• KDM1
  • KDM2
  • KDM3
  • KDM4
  • KDM5
  • KDM6

KDM2 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S4800 Daminozide Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases. Selective KDM2A, IC50: 1.5 μM
S7234 IOX1 IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. Pan KDM2A, IC50: 1.8 μM