Gamma-secretase Inhibition | Gamma-secretase Inhibitor Review

Catalog No.	Product Name	Information	Product Use Citations
S8185	FPS-ZM1	FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.	Circ J, 2025, 10.1253/circj.CJ-24-0878 Clin Immunol, 2024, 262:110178 Pharmacol Res, 2023, 192:106791
S7169	Crenigacestat (LY3039478)	Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.	Cancer Commun (Lond), 2025, 10.1002/cac2.70021 J Exp Clin Cancer Res, 2024, 43(1):286 Cell Death Dis, 2024, 15(1):53
S8185	FPS-ZM1	FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.	Circ J, 2025, 10.1253/circj.CJ-24-0878 Clin Immunol, 2024, 262:110178 Pharmacol Res, 2023, 192:106791
S7169	Crenigacestat (LY3039478)	Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.	Cancer Commun (Lond), 2025, 10.1002/cac2.70021 J Exp Clin Cancer Res, 2024, 43(1):286 Cell Death Dis, 2024, 15(1):53

Gamma-secretase