Ganciclovir (BW 759)

Catalog No.S1878 Synonyms: RS-21592, 2'-Nor-2'-deoxyguanosine

For research use only.

Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

Ganciclovir (BW 759) Chemical Structure

CAS No. 82410-32-0

Selleck's Ganciclovir (BW 759) has been cited by 14 publications

Purity & Quality Control

Choose Selective CMV Inhibitors

Biological Activity

Description Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro

Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. [1] Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. [2] Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. [3] Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. [4] Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. [5] Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines M{fj[WZ2dmO2aX;uJIF{e2G7 Mmq2SYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKCiKU2[tNkkhcW6mdXPl[EBkgXSxcHH0bIlkcXS7IHL5JFUxLSCrbjDFOnNOKGOnbHygcIlv\XNuIFXDOVA:OS5{IH7N MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR7NUW4Okc,OTF2OUW1PFY9N2F-
OST TK- cells NVXkdFRiS3m2b4TvfIlkcXS7IHHzd4F6 NU\uSZI5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFusJGlEPTB;MD6wNFE6|ryPLh?= Mn35QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOVgoRjF5MUixNVU5RC:jPh?=
HEL M{K3[mFvfGm4aYLhcEBie3OjeR?= NGrId|dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFegbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDNTWM:OC5yME[0{txONg>? Mnj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4N{K0OFUoRjF5NkeyOFQ2RC:jPh?=
HEL MkOwRY51cX[rcnHsJIF{e2G7 NFfKW4FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFHPxE1w MnPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{K4NlgoRjJzMkOyPFI5RC:jPh?=
HEL NEnXNnFCdnSrdnnyZYwh[XO|YYm= NGS5eYtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMjDHJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wNe69VS5? MoH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUWyN|goRjJ|N{m1NlM5RC:jPh?=
HEL MVfBcpRqfmm{YXygZZN{[Xl? NIHESGNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZvMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2wMlAy|ryPLh?= M4DuZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{m1NlM5Lz5{M{e5OVI{QDxxYU6=
HEL Mof0RY51cX[rcnHsJIF{e2G7 M1\iWVMh\GG7cx?= Mne1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNibXX0bI9lNCCHQ{WwQVAvODIQvF2u NHi1dWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK4Olk2Oid-M{CyPFY6PTJ:L3G+
HEL MoTORY51cX[rcnHsJIF{e2G7 NULFbI11OyCmYYnz NEjt[2lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKHO2cnHpckBIKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJI1mfGixZDygSWM2OD1yLkCx{txONg>? MmDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OE[5OVIoRjNyMki2PVUzRC:jPh?=
HEL NYrOc3h6SW62aY\pdoFtKGG|c3H5 MkXURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yMUROwG0v MkHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOUmwPVcoRjJ|MEm5NFk4RC:jPh?=
HEL MoO1RY51cX[rcnHsJIF{e2G7 NH;6d41CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNFE2|ryPLh?= NGXKZWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C5PVA6Pyd-MkOwPVkxQTd:L3G+
OST TK- cells NY[4OmxXS3m2b4TvfIlkcXS7IHHzd4F6 MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAzNjVidV2gNU1cPi1qdILpdIhmdnmubXX0bI95gSmqZYj5cH11cHmvaX7lMEBKSzVyPUCuNFE5|ryPLh?= NHHORXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL Mn65RY51cX[rcnHsJIF{e2G7 NXXwPI5QSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW5iSFXMJINmdGy|LDDFR|UxRTBwMEG5{txONg>? NYWwRWlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjJpPkG3NVgyOTZ{PD;hQi=>
HEL MlHCRY51cX[rcnHsJIF{e2G7 M3nWO|IhfG9iMzDkZZl{ NEnpWmFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjCyJJRwKDNiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD1yLkCxPe69VS5? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3MEezOEc,Ojl3NUC3N|Q9N2F-
HEL MVjBcpRqfmm{YXygZZN{[Xl? MnG0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOSCNT2OgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yMt88UU4> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MUKyOUc,OTl{OEGyNlU9N2F-
HEL MmnXRY51cX[rcnHsJIF{e2G7 NFXGVVg1KGSjeYO= NFO4PVhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IESg[IF6eyxiRVO1NF0xNjB{zszNMi=> NFnsWVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL M1f4UGFvfGm4aYLhcEBie3OjeR?= NFHFXIpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD6wNu69VS5? NV3rT4k3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFE{PDRpPkK2NFAyOzR2PD;hQi=>
HEL NYW5WJlHSW62aY\pdoFtKGG|c3H5 MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOs7:TT6= NXvUSFVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PFAzPTFpPkK5PFgxOjVzPD;hQi=>
HEL MonjRY51cX[rcnHsJIF{e2G7 M3y3PWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4xOs7:TT6= MlP6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
Vero MnPuRY51cX[rcnHsJIF{e2G7 NIrLO3c4OiCqcoO= NYDiOnltSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFfGVEBmgHC{ZYPzbY9vKGGodHXyJFczKGi{czDifUBITlBvYnHz[YQh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuNFI2|ryPLh?= NHLLc489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUWwN|Q4Pid-M{G1NFM1PzZ:L3G+
HEL MX3BcpRqfmm{YXygZZN{[Xl? M{HFR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhTyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB{N988UU4> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4NUWxOkc,OjF3NkW1NVY9N2F-
HEL NEHObZNCdnSrdnnyZYwh[XO|YYm= M33KTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCkeTD2bZJidCCFUFWgZZN{[XluIFXDOVA:OC5yMkhOwG0v NXK4UI5sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OVgzOjJpPkKyPFU5OjJ{PD;hQi=>
HEL NIrvfYVCdnSrdnnyZYwh[XO|YYm= MkDxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{BjgSC4aYLhcEBEWEViYYPzZZktKEWFNUC9NE4xOjoQvF2u NYS2bGhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OVgzOjJpPkKyPFU5OjJ{PD;hQi=>
HEL NHHSdohCdnSrdnnyZYwh[XO|YYm= NXrmTm1jOiC2bzCzJIRigXN? MoO3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYN6[2yxdnnyMZNmdnOrdHn2[UBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEROwG0v M3LQeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEO0O|EyLz5{MECzOFcyOTxxYU6=
HEL NFTGZldCdnSrdnnyZYwh[XO|YYm= MnzlNkB1dyB|IHThfZM> M1v1cGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIZzd21idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCyJJRwKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:OC5yM988UU4> NYfk[JBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwN|Q4OTFpPkKwNFM1PzFzPD;hQi=>
HEL MlX4RY51cX[rcnHsJIF{e2G7 Mn;oNkB1dyB|IHThfZM> MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iZoLvcUB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDJidH:gN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA{|ryPLh?= MoOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByM{S3NVEoRjJyMEO0O|EyRC:jPh?=
HEL M3qwdGFvfGm4aYLhcEBie3OjeR?= M2TJflQh\GG7cx?= MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFQh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB|zszNMi=> M2XKbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkm2PVY{Lz5{MU[5Olk3OzxxYU6=
HEL M1vzOGFvfGm4aYLhcEBie3OjeR?= MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSxiRVO1NF0xNjB|zszNMi=> M2jmbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL MlS0RY51cX[rcnHsJIF{e2G7 NFnzTXg1KGSjeYO= NVm0cYhUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNvMjDHJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPCCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEROwG0v MnzHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4OU[5OlMoRjJzNkm2PVY{RC:jPh?=
HEL NYDOPJA6SW62aY\pdoFtKGG|c3H5 M3fwblQh\GG7cx?= M2jCNmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDRiZHH5d{whTUN3ME2wMlA{|ryPLh?= NGTkdmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1PVg4Pid-MkK0OVk5PzZ:L3G+
HEL NHnFZlNCdnSrdnnyZYwh[XO|YYm= MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFPPxE1w M2\X[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL MUfBcpRqfmm{YXygZZN{[Xl? NGLQbI5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1zIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OC5yM988UU4> NWj4V4V7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HEL NIDnd|JCdnSrdnnyZYwh[XO|YYm= MWnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u Mnr2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEGzOFQoRjJ4MECxN|Q1RC:jPh?=
HEL NV;Bb5hNSW62aY\pdoFtKGG|c3H5 Ml7yRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|IIDsZZF2\SCob4LtZZRqd25uIFXDOVA:OC5yM988UU4> M1XK[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HELF NVXRNoNbSW62aY\pdoFtKGG|c3H5 M3PvXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFEhU0:VIIP0doFqdiCrbn\lZ5Rm\CCrbjDISWxHKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0xNjB|zszNMi=> NF;Qepg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HELF MWfBcpRqfmm{YXygZZN{[Xl? NFHKbJJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKEdic4TyZYlvKGmwZnXjeIVlKGmwIFjFUGYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVAvODQQvF2u M1e5XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HEL MmTzRY51cX[rcnHsJIF{e2G7 MoXGRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB|zszNMi=> MnfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6Mkm5NVMoRjJ6OEK5PVE{RC:jPh?=
HEL NXXSXmQzSW62aY\pdoFtKGG|c3H5 NH;MTlJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDygSWM2OD1yLkCz{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3N{GwNkc,Ojh5NUexNFI9N2F-
HEL Mnj1RY51cX[rcnHsJIF{e2G7 MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKGmwIFjFUEBk\WyuczygSWM2OD1yLkCzNu69VS5? NXvDc5R[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjJpPkG3NVgyOTZ{PD;hQi=>
HEL NUWyUpdqSW62aY\pdoFtKGG|c3H5 NELsTXVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJG1KSz1yLkCzNu69VS5? NXrGdo02RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2O|I1PDVpPkG3OlczPDR3PD;hQi=>
HEL M3zlWGFvfGm4aYLhcEBie3OjeR?= NUnjdpNXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuNFMz|ryPLh?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
OST TK- cells NETscWxEgXSxdH;4bYNqfHliYYPzZZk> NY\ySYRIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiNTD1UUAyNVt4LTj0dolxcGWweXzt[ZRpd3i7KXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xOzQQvF2u MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
fibroblast cells NYHIUXBqSW62aY\pdoFtKGG|c3H5 NITvWVNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4h\m:{ZYPrbY4h\mmkcn;icIF{fCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RuIFXDOVA:OC5yNN88UU4> NI\mSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5O|I4OSd-MUmzPVczPzF:L3G+
HEL NH;y[nBCdnSrdnnyZYwh[XO|YYm= MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCxiRVO1NF0xNjB2zszNMi=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|MkiyPEc,OjF{M{K4Nlg9N2F-
HFF M{TCc2FvfGm4aYLhcEBie3OjeR?= NIXTNY8yKGi{ Mn3FRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KCi|dILhbY4hSURzNkmpJIlv\mWldHXkJIlvKDFiaIKgdJJmfHKnYYTl[EBpfW2jbjDISmYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtNWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nlibnX1eJJidCC{ZXSgeZB1[WunIHHzd4F6NCCHQ{WwQVAvODUQvF2u NUDUbHl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO|Y1OjlpPkKxN|c3PDJ7PD;hQi=>
HEL MYjBcpRqfmm{YXygZZN{[Xl? MmPMRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOiCJIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= Mnj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6Mkm5NVMoRjJ6OEK5PVE{RC:jPh?=
HEL NEHNbHNCdnSrdnnyZYwh[XO|YYm= NXv3WFBPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9NE4xPM7:TT6= MoHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
Vero MY\BcpRqfmm{YXygZZN{[Xl? MmTRN|YhcHK| NGq3eWdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZiMTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgN|YhcHK|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuNFTPxE1w NEX2WWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
OST TK- cells M1XNeWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPV3QhXEtvIHPlcIx{KGW6cILld5NqdmdiSGPWNUBVUyCrbjDwdoV{\W6lZTDv[kAyOCC3TTCxMXs3NSi2cnnwbIVvgWyvZYToc5h6MWineInsYZRpgW2rbnWsJGlEPTB;MD6wOFHPxE1w NGXxUFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE2QCd-MUexPFEyPTh:L3G+
HEL M{W0XWFvfGm4aYLhcEBie3OjeR?= M4r6WFIhfG9iMzDkZZl{ M{j4bmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNkB1dyB|IHThfZMheG:|dDDpcoZm[3Srb36sJGVEPTB;MD6wOFXPxE1w MnLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUC3N|QoRjJ7NUWwO|M1RC:jPh?=
OST TK- cells NYjCNXl[S3m2b4TvfIlkcXS7IHHzd4F6 MojFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3NVKFSNLTDj[YxteyCneIDy[ZN{cW6pIFjTWlEhXEtiaX6gdJJme2WwY3Wgc4YhOi53IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xPc7:TT6= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
human MnzORY51cX[rcnHsJIF{e2G7 NHS0NXE4KGSjeYO= M4PU[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJiRzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgO{Bl[Xm|LDDFR|UxRTBwMEZOwG0v MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF{OE[2Okc,OjFzMki2OlY9N2F-
HEL NIT1foFCdnSrdnnyZYwh[XO|YYm= NHXxSGYzKHSxIEOg[IF6ew>? MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCvZXHzeZJm\CCjZoTldkAzKHSxIEOg[IF6eyCyb4P0MYlv\mWldHnvckwhTUN3ME2wMlA2Oc7:TT6= NHywWGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NFcxPSd-Mkm2O|A4ODV:L3G+
HEL NUnEW5RzSW62aY\pdoFtKGG|c3H5 NGn0e|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTBwMEW1{txONg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd3MEG1OEc,Ojd5NUCxOVQ9N2F-
HEL MYnBcpRqfmm{YXygZZN{[Xl? M1\l[FIhfG9iMzDkZZl{ MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IH3lZZN2emWmIHHmeIVzKDJidH:gN{Bl[Xm|IIDvd5QucW6oZXP0bY9vNCCHQ{WwQVAvODV5zszNMi=> M3rpUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkewO|A2Lz5{OU[3NFcxPTxxYU6=
HEL M3TtR2Z2dmO2aX;uJIF{e2G7 NGjsZnpEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqNX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFqRzmgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvODcQvF2u Ml\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR4NEOzNlgoRjF2NkSzN|I5RC:jPh?=
Hel NX7kXopZTnWwY4Tpc44h[XO|YYm= NIXRblBG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JIhmenCnczDzbY1xdGW6II\pdpV{KHS7cHWgNUBMd3Nic4TyZYlvKGmwZIXj[YQh[3m2b4DheIhq[2m2eTDpckBJ\WxiY3XscJMtKEWFNUC9NE4xPs7:TT6= NGLHUHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[1PFg2QCd-MUW2OVg5PTh:L3G+
HEL NWjwWnYySW62aY\pdoFtKGG|c3H5 MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpckBJTUxiY3XscJMtKEWFNUC9NE4xPs7:TT6= M13pRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{myO|kyLz5zNkO5Nlc6OTxxYU6=
HEL MlLVRY51cX[rcnHsJIF{e2G7 MoizRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiCJIHnuJGhGVCClZXzsd{whTUN3ME2wMlA3|ryPLh?= Mo[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ|OUK3PVEoRjF4M{myO|kyRC:jPh?=
HEL NE\5TnZCdnSrdnnyZYwh[XO|YYm= NHfa[Gk{KGSjeYO= M4\TV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFIhe3S{YXnuJGchcW6oZXP0[YQhcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBkd2yxcnnt[ZRzcWNiZn;ycYF7[W5vYnHz[YQhVVSVIHHzd4F6NCCHQ{WwQVAvODgQvF2u NIDIZWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi:FaFXNRmwoRkOqRV3CUFww[T5?
HEL MYnBcpRqfmm{YXygZZN{[Xl? M33mUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjB5zszNMi=> NVLKUFZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|g3PTNpPkOwO|M5PjV|PD;hQi=>
HELF NHTzfJRCdnSrdnnyZYwh[XO|YYm= NXW5T2dlPyCmYYnz NFvtSYpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUyIIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHnuZ5Vj[XSnZDDmc5IhPyCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEhOwG0v NInCNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUW4Olg{Oid-M{G1PFY5OzJ:L3G+
HEL NFS2VoVCdnSrdnnyZYwh[XO|YYm= NH3JTFI4KGSjeYO= NEHhdZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYX\0[ZIhPyCmYYnzMEBGSzVyPUCuNFjPxE1w NWizPGQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlg3PjZpPkKxNVI5PjZ4PD;hQi=>
HEL NELLSFVCdnSrdnnyZYwh[XO|YYm= Ml\JN{Bl[Xm| NFHtR|ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{AzKHO2cnHpckBIKGmwZnXjeIVlKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD1yLkC4{txONg>? NViyfFY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL MYTBcpRqfmm{YXygZZN{[Xl? MnTMN{Bl[Xm| MkLoRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlA5|ryPLh?= M1PWeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493N0OqRV3CUEc,S2iHTVLMQE9iRg>?
OST TK- cells MlPJR5l1d3SxeHnjbZR6KGG|c3H5 NFjsPG5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQW1RiVFutJINmdGy|IHX4dJJme3OrbnegTHNXOSCWSzDpckBxemW|ZX7j[UBw\iB3IIXNJFEuYzZvW{GsNU0p\GmyaHXufYwqNTFvKEStdJlzcWS7bDnt[ZRpd3i7XXjlfJltZXSqeX3pcoUtKEmFNUC9NE4xQDIQvF2u MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG1PEc,OTdzOEGxOVg9N2F-
HEL NGfNRmhCdnSrdnnyZYwh[XO|YYm= NXXBPJoyOyCmYYnz MnXSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgNUB{fHKjaX6gT29UKGmwZnXjeIVlKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkh[2:ub4LpcYV1emmlIH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NF0xNjB7zszNMi=> NY\FenJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxQ3jFUWJNLz6FaFXNRmw9N2F-
HEL NV3UNVhXSW62aY\pdoFtKGG|c3H5 MmXRRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1yLkC5{txONg>? NXjDeXJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjhpPkK3OlM6OzZ6PD;hQi=>
E6SM NID3VnBCdnSrdnnyZYwh[XO|YYm= NVzYXIVxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdiCHNmPNJINmdGy|LDDNTWM:OC5yOUdOwG0v NGW5VlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C5NlczQCd-MUewPVI4Ojh:L3G+
E6SM NWi3TJpmSW62aY\pdoFtKGG|c3H5 NGPjOGJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1Z{IFetbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpckBGPlOPIHPlcIx{NCCPSVO9NE4xQTcQvF2u M1jsTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
HEL NUTtUVZPSW62aY\pdoFtKGG|c3H5 MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnIHTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6x{txONg>? Mmq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{K4NlgoRjJzMkOyPFI5RC:jPh?=
HEL M3;q[mFvfGm4aYLhcEBie3OjeR?= NWXSdWxzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfGi7bXnkbY5mKGurbnHz[U1l\W[rY3nlcpQhSUOYLYLld4l{fGGwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMd88UU4> M{DOVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
OST TK- cells NVHrW|cxS3m2b4TvfIlkcXS7IHHzd4F6 NXTqV|NlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hV1OWIGTLMUBk\WyuczDlfJBz\XO|aX7nJGhUXjFiVFugbY4heHKnc3XuZ4Uhd2ZiMUCgeW0hOS2dNj3bNUwyNSimaYDo[Y56dClvMT2oOE1xgXKrZInsLY1mfGixeIndbIV5gWyfdHj5cYlv\SxiSVO1NF0xNjFzzszNMi=> M4DodlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVU5Lz5zN{G4NVE2QDxxYU6=
HFF NUHaSFFrSW62aY\pdoFtKGG|c3H5 NHPLfY8yOCCmYYnz NHzk[GRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIGTve45mKGmwZnXjeIVlKGmwIFjGSkBk\WyuczDpcoN2[mG2ZXSg[o9zKDFyIHThfZMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlE1|ryPLh?= MkPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NlAoRjJzOEGyOFIxRC:jPh?=
HFF M13obGZ2dmO2aX;uJIF{e2G7 M3THWWlvcGmkaYTpc44hd2ZiSFPNWkBCTDF4OTDy[ZBtcWOjdHnvckBqdiCKRl[gZ4VtdHNiYomgZ5l1d3CjdHjpZ{Bm\m[nY4SgZZN{[XluIFXDOVA:OC5zNd88UU4> NUDJZlZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewNFQ4OjZpPkG3NFA1PzJ4PD;hQi=>
MCA-TK NELzUHlEgXSxdH;4bYNqfHliYYPzZZk> M3\aeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2FQT3UT{Bk\WyuczygTWM2OD1yLkG1{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4MEmyOkc,OTd7NkC5NlY9N2F-
vero NV7ZVJFOSW62aY\pdoFtKGG|c3H5 NXXZSVVHSW62aY\pdoFtKGGldHn2bZR6KHejczDk[ZRmem2rbnXkJIlvKHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmgbY4hfmW{bzDj[YxteyCjZ3HpcpN1KEiVVj2xJGYhe3S{YXnuMEBKTDVyPUCuNu69VS5? NHHaeIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|OEexPFYxLz5|OEexPFYxRC:jPh?=
Vero MX7BcpRqfmm{YXygZZN{[Xl? MmLyTY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCjZ3HpcpN1KEiVVj2xLGYqKGmwIG\ldo8h[2WubIOsJGlFPTB;MD6y{txONg>? NF3UW4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFEyLz5|MEC5PFEyRC:jPh?=
Vero MmSwRY51cX[rcnHsJIF{e2G7 M{\wTWFvfGm4aYLhcEBi[3Srdnn0fUBl\XSncn3pcoVlKGGpYXnud5QhcGW{cHXzJJNqdXCuZYigeJlx\SBzIDjGJJN1emGrbjmgZpkheGyjcYXlJJJm\HWldHnvckBqdiCYZYLvJINmdGy|LDDJSFUxRTBwMt88UU4> MkH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzNkK2N{c,OzBzNkK2N|ww[T5?
HEL MmexRY51cX[rcnHsJIF{e2G7 MYnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YzKEdiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJBzd3SnY4Tpc44h[WejaX7zeEB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE4z|ryPLh?= Mn;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEGyNlUoRjF7MkixNlI2RC:jPh?=
HEL NHHMfpRCdnSrdnnyZYwh[XO|YYm= MkPJN{Bl[Xm| NHj0e|lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi[3mlbH;2bZIuemW|aYP0ZY51KFSNLXTl[oVkcWWwdDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBpfW2jbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCvZYToc4QtKEWFNUC9NE4z|ryPLh?= NXr4c24yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFY6PTJpPkOwNlg3QTV{PD;hQi=>
fibroblast cells MV7GeY5kfGmxbjDhd5NigQ>? NW\hbpVLUW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhcW5ibX;uc4xigWW{czDv[kBJW1ZvMjDBSEBX\XKxIHPlcIx{KGK7IEWwKUwhTUN3ME2wMlI{|ryPLh?= MlrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OEW0OVcoRjFzNUi1OFU4RC:jPh?=
HEL M4HrWGFvfGm4aYLhcEBie3OjeR?= NXPEeoFpSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGFFOTZ7IHnu[oVkfGWmIHnuJGhGVCClZXzsd{whTUN3ME2wMlI2|ryPLh?= NYjtdYJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyPzhpPkK3NVI5OTd6PD;hQi=>
vero NHzMdGtCdnSrdnnyZYwh[XO|YYm= M2LFU2lvKH[rdILvJIFvfGm4aYLhcEBidmRiYX70bYNmdGy3bHHyJIFkfGm4aYT5JJdieyCndnHseYF1\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB3cXK3czDIV3YuOSBqRjDzeJJicW5rIHnuJJZmem9iY3XscJMhfGm|c4XlJIN2dHS3cnWsJGlFPTB;MD6z{txONg>? NHHrNmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOlE2Lz5{OUmzOlE2RC:jPh?=
HELF MoX3RY51cX[rcnHsJIF{e2G7 NH:xW3U4KGSjeYO= NIjzfZJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyB{IFegbY5n\WO2ZXSgbY4hcHWvYX6gTGVNTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCrbnP1ZoF1\WRiZn;yJFch\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0xNjQQvF2u NUnhc2luRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HS27 MUjBcpRqfmm{YXygZZN{[Xl? NEjGU5E4KGSjeYO= M4rLdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKU{K3JINmdGy|IHHmeIVzKDdiZHH5d{BjgSCJRmCtZoF{\WRiZnz1c5Jme2OnboSgdoVlfWO2aX;uJIF{e2G7LDDFR|UxRTBwM{NOwG0v NXniV4ZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOFc6OTFpPkKwNFQ4QTFzPD;hQi=>
HEL MkHtRY51cX[rcnHsJIF{e2G7 M4nQVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36sJGVEPTB;MD6zPO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
HEL MYDBcpRqfmm{YXygZZN{[Xl? M3j0RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyByNz:xJIlv\mWldHXkJIlvKEiHTDDj[YxteyxiRVO1NF0xNjUQvF2u MlrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixO|goRjJ5MUK4NVc5RC:jPh?=
HEL NUXHZ|NuSW62aY\pdoFtKGG|c3H5 MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{AzKEdiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzMEBGSzVyPUCuOO69VS5? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HEL NGfKcWVCdnSrdnnyZYwh[XO|YYm= M1zDfmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlvKEiHTDDj[YxteyxiRVO1NF0xNjR6zszNMi=> NGf3b2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3Oid-MUexPFEyPjJ:L3G+
HFF NWLL[HFqTnWwY4Tpc44h[XO|YYm= M4LCbGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCleYTvdIF1cGmlIHXm[oVkfCCob4KgRWQyPjlic4TyZYlvKG:oIHXwd5RmcW5iYnHydkB3cXK3cz2yJEhJS02YKTDpckBpfW2jbjDISmYh[2WubIOsJGVEPTB;MD61{txONg>? NHOwT4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96M{m0PVM{Lz56M{m0PVM{RC:jPh?=
HEL NUDuSo1bTnWwY4Tpc44h[XO|YYm= NGTvVZVKdmirYnn0bY9vKG:oIHj1cYFvKEOPVjDEUmEhe3mwdHjld4l{KGmwIFPNWk1qdm[nY4Tl[EBJTUxiY3XscJMtKEmFNUC9NE42|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PzV{MkC1K|44PzV{MkC1QE9iRg>?
HEL NH35SY9CdnSrdnnyZYwh[XO|YYm= MnG5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZT3k[YZq[2mnboSgZYN6[2yxdnnyMZJme2m|dHHueEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;MD61{txONg>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
HELF NVPXWGs6SW62aY\pdoFtKGG|c3H5 NEDBXoVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlMYRm\mmlaXXueEBi[3mlbH;2bZIuemW|aYP0ZY51KEi3bXHuJIhmenCnc4\pdpV{KDFiS1;TJJN1emGrbjDpcoZm[3SnZDDpckBJTUyIIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD1yLkZOwG0v NWnIVnZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg1QDFpPkOwNFk5PDhzPD;hQi=>
Vero MXHBcpRqfmm{YXygZZN{[Xl? NVXWT2VROzZiaILz MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YhOiCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBxdGGzdXWg[o9zdWG2aX;uJIlv[3WkYYTl[EBnd3JiM{[gbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKGKjc3XkJIF{e2G7LDDFR|UxRTBwNUlOwG0v NVWxbVVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
HEL MWjBcpRqfmm{YXygZZN{[Xl? NHjZZZQ2KGSjeYO= M{PzOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZiemmlZXzsZUB7d3O2ZYKgeolzfXNiT1vBJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC1JIRigXNuIFXDOVA:OC53Od88UU4> NF\mPVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HEL NGX3R2ZCdnSrdnnyZYwh[XO|YYm= M2PUTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLk[2{txONg>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{NkG0NEc,OTl{Mk[xOFA9N2F-
HEL MWDBcpRqfmm{YXygZZN{[Xl? M3PlPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UAyKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLk[5{txONg>? MlfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HEL Mo\JRY51cX[rcnHsJIF{e2G7 MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC55zszNMi=> MkHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
Vero MXrBcpRqfmm{YXygZZN{[Xl? MVGzOkB1dyB2ODDodpM> NHfKWXpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIF[gbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BxdGGzdXWgdoVlfWO2aX;uJIFnfGW{IEO2JJRwKDR6IHjyd{whTUN3ME2wMlfPxE1w MmPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOlEoRjF5NEO4NFYyRC:jPh?=
HFF M3T0UGFvfGm4aYLhcEBie3OjeR?= NVf3Xmg1QCC2bzCxNEBl[Xm| M{HJbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVFK0NEBqdm[nY4Tl[EBqdiCqdX3hckBJTkZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJBt[XG3ZTDmc5Ju[XSrb36geJJm[XSnZDD3bZRpKGOxbYDveY5lKG[xbHzve4lv\yC4aYLhcEBqdm[nY4Tpc44h[W6mIHnuZ5Vj[XSnZDDmc5IhQCC2bzCxNEBl[Xm|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHLhd4VlKGG|c3H5MEBGSzVyPUCuO|LPxE1w M2DSOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MUmxOFU3Lz5|MkG5NVQ2PjxxYU6=
fibroblast cells NYHXd5pFSW62aY\pdoFtKGG|c3H5 MYqxJIhwfXJ? MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSWRzNkmgLHdVMSCybHHxeYUh\m:{bXnu[{B2dmm2IHfyc5dvKG:wIFj1cYFvKG[xcnXzb4lvKG[rYoLvZoxie3RiY3XscJMhfXCxbjDpcoN2[mG2aX;uJIZweiBzIHjveZIh[XRiM{eg[IVoemWnczDDJJdqfGhiY3;tdI92dmRiZHnzd49tfmWmIHnuJGROW09uIFnDOVA:OC56zszNMi=> Ml3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzM{S5OFYoRjF4MUO0PVQ3RC:jPh?=
fibroblast cells NGOwendCdnSrdnnyZYwh[XO|YYm= M364Z|EhcG:3ch?= M12wVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDZEG2PUApXjh{M1GpJJBt[XG3ZTDmc5JucW6pIIXubZQh\3Kxd36gc44hUHWvYX6g[o9z\XOtaX6g[oljem:kbHHzeEBk\WyuczD1dI9vKGmwY4XiZZRqd25iZn;yJFEhcG:3cjDheEA{PyCmZXfy[YV{KENid3n0bEBkd22yb4Xu[EBlcXO|b3z2[YQhcW5iRF3TU{whUUN3ME2wMljPxE1w MlThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzM{S5OFYoRjF4MUO0PVQ3RC:jPh?=
E6SM MXzBcpRqfmm{YXygZZN{[Xl? M2i0dmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiVFutJGtQWyCDQ2[tbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDpckBGPlOPIHPlcIx{NCCPSVO9NE45|ryPLh?= M{\CbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEmyO|I5Lz5zN{C5NlczQDxxYU6=
HEL NYOx[nZzSW62aY\pdoFtKGG|c3H5 MWS0JIRigXN? M1[xc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhXEtvZHXmbYNq\W62IFjldpBmeyC|aX3wcIV5KH[rcoXzMVEhU0:VIHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVAvQM7:TT6= NHHCTYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[5Olk3Oyd-MkG2PVY6PjN:L3G+
HEL MX7BcpRqfmm{YXygZZN{[Xl? M{DDUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTBwON88UU4> MlvkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
HEL MnzURY51cX[rcnHsJIF{e2G7 M4LYeGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY3njcI93cXJicnXzbZN1[W62IHjldpBmeyC|aX3wcIV5KH[rcoXzJFEhU0:VIHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMljPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|OE[1N{c,OzB5M{i2OVM9N2F-
HELF NG\KRodCdnSrdnnyZYwh[XO|YYm= MUS3JIRigXN? MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKFSNLVvPV{1CS1ZiaX7m[YN1\WRiaX6gbJVu[W5iSFXMSkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{whTUN3ME2wMljPxE1w M{XnTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi2PFMzLz5|MUW4Olg{OjxxYU6=
HEL MnvzRY51cX[rcnHsJIF{e2G7 MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{0zKEdiaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUCuPe69VS5? NE[3VYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxNVg2Pid-MkO5NVE5PTZ:L3G+
CRFK Mmn0RY51cX[rcnHsJIF{e2G7 MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDG[YxqdmViSHXydIV{KH[rcoXzJIlv\mWldHXkJIlvKGOjdDDDVmZMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDNWHMh[XO|YYmsJGVEPTB;MD65{txONg>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzlzMUi1Okc,OjN7MUG4OVY9N2F-
Vero MUXBcpRqfmm{YXygZZN{[Xl? MU[zJIRigXN? NYHRPFNnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDzeJJicW5iRjDWVk04OzNiaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVAvQc7:TT6= MmnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkC4PFMoRjJ4NE[wPFg{RC:jPh?=
MRC5 NHPmboFCdnSrdnnyZYwh[XO|YYm= NUDndIhjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDpckBOWkN3IHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9NE46Oc7:TT6= Mn3ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVQoRjF5MkO5OVk1RC:jPh?=
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HFF M4OwTGFvfGm4aYLhcEBie3OjeR?= NIfqeYg2KGSjeYO= MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwZnXjeIVlKEiIRjDj[YxteyCjZoTldkA2KGSjeYOgZpkh\G:2IHLsc5Qh[XO|YYmsJGlEPTB;Md88UU4> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN{OUGwN{c,OTd|MkmxNFM9N2F-
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HFF M4T3cWFvfGm4aYLhcEBie3OjeR?= NYXBclVXSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfG:5bnWgd5Rz[WmwIFjDUXYhf2G|IHTleIVzdWmwZXSgZpkhgWmnbHSgdoVlfWO2aX;uJIF{e2G7IHnuJIR2eGyrY3H0[UB4\WyuczD1d4lv\yCKRl[gZ4VtdHNuIFnDPVA:OS54zszNMi=> MoG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6OEKzO|AoRjFyOEiyN|cxRC:jPh?=
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HEL Mon4RY51cX[rcnHsJIF{e2G7 NEjteHo1KGSjeYO= MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgOEBl[Xm|LDDFR|UxRTFwNkZOwG0v MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3OUi3Okc,OjJ2NUm4O|Y9N2F-
HEL NWrMWXBiSW62aY\pdoFtKGG|c3H5 MoniOEBl[Xm| NFzGZWdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckBi\nSncjC0JIRigXNuIFXDOVA:OS54Nd88UU4> MnX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUm4O|YoRjJ{NEW5PFc3RC:jPh?=
HFF M2\nUmZ2dmO2aX;uJIF{e2G7 M1jkVGlvcGmkaYTpc44hd2ZiSFPNWkB1d3ewZTDy[ZBtcWOjdHnvckBqdiCKRl[gZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF0yNjkQvF2u M4nB[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC0O|I3Lz5zN{CwOFczPjxxYU6=
HFF MWjBcpRqfmm{YXygZZN{[Xl? MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gRWQyPjliaX6gTGZHKGOnbHzzJIJ6KFCUQTygTWM2OD1zLkpOwG0v NXXBZpFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
HEL M2P1W2FvfGm4aYLhcEBie3OjeR?= NF7X[m04KGSjeYO= M33MR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUNOwG0v M2HRTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF MkDtSpVv[3Srb36gZZN{[Xl? MUPJcohq[mm2aX;uJI9nKEiFTW[gWI94dmVicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{KGK7IIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZktKEWFNUC9Nk4y|ryPLh?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
HFF MkT3RY51cX[rcnHsJIF{e2G7 NXm0cIluQCCmYYnz MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgPEBl[Xm|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Oi5zzszNMi=> NHTLbmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[wO|g5Oyd-MkK2NFc5QDN:L3G+
HEL M4XIOGFvfGm4aYLhcEBie3OjeR?= MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1{LkJOwG0v M{nIcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y5Lz5{N{[zPVM3QDxxYU6=
HFF NWHp[3hKSW62aY\pdoFtKGG|c3H5 NGeze5Q5KHSxIEGwJIRigXN? MVnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKFSxd37lJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gdIxieXWnIH\vdo1ifGmxbjD0doVifGWmIIfpeIgh[2:vcH;1coQh\m:ubH;3bY5oKH[rcnHsJIlv\mWldHnvckBidmRiaX7jeYJifGWmIH\vdkA5KHSxIEGwJIRigXNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYnHz[YQh[XO|YYmsJGVEPTB;Mj6x{txONg>? NH\oNXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkG5NVQ2Pid-M{KxPVE1PTZ:L3G+
Vero MojHRY51cX[rcnHsJIF{e2G7 MYSzJIRigXN? MnjjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJHZTNThyNzDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oi5zNN88UU4> M4TlblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[wPFg{Lz5{NkS2NFg5OzxxYU6=
HFF NHztW3BHfW6ldHnvckBie3OjeR?= M1L3WmlvcGmkaYTpc44hd2ZiSFPNWkBCTDF4OTDy[ZBtcWOjdHnvckBqdiCKRl[gZ4VtdHNiYomgR3BGKGmwaHnibZRqd25iYYPzZZktKEWFNUC9Nk4z|ryPLh?= NIfpXGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[xOVU1PSd-MUW2NVU2PDV:L3G+
HEL M{O2WmFvfGm4aYLhcEBie3OjeR?= MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVIvOjoQvF2u M3TTOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEiwNlUyLz5{OUi4NFI2OTxxYU6=
HEL NIjXVmxCdnSrdnnyZYwh[XO|YYm= MYq1JIRigXN? MkK1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWGssKF[cVjDZV{BqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNTDkZZl{NCCHQ{WwQVIvO87:TT6= NWDLcFZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NlIyOjhpPkG3OlIzOTJ6PD;hQi=>
HELF MVrBcpRqfmm{YXygZZN{[Xl? MniwO{Bl[Xm| M1nkU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDEZZZqeyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVzGJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIlv[3WkYYTl[EBnd3JiNzDkZZl{KGK7IFfp[Y1{[SC|dHHpcolv\yCkYYPl[EBucWO{b4Pjc5Bq[yCjbnHsfZNqeyxiRVO1NF0zNjQQvF2u NUPTWmpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFY5OzJpPkOxOVg3QDN{PD;hQi=>
HEL299 MVfBcpRqfmm{YXygZZN{[Xl? NXvRPJN5PyCmYYnz NHnPU45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gTGVNOjl7IHPlcIx{KGGodHXyJFch\GG7czDifUBITlBvYnHz[YQh\my3b4Lld4NmdnRicnXkeYN1cW:wIHHzd4F6NCCHQ{WwQVIvOzoQvF2u MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB2N{mxNUc,OjByNEe5NVE9N2F-
HFF MlnlSpVv[3Srb36gZZN{[Xl? NFzL[3ZKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJGM1KHO2cnHpckApXUx3NjCrJHVNQDlibYX0ZY51KGenbnWpJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2yMlXPxE1w NXfrT3M1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPzZpPkG1OVA6OTd4PD;hQi=>
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HEL MnLNRY51cX[rcnHsJIF{e2G7 MYG3JIRigXN? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhTGG4aYOgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2yMlXPxE1w Moi4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|M{mwPFIoRjF7M{O5NFgzRC:jPh?=
HEL M4r1bWFvfGm4aYLhcEBie3OjeR?= NWnwbWlPPSCmYYnz MonuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeIh6dWmmaX7lJItqdmG|ZTDk[YZq[2mnboSgWoFzcWOnbHzhJJpwe3SncjD2bZJ2eyByNz:xJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC1JIRigXNuIFXDOVA:Oi53zszNMi=> NHX6PYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOzPVA5Oid-MUmzN|kxQDJ:L3G+
HFF NXn4bHpmTnWwY4Tpc44h[XO|YYm= MYrJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBkgXSxbXXnZYxwfmm{dYOgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IIfhd{Bl\XSncn3pcoVlKGK7IHP5eI9x[XSqaXOg[YZn\WO2IHnubIljcXSrb36gZZN{[XluIFnDOVA:Oi54zszNMi=> NVLaR3hTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUSzPFAyPyd-OUSzPFAyPzxxYU6=
HEL NFfuVJVCdnSrdnnyZYwh[XO|YYm= NG\sV2hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBnd3OlYYLu[ZQuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhSyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Mj62{txONg>? M4LWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF NVj5[IVqSW62aY\pdoFtKGG|c3H5 MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPDF5IIfpeIgheG:uIFG4NFlXKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTJwNt88UU4> NYHYVFM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFk1PjhpPkG3O|A6PDZ6PD;hQi=>
HEL M2H5T2FvfGm4aYLhcEBie3OjeR?= MVS3JIRigXN? NWHMTlhWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS02YIFTheol{KGmwIHj1cYFvKEiHTDDj[YxteyCjZoTldkA4KGSjeYOsJGVEPTB;Mj62{txONg>? NHzvdIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
CRFK NGLjfnNCdnSrdnnyZYwh[XO|YYm= MlToRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcW6nIHjldpBme3[rcoXzJIlv\mWldHXkJIlvKGOjdDDDVmZMKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iZoLvcUB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlbPxE1w NGK4TJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECzOFcyOSd-MkCwN|Q4OTF:L3G+
HFF MVvBcpRqfmm{YXygZZN{[Xl? M2j2WWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ3NEKge4l1cCCyb3ygWFgyO1NibYX0ZY51KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mj63{txONg>? NEK0fXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewPVQ3QCd-MUe3NFk1Pjh:L3G+
HEL MXHBcpRqfmm{YXygZZN{[Xl? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1{Lke1{txONg>? M1r6OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUG4OFU6Lz5zN{WxPFQ2QTxxYU6=
HEL NGi4XpNCdnSrdnnyZYwh[XO|YYm= NVnmbppESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9Nk46Ps7:TT6= M13rTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{W3NVAzLz5{OEe1O|ExOjxxYU6=
BSC-1 MkTQRY51cX[rcnHsJIF{e2G7 MkPzRY51cX[rcnHsJIFkfGm4aYT5JI9nKHSqZTDjc41xd3WwZDD3ZZMh\X[jbIXheIVlKGGpYXnud5QhfGinIFjldpBmeyC|aX3wcIV5KH[rcoXzJJR6eGVvMTDpckBDW0NvMTDj[YxteyxiSVO1NF0{|ryPLh?= M4HabFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOzNFAoRjJ7MUOzNFA9N2F-
MRC5 MVvGeY5kfGmxbjDhd5NigQ>? NWTxN29JUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgRWQyPjlic4TyZYlvKG:oIFjDUXYhcW5iTWLDOUBk\WyuczygTWM2OD1|zszNMi=> Mn3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2NUS0OlUoRjFzNEW0OFY2RC:jPh?=
HFF NIfWbHpCdnSrdnnyZYwh[XO|YYm= M3PsPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiVH;3coUhcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:O87:TT6= NXzTTng6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOlE6PDZpPkG3NVYyQTR4PD;hQi=>
hhTERT-BJ1 M3j5emFvfGm4aYLhcEBie3OjeR?= NFizV2UzKGSjeYO= M{PI[2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCWb4fu[UBqdm[nY4Tl[EBqdiCqdX3hckBpcFSHUmStRmoyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNibXXkbYF1\WRiRF7BJJN6dnSqZYPpd{Bi\nSncjCyJIRigXNuIFXDOVA:O87:TT6= Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NUixNlQoRjF6NEW4NVI1RC:jPh?=
HEL M4f2OWFvfGm4aYLhcEBie3OjeR?= NFzEcW44KGSjeYO= M2mze2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFkgWOub4\pdk1z\XOrc4ThcpQhfGi7bXnkbY5mKGurbnHz[UBl\W[rY3nlcpQhUFOYMTDLU3MhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDdiZHH5d{whTUN3ME2z{txONg>? NX\qbWhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlg3PjZpPkKxNVI5PjZ4PD;hQi=>
HFF NUfrWlU5SW62aY\pdoFtKGG|c3H5 MWKxNEBl[Xm| NFzOdmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiVH;3coUhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGGodHXyJFExKGSjeYOsJGlEPTB;M988UU4> MkPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NEGyNVgoRjJzNkSxNlE5RC:jPh?=
HEL NELVSHZCdnSrdnnyZYwh[XO|YYm= M{DrUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDBSE0yPjliaX7m[YN1\WRiaX6gbJVu[W5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUOuNe69VS5? NUj1fGhRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVE5PTZpPkKzPVEyQDV4PD;hQi=>
HEL NHjadJVCdnSrdnnyZYwh[XO|YYm= MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdIxieXWnIH\vdo1ifGmxbjygSWM2OD1|LkJOwG0v MnPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlgoRjJ5NkO5N|Y5RC:jPh?=
HELF MVPBcpRqfmm{YXygZZN{[Xl? MVm3JIRigXN? MnLVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgbY5kfWKjdHXkJIZweiB5IHThfZMh[nliR3nlcZNiKHO2YXnubY5oKGKjc3XkJI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVMvOTYQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NkizNkc,OzF3OE[4N|I9N2F-
HFF NFS5fllCdnSrdnnyZYwh[XO|YYm= MkjERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIue2Wwc3n0bZZmKEiFTW[xJIl{d2yjdHWgdoVxdGmlYYTpc44hcW5iSF\GJINmdGy|IHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Oy5{Mt88UU4> M2jIeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEGwOlg1Lz5zOUCxNFY5PDxxYU6=
HFF MXnGeY5kfGmxbjDhd5NigQ>? NY[yVmhvS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\C22eYDlJGFFOTZ7IIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEQTB;Mz6z{txONg>? NIDsUnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PCd-MUC4PFI{PzR:L3G+
HEL NHH2fpNCdnSrdnnyZYwh[XO|YYm= MkHKOkB1dyB5IHThfZM> NIfZN|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2LXnu[oVkfGmxbjygSWM2OD1|LkOx{txONg>? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
MEF NVzl[ll3TnWwY4Tpc44h[XO|YYm= NGfMVGlKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDteZJqdmViY4n0c41m\2Gub4\pdpV{KHKncHzpZ4F1cW:wIHnuJG1GTiClZXzsd{B4[XNiZHX0[ZJucW6nZDDifUBxdGGzdXWgdoVlfWO2aX;uJIF{e2G7LDDJR|UxRTNwNN88UU4> Ml;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR|OECxO{c,QTR|OECxO|ww[T5?
BSC-1 NFq5RYtCdnSrdnnyZYwh[XO|YYm= NVvyNW1qSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYLUGgLIhmenCnczDzbY1xdGW6II\pdpV{MSxiZHX0[ZJucW6nZDDifUBGVEmVQTDpckByfWGmcoXwcIlk[XSnIIflcIx{KHW|aX7nJGJUSy1zIHPlcIx{NCCLQ{WwQVMvPc7:TT6= NEH3[m09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4OCd-MUC4PFI{PzB:L3G+
BSC-1 NF:3ZVBHfW6ldHnvckBie3OjeR?= NHXObJNGVEmVQTDhd5NigSC5YYOgdIVz\m:{bXXkJJV{cW6pIFLTR{0yKGOnbHzzJJRwKGSndHXycYlv\SCjY4Tpeol1gSCjZ3HpcpN1KEiVVj2xMEBKSzVyPUOuOe69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3Nkc,OTB6OEKzO|I9N2F-
BSC-1 M4HSWGFvfGm4aYLhcEBie3OjeR?= Mlu5TY4hfmm2cn:gZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFidnnyeZMhcW5iQmPDMVEhMG2xbnvlfUBscWSwZYmpJINmdGy|LDDJR|UxRTNwNd88UU4> NVn3NVdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3PSd-OUC1O|g3PTxxYU6=
HEL M17N[GFvfGm4aYLhcEBie3OjeR?= NXf6cFhoSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhWE2HRFHQMZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJFQhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTNwNd88UU4> M{nBNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HFF NEnveXpCdnSrdnnyZYwh[XO|YYm= MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPDJyIIfpeIgheG:uIFe4OFFCKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTNwNd88UU4> M{TXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
BSC-1 NFfzRmZHfW6ldHnvckBie3OjeR?= MXjJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRiYXfhbY5{fCCqZYLw[ZMhe2mvcHzlfEB3cXK3czD0fZBmNTFiKFjTWk0yMSCneIDy[ZN{\WRiaX6gRnNENTFiY3XscJMhf2G|IHTleIVzdWmwZXSgZpkhTUyLU1GgZZN{[XluIFnDOVA:Oy53zszNMi=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OEc,OTV3MEmxO|Q9N2F-
BSC-1 MkjvSpVv[3Srb36gZZN{[Xl? NGjFO41KdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgLGhUXi1zKTDlfJBz\XO|ZXSgbY4hSlOFLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nliRVzJV2Eh[XO|YYmsJGlEPTB;Mz61{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG3OUc,OTV3MEmxO|U9N2F-
BSC-1 NVHCT4o6TnWwY4Tpc44h[XO|YYm= M{D1O2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDDh[4FqdnO2IHjldpBmeyC|aX3wcIV5KH[rcoXzJJR6eGVvMTCoTHNXNTFrIHX4dJJme3OnZDDpckBDW0NvMTDj[YxteyC5YYOg[IV1\XKvaX7l[EBjgSCHTFnTRUBie3OjeTygTWM2OD1|LkZOwG0v NGTtdYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE4Pid-MUW1NFkyPzZ:L3G+
HFF NGP3[pdHfW6ldHnvckBie3OjeR?= NGP6dFdEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCyPVE3KEGGMU[5JJN1emGrbjDv[kBJS02YIHnuJJlq\WymIILl[JVkfGmxbjDhd5NigSC3c3nu[{BJTkZiY3XscJMtKEmFOUC9N{43|ryPLh?= NWnWRlF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HEL NFrEbpBCdnSrdnnyZYwh[XO|YYm= MkTSO{Bl[Xm| NG\3dGJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2zMlbPxE1w MlLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Mk[xOFAoRjF7MkK2NVQxRC:jPh?=
HFF M{j3VGFvfGm4aYLhcEBie3OjeR?= MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzOjV6IIfpeIghXUx7NzDDOVkzTyCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1|LkpOwG0v MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL NF3mOWpCdnSrdnnyZYwh[XO|YYm= M3j2T|IhfG9iMzDkZZl{ M37nemFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wt[IVncWOrZX70JGFEXi2{ZYPpd5RidnRiSHXydIV{KHOrbYDs[Zghfmm{dYOgNUBMV1NiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdIxieXWnIH\vdo1ifGmxbjDt[YF{fXKnZDDh[pRmeiB{IITvJFMh\GG7czDwc5N1KGmwZnXjeIlwdixiRVO1NF0{NjlzzszNMi=> NVq2W3N5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC-5 MXPBcpRqcGW{cHXzeolzfXNiYYPzZZk> MVXJckB3cXS{bzDhcpRqcGW{cHXzeolzfXNiYXP0bZZqfHliYXfhbY5{fCCPUlOtOUBk\WyuczDpcoZm[3SnZDD3bZRpKEiFTW[gLGFFNTF4OTDzeJJicW5rLDDJR|UxRTUQvF2u NHnvU3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{KzOlc5Lz5zM{KzOlc5RC:jPh?=
HEL NFLBUnlCdnSrdnnyZYwh[XO|YYm= MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDjbYRw\m:4aYKgTGNOXiCDREG2PUBkdG:wZTC1JIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME20{txONg>? M4jsO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkK2NVQxLz5zOUKyOlE1ODxxYU6=
HEL NFjje3NCdnSrdnnyZYwh[XO|YYm= NETsOoJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB1cHmvaXTpcoUhc2mwYYPlJIRm\mmlaXXueEBidmRiYXP5Z4xwfmm{LYLld4l{fGGwdDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTUQvF2u NUD2UmxJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPVkxQTdpPkKzNFk6ODl5PD;hQi=>
HEL NEX5bFFCdnSrdnnyZYwh[XO|YYm= M1TiUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHRMNW6nZ3H0bZZmKEincoDld{B{cW2ybHX4JJZqenW|IEGgT29UKGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> M3LFOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGxNFk{Lz5{M{ixNVA6OzxxYU6=
HEL NF\rc2ZCdnSrdnnyZYwh[XO|YYm= MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD0bJlucWSrbnWgb4lv[XOnLXTl[olkcWWwdDDhZ5lkdG:4aYKtdoV{cXO2YX70JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD12zszNMi=> M2TSRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVU1Lz5{N{e1NFE2PDxxYU6=
HEL M2\OT2FvfGm4aYLhcEBie3OjeR?= NF3VN3dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME20MlA2|ryPLh?= NITkVlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k6OCd-Mkm0NFc6QTB:L3G+
HFF M3\UWGZ2dmO2aX;uJIF{e2G7 Mn7qR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3RiQz20JHRwf26nIIP0doFqdiCxZjDIR21XKGmwIInp[YxlKHKnZIXjeIlwdiCjc4PhfUB2e2mwZzDISmYh[2WubIOsJGlEPTB;ND6x{txONg>? NF7aOXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4PCd-MUC4PFI{PzR:L3G+
HFF MV\BcpRqfmm{YXygZZN{[Xl? MlniRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjlzIHnuJGhHTiClZXzsd{BjgSCSUlGsJGlEPTB;ND6x{txONg>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
CRFK NF7XNGhCdnSrdnnyZYwh[XO|YYm= NYnoOGNRPCCmYYnz MmjJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSoVtcW6nIHjldpBme3[rcoXzJIlv\mWldHXkJIlvKGOjdDDDVmZMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA1KGSjeYOgZpkh[2:ub4LpcYV1emmlIH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NF01NjIQvF2u M4DSb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEW5PFc3Lz5{MkS1PVg4PjxxYU6=
CRFK Mo\iRY51cX[rcnHsJIF{e2G7 M2TmTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZmdGmwZTDo[ZJx\XO4aYL1d{Bqdm[nY4Tl[EBqdiClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCkeTDNWHMh[XO|YYmsJGVEPTB;ND6x{txONg>? MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
HEL M{W0VGFvfGm4aYLhcEBie3OjeR?= NFexTVhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBo[W6laXPsc5Zqei2{ZYPpd5RidnRiSFPNWkBCTDF4OTDjcI9v\SB2IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME20MlPPxE1w NGHqWVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyOlE1OCd-MUmyNlYyPDB:L3G+
HEL MWHBcpRqfmm{YXygZZN{[Xl? MmKxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWNXNXKnc3nzeIFvfCC2aIntbYRqdmVia3nuZZNmKGSnZnnjbYVvfCCKZYLw[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUSuN:69VS5? NEXTUm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HFF MVTGeY5kfGmxbjDhd5NigQ>? MoC3R49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3Rid3ns[E11gXCnIGTve45mKHO2cnHpckBw\iCKQ13WJIlvKHmrZXzkJJJm\HWldHnvckBie3OjeTD1d4lv\yCKRl[gZ4VtdHNuIFnDOVA:PC53zszNMi=> NXP1OmlERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzRpPkGwPFgzOzd2PD;hQi=>
HEL NHexd2VCdnSrdnnyZYwh[XO|YYm= NIjkOG04KGSjeYO= NWK4d456SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGW6cILld5Nm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDsZZF2\SCob4LtZZRqd25iaX7jeYJifGWmIH\vdkA4KGSjeYOgZpkhT2mnbYPhJJN1[WmwIHLhd4VlKG2rY4Lvd4NweHluIFXDOVA:PC55Mt88UU4> MlTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUGwN|goRjJ4MkmxNFM5RC:jPh?=
HEL Mkm1RY51cX[rcnHsJIF{e2G7 NWLI[3JoPyCmYYnz M2PSSWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTRwON88UU4> MljDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3M{m2NlIoRjF5NUO5OlIzRC:jPh?=
HEL NVjXV|FoSW62aY\pdoFtKGG|c3H5 MW[zJIRigXN? M1fTPGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF01NjkQvF2u MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4MUi1NUc,OTd7NkG4OVE9N2F-
HEL NFTxWIlCdnSrdnnyZYwh[XO|YYm= NH7oU2I3KHSxIEeg[IF6ew>? NYLofIRmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPiC2bzC3JIRigXNicH;zeEBqdm[nY4Tpc44tKEWFNUC9OE45O87:TT6= NVn2Rpc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVA4OzRpPkK5OVUxPzN2PD;hQi=>
MRC5 M3K5N2FvfGm4aYLhcEBie3OjeR?= NH3hcZJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXG:5bnWgbY4hVVKFNTDj[YxteyCkeTDQVmEtKEmFNUC9OE46|ryPLh?= NVGwcYFZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
MRC5 MWrBcpRqfmm{YXygZZN{[Xl? M2Dpe2lvKH[rdILvJIFvfGm4aYLhcEBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYXfhbY5{fCCKQ13WLGFFNTF4OTmgbY4hVVKFNTDj[YxteyxiSVS1NF02|ryPLh?= NWnYZ3dxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVgyOSd-M{CwPVgyOTxxYU6=
H-1 NHywflFHfW6ldHnvckBie3OjeR?= MknXSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDFdJN1\WmwLXLhdpIhfmm{dYOgdoVxdGmlYYTpc44hcW5iSD2xJINmdGy|IHnuJGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u NWGxT3lyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2N|QxODNpPkG1OlM1ODB|PD;hQi=>
H1 M2DXTWZ2dmO2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKEWEVjDy[ZBtcWOjdHnvckBqdiCKMTDj[YxteyCkeTDEUmEhcHmkcnnkbZpifGmxbjDhd5NigSxiRVO1NF02|ryPLh?= MlXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
H1 NInPRVNHfW6ldHnvckBie3OjeR?= M1fkT2lvcGmkaYTpc44hd2ZiRVLWJJJmeGyrY3H0bY9vKGmwIFixJINmdGy|IHL5JGRPSSCqeXLybYRqgmG2aX;uJIF{e2G7LDDFR|UxRTYQvF2u NW\l[Jd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2NVU2PDVpPkG1OlE2PTR3PD;hQi=>
CEM NXPIfXNRS3m2b4TvfIlkcXS7IHHzd4F6 M2fEUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEOHTTDj[YxteyxiQ1O1NF02|ryPLh?= MkTGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1OFUoRjF3NkG1OVQ2RC:jPh?=
HFF MnPSRY51cX[rcnHsJIF{e2G7 Mn;lOUB1dyB5IHThfZM> MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKGmwZnXjeIVlKEiIRjDj[YxteyCjZoTldkA2KHSxIEeg[IF6eyCkeTD2bZJidCC7aXXs[EBie3OjeTygSWM6QS57PUZOwG0v NX;pSnlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezNlkyODNpPkG3N|I6OTB|PD;hQi=>
HEL M{XWb2FvfGm4aYLhcEBie3OjeR?= M2nETFch\GG7cx?= MmfNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzJJBt[XG3ZTDmc5Ju[XSrb36gZYZ1\XJiNzDkZZl{NCCHQ{WwQVUvOc7:TT6= NUn2ZXVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NlIyOjhpPkG3OlIzOTJ6PD;hQi=>
HEL MnLnRY51cX[rcnHsJIF{e2G7 MUi3JIRigXN? MXjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKEGGMU[5M2Rifmm|IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjC3JIRigXNuIFXDOVA:PS5{zszNMi=> NI\tRVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyPFY3Pid-MkGxNlg3PjZ:L3G+
AKATA NIDVPFNCdnSrdnnyZYwh[XO|YYm= NXjQZmp1PDhiaILz NXvuOFRDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTUKYIHnu[oVkfGWmIHnuJIh2dWGwIFHLRXRCKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDJ[2cucW6mdXPl[EBtgXSrYzD2bZJ2eyC{ZYDsbYNifGmxbjDt[YF{fXKnZDDheEA1QCCqcoOgdI9{fC2ueYTpZ{BqdmS3Y4Tpc44h[nlicWLUMXBEWiCjbnHsfZNqeyxiRVO1NF02NjMQvF2u NX3uSVVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KxPVE1PTZpPkOyNVkyPDV4PD;hQi=>
MRC5 NF34OnlCdnSrdnnyZYwh[XO|YYm= M13sWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVOjJ7NjDpckBOWkN3IHPlcIx{KGK7IGDSRUwhUUN3ME21MlTPxE1w M4j5OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
fibroblast cells MWrBcpRqfmm{YXygZZN{[Xl? M1qyXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNiaX7m[YN1\WRiaX6gcY92e2ViZX3idplwdmmlIH\pZpJw[myjc4SgZ4VtdHNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjYQvF2u M4PrXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3NlcyLz5zOUO5O|I4OTxxYU6=
HFF MUXBcpRqfmm{YXygZZN{[Xl? MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzQTNiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:PS54zszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB2M{GyPEc,OTdyNEOxNlg9N2F-
HEL NWDLbnpTSW62aY\pdoFtKGG|c3H5 NWmzclFzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9OU43O87:TT6= M{Hqb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVkxLz5{OUSwO|k6ODxxYU6=
NIH 3T3 NX;ES5lJSW62aY\pdoFtKGG|c3H5 NG\CS|g1KHSxIEWg[IF6ew>? M{XifmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDjfZRwdWWpYXzveolzfXNic4TyZYlvKFOvaYToJIlv\mWldHXkJIlvKG2xdYPlJG5KUCB|VEOgZ4VtdHNiYX\0[ZIhPCC2bzC1JIRigXNiYomgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiRVO1NF02NjgQvF2u NH36NWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES1PFEzPCd-MUi0OVgyOjR:L3G+
RG2TK+ NUfFPWdsS3m2b4TvfIlkcXS7IHHzd4F6 MX63NkBpenN? MmO1R5l1d3SxeHnjbZR6KGGpYXnud5QhUFOYMT30b{Bo\W6nIH;2[ZJmgHC{ZYPzbY5oKFKJMmTLL{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTVwOEdOwG0v NFrEVGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiwNFc3PCd-MUi4NFA4PjR:L3G+
MRC-5 M4LB[2Z2dmO2aX;uJIF{e2G7 NInOcXpEd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD2bZJidCCybHHxeYUh\m:{bXH0bY9vKGK7IFj1cYFvKEO7dH;t[YdidG:4aYL1d{ApUEOPVjmgLJN1emGrbjDBSE0yPjlrIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVUvQc7:TT6= NYC4bI1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC5OlY4PDBpPkGwPVY3PzRyPD;hQi=>
HEL MXLBcpRqfmm{YXygZZN{[Xl? NI\RcHdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;NT65{txONg>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh3OEKyNkc,OjJ6NUiyNlI9N2F-
HEL NYDs[Ho6SW62aY\pdoFtKGG|c3H5 MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBxdGGzdXWg[o9zdWG2aX;uMEBGSzVyPUWuPVjPxE1w NVribFRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQTNpPkKzPFEyODl|PD;hQi=>
HCMV AD 169 NILnTWJCdnSrdnnyZYwh[XO|YYm= MoDyTY4hfmm2cn:gZY51cX[rcnHsJIFv\CCjboTpZ4VtdHWuYYKgZYN1cX[rdImge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KGi3bXHuJIN6fG:vZXfhcI93cXK3czCoTGNOXiCDRDCxOlkqKGmwIDjIR21XKEGGIEG2PUkh[2WubIOsJGlFPTB;Nt88UU4> NUD1NmZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5N|YyPSd-Mkm5N|YyPTxxYU6=
HEL MlXiRY51cX[rcnHsJIF{e2G7 MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;Nt88UU4> M13uclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[1OVE3Lz5{MUW2OVUyPjxxYU6=
HEL MYfBcpRqfmm{YXygZZN{[Xl? M3\2fFMh\GG7cx?= MX3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDhZ5lkdG:4aYKtdoV{cXO2YX70JHRMNWSnZnnjbYVvfCCKZYDy[ZMhe2mvcHzlfEB3cXK3czCxJGtQWyCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9Ou69VS5? NFvmeYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi:FaFXNRmwoRkOqRV3CUFww[T5?
HFF NW[2eINMSW62aY\pdoFtKGG|c3H5 MX\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQ13WJHQzPzh2IIfpeIgheG:uIFG4NFlXKFWOOUegR|U6OkdiZH;1ZoxmKG23dHHueEBqdm[nY4Tl[EBqdiCKRl[gZ4VtdHNiYomgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTZwMd88UU4> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL MVXBcpRqfmm{YXygZZN{[Xl? NIrU[Is4KGSjeYO= M1XuVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHP5eI9u\WejbH;2bZJ2eyCDREG2PUBmgHC{ZYPz[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCybHHxeYUh\m:{bXH0bY9vKGmwY4XiZZRm\CCob4KgO{Bl[Xm|IHL5JGdq\W2|YTDzeIFqdiCkYYPl[EBucWO{b4Pjc5B6NCCHQ{WwQVYvOTMQvF2u NH\SV2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK5NVA{QCd-Mk[yPVExOzh:L3G+
MRC-5 NH\wN|RHfW6ldHnvckBie3OjeR?= NHmzSVdKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36g[o9zKGGwdHmtTGNOXiCjY4Tpeol1gSCjZ3HpcpN1KEGGLUG2PUB{fHKjaX6gbY4hVVKFLUWgZ4VtdHNuIFnDOVA:Pi5|zszNMi=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDN4NkGzK|46QDN4NkGzQE9iRg>?
HEL NIHHbXpCdnSrdnnyZYwh[XO|YYm= NH7CWohCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMheGyjcYXlJIZwem2jdHnvckwhTUN3ME22MlPPxE1w NGrPSXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WxPFQ2QSd-MUe1NVg1PTl:L3G+
HEL NH;y[WJCdnSrdnnyZYwh[XO|YYm= MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME22MlPPxE1w MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByMUO0OEc,OjZyMEGzOFQ9N2F-
HEL M{jpVmFvfGm4aYLhcEBie3OjeR?= MkTZOkB1dyB5IHThfZM> MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBu\WG|dYLl[EBi\nSncjC2JJRwKDdiZHH5d{Bxd3O2IHnu[oVkfGmxbjygSWM2OD14LkS2{txONg>? M2HsZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUWwO|M1Lz5{OUW1NFc{PDxxYU6=
HEL NH3NdG9CdnSrdnnyZYwh[XO|YYm= NGP0OGk4KGSjeYO= NYDxPFNnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS02YIFHENVY6KGmwIHj1cYFvKEiHTDDj[YxteyCjZoTldkA4KGSjeYOsJGVEPTB;Nj61{txONg>? NEjjNJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[3NlQ1PSd-MUe2O|I1PDV:L3G+
HEL M2[1R2FvfGm4aYLhcEBie3OjeR?= NIrtW3pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgSIF3cXNiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJ2eyCybHHxeYUh\m:{bXH0bY9vNCCHQ{WwQVYvPc7:TT6= NFvSUFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE2PCd-Mke3OVAyPTR:L3G+
HELF M4Lmb2FvfGm4aYLhcEBie3OjeR?= NHixb|VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiRHH2bZMhe3S{YXnuJIlv\mWldHXkJIlvKEiHTF[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPU[uOVLPxE1w NHfnUY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFQ5OSd-M{CwPVg1QDF:L3G+
HEL NE\5[5NCdnSrdnnyZYwh[XO|YYm= MlzERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIFo[Wmwc4SgeolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPU[uOVTPxE1w NYjKZ|dyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlU2OTZpPkKxOVY2PTF4PD;hQi=>
HFF M3rKe2FvfGm4aYLhcEBie3OjeR?= Mke4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjd7ODD3bZRpKHCxbDDUPFE{WyCXTEm3JGM2QTKJIHTveYJt\SCvdYThcpQhcW6oZXP0[YQhcW5iSF\GJINmdGy|IHL5JHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD14LkdOwG0v M3mzc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C5OFY5Lz5zN{ewPVQ3QDxxYU6=
HEL NHLjO3VCdnSrdnnyZYwh[XO|YYm= MmTQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nj63Pe69VS5? MoXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NUexNFIoRjJ6N{W3NVAzRC:jPh?=
HEL MoDOSpVv[3Srb36gZZN{[Xl? NWX5VJU6UW6qaXLpeIlwdiCjZ3HpcpN1KESQQTDv[kB2dmmwZnXjeIVlKEiHTDDj[YxteyCkeTDpcoNwenCxcnH0bY9vKG:oIGuzTH1V\FJuIFnDOVA:P87:TT6= NF3pXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95N{WyNlA2Lz55N{WyNlA2RC:jPh?=
HFF M3WwTGFvfGm4aYLhcEBie3OjeR?= NIDyV3ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXDJ{OUGgbY4hUE[IIHPlcIx{KGK7IGPFRXAh[XO|YYmsJGlEPTB;Nz6x{txONg>? NXeze5lGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOFMyOjhpPkG3NFQ{OTJ6PD;hQi=>
HEL NGf5eJJCdnSrdnnyZYwh[XO|YYm= MlXLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVcvOc7:TT6= NHzocGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW3PFc5Oyd-MkK1O|g4QDN:L3G+
HEL NUPOPYVDSW62aY\pdoFtKGG|c3H5 NYTpWFBuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGRifmm|IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjIQvF2u NIfkNI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwNVM1PCd-Mk[wNFE{PDR:L3G+
CRFK MnvmRY51cX[rcnHsJIF{e2G7 MVKzJIRigXN? NUnmcmRtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTmWuaXSgbIVzeGW|dnnyeZMhOSCrbn\lZ5Rm\CClYYSgR3JHUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA{KGSjeYOgZpkh[2:ub4LpcYV1emmlIH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NF04NjQQvF2u MnjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwS2iHTVLMK|5EcEWPQly8M4E,
HEL NHftdo5CdnSrdnnyZYwh[XO|YYm= M2XOTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHP5eI9u\WejbH;2bZJ2eyCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTdwM988UU4> M{T1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEK5PVE{Lz5{OEiyPVkyOzxxYU6=
HFF M{HiV2FvfGm4aYLhcEBie3OjeR?= M4\0ZWlvKH[rdILvJIFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiKGTve45mKHO2cnHpckkhcW5iSF\GJEhpfW2jbjDmbYJzd2KuYYP0LUBk\WyuczygTWM2OD15LkVOwG0v M3fhR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyNUe4OlUoRjlyNUe4OlU9N2F-
HFF M{DXOmZ2dmO2aX;uJIF{e2G7 NHnGcHlKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhemWybHnjZZRqd25iaX6gTGZHKGOnbHzzJJdieyCmZYTldo1qdmWmIHL5JJBt[XG3ZTDy[YR2[3Srb36gZZN{[XluIFnDOVA:Py52zszNMi=> M2HH[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl2M{iwNVcoRjl2M{iwNVc9N2F-
HFF MmnESpVv[3Srb36gZZN{[Xl? NHm1dYREd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDUc5dv\SC|dILhbY4hd2ZiSFPNWkBqdiCjIIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZkhfXOrbnegTGZHKGOnbHzzMEBKSzVyPUeuOO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh6MkO3OEc,OTB6OEKzO|Q9N2F-
HFF MXnGeY5kfGmxbjDhd5NigQ>? NWCwNm46S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KCiKQ13WLUBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v NVXHeJJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4PFI{PzVpPkGwPFgzOzd3PD;hQi=>
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HFF M4PFTmFvfGm4aYLhcEBie3OjeR?= MnrlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiC5YYOg[IV1\XKvaX7l[EBjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5JJV{cW6pIFjGSkBk\WyuczygTWM2OD15LkVOwG0v NIn1SYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi4NlM4Oid-MUC4PFI{PzJ:L3G+
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HFF Mk\6SpVv[3Srb36gZZN{[Xl? NEfXSohKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhMEiFTW[pJIV5eHKnc4Pl[EBqdiCKRl[gZ4VtdHNid3HzJIRmfGW{bXnu[YQh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME23MlTPxE1w M2jwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVc2Lz5zNUWwPVE4PTxxYU6=
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HEL M2fOTGFvfGm4aYLhcEBie3OjeR?= NFPqepdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjfZRwdWWpYXzveolzfXNiQVStNVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;Nz60{txONg>? NE\PZ2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiyPVkyOyd-Mki4Nlk6OTN:L3G+
HEL NYTZSpFMSW62aY\pdoFtKGG|c3H5 M13RelYhfG9iNzDkZZl{ NWruVGc6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QhdWWjc4Xy[YQh[W[2ZYKgOkB1dyB5IHThfZMheG:|dD3pcoZm[3Srb36sJGVEPTB;Nz60Ne69VS5? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MEewOUc,Ojl4N{C3NFU9N2F-
HEL M3LjSmFvfGm4aYLhcEBie3OjeR?= NWTHV3JDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTdwNd88UU4> NFjEd3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW3PFc5Oyd-MkK1O|g4QDN:L3G+
HFF MWTBcpRqfmm{YXygZZN{[Xl? MV3BcpRqfmm{YXygZYN1cX[rdImge4F{KGSndHXycYlv\WRiYomgeIhmKEiFTW[gdIxieXWnIHHzd4F6KHW|aX7nJGhHTiClZXzsd{whUUN3ME23MlfPxE1w NWqybHBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUC1O|g3Pid-OUC1O|g3PjxxYU6=
HEL NXq3UIg4SW62aY\pdoFtKGG|c3H5 MlGwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD15LklOwG0v NVvCcFBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFM2PTBpPkK2OFQ{PTVyPD;hQi=>
HEL NWq2WZdiSW62aY\pdoFtKGG|c3H5 NFHmXHFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgRWQuOTZ7IHnu[oVkfGWmIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZicHzhdZVmKG[xcn3heIlwdixiRVO1NF04Njh5zszNMi=> Ml;mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUGwPVMoRjJ|OEGxNFk{RC:jPh?=
CRFK NVK4[VF{SW62aY\pdoFtKGG|c3H5 MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDG[YxqdmViaHXydIV{fmm{dYOgbY5n\WO2ZXSgbY4hS1KISzDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIFo[Wmwc4SgeolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUiuNe69VS5? NHrqRmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW2OVUyPid-MkG1OlU2OTZ:L3G+
HEL NHqzO4VCdnSrdnnyZYwh[XO|YYm= MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCFeYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGGodHXyMEBGSzVyPUiuNu69VS5? NYPk[HM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVE5PTRpPkKzPVEyQDV2PD;hQi=>
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HFF M3i2RmFvfGm4aYLhcEBie3OjeR?= NVrsTJVSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS3m2b33l[4Ftd3[rcoXzJGNOXiB{OEG3JJdqfGhicH;sJGc5PDGDIGXMPVchSzV7Mleg[I92[mynIH31eIFvfCCrbn\lZ5Rm\CCrbjDISmYh[2WubIOgZpkhW0WDUDDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUiuOO69VS5? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdyOUS2PEc,OTd5MEm0Olg9N2F-
HEL MlzJRY51cX[rcnHsJIF{e2G7 MWO3JIRigXN? M4n5bGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{BxdGGzdXWg[o9zdWG2aX;uJIFnfGW{IEeg[IF6eyxiRVO1NF05NjgQvF2u MmXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MkKxNlgoRjF5NkKyNVI5RC:jPh?=
HEL Moq3RY51cX[rcnHsJIF{e2G7 NXH6WYxjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZ5l1d22nZ3Hsc5ZqenW|IFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QtKEWFNUC9PE44|ryPLh?= MoPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEKwOlcoRjJ6NkiyNFY4RC:jPh?=
HEL NFjSUHdCdnSrdnnyZYwh[XO|YYm= M3PCNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3Wg[IVncWOrZX70JIFv\CCjY4njcI93cXJicnXzbZN1[W62IFjTWlEhU0:VIHnuJIh2dWGwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVnPxE1w NFjvelc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK4NVIzPSd-MUmyPFEzOjV:L3G+
HEL Mm\QRY51cX[rcnHsJIF{e2G7 NHLiW5JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDifUB3cXKjbDDDVGUh[XO|YYmsJGVEPTB;OT6x{txONg>? M3Tq[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
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HEL M4KwXGFvfGm4aYLhcEBie3OjeR?= NGHZPVFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDjfZRwdWWpYXzveolzfXNiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDFR|UxRTFzLkSz{txONg>? MlnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6OECyOVEoRjJ7OEiwNlUyRC:jPh?=
HELF NYLHOFMySW62aY\pdoFtKGG|c3H5 MkXwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JJN1emGrbjDpcoZm[3SnZDDpckBJTUyIIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD1zMT63Oe69VS5? M2jSV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm4OFgyLz5|MEC5PFQ5OTxxYU6=
HFF NWf4PVJqSW62aY\pdoFtKGG|c3H5 NVXZWFJvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{M{GxJIlvKEiIRjDj[YxteyCkeTDQVmEtKEmFNUC9NVIvPM7:TT6= M4nQS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MESzNVI5Lz5zN{C0N|EzQDxxYU6=
HEL NVTjUYRESW62aY\pdoFtKGG|c3H5 MUC3JIRigXN? MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDoeY1idiCleYTvcYVo[WyxdnnyeZMhSURzNkmgbY5n\WO2ZXSgbY4hcHWvYX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0JIlv\mWldHnvckwhTUN3ME2xNk43|ryPLh?= NWO0bItkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzN|kxQDJpPkG5N|M6ODh{PD;hQi=>
HEL NGnVdZZCdnSrdnnyZYwh[XO|YYm= MlHuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iY4n0c41m\2Gub4\pdpV{KEGGMU[5JIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdIxieXWnIH\vdo1ifGmxbjygSWM2OD1zMz65{txONg>? NUn4T4hMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFM2PTBpPkK2OFQ{PTVyPD;hQi=>
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HEL NH3qTGxCdnSrdnnyZYwh[XO|YYm= M2nlOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJRpgW2rZHnu[UBscW6jc3WgcoVo[XSrdnWgZY5lKEGFVjDy[ZNqe3SjboSgTHNXOSCNT2OgbY5n\WO2ZXSgbY4hUEWOIHPlcIx{KGK7II\pdoFtKEOSRTDhd5NigSxiRVO1NF0yPC55zszNMi=> M3raV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEW4NlIzLz5{Mki1PFIzOjxxYU6=
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Assay
Methods Test Index PMID
Growth inhibition assay Cell viability 29845211
In vivo Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response[7].

Protocol (from reference)

Cell Research:

[7]

  • Cell lines: BV-2 cells 
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    To assess cell proliferation by thymidine incorporation, a total of 2 × 10<sup>4</sup> BV-2 cells were seeded in a 96-well plate for a maximum of 12 h in 10% FBS containing DMEM and then serum starved for an additional 12 h before the addition of varying concentrations of GCV for a total of 24 h. Cultures were pulsed for the final 8 h with 1 µCi/well [3H]thymidine before incorporated radioactivity was measured using a β plate scintillation counter.

Animal Research:

[7]

  • Animal Models: C57BL/6 mice
  • Dosages: 100 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

2mg/mL

Chemical Information

Molecular Weight 255.23
Formula

C9H13N5O4

CAS No. 82410-32-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04706507 Recruiting Drug: IV Ganciclovir Acute Respiratory Failure Fred Hutchinson Cancer Center|National Heart Lung and Blood Institute (NHLBI) June 29 2021 Phase 3
NCT04478474 Unknown status Drug: Ganciclovir Cytomegalovirus Infections New York Medical College|Merck Sharp & Dohme LLC September 15 2020 --
NCT03698435 Unknown status Drug: Ganciclovir|Drug: Valganciclovir Cytomegalovirus Infections University Medical Center Groningen May 25 2018 --
NCT02606266 Terminated Drug: Valganciclovir Congenital Cytomegalovirus (CMV) Assistance Publique - Hôpitaux de Paris July 11 2017 Phase 2|Phase 3
NCT03088553 Unknown status Drug: Therapeutic Drug Monitoring Solid Organ Transplantation Rennes University Hospital February 22 2017 --
NCT02943057 Recruiting Drug: 2% guttae ganciclovir Cytomegalovirus Infections Singapore National Eye Centre October 2016 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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