MAP4K

Choose Selective MAP4K Inhibitors

MAP4K Products

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  • MAP4K Inhibitors (5)
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Catalog No. Product Name Information Product Use Citations Product Validations
E1161New CompK
S0268 DMX-5084 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
S6499 PF-6260933 PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
J Cell Sci, 2020, 14;133(9) pii: jcs240077
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
Sci Rep, 2022, 12(1):7
Neoplasia, 2019, 21(4):389-400
J Biol Chem, 2018, 293(52):20014-20028
S8868 NG25 NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.
Lab Invest, 2021, 10.1038/s41374-021-00671-w
E1161New CompK
S0268 DMX-5084 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
S6499 PF-6260933 PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
J Cell Sci, 2020, 14;133(9) pii: jcs240077
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
Sci Rep, 2022, 12(1):7
Neoplasia, 2019, 21(4):389-400
J Biol Chem, 2018, 293(52):20014-20028
S8868 NG25 NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.
Lab Invest, 2021, 10.1038/s41374-021-00671-w
E1161New CompK
Tags: MAP4K inhibitor|MAP4K agonist|MAP4K activator|MAP4K inducer|MAP4K antagonist|MAP4K signaling pathway|MAP4K assay kit