Home GPCR & G Protein -Immunology & Inflammation Prostaglandin Receptor PGE4 Selective Inhibitors | Antagonists

PGE4 Selective Inhibitors | Antagonists

  • PGD1
  • PGD2
  • PGE2
  • PGE4
  • PGF2α
  • PGI2
  • TXA2
  • TXB2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6649 E7046 (ER-886406) E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM. Selective EP4, IC50: 13.5nM; EP4, Ki: 23.14 nM
S6694 Grapiprant (CJ-023,423) Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively. Pan EP4, IC50: 35 nM; EP4, Ki: 24 nM; rat EP4 receptor, Ki: 20 nM; human EP4 receptor, Ki: 13 nM