• Menin-MLL interaction
  • WDR5-MLL interaction

WDR5-MLL-interaction Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7833 OICR-9429 OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM. Pan WDR5, Kd: 93 nM; Wdr5-MLL interaction, :
S2184 WDR5-0103 WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. Pan WDR5-MLL interaction, : ; WDR5, Kd: 450 nM