Home Endocrinology & Hormones Glucocorticoid Receptor agonist Flumethasone

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Flumethasone Glucocorticoid Receptor agonist

Cat.No.S4088

Flumethasone (RS-2177, NSC-54702, Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Flumethasone Glucocorticoid Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 410.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S408801 DMSO]82 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.79%
99.79

Chemical Information, Storage & Stability

Molecular Weight 410.45 Formula

C22H28F2O5

 Storage (From the date of receipt)
CAS No. 2135-17-3 Download SDF Storage of Stock Solutions

Synonyms RS-2177, NSC-54702,Flumetasone Smiles CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Solubility

In vitro
Batch:

DMSO : 82 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
glucocorticoid receptor [1]
In vivo

Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. [1] This compound combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. [2] It (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. This chemical (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. [3] The level of this compound in the treated animals is generally above the detection limit although, in most cases, the concentration is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. It is also detectable in the accompanying urine samples in calves. This chemical binds to plasma transcortin, and it becomes active when it is not bound to transcortin. [4]
References

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