Peramivir Trihydrate

For research use only.

Catalog No.S2716 Synonyms: BCX-1812,RWJ-270201, S-021812

2 publications

Peramivir Trihydrate Chemical Structure

Molecular Weight(MW): 382.45

Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

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Selleck's Peramivir Trihydrate has been cited by 2 publications

1 Customer Review

  • Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.

    Emerg Microbes Infect, 2014, 3(11): e78.. Peramivir Trihydrate purchased from Selleck.

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Biological Activity

Description Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.
In vivo Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. [1] Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. [2] Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. [3] Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. [4] Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model. [5]

Protocol

Solubility (25°C)

In vitro DMSO 0.2 mg/mL (0.52 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 382.45
Formula

C15H28N4O4.3H2O

CAS No. 1041434-82-5
Storage powder
in solvent
Synonyms BCX-1812,RWJ-270201, S-021812

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02635724 Completed Drug: Peramivir Influenza BioCryst Pharmaceuticals December 2015 Phase 3
NCT02369159 Recruiting Drug: Peramivir|Drug: Oseltamivir Influenza BioCryst Pharmaceuticals February 2015 Phase 3
NCT01224795 Terminated Drug: Peramivir|Drug: Placebo Comparator Influenza BioCryst Pharmaceuticals|Department of Health and Human Services October 2010 Phase 3
NCT01146353 Withdrawn -- Influenza|Renal Failure Midwestern University|Northwestern University|BioCryst Pharmaceuticals February 2010 --
NCT00610935 Terminated Drug: Peramivir|Drug: Placebo Influenza BioCryst Pharmaceuticals January 2007 Phase 3
NCT01063933 Withdrawn Drug: Peramivir Influenza National Institute of Allergy and Infectious Diseases (NIAID) Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID