For research use only.
Catalog No.S1992 Synonyms: CCI-187881
CAS No. 80474-14-2
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
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Choose Selective Glucocorticoid Receptor Inhibitors
|Description||Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.|
Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts.  Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation.  Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. 
|In vivo||Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. |
|In vitro||DMSO||100 mg/mL (199.77 mM)|
|Ethanol||5 mg/mL (9.98 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04918394||Not yet recruiting||Other: Questionnaire of Mold / moisture exposure||Asthma in Children||University Hospital Lille||September 2021||--|
|NCT02630121||Recruiting||Drug: Oxymetazoline Hydrochloride|Drug: Placebo||Sleep Apnea|Chronic Nasal Congestion||University of South Florida||July 2021||Phase 4|
|NCT03755544||Completed||--||Asthma|Chronic Obstructive Pulmonary Disease||Orion Corporation Orion Pharma||January 16 2019||--|
|NCT03524066||Completed||Drug: Inhalation|Drug: Systemic|Other: Bronchoscopy||Healthy||Fraunhofer-Institute of Toxicology and Experimental Medicine|AstraZeneca||April 10 2018||Not Applicable|
|NCT03238482||Completed||Drug: salmeterol-fluticasone||Asthma||Orion Corporation Orion Pharma||August 16 2017||Phase 1|
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