cGAS

Inhibitory Selectivity

cGAS Products

Catalog No. Information Product Use Citations Product Validations
S6841New

RU.521

RU.521 is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.

S9615New

PF-06928215

PF-06928215 is a high affinity active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM.

S0775New

IRAK4-IN-4

IRAK4-IN-4 is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

S8944New

G150

G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.

Catalog No. Information Product Use Citations Product Validations
S6841New

RU.521

RU.521 is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.

S9615New

PF-06928215

PF-06928215 is a high affinity active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM.

S0775New

IRAK4-IN-4

IRAK4-IN-4 is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

S8944New

G150

G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.