F6 MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NVtzLEGtLIRqeGinbonsLU0yNSh2LYD5dollgWxrbXX0bI95gV2qZYj5cH11cHmvaX7lMEBKSzVyPUCuNVHPxE1w NUTi[45qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPThpPkG3NVgyOTV6PD;hQi=>
HFF MnqwRY51cX[rcnHsJIF{e2G7 MUixNEBl[Xm| M4L4ZWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVH;3coUhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOTBiZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUCuNVTPxE1w MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSyNEc,OjF6MUK0NlA9N2F-
HFF MV\GeY5kfGmxbjDhd5NigQ>? NWq5bGlyUW6qaXLpeIlwdiCxZjDIR21XKEGGMU[5JJJmeGyrY3H0bY9vKGmwIFjGSkBk\WyuczDifUBkgXSxcHH0bIlkKGWoZnXjeEBie3OjeTygSWM2OD1yLkG1{txONg>? M1GwfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC0O|I3Lz5zN{CwOFczPjxxYU6=
MCA-TK NVLlU5E1S3m2b4TvfIlkcXS7IHHzd4F6 NUDRWG93S3m2b4TvfIlkcXS7IHHnZYlve3RiTVPBMXRMKGOnbHzzMEBKSzVyPUCuNVXPxE1w Mn;mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7NkC5NlYoRjF5OU[wPVI3RC:jPh?=
vero MWrBcpRqfmm{YXygZZN{[Xl? NX7T[YlxSW62aY\pdoFtKGGldHn2bZR6KHejczDk[ZRmem2rbnXkJIlvKHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgbY4hfmW{bzDj[YxteyCjZ3HpcpN1KEiVVj2xJGYhe3S{YXnuMEBKTDVyPUCuNu69VS5? NHHrTmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|OEexPFYxLz5|OEexPFYxRC:jPh?=
Vero NVPWS4JkSW62aY\pdoFtKGG|c3H5 NHnhRZlKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHnZYlve3RiSGPWMVEpTiliaX6gWoVzdyClZXzsd{whUUR3ME2wMlLPxE1w NGXkVYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFEyLz5|MEC5PFEyRC:jPh?=
Vero MXLBcpRqfmm{YXygZZN{[Xl? NEjjcGxCdnSrdnnyZYwh[WO2aY\peJkh\GW2ZYLtbY5m\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJR6eGViMTCoSkB{fHKjaX6pJIJ6KHCuYYH1[UBz\WS3Y4Tpc44hcW5iVnXyc{Bk\WyuczygTWQ2OD1yLkNOwG0v Ml[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNkK2N{c,OzBzNkK2N|ww[T5?
HEL MWLBcpRqfmm{YXygZZN{[Xl? MY\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4z|ryPLh?= MkHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEGyNlUoRjF7MkixNlI2RC:jPh?=
HEL MkHKRY51cX[rcnHsJIF{e2G7 NFvOeFI{KGSjeYO= NXT1O2o1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WO7Y3zveolzNXKnc3nzeIFvfCCWSz3k[YZm[2mnboSgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNibXX0bI9lNCCHQ{WwQVAvOs7:TT6= MorLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
fibroblast cells MVXGeY5kfGmxbjDhd5NigQ>? NIXBZodKdmirYnn0bY9vKG:oII\pdoFtKGO7dH;wZZRpcWNiZX\m[YN1KGmwIHnu[oVkfGWmIHj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscEBqdiCvb37vcIF6\XK|IH;mJGhUXi1{IFHEJHZmem9iY3XscJMh[nliNUClMEBGSzVyPUCuNlPPxE1w NGLKZ4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUW4OVQ2Pyd-MUG1PFU1PTd:L3G+
HEL NUTOSWtYSW62aY\pdoFtKGG|c3H5 NFW0TYxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQyPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzMEBGSzVyPUCuNlXPxE1w M1f3XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc5Lz5{N{GyPFE4QDxxYU6=
vero NEDjPHRCdnSrdnnyZYwh[XO|YYm= MoXlTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJZqenW|IFjTWk0yKCiIIIP0doFqdiliaX6geoVzdyClZXzsd{B1cXO|dXWgZ5VtfHW{ZTygTWQ2OD1yLkROwG0v NHTUXm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOlE2Lz5{OUmzOlE2RC:jPh?=
HELF MUjBcpRqfmm{YXygZZN{[Xl? Ml3DO{Bl[Xm| M4H4Z2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvO87:TT6= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HS27 NUmxSnRzSW62aY\pdoFtKGG|c3H5 M1PYN|ch\GG7cx?= NFfh[oFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSGOyO{Bk\WyuczDh[pRmeiB5IHThfZMh[nliR1\QMYJie2WmIH\seY9z\XOlZX70JJJm\HWldHnvckBie3OjeTygSWM2OD1yLkOy{txONg>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB2N{mxNUc,OjByNEe5NVE9N2F-
HEL MUDBcpRqfmm{YXygZZN{[Xl? NWPUTGx2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2wMlM5|ryPLh?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
HEL NV3vcHNkSW62aY\pdoFtKGG|c3H5 Mn\4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KDB5L{GgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvPM7:TT6= NVvxUpVXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyPzhpPkK3NVI5OTd6PD;hQi=>
HEL M4nUXWFvfGm4aYLhcEBie3OjeR?= MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuOO69VS5? NIDNdZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEezPFY2Oyd-M{C3N|g3PTN:L3G+
HEL MWPBcpRqfmm{YXygZZN{[Xl? M4PKfmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlvKEiHTDDj[YxteyxiRVO1NF0xNjR6zszNMi=> M1X0V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVYzLz5zN{G4NVE3OjxxYU6=
HFF NWTrVHFCTnWwY4Tpc44h[XO|YYm= NVjH[|B4UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJI9nKHSqZTDkdpVoKGGpYXnud5QhfGinIHP5eI9x[XSqaXOg[YZn\WO2IH\vdkBCTDF4OTDzeJJicW5ib3[g[ZB{fGWrbjDiZZJzKH[rcoXzMVIhMEiFTW[pJIlvKGi3bXHuJGhHTiClZXzsd{whTUN3ME2wMlXPxE1w MmPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDN7NEmzN{c,QDN7NEmzN|ww[T5?
HEL M3HpNmZ2dmO2aX;uJIF{e2G7 MVHJcohq[mm2aX;uJI9nKGi3bXHuJGNOXiCGTlGgd5lvfGinc3nzJIlvKEOPVj3pcoZm[3SnZDDISWwh[2WubIOsJGlEPTB;MD61{txONg>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HEL NHjGVoxCdnSrdnnyZYwh[XO|YYm= NGr2eFdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlXPxE1w MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
HELF MoTYRY51cX[rcnHsJIF{e2G7 NWDXS|F2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[U1l\W[rY3nlcpQh[WO7Y3zveolzNXKnc3nzeIFvfCCKdX3hckBp\XKyZYP2bZJ2eyBzIFvPV{B{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD61{txONg>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OES4NUc,OzByOUi0PFE9N2F-
Vero MU\BcpRqfmm{YXygZZN{[Xl? NGC1[W8{PiCqcoO= NVH0RY9wSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYIEKgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5icHzhdZVmKG[xcn3heIlwdiCrbnP1ZoF1\WRiZn;yJFM3KGi{czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhTUN3ME2wMlU5|ryPLh?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjF7MUS1Okc,OzJzOUG0OVY9N2F-
HEL MYTBcpRqfmm{YXygZZN{[Xl? Ml;aOUBl[Xm| MnKxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWoFzcWOnbHzhJJpwe3SncjD2bZJ2eyCRS1GgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEWg[IF6eyxiRVO1NF0xNjV7zszNMi=> MmXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|M{mwPFIoRjF7M{O5NFgzRC:jPh?=
HEL M17FeGFvfGm4aYLhcEBie3OjeR?= MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC54Nt88UU4> NXPC[4l3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HEL NHfteHpCdnSrdnnyZYwh[XO|YYm= NFLwb5RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhOSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD62Pe69VS5? M1yxfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL MXzBcpRqfmm{YXygZZN{[Xl? NYDYcXpDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiFTW[gRWQyPjliaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuO:69VS5? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
Vero NGDseGVCdnSrdnnyZYwh[XO|YYm= NV7jXHZEOzZidH:gOFghcHK| MoW5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCIIHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgdIxieXWnIILl[JVkfGmxbjDh[pRmeiB|NjD0c{A1QCCqcoOsJGVEPTB;MD63{txONg>? M17TbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFYyLz5zN{SzPFA3OTxxYU6=
HFF MXfBcpRqfmm{YXygZZN{[Xl? MoP5PEB1dyBzMDDkZZl{ MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSENECgbY5n\WO2ZXSgbY4hcHWvYX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDwcIFyfWViZn;ycYF1cW:wIITy[YF1\WRid3n0bEBkd22yb4Xu[EBnd2yub4fpcochfmm{YXygbY5n\WO2aX;uJIFv\CCrbnP1ZoF1\WRiZn;yJFghfG9iMUCg[IF6eyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yCkYYPl[EBie3OjeTygSWM2OD1yLkey{txONg>? NFToOGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
fibroblast cells NIHnVnBCdnSrdnnyZYwh[XO|YYm= NXn2eW5nOSCqb4Xy M3TDS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDZEG2PUApX1RrIIDsZZF2\SCob4LtbY5oKHWwaYSg[5Jwf25ib36gTJVu[W5iZn;y[ZNscW5iZnnido9jdGG|dDDj[YxteyC3cH;uJIlv[3WkYYTpc44h\m:{IEGgbI92eiCjdDCzO{Bl\We{ZXXzJGMhf2m2aDDjc41xd3WwZDDkbZN{d2y4ZXSgbY4hTE2VTzygTWM2OD1yLklOwG0v MljYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzM{S5OFYoRjF4MUO0PVQ3RC:jPh?=
fibroblast cells MYHBcpRqfmm{YXygZZN{[Xl? MVSxJIhwfXJ? NYPwRlRjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHkNVY6KCiYOEKzRUkheGyjcYXlJIZwem2rbnegeY5qfCCpcn;3ckBwdiCKdX3hckBnd3Knc3vpckBncWK{b3LsZZN1KGOnbHzzJJVxd25iaX7jeYJifGmxbjDmc5IhOSCqb4XyJIF1KDN5IHTl[5Jm\XNiQzD3bZRpKGOxbYDveY5lKGSrc4PvcJZm\CCrbjDEUXNQNCCLQ{WwQVAvQM7:TT6= NYfzfZhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xN|Q6PDZpPkG2NVM1QTR4PD;hQi=>
E6SM MmP0RY51cX[rcnHsJIF{e2G7 NHLqcGFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIGTLMUBMV1NiQVPWMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY4hTT[VTTDj[YxteyxiTVnDQVAvQM7:TT6= NIrqd2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C5NlczQCd-MUewPVI4Ojh:L3G+
HEL MUDBcpRqfmm{YXygZZN{[Xl? NW\5[|RVPCCmYYnz M{G5emFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzMVEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TT6= M1TvdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL NHjlSXFCdnSrdnnyZYwh[XO|YYm= M2D1RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwON88UU4> NYHNbGt[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL MonSRY51cX[rcnHsJIF{e2G7 M161RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY3njcI93cXJicnXzbZN1[W62IHjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMljPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HELF MWXBcpRqfmm{YXygZZN{[Xl? NHPOcYk4KGSjeYO= MlPpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCWSz3LU3MuSUOYIHnu[oVkfGWmIHnuJIh2dWGwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkhcW6ldXLheIVlKG[xcjC3JIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9NE45|ryPLh?= M2PVUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HEL NW[5W5h5SW62aY\pdoFtKGG|c3H5 NFvUNYJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvQc7:TT6= MlPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MUG4OVYoRjJ|OUGxPFU3RC:jPh?=
CRFK MXXBcpRqfmm{YXygZZN{[Xl? M33vVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDI[ZJx\XNidnnyeZMhcW6oZXP0[YQhcW5iY3H0JGNTTktiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlnPxE1w MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
Vero Mk\4RY51cX[rcnHsJIF{e2G7 NED6fGE{KGSjeYO= MkL4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSC|dILhbY4hTiCYUj23N|MhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUCuPe69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4MEi4N{c,OjZ2NkC4PFM9N2F-
MRC5 M1rkWWFvfGm4aYLhcEBie3OjeR?= NHfOToxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIHnuJG1TSzViY3XscJMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlky|ryPLh?= MkjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVQoRjF5MkO5OVk1RC:jPh?=
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HFF M1LOdGFvfGm4aYLhcEBie3OjeR?= MmTURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeI94dmVic4TyZYlvKEiFTW[ge4F{KGSndHXycYlv\WRiYomgfYlmdGRicnXkeYN1cW:wIHHzd4F6KGmwIHT1dIxq[2G2ZTD3[YxteyC3c3nu[{BJTkZiY3XscJMtKEmFOUC9NU43|ryPLh?= M3nMbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOEiyN|cxLz5zMEi4NlM4ODxxYU6=
HFF MX;BcpRqfmm{YXygZZN{[Xl? Ml3yRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSC7aXXs[EBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|kxRTFwNt88UU4> MkXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|IoRjFyOEiyN|czRC:jPh?=
MRC5 MULBcpRqfmm{YXygZZN{[Xl? MoD6O{Bl[Xm| NFm0V5BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iTWLDOUBk\WyuczDh[pRmeiB5IHThfZMh[nliR1\QMYJie2WmIH\seY9z\XOlZX70JJJm\HWldHnvckBie3OjeTygSWM2OD1zLk[1{txONg>? NIXrU3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC0O|kyOSd-MkCwOFc6OTF:L3G+
HEL MWnBcpRqfmm{YXygZZN{[Xl? MkLhOEBl[Xm| NYTWUW04SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFNTF4OTDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDwcIFyfWViZn;ycYF1cW:wIHHmeIVzKDRiZHH5d{whTUN3ME2xMlY2|ryPLh?= NFj5SWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL NI\OOVNCdnSrdnnyZYwh[XO|YYm= MY[0JIRigXN? NULN[4x3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgOEBl[Xm|LDDFR|UxRTFwNkZOwG0v NX\LT45oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVk5PzZpPkKyOFU6QDd4PD;hQi=>
HFF MnLPSpVv[3Srb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKEiFTW[geI94dmVicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9NU45|ryPLh?= M{Hj[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC0O|I3Lz5zN{CwOFczPjxxYU6=
HFF NU\0eopHSW62aY\pdoFtKGG|c3H5 MmnkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJGFFOTZ7IHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;MT65{txONg>? NWjuXG56RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
HEL NYDRS4dWSW62aY\pdoFtKGG|c3H5 NFzEWmM4KGSjeYO= M4fFZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUNOwG0v MlPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HFF MWLGeY5kfGmxbjDhd5NigQ>? MmXiTY5pcWKrdHnvckBw\iCKQ13WJHRwf26nIILldIxq[2G2aX;uJIlvKEiIRjDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvOc7:TT6= M2XreFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkG1OVQ2Lz5zNU[xOVU1PTxxYU6=
HFF MVPBcpRqfmm{YXygZZN{[Xl? M1;0UFgh\GG7cx?= M3\Yd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiaX7m[YN1\WRiaX6gbJVu[W5iSF\GJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA5KGSjeYOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1{LkJOwG0v MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZyN{i4N{c,OjJ4MEe4PFM9N2F-
HEL M{fpbGFvfGm4aYLhcEBie3OjeR?= M3\Pb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUKuNe69VS5? Mn7uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlgoRjJ5NkO5N|Y5RC:jPh?=
HFF MVjBcpRqfmm{YXygZZN{[Xl? MlW2PEB1dyBzMDDkZZl{ MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSxd37lJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gdIxieXWnIH\vdo1ifGmxbjD0doVifGWmIIfpeIgh[2:vcH;1coQh\m:ubH;3bY5oKH[rcnHsJIlv\mWldHnvckBidmRiaX7jeYJifGWmIH\vdkA5KHSxIEGwJIRigXNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGVEPTB;Mj6x{txONg>? M{HsZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
Vero MUTBcpRqfmm{YXygZZN{[Xl? M133bFMh\GG7cx?= NGPrempCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhXlJvOEC3JIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1{LkG0{txONg>? NEnBfFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2NFg5Oyd-Mk[0OlA5QDN:L3G+
HFF MX\GeY5kfGmxbjDhd5NigQ>? M{nWN2lvcGmkaYTpc44hd2ZiSFPNWkBCTDF4OTDy[ZBtcWOjdHnvckBqdiCKRl[gZ4VtdHNiYomgR3BGKGmwaHnibZRqd25iYYPzZZktKEWFNUC9Nk4z|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
HEL NVPhOXdrSW62aY\pdoFtKGG|c3H5 NVfTU5ZTSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1{LkK5{txONg>? Mnj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
HEL NEjyRoZCdnSrdnnyZYwh[XO|YYm= M1m5TFUh\GG7cx?= Mme2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWGssKF[cVjDZV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNTDkZZl{NCCHQ{WwQVIvO87:TT6= NEXxNYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[yNlEzQCd-MUe2NlIyOjh:L3G+
HELF MWTBcpRqfmm{YXygZZN{[Xl? MV63JIRigXN? MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpcoN2[mG2ZXSg[o9zKDdiZHH5d{BjgSCJaXXtd4Ehe3SjaX7pcoch[mG|ZXSgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUC9Nk4{|ryPLh?= MkXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OE[4N|IoRjNzNUi2PFMzRC:jPh?=
HEL299 M3uxW2FvfGm4aYLhcEBie3OjeR?= MkDkO{Bl[Xm| NIjFSIVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gTGVNOjl7IHPlcIx{KGGodHXyJFch\GG7czDifUBITlBvYnHz[YQh\my3b4Lld4NmdnRicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvOzoQvF2u M{\DR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMES3PVEyLz5{MEC0O|kyOTxxYU6=
HFF MVPGeY5kfGmxbjDhd5NigQ>? MlvWTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDDOEB{fHKjaX6gLHVNPTZiKzDVUFg6KG23dHHueEBo\W6nKTDlfJBz\XO|ZXSgbY4hUE[IIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Mj61{txONg>? M1zhc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HFF NHXFSHRCdnSrdnnyZYwh[XO|YYm= NHHOWpVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiVH;3coUhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFXDOVA:Oi53zszNMi=> MkPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEK0NVAoRjF6MEiyOFExRC:jPh?=
HEL M1TveGFvfGm4aYLhcEBie3OjeR?= Ml;YO{Bl[Xm| MoK1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9Nk42|ryPLh?= NIjvcIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL NHzhbJJCdnSrdnnyZYwh[XO|YYm= MXu1JIRigXN? MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDWZZJq[2WubHGgfo9{fGW{II\pdpV{KDB5L{GgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEWg[IF6eyxiRVO1NF0zNjYQvF2u MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN|OUC4Nkc,OTl|M{mwPFI9N2F-
HFF MXPGeY5kfGmxbjDhd5NigQ>? MmrQTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJJJmeGyrY3H0bY9vKGmwIFjGSkBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCkeTDjfZRweGG2aHnjJIVn\mWldDDpcohq[mm2aX;uJIF{e2G7LDDJR|UxRTJwNt88UU4> M2nIXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl2M{iwNVcoRjl2M{iwNVc9N2F-
HEL NEPyWXNCdnSrdnnyZYwh[XO|YYm= NVLHToM1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\m:|Y3HycoV1NXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKENiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUKuOu69VS5? NYnoUIloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HFF M4i3cGFvfGm4aYLhcEBie3OjeR?= MoP4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjRzNzD3bZRpKHCxbDDBPFA6XiCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{LkdOwG0v MnfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL NF\wWFFCdnSrdnnyZYwh[XO|YYm= NUmzbFA4PyCmYYnz MmjLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR21XKESjdnnzJIlvKGi3bXHuJGhGVCClZXzsd{Bi\nSncjC3JIRigXNuIFXDOVA:Oi54zszNMi=> NXnabJlKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2O|I1PDVpPkG3OlczPDR3PD;hQi=>
CRFK NV[5ZodRSW62aY\pdoFtKGG|c3H5 NVvTPHEySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTmWuaX7lJIhmenCnc4\pdpV{KGmwZnXjeIVlKGmwIHPheEBEWk[NIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36g[pJwdSC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIJ6KE2WVDDhd5NigSxiRVO1NF0zNjcQvF2u NIDUVoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECzOFcyOSd-MkCwN|Q4OTF:L3G+
HFF M1vZb2FvfGm4aYLhcEBie3OjeR?= MljMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjV2MjD3bZRpKHCxbDDUPFE{WyCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{LkhOwG0v NX30XoVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL MVjBcpRqfmm{YXygZZN{[Xl? NInXcpNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME2yMlc2|ryPLh?= NHWwNJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WxPFQ2QSd-MUe1NVg1PTl:L3G+
HEL NWr3VW8zSW62aY\pdoFtKGG|c3H5 MkjJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Mj65Ou69VS5? NGGxSoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe1O|ExOid-Mki3OVcyODJ:L3G+
BSC-1 M4nkWmFvfGm4aYLhcEBie3OjeR?= M3zhSGFvfGm4aYLhcEBi[3Srdnn0fUBw\iC2aHWgZ49ueG:3bnSge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KHSqZTDI[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgbY4hSlOFLUGgZ4VtdHNuIFnDOVA:O87:TT6= NWm1bXkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|MxOCd-MkmxN|MxODxxYU6=
MRC5 MX7GeY5kfGmxbjDhd5NigQ>? NH72[HRKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDBSFE3QSC|dILhbY4hd2ZiSFPNWkBqdiCPUlO1JINmdGy|LDDJR|UxRTQQvF2u NXO2d41pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG0OVQ1PjVpPkGxOFU1PDZ3PD;hQi=>
HFF NYHkRmRuSW62aY\pdoFtKGG|c3H5 NHWzZ3VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwIFjGSkBk\WyuczDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDJR|UxRTQQvF2u NEjZcpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G2NVk1Pid-MUexOlE6PDZ:L3G+
hhTERT-BJ1 MlHVRY51cX[rcnHsJIF{e2G7 NXLRUoJHOiCmYYnz NWDsOmZ{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IGTve45mKGmwZnXjeIVlKGmwIHj1cYFvKGiqVFXSWE1DUjFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDt[YRq[XSnZDDEUmEhe3mwdHjld4l{KGGodHXyJFIh\GG7czygSWM2OD1|zszNMi=> M4DnW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEW4NVI1Lz5zOES1PFEzPDxxYU6=
HEL Mn\FRY51cX[rcnHsJIF{e2G7 NX;BZYVUPyCmYYnz NH\uWphCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEiVVkGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDh[pRmeiB5IHThfZMtKEWFNUC9N:69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF{OE[2Okc,OjFzMki2OlY9N2F-
HFF M1fSWWFvfGm4aYLhcEBie3OjeR?= MVGxNEBl[Xm| M4ruR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgNVAh\GG7czygTWM2OD1|zszNMi=> MoPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NEGyNVgoRjJzNkSxNlE5RC:jPh?=
HEL NEP1OolCdnSrdnnyZYwh[XO|YYm= MkHrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Mz6x{txONg>? M{HFc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUGxPFU3Lz5{M{mxNVg2PjxxYU6=
HEL MmjkRY51cX[rcnHsJIF{e2G7 NWL5eFRzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9N{4y|ryPLh?= M3TlU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HELF M1zE[2FvfGm4aYLhcEBie3OjeR?= MYW3JIRigXN? MmW1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY5kfWKjdHXkJIZweiB5IHThfZMh[nliR3nlcZNiKHO2YXnubY5oKGKjc3XkJI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVMvOTYQvF2u M2fJS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HFF M1zKO2FvfGm4aYLhcEBie3OjeR?= NIHLW4dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBo[W6laXPsc5Zqei2|ZX7zbZRqfmViSFPNWlEhcXOxbHH0[UBz\XCuaXPheIlwdiCrbjDISmYh[2WubIOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD1|LkKy{txONg>? NFrIXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCxNFY5PCd-MUmwNVA3QDR:L3G+
HFF NIrR[GlHfW6ldHnvckBie3OjeR?= MVXDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkMZR6eGViQVSxOlkhe3S{YXnuJI9nKEiFTW[gbY4hgWmnbHSgdoVlfWO2aX;uJIF{e2G7IIXzbY5oKEiIRjDj[YxteyxiSVO5NF0{NjQQvF2u MkLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HEL NF;abZVCdnSrdnnyZYwh[XO|YYm= NXzGR2J7PiC2bzC3JIRigXN? MlXzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgZYZ1\XJiNjD0c{A4KGSjeYOgdI9{fC2rbn\lZ5Rqd25uIFXDOVA:Oy5|Md88UU4> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
MEF NWnROY9JTnWwY4Tpc44h[XO|YYm= Moe3TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RibYXybY5mKGO7dH;t[YdidG:4aYL1d{Bz\XCuaXPheIlwdiCrbjDNSWYh[2WubIOge4F{KGSndHXycYlv\WRiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0{NjUQvF2u M3rOXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl2M{iwNVcoRjl2M{iwNVc9N2F-
BSC-1 MU\BcpRqfmm{YXygZZN{[Xl? MkPxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFiKHjldpBmeyC|aX3wcIV5KH[rcoXzLUwh\GW2ZYLtbY5m\CCkeTDFUGlUSSCrbjDxeYFlenWybHnjZZRmKHenbHzzJJV{cW6pIFLTR{0yKGOnbHzzMEBKSzVyPUOuOe69VS5? NXq0ZZBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzBpPkGwPFgzOzdyPD;hQi=>
BSC-1 NGrPe3pHfW6ldHnvckBie3OjeR?= MYjFUGlUSSCjc4PhfUB4[XNicHXy[o9zdWWmIIXzbY5oKEKVQz2xJINmdGy|IITvJIRmfGW{bXnu[UBi[3Srdnn0fUBi\2GrboP0JGhUXi1zLDDJR|UxRTNwNd88UU4> NF7IR2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4Oid-MUC4PFI{PzJ:L3G+
BSC-1 MWPBcpRqfmm{YXygZZN{[Xl? MoLyTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFidnnyeZMhcW5iQmPDMVEhMG2xbnvlfUBscWSwZYmpJINmdGy|LDDJR|UxRTNwNd88UU4> MkHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTB3N{i2OUc,QTB3N{i2OVww[T5?
HEL M3LkfWFvfGm4aYLhcEBie3OjeR?= MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDQUWVFSVBvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9N{42|ryPLh?= NIDXWYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HFF M4PUW2FvfGm4aYLhcEBie3OjeR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPDJyIIfpeIgheG:uIFe4OFFCKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTNwNd88UU4> MnfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
BSC-1 MlLWSpVv[3Srb36gZZN{[Xl? MojXTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIDjIV3YuOSliZYjwdoV{e2WmIHnuJGJUSy1zIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KEWOSWPBJIF{e2G7LDDJR|UxRTNwNd88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OEc,OTV3MEmxO|Q9N2F-
BSC-1 MomzSpVv[3Srb36gZZN{[Xl? NFLCWHFKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? MnrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|UoRjF3NUC5NVc2RC:jPh?=
BSC-1 MWfGeY5kfGmxbjDhd5NigQ>? NY\jXFJWUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJEhJW1ZvMTmg[ZhxemW|c3XkJIlvKEKVQz2xJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IFXMTXNCKGG|c3H5MEBKSzVyPUOuOe69VS5? NVzheXE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzZpPkG1OVA6OTd4PD;hQi=>
HFF M1zzPWZ2dmO2aX;uJIF{e2G7 M172dmNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IEK5NVYhSURzNkmgd5Rz[WmwIH;mJGhEVVZiaX6gfYlmdGRicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN7ME2zMlbPxE1w MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HEL M3;H[2FvfGm4aYLhcEBie3OjeR?= MnfzO{Bl[Xm| NV\0[ox1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[W[2ZYKgO{Bl[Xm|IIDvd5Rqdm[nY4Tpc44tKEWFNUC9N{43|ryPLh?= NYPoOFVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlYyPDBpPkG5NlI3OTRyPD;hQi=>
HFF NVGwNnVtSW62aY\pdoFtKGG|c3H5 NU\NeoRlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMkK1PEB4cXSqIGXMPVchSzV7MlegcZV1[W62IHnu[oVkfGWmIHnuJGhHTiClZXzsd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{46|ryPLh?= MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEm0OlgoRjF5N{C5OFY5RC:jPh?=
HEL MUPBcpRqfmm{YXygZZN{[Xl? NWDkeYR4OiC2bzCzJIRigXN? MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDBR3YuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9N{46Oc7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3MEezOEc,Ojl3NUC3N|Q9N2F-
MRC-5 MXjBcpRqcGW{cHXzeolzfXNiYYPzZZk> NWTMSZdxUW5idnn0do8h[W62aXjldpBme3[rcoXzJIFkfGm4aYT5JIFo[Wmwc4SgUXJENTViY3XscJMhcW6oZXP0[YQhf2m2aDDIR21XKCiDRD2xOlkhe3S{YXnuLUwhUUN3ME20{txONg>? NH7JOZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{KzOlc5Lz5zM{KzOlc5RC:jPh?=
HEL MonWRY51cX[rcnHsJIF{e2G7 M3PrNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JINq\G:ob4\pdkBJS02YIFHENVY6KGOub37lJFUhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVTPxE1w NFrXTnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL NWC4W3lWSW62aY\pdoFtKGG|c3H5 M2rJUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY4njcI93cXJvcnXzbZN1[W62IFjTWlEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:PM7:TT6= MlzmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
HEL MoL0RY51cX[rcnHsJIF{e2G7 NYLh[|d2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXEtvbnXnZZRqfmViSHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUVOwG0v NIjFe|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNVA6Oyd-MkO4NVExQTN:L3G+
HEL M4LMPWFvfGm4aYLhcEBie3OjeR?= NEPKOnBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME20{txONg>? NWrWeWhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyPTRpPkK3O|UxOTV2PD;hQi=>
HEL MX\BcpRqfmm{YXygZZN{[Xl? M3rncWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUSuNFXPxE1w M3zNWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVkxLz5{OUSwO|k6ODxxYU6=
HFF M2XYUGZ2dmO2aX;uJIF{e2G7 NH3KcZlEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDMVQhXG:5bnWgd5Rz[WmwIH;mJGhEVVZiaX6gfYlmdGRicnXkeYN1cW:wIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME20MlHPxE1w MkDzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|QoRjFyOEiyN|c1RC:jPh?=
HFF MY\BcpRqfmm{YXygZZN{[Xl? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTFiaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD12LkJOwG0v NEj2PI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
CRFK NX64[JRzSW62aY\pdoFtKGG|c3H5 NVftVWo3PCCmYYnz M1TkfGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KGOxbH;ybY1mfHKrYzDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVA:PC5zzszNMi=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3OUi3Okc,OjJ2NUm4O|Y9N2F-
CRFK MYfBcpRqfmm{YXygZZN{[Xl? M2T4SGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDNWHMh[XO|YYmsJGVEPTB;ND6x{txONg>? M3i5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL MWDBcpRqfmm{YXygZZN{[Xl? MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDnZY5kcWOub4\pdk1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UA1KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD12LkROwG0v NGG3dWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL NFjSW4dCdnSrdnnyZYwh[XO|YYm= MXjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDBR3YuemW|aYP0ZY51KHSqeX3p[Ilv\SCtaX7hd4Uh\GWoaXPp[Y51KEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;ND6z{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HFF NFi3fHBHfW6ldHnvckBie3OjeR?= NX7YdG1FS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\C22eYDlJHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND61{txONg>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HEL NYnzVJV5SW62aY\pdoFtKGG|c3H5 MkHlO{Bl[Xm| MnfhRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIV5eHKnc4Pl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCuYYH1[UBnd3KvYYTpc44hcW6ldXLheIVlKG[xcjC3JIRigXNiYomgS4lmdXOjIIP0ZYlvKGKjc3XkJI1q[3Kxc3PvdJktKEWFNUC9OE44Os7:TT6= NYT3Z5JVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yPVExOzhpPkK2NlkyODN6PD;hQi=>
HEL M37hPGFvfGm4aYLhcEBie3OjeR?= NV64[ldSPyCmYYnz MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IEeg[IF6eyxiRVO1NF01NjkQvF2u NETXblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WzPVYzOid-MUe1N|k3OjJ:L3G+
HEL NXf4cFNlSW62aY\pdoFtKGG|c3H5 NFS1SXE{KGSjeYO= NGHvfI5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:PC56zszNMi=> NVfLOYxLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OlE5PTFpPkG3PVYyQDVzPD;hQi=>
HEL MnnLRY51cX[rcnHsJIF{e2G7 MnLQOkB1dyB5IHThfZM> NH;Gc5lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCvZXHzeZJm\CCjZoTldkA3KHSxIEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME20Mlg{|ryPLh?= MmHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
MRC5 M4TRTWFvfGm4aYLhcEBie3OjeR?= M4rkNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVd3ewZTDpckBOWkN3IHPlcIx{KGK7IGDSRUwhUUN3ME20MlnPxE1w NGfHeW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C0N|EzQCd-MUewOFMyOjh:L3G+
MRC5 M2XYfmFvfGm4aYLhcEBie3OjeR?= NXvnTnVVUW5idnn0do8h[W62aY\pdoFtKGGldHn2bZR6KHejczDt[YF{fXKnZDDh[4FqdnO2IFjDUXYpSURvMU[5LUBqdiCPUlO1JINmdGy|LDDJSFUxRTYQvF2u NYfKXopGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVgyOSd-M{CwPVgyOTxxYU6=
H-1 MVvGeY5kfGmxbjDhd5NigQ>? NXTVbnJjTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBGeHO2ZXnuMYJienJidnnyeZMhemWybHnjZZRqd25iaX6gTE0yKGOnbHzzJIlvKESQQTDofYJzcWSrenH0bY9vKGG|c3H5MEBGSzVyPUZOwG0v M4\vRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkO0NFA{Lz5zNU[zOFAxOzxxYU6=
H1 NVL0SmVnTnWwY4Tpc44h[XO|YYm= NXrPe|BrUW6qaXLpeIlwdiCxZjDFRnYhemWybHnjZZRqd25iaX6gTFEh[2WubIOgZpkhTE6DIHj5ZpJq\Gm8YYTpc44h[XO|YYmsJGVEPTB;Nd88UU4> M{XjOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC0O|I3Lz5zN{CwOFczPjxxYU6=
H1 NFLkNFJHfW6ldHnvckBie3OjeR?= NGXSbIRKdmirYnn0bY9vKG:oIFXCWkBz\XCuaXPheIlwdiCrbjDINUBk\WyuczDifUBFVkFiaInidollcXqjdHnvckBie3OjeTygSWM2OD13zszNMi=> M2PUfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkG1OVQ2Lz5zNU[xOVU1PTxxYU6=
CEM MmLzR5l1d3SxeHnjbZR6KGG|c3H5 MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBETU1iY3XscJMtKEOFNUC9Oe69VS5? M1HtOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkG1OVQ2Lz5zNU[xOVU1PTxxYU6=
HFF NFSyRXhCdnSrdnnyZYwh[XO|YYm= M1TzWVUhfG9iNzDkZZl{ M3v5V2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiaX7m[YN1\WRiSF\GJINmdGy|IHHmeIVzKDVidH:gO{Bl[Xm|IHL5JJZqemGuIInp[YxlKGG|c3H5MEBGSzl7Lkm9Oe69VS5? Mn3DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MkmxNFMoRjF5M{K5NVA{RC:jPh?=
HEL MVvBcpRqfmm{YXygZZN{[Xl? M3XxeFch\GG7cx?= M4ThU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IEeg[IF6eyxiRVO1NF02NjIQvF2u Ml;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MkKxNlgoRjF5NkKyNVI5RC:jPh?=
HEL MX\BcpRqfmm{YXygZZN{[Xl? MVK3JIRigXN? NWHSbGhxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QS:GYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPyCmYYnzMEBGSzVyPUWuNu69VS5? NU\hPXhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlg3PjZpPkKxNVI5PjZ4PD;hQi=>
AKATA MlrCRY51cX[rcnHsJIF{e2G7 NGjIRlI1QCCqcoO= NWOyeIpDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTUKYIHnu[oVkfGWmIHnuJIh2dWGwIFHLRXRCKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDJ[2cucW6mdXPl[EBtgXSrYzD2bZJ2eyC{ZYDsbYNifGmxbjDt[YF{fXKnZDDheEA1QCCqcoOgdI9{fC2ueYTpZ{BqdmS3Y4Tpc44h[nlicWLUMXBEWiCjbnHsfZNqeyxiRVO1NF02NjMQvF2u M1HGcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
MRC5 MYDBcpRqfmm{YXygZZN{[Xl? NV\0eFcySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{Mkm2JIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVUvPM7:TT6= MlKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
fibroblast cells MknnRY51cX[rcnHsJIF{e2G7 MnXJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIHP5eI9u\WejbH;2bZJ2eyCrbn\lZ5Rm\CCrbjDtc5V{\SCnbXLyfY9vcWNiZnnido9jdGG|dDDj[YxteyCkeTDwcIFyfWVicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVUvPc7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7N{K3NUc,OTl|OUeyO|E9N2F-
HFF NXvsTmQ2SW62aY\pdoFtKGG|c3H5 MkLGRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjl|IHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTVwNt88UU4> Ml7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNEOxNlgoRjF5MESzNVI5RC:jPh?=
HEL NWfBVYhJSW62aY\pdoFtKGG|c3H5 NWTyUIc{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OU43O87:TT6= NITo[Vk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k6OCd-Mkm0NFc6QTB:L3G+
NIH 3T3 M1jIXmFvfGm4aYLhcEBie3OjeR?= MYq0JJRwKDViZHH5dy=> NGezWnFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBOfXKrbnWgZ5l1d22nZ3Hsc5ZqenW|IIP0doFqdiCVbXn0bEBqdm[nY4Tl[EBqdiCvb4Xz[UBPUUhiM2SzJINmdGy|IHHmeIVzKDRidH:gOUBl[Xm|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFXDOVA:PS55zszNMi=> NX3peW1uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OVgyOjRpPkG4OFU5OTJ2PD;hQi=>
RG2TK+ NHP0PVdEgXSxdH;4bYNqfHliYYPzZZk> MYW3NkBpenN? NFyxeI5EgXSxdH;4bYNqfHliYXfhbY5{fCCKU2[xMZRsKGenbnWgc5ZmemW6cILld5NqdmdiUleyWGssKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;NT64Ou69VS5? Mo\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlQoRjF6OECwO|Y1RC:jPh?=
MRC-5 MmfhSpVv[3Srb36gZZN{[Xl? NF\SfpNEd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD2bZJidCCybHHxeYUh\m:{bXH0bY9vKGK7IFj1cYFvKEO7dH;t[YdidG:4aYL1d{ApUEOPVjmgLJN1emGrbjDBSE0yPjlrIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVUvQc7:TT6= M1i4SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOU[2O|QxLz5zMEm2Olc1ODxxYU6=
HEL M3v6[GFvfGm4aYLhcEBie3OjeR?= NEP3T4ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;NT65{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
HEL M{DZdmFvfGm4aYLhcEBie3OjeR?= M4S5TGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44tKEWFNUC9OU46QM7:TT6= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMUC5N{c,OjN6MUGwPVM9N2F-
HCMV AD 169 M1nQb2FvfGm4aYLhcEBie3OjeR?= NGq3[pRKdiC4aYTyc{BidnSrdnnyZYwh[W6mIHHueIlk\WyudXzhdkBi[3Srdnn0fUB4[XNiZY\hcJVifGWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YIFHEJFE3QSliaX6gLGhEVVZiQVSgNVY6MSClZXzsd{whUUR3ME22{txONg>? NGPTWJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOlE2Lz5{OUmzOlE2RC:jPh?=
HEL MlvTRY51cX[rcnHsJIF{e2G7 M3vsOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBi\2GrboP0JJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME22{txONg>? MmC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkW1NVYoRjJzNU[1OVE3RC:jPh?=
HEL NULabIRbSW62aY\pdoFtKGG|c3H5 NYXK[I5{OyCmYYnz M2WxSWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldJJmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF03|ryPLh?= NHvRSIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi:FaFXNRmwoRkOqRV3CUFww[T5?
HFF MWDBcpRqfmm{YXygZZN{[Xl? NYX3cpQ2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiCWMke4OEB4cXSqIIDvcEBCQDB7VjDVUFk4KEN3OULHJIRwfWKuZTDteZRidnRiaX7m[YN1\WRiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME22MlHPxE1w NGf4OJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL MYfBcpRqfmm{YXygZZN{[Xl? MkXNO{Bl[Xm| NW[4NFVbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:Pi5zMt88UU4> MlLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUGwN|goRjJ4MkmxNFM5RC:jPh?=
MRC-5 NU[2bmdkTnWwY4Tpc44h[XO|YYm= MVzJcohq[mm2b4L5JINwdmOnboTyZZRqd25iZn;yJIFvfGlvSFPNWkBi[3Srdnn0fUBi\2GrboP0JGFFNTF4OTDzeJJicW5iaX6gUXJENTViY3XscJMtKEmFNUC9Ok4{|ryPLh?= NXP3dIZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUizOlYyOyd-OUizOlYyOzxxYU6=
HEL MlS2RY51cX[rcnHsJIF{e2G7 MlzTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;Nj6z{txONg>? M2rwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL MWDBcpRqfmm{YXygZZN{[Xl? NVnhOoV5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFNTF4OTDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:Pi5|zszNMi=> Ml60QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NHzaWGtCdnSrdnnyZYwh[XO|YYm= NYrud5UyPiC2bzC3JIRigXN? NFXoRm5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCvZXHzeZJm\CCjZoTldkA3KHSxIEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME22MlQ3|ryPLh?= MofVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
HEL MYDBcpRqfmm{YXygZZN{[Xl? MWW3JIRigXN? MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDUXYhSURzNkmgbY4hcHWvYX6gTGVNKGOnbHzzJIFnfGW{IEeg[IF6eyxiRVO1NF03NjYQvF2u MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ5MkS0OUc,OTd4N{K0OFU9N2F-
HEL Mln3RY51cX[rcnHsJIF{e2G7 MlPHRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME22MlXPxE1w M1zneFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
HELF M{HCUWFvfGm4aYLhcEBie3OjeR?= M2LlPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{B{fHKjaX6gbY5n\WO2ZXSgbY4hUEWORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Nj61Nu69VS5? NILiblU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HEL NIHQXlZCdnSrdnnyZYwh[XO|YYm= MmO0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIFo[Wmwc4SgeolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPU[uOVTPxE1w MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HFF M3LxXmFvfGm4aYLhcEBie3OjeR?= Mlm1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjd7ODD3bZRpKHCxbDDUPFE{WyCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD14LkdOwG0v NUWyd3J{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL NVfZfZg3SW62aY\pdoFtKGG|c3H5 MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD14Lke5{txONg>? NX7OdWIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVcyODJpPkK4O|U4OTB{PD;hQi=>
HEL MXfGeY5kfGmxbjDhd5NigQ>? NG\tN4xKdmirYnn0bY9vKGGpYXnud5QhTE6DIH;mJJVvcW6oZXP0[YQhUEWOIHPlcIx{KGK7IHnuZ49zeG:{YYTpc44hd2ZiW{PIYXRlWixiSVO1NF04|ryPLh?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HFF M2TlcWFvfGm4aYLhcEBie3OjeR?= NITwXmtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUGgbY4hUE[IIHPlcIx{KGK7IGPFRXAh[XO|YYmsJGlEPTB;Nz6x{txONg>? NYLxVm06RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
HEL NXvwd5dUSW62aY\pdoFtKGG|c3H5 NYjLNYVnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTdwMd88UU4> MmPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3N{i3PFMoRjJ{NUe4O|g{RC:jPh?=
HEL NWHLWHU2SW62aY\pdoFtKGG|c3H5 NYXmcYN1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjIQvF2u MnLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
CRFK NHvUSHhCdnSrdnnyZYwh[XO|YYm= Ml\UN{Bl[Xm| M2r0WGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGZmdGmmIHjldpBme3[rcoXzJFEhcW6oZXP0[YQh[2G2IFPSSmsh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JINwdG:{aX3leJJq[yCob4LtZZpidi2kYYPl[EBOXFNiYYPzZZktKEWFNUC9O{4{|ryPLh?= MnzTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL Moq5RY51cX[rcnHsJIF{e2G7 MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF04NjQQvF2u MmDUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6Mkm5NVMoRjJ6OEK5PVE{RC:jPh?=
HFF MoTpRY51cX[rcnHsJIF{e2G7 M1\McWlvKH[rdILvJIFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiKGTve45mKHO2cnHpckkhcW5iSF\GJEhpfW2jbjDmbYJzd2KuYYP0LUBk\WyuczygTWM2OD15LkVOwG0v M{HMPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyNUe4OlUoRjlyNUe4OlU9N2F-
HFF NXyzVFFjTnWwY4Tpc44h[XO|YYm= NIjYcVNKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhemWybHnjZZRqd25iaX6gTGZHKGOnbHzzJJdieyCmZYTldo1qdmWmIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Py52zszNMi=> NYDWcnBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUSzPFAyPyd-OUSzPFAyPzxxYU6=
HFF MoTmSpVv[3Srb36gZZN{[Xl? M4LKWmNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIl3cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IGTve45mKHO2cnHpckBw\iCKQ13WJIlvKGFicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;Nz60{txONg>? NU\PXm9yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HFF NWDOZWkzTnWwY4Tpc44h[XO|YYm= MWPDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XlidYPpcochUE[IIHPlcIx{NCCLQ{WwQVcvPM7:TT6= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OUc,OTB6OEKzO|U9N2F-
HFF NGjpRmZCdnSrdnnyZYwh[XO|YYm= NV3ocpI1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfG:5bnWgd5Rz[WmwIFjDUXYhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTDpckBlfXCuaXPheIUhf2WubIOgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> NX\ndJhqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzBpPkGwPFgzOzdyPD;hQi=>
HFF MV;BcpRqfmm{YXygZZN{[Xl? MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgeZNqdmdiSF\GJINmdGy|LDDJR|UxRTdwNN88UU4> NFfkc2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4Oid-MUC4PFI{PzJ:L3G+
HFF MnvNSpVv[3Srb36gZZN{[Xl? MX;Jcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHX4dJJme3OnZDDpckBJTkZiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygTWM2OD15LkVOwG0v M4LwZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc1Lz5zNUWwPVE4PDxxYU6=
HFF M2nPeWZ2dmO2aX;uJIF{e2G7 MnPZTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIHHnZYlve3RiaIXtZY4h[3m2b33l[4Ftd3[rcoXzJEhJS02YKTDlfJBz\XO|ZXSgbY4hUE[IIHPlcIx{KHejczDk[ZRmem2rbnXkJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTB;Nz60{txONg>? Ml7rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxO|UoRjF3NUC5NVc2RC:jPh?=
HFF M2fafmZ2dmO2aX;uJIF{e2G7 NUfk[Y86UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJJJmeXWrcnXkJIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBmgHC{ZYPz[YQhcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9O{41|ryPLh?= M4joOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc3Lz5zNUWwPVE4PjxxYU6=
HEL MYfBcpRqfmm{YXygZZN{[Xl? NX;SXVZ{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHEMVE3QSCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUeuOO69VS5? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh{OUmxN{c,Ojh6Mkm5NVM9N2F-
HEL NInme4VCdnSrdnnyZYwh[XO|YYm= MkHDOkB1dyB5IHThfZM> MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDh[pRmeiB4IITvJFch\GG7czDwc5N1NWmwZnXjeIlwdixiRVO1NF04NjRzzszNMi=> NVrvTllVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O|A4ODVpPkK5OlcxPzB3PD;hQi=>
HEL NHjYSFJCdnSrdnnyZYwh[XO|YYm= MniyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVcvPc7:TT6= NX7Cb4s2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1O|g4QDNpPkKyOVc5Pzh|PD;hQi=>
HFF M{nZOGFvfGm4aYLhcEBie3OjeR?= MUHBcpRqfmm{YXygZYN1cX[rdImge4F{KGSndHXycYlv\WRiYomgeIhmKEiFTW[gdIxieXWnIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlfPxE1w NHHSUnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MEW3PFY3Lz57MEW3PFY3RC:jPh?=
HEL MVjBcpRqfmm{YXygZZN{[Xl? MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDwcIFyfWViZn;ycYF1cW:wLDDFR|UxRTdwON88UU4> Mln6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NEO1OVAoRjJ4NESzOVUxRC:jPh?=
HEL NIPR[|BCdnSrdnnyZYwh[XO|YYm= MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGyjcYXlJIZwem2jdHnvckwhTUN3ME23Mlg4|ryPLh?= M3fUV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
CRFK Mo\wRY51cX[rcnHsJIF{e2G7 NFLLdlBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBH\WyrbnWgbIVzeGW|dnnyeZMhcW6oZXP0[YQhcW5iQ2LGT{Bk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVgvOc7:TT6= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL MlHYRY51cX[rcnHsJIF{e2G7 NHzTfY5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7IHHmeIVzNCCHQ{WwQVgvOs7:TT6= NF;ne4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxNVg2PCd-MkO5NVE5PTR:L3G+
HFF M4S3c2Z2dmO2aX;uJIF{e2G7 NHvKUYtKdiC4aYTyc{BqdmirYnn0bY9vKG:oIHj1cYFvKGO7dH;t[YdidG:4aYL1d{BqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF05NjUQvF2u Ml7NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HFF NW[4N4xvSW62aY\pdoFtKGG|c3H5 NHX0eIVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKDJ6MUege4l1cCCyb3ygS|g1OUFiVVy5O{BEPTl{RzDkc5VjdGVibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;OD60{txONg>? NV3Yd4oxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL M3y5TmFvfGm4aYLhcEBie3OjeR?= Mmi3O{Bl[Xm| NHTUXIdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckBi\nSncjC3JIRigXNuIFXDOVA:QC55zszNMi=> M4DZe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkKyNVI5Lz5zN{[yNlEzQDxxYU6=
HEL MoX1RY51cX[rcnHsJIF{e2G7 M{LrVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUiuO:69VS5? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6MkC2O{c,Ojh4OEKwOlc9N2F-
HEL MY\BcpRqfmm{YXygZZN{[Xl? MoHuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgZY5lKGGleXPsc5ZqeiC{ZYPpd5RidnRiSGPWNUBMV1NiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9Pe69VS5? MoLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEGyNlUoRjF7MkixNlI2RC:jPh?=
HEL NEPYTHFCdnSrdnnyZYwh[XO|YYm= NVvIRlJbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZpkhfmm{YXygR3BGKGG|c3H5MEBGSzVyPUmuNe69VS5? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
MRC-5 NUnUTG0{TnWwY4Tpc44h[XO|YYm= M1X4fmlvcGmkaYTvdpkh[WO2aY\peJkhd2ZiY3;tdI92dmRiYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgLGhEVVZrIHnuJG1TSy13IHPlcIx{NCCHQ{WwQVkvPM7:TT6= M2e4XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{KzPVUyLz5zMkeyN|k2OTxxYU6=
Vero NWHicFZRSW62aY\pdoFtKGG|c3H5 MnPuTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiVVj2xJEhHKGSnbIThJFMxPSliaX6gWoVzdyClZXzsd{whUUR3ME2xNO69VS5? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEGxK|4{ODB7OEGxQE9iRg>?
HFF NITrZWlCdnSrdnnyZYwh[XO|YYm= NGrNfnpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUOgbY4hUE[IIHPlcIx{KGK7IGDSRUwhUUN3ME2xNO69VS5? M{XYTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
Vero NXrMRoJTSW62aY\pdoFtKGG|c3H5 Mn7QN{Bl[Xm| NIO2bnhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[XKrY3XscIEugm:|dHXyJJZqenW|IFXscIVvKF[ULUGzOlchcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBGSzVyPUGxMlHPxE1w NVTU[oFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlA5QDNpPkK2OFYxQDh|PD;hQi=>
HEL MnjBRY51cX[rcnHsJIF{e2G7 NXzDVYdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1zMT60N:69VS5? NVvOT5JTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HELF NGXHcopCdnSrdnnyZYwh[XO|YYm= NIj1WYVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhe3S{YXnuJIlv\mWldHXkJIlvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUGxMlc2|ryPLh?= NUfJUllsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
HFF M3G2eWFvfGm4aYLhcEBie3OjeR?= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFI{OTFiaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD1zMj60{txONg>? M13nZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL M4\hbmFvfGm4aYLhcEBie3OjeR?= NXr3NIdVPyCmYYnz MY\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2xNk43|ryPLh?= NV;MeGcxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzN|kxQDJpPkG5N|M6ODh{PD;hQi=>
HEL M1zYWmFvfGm4aYLhcEBie3OjeR?= MkHpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD1zMz65{txONg>? M3HuXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NESzOVUxLz5{NkS0N|U2ODxxYU6=
Vero MXjBcpRqfmm{YXygZZN{[Xl? NIO4PJA{PiC2bzC0PEBpenN? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNiQjD2bZJ2eyB{NEGwOUBqdm[nY4Tl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KHCuYYH1[UBz\WS3Y4Tpc44h[W[2ZYKgN|YhfG9iNEigbJJ{NCCHQ{WwQVE1NjYQvF2u NWD4VXk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|gxPjFpPkG3OFM5ODZzPD;hQi=>
HEL MkLyRY51cX[rcnHsJIF{e2G7 MmDKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDu[YdifGm4ZTDhcoQhSUOYIILld4l{fGGwdDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[nlidnnyZYwhS1CHIHHzd4F6NCCHQ{WwQVE1NjgQvF2u MkTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiyNlIoRjJ{OEW4NlIzRC:jPh?=
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Assay
Methods Test Index PMID
Growth inhibition assay Cell viability 29845211
In vivo Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response[7].

Protocol (from reference)

Cell Research:

[7]

  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    To assess cell proliferation by thymidine incorporation, a total of 2 × 10<sup>4</sup> BV-2 cells were seeded in a 96-well plate for a maximum of 12 h in 10% FBS containing DMEM and then serum starved for an additional 12 h before the addition of varying concentrations of GCV for a total of 24 h. Cultures were pulsed for the final 8 h with 1 µCi/well [3H]thymidine before incorporated radioactivity was measured using a β plate scintillation counter.

  • (Only for Reference)
Animal Research:

[7]

  • Animal Models: C57BL/6 mice
  • Dosages: 100 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 27 mg/mL warmed
(105.78 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 255.23
Formula

C9H13N5O4

CAS No. 82410-32-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04478474 Not yet recruiting Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme Corp. September 15 2020 --
NCT03698435 Unknown status Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4
NCT02152358 Unknown status Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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