New DUB Inhibitors

Catalog No.	Product Name	Information
E6603	USP5-IN-1	USP5‑IN‑1 (compound 64) is a selective, competitive inhibitor of the USP5 zinc finger ubiquitin‑binding domain (ZnF‑UBD) with a KD of 2.8 μM. It also suppresses USP5 catalytic activity and inhibits the hydrolysis of unanchored ubiquitin chains.
E6671	CMPD-39	CMPD-39 (Compound 39) is a selective non-covalent inhibitor of USP30 with an IC50 of ~20 nM in in vitro enzyme assays.
E6502	USP7-IN-1	USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7 with an IC50 of 77 Μm and exhibits antiproliferative activity, inhibiting the growth of HCT116 colorectal cancer cells with a GI50 of 67 μM.
≡ All DUB Inhibitors