For research use only. Not for use in humans.
Catalog No.S1992 Synonyms: CCI-187881
Molecular Weight(MW): 500.57
Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
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|Description||Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.|
Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts.  Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation.  Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. 
|In vivo||Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. |
|In vitro||DMSO||100 mg/mL (199.77 mM)|
|Ethanol||5 mg/mL (9.98 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02630121||Recruiting||Drug: Oxymetazoline Hydrochloride|Drug: Placebo||Sleep Apnea|Chronic Nasal Congestion||University of South Florida||June 3 2019||Phase 4|
|NCT03755544||Recruiting||--||Asthma|Chronic Obstructive Pulmonary Disease||Orion Corporation Orion Pharma||January 16 2019||--|
|NCT03524066||Completed||Drug: Inhalation|Drug: Systemic|Other: Bronchoscopy||Healthy||Fraunhofer-Institute of Toxicology and Experimental Medicine|AstraZeneca||April 10 2018||Not Applicable|
|NCT03238482||Completed||Drug: salmeterol-fluticasone||Asthma||Orion Corporation Orion Pharma||August 16 2017||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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