Fluticasone propionate

For research use only.

Catalog No.S1992 Synonyms: CCI-187881

1 publication

Fluticasone propionate  Chemical Structure

CAS No. 80474-14-2

Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.

Selleck's Fluticasone propionate has been cited by 1 publication

Purity & Quality Control

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Biological Activity

Description Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Glucocorticoid receptor [1]
In vitro

Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. [1] Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. [2] Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. [3]

In vivo Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. [4]


Solubility (25°C)

In vitro DMSO 100 mg/mL (199.77 mM)
Ethanol 5 mg/mL (9.98 mM)
Water Insoluble

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Chemical Information

Molecular Weight 500.57


CAS No. 80474-14-2
Storage powder
in solvent
Synonyms CCI-187881
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04918394 Not yet recruiting Other: Questionnaire of Mold / moisture exposure Asthma in Children University Hospital Lille September 2021 --
NCT02630121 Recruiting Drug: Oxymetazoline Hydrochloride|Drug: Placebo Sleep Apnea|Chronic Nasal Congestion University of South Florida July 2021 Phase 4
NCT03755544 Completed -- Asthma|Chronic Obstructive Pulmonary Disease Orion Corporation Orion Pharma January 16 2019 --
NCT03524066 Completed Drug: Inhalation|Drug: Systemic|Other: Bronchoscopy Healthy Fraunhofer-Institute of Toxicology and Experimental Medicine|AstraZeneca April 10 2018 Not Applicable
NCT03238482 Completed Drug: salmeterol-fluticasone Asthma Orion Corporation Orion Pharma August 16 2017 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID