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VDA Signaling Pathway Map

VDA Signaling Pathways

VDA Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1176 Plinabulin (NPI-2358) Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
J Med Chem, 2022, 65(13):9159-9173
ACS Omega, 2022, 7(25):21465-21472
J Biol Chem, 2019, 294(20):8161-8170
S1537 Vadimezan (ASA404) Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
Cell, 2022, 185(1):169-183.e19
Nat Immunol, 2022, 23(2):287-302
Nat Cell Biol, 2022, 24(5):766-782
S1786 Verteporfin (CL 318952) Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Nat Commun, 2022, 13(1):3117
Nat Commun, 2022, 13(1):50
Redox Biol, 2022, 54:102384
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