• Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8006 BIX 01294 98 mg/mL 98 mg/mL 8 mg/mL
S8071 UNC0638 6 mg/mL 100 mg/mL 100 mg/mL
S7230 UNC0642 <1 mg/mL 100 mg/mL 100 mg/mL
S8068 Chaetocin <1 mg/mL 100 mg/mL <1 mg/mL
S7572 A-366 <1 mg/mL 65 mg/mL 65 mg/mL
S7591 BRD4770 <1 mg/mL 27 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations

BIX 01294

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases.



UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets.



UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.



Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.



A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.



BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.

Tags: G9a/GLP inhibitor | G9a/GLP activator | G9a/GLP Inhibition