Peramivir Trihydrate

Catalog No.S2716 Synonyms: BCX-1812,RWJ-270201, S-021812

Peramivir Trihydrate Chemical Structure

Molecular Weight(MW): 382.45

Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

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Cited by 1 Publication

1 Customer Review

  • Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.

    Emerg Microbes Infect, 2014, 3(11): e78.. Peramivir Trihydrate purchased from Selleck.

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Biological Activity

Description Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.
In vivo Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. [1] Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. [2] Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. [3] Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. [4] Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model. [5]

Protocol

Solubility (25°C)

In vitro DMSO 0.2 mg/mL (0.52 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 382.45
Formula

C15H28N4O4.3H2O

CAS No. 1041434-82-5
Storage powder
in solvent
Synonyms BCX-1812,RWJ-270201, S-021812

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02635724 Completed Influenza BioCryst Pharmaceuticals December 2015 Phase 3
NCT02635724 Completed Influenza BioCryst Pharmaceuticals December 2015 Phase 3
NCT02609399 Active not recruiting Influenza Johns Hopkins University|Department of Health and Human Services November 1 2015 Phase 4
NCT02609399 Active not recruiting Influenza Johns Hopkins University|Department of Health and Human Services November 1 2015 Phase 4
NCT02369159 Recruiting Influenza BioCryst Pharmaceuticals February 2015 Phase 3
NCT02369159 Recruiting Influenza BioCryst Pharmaceuticals February 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID