New 5-HT Receptor Modulators

Catalog No. Product Name Information
E6066 cyproheptadine Cyproheptadine is a potent and orally active antagonist of 5-HT2A receptor with antiserotonergic and antidepressant effects. It also exhibits antiplatelet activities and has the potential to treat thromboembolic and depressive disorders.
S5987 Ritanserin (R 55667) Ritanserin (R 55667) is a highly potent, selective, orally active, and long-acting antagonist of 5-HT2 receptor with an IC50 of 0.9 nM. It exhibits minimal activity at H1, D2, and adrenergic receptors and enhances midbrain dopamine neuron activity by blocking 5-HT2-mediated inhibition.
E6060 BUSPIRONE BUSPIRONE (Ansial) is a potent agonist of serotonin 5-HT1A receptor as well as an antagonist of dopamine D2 autoreceptor. It exhibits anxiolytic and antidepressant activity, alleviates anxiety, depression, and colitis, suppresses neuroinflammation, modulates gut microbiota, and can be used in research for treating anxiety and depression.
S6351 Serotonin Serotonin is a monoamine neurotransmitter in the Central Nervous System (CNS) and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor.
E4952 Nefazodone Nefazodone is a selective antagonist of 5-HT2Areceptors and moderately inhibits serotonin and norepinephrine reuptake, enhancing 5-HT synaptic transmission. It is also a potent inhibitor of CYP3A4 with reduced anticholinergic, alpha-adrenolytic, and sedative effects, along with notable immunoprotective properties.
All 5-HT Receptor Modulators