PAR

Inhibitory Selectivity

Isoform-specific Inhibitors

PAR Products

Catalog No. Information Product Use Citations Product Validations
S9915New

FSLLRY-NH2 TFA

FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.

S2916

ML161 (Parmodulin 2)

ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

S9744New

AZ3451

AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.

S8067

Vorapaxar (MK-5348)

Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

E0102New

I-191

I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. I-191 also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.

Catalog No. Information Product Use Citations Product Validations
S9915New

FSLLRY-NH2 TFA

FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.

S2916

ML161 (Parmodulin 2)

ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

Catalog No. Information Product Use Citations Product Validations
S9744New

AZ3451

AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.

S8067

Vorapaxar (MK-5348)

Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

E0102New

I-191

I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. I-191 also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.