PAR

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Isoform-selective Inhibitors

PAR Products

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Catalog No. Product Name Information Product Use Citations Product Validations
E0341New IUN76750 IUN76750 is a PAR-2 signaling pathway inhibitor.
S2916 ML161 (Parmodulin 2) ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
S9915 FSLLRY-NH2 TFA FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.
E0102 I-191 I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. I-191 also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.
S0342 Atopaxar Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist.
S8067 Vorapaxar (MK-5348) Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
Biomolecules, 2022, 12(1)117
Cell Rep, 2021, 35(11):109233
EMBO Mol Med, 2020, 12(8):e11987
S9744 AZ3451 AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
S9916New SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM.
E0341New IUN76750 IUN76750 is a PAR-2 signaling pathway inhibitor.
S2916 ML161 (Parmodulin 2) ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
S9915 FSLLRY-NH2 TFA FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.
E0102 I-191 I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. I-191 also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.
S0342 Atopaxar Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist.
S8067 Vorapaxar (MK-5348) Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
Biomolecules, 2022, 12(1)117
Cell Rep, 2021, 35(11):109233
EMBO Mol Med, 2020, 12(8):e11987
S9744 AZ3451 AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
S9916New SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM.
E0341New IUN76750 IUN76750 is a PAR-2 signaling pathway inhibitor.
S9916New SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM.
Tags: PAR inhibitor|PAR agonist|PAR activator|PAR inducer|PAR antagonist|PAR signaling pathway|PAR assay kit