Aldose Reductase

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Aldose Reductase Products

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Aldose Reductase Inhibitors (7)
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Catalog No.	Product Name	Information	Product Use Citations
S0878	AT-001	AT-001 (Aldose reductase-IN-1) is an aldose reductase inhibitor with IC50 of 28.9 pM.
S2035	Epalrestat (ONO-2235)	Epalrestat (ONO-2235) is an aldose reductase inhibitor with IC50 of 72 nM.	Free Radic Biol Med, 2021, 163:220-233 J Agric Food Chem, 2020, 68(42):11747-11757 Int J Med Sci, 2020, 17(9):1246-1256
S2404	Isoliquiritigenin	Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.	Biomedicines, 2022, 10(3)638 Cancer Res, 2021, 81(16):4257-4274 Transl Vis Sci Technol, 2020, 9(9):39
S3245	Nodakenetin	Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S5446	2-Chloro-1-(4-fluorobenzyl)benzimidazole	2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative.
S5803	Alrestatin	Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.	iScience, 2022, 25(4):104153
S9196	Calceolarioside B	Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property.Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM.
S0878	AT-001	AT-001 (Aldose reductase-IN-1) is an aldose reductase inhibitor with IC50 of 28.9 pM.
S2035	Epalrestat (ONO-2235)	Epalrestat (ONO-2235) is an aldose reductase inhibitor with IC50 of 72 nM.	Free Radic Biol Med, 2021, 163:220-233 J Agric Food Chem, 2020, 68(42):11747-11757 Int J Med Sci, 2020, 17(9):1246-1256
S2404	Isoliquiritigenin	Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.	Biomedicines, 2022, 10(3)638 Cancer Res, 2021, 81(16):4257-4274 Transl Vis Sci Technol, 2020, 9(9):39
S3245	Nodakenetin	Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S5446	2-Chloro-1-(4-fluorobenzyl)benzimidazole	2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative.
S5803	Alrestatin	Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.	iScience, 2022, 25(4):104153
S9196	Calceolarioside B	Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property.Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM.