Carbonic Anhydrase II Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1375 Dorzolamide HCl

Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.

Selective Carbonic anhydrase II, Ki: 1.9 nM
S3178 Brinzolamide

Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

Selective CAII, IC50: 3.19 nM
S4039 Methazolamide

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Pan hCAII, Ki: 14 nM
S2866 U-104

U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.

Pan CAII, Ki: 9.64 μM