Fosaprepitant dimeglumine salt

Synonyms: MK-0517

Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

Fosaprepitant dimeglumine salt Chemical Structure

Fosaprepitant dimeglumine salt Chemical Structure

CAS No. 265121-04-8

Purity & Quality Control

Fosaprepitant dimeglumine salt Related Products

Biological Activity

Description Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
Targets
NK-1 receptor [1]
In vitro
In vitro Fosaprepitant (MK-0517, L-758,298) is a phosphoryl prodrug for aprepitant. Aprepitant is a selective substance P (NK-1 receptor) antagonist approved as part of combination therapy with a corticosteroid and a 5-HT 3 receptor antagonist for the prevention of acute and delayed Chemotherapy-induced nausea and vomiting. [1]
In Vivo
In vivo Fosaprepitant is converted to aprepitant within 30 min after intravenous administration via the action of ubiquitous phosphatases when administered intravenously. Fosaprepitant is well tolerated up to 150 mg (1 mg/ml), and Fosaprepitant 115 mg is bioequivalent in its AUC to aprepitant 125 mg. Fosaprepitant 115 mg has been submitted for FDA approval as an alternative on day 1 of a 3-day oral aprepitant regimen, with oral aprepitant administered on days 2 and 3. [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05755659 Recruiting
Neoplasms
Xijing Hospital
July 15 2022 Not Applicable
NCT02407600 Unknown status
Non-small Cell Lung Cancer|Vomiting|Nausea|Emesis
Ajeet Gajra|Merck Sharp & Dohme LLC|State University of New York - Upstate Medical University
April 2015 Phase 2
NCT01074697 Completed
Nausea|Vomiting|Genital Neoplasms Female
Odense University Hospital|Helsinn Healthcare SA
April 2010 Phase 3

Chemical Information & Solubility

Molecular Weight 1004.83 Formula

C23H22F7N4O6P.2C7H17NO5

CAS No. 265121-04-8 SDF Download Fosaprepitant dimeglumine salt SDF
Smiles CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNCC(C(C(C(CO)O)O)O)O.CNCC(C(C(C(CO)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (99.51 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Fosaprepitant dimeglumine salt | Fosaprepitant dimeglumine salt ic50 | Fosaprepitant dimeglumine salt price | Fosaprepitant dimeglumine salt cost | Fosaprepitant dimeglumine salt solubility dmso | Fosaprepitant dimeglumine salt purchase | Fosaprepitant dimeglumine salt manufacturer | Fosaprepitant dimeglumine salt research buy | Fosaprepitant dimeglumine salt order | Fosaprepitant dimeglumine salt mouse | Fosaprepitant dimeglumine salt chemical structure | Fosaprepitant dimeglumine salt mw | Fosaprepitant dimeglumine salt molecular weight | Fosaprepitant dimeglumine salt datasheet | Fosaprepitant dimeglumine salt supplier | Fosaprepitant dimeglumine salt in vitro | Fosaprepitant dimeglumine salt cell line | Fosaprepitant dimeglumine salt concentration | Fosaprepitant dimeglumine salt nmr