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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8067 Vorapaxar (MK-5348) Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
Cell Rep Med, 2025, 6(10):102371
Cardiovasc Diabetol, 2025, 24(1):323
J Immunother Cancer, 2024, 12(11)e009805
S9915 FSLLRY-NH2 TFA FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.
Am J Transl Res, 2024, 16(12):7416-7426
S9744 AZ3451 AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
Front Immunol, 2024, 15:1477072
E0102 I-191 I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. This compound also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.
Front Immunol, 2024, 15:1477072
E4452 Trypsin Trypsin(Cocoonase) is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. It activates PAR2 and PAR4 and induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. It also promotes cell proliferation and differentiation and can be used in the research of wound healing and neurogenic inflammation.
E7046 TRAP-6 TRAP-6 (PAR-1 agonist peptide) is a synthetic hexapeptide (SFLLRN) that acts as a agonist of PAR-1 (protease-activated receptor-1). It also activates GPR15 on T-cells, regulating immune responses by suppressing acute GvHD while maintaining GvT activity.
E4841 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate) is a selective and orally active antagonist of protease-activated receptor (PAR-1), with a Ki value of 8.1 nM. This compound reduces thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
E7294 TFLLR-NH2 TFLLR-NH2 is a selective and potent agonist of proteinase-activated receptor 1 (PAR1) with an EC50 of 1.9 μM. It has potential for researching early tumor metastasis and supports early antiplatelet therapy to suppress colorectal cancer spread and improve survival rates.
S0342 Atopaxar Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist.
E0341 IUN76750 IUN76750 is a PAR-2 signaling pathway inhibitor.