Home Hippo -MAPK MAP4K MAP4K4 Selective Inhibitors

MAP4K4 Selective Inhibitors

  • MAP4K2
  • MAP4K4
  • MAP4K6
  • MAP4K7
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6499 PF-6260933 PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. Selective MAP4K4, IC50: 3.7 nM
S0268 DMX-5084 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. Pan human MAP4K4, IC50: 3 nM; human MAP4K4, pIC50: 8.55