New 5-HT Receptor Modulators

Catalog No. Product Name Information
E6067 Frovatriptan succinate hydrate Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate, SB 209509 succinate) is a potent, selective and orally active agonist of 5-HT1B with pEC50 value of 8.2 and 5-HT1D receptor. It displays >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and a >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor.
E6066 cyproheptadine Cyproheptadine is a potent and orally active antagonist of 5-HT2A receptor with antiserotonergic and antidepressant effects. It also exhibits antiplatelet activities and has the potential to treat thromboembolic and depressive disorders.
S5987 Ritanserin (R 55667) Ritanserin (R 55667) is a highly potent, selective, orally active, and long-acting antagonist of 5-HT2 receptor with an IC50 of 0.9 nM. It exhibits minimal activity at H1, D2, and adrenergic receptors and enhances midbrain dopamine neuron activity by blocking 5-HT2-mediated inhibition.
E6060 BUSPIRONE BUSPIRONE (Ansial) is a potent agonist of serotonin 5-HT1A receptor as well as an antagonist of dopamine D2 autoreceptor. It exhibits anxiolytic and antidepressant activity, alleviates anxiety, depression, and colitis, suppresses neuroinflammation, modulates gut microbiota, and can be used in research for treating anxiety and depression.
S6351 Serotonin Serotonin is a monoamine neurotransmitter in the Central Nervous System (CNS) and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor.
All 5-HT Receptor Modulators