Flumethasone

Catalog No.S4088 Synonyms: RS-2177, NSC-54702

Flumethasone Chemical Structure

Molecular Weight(MW): 410.45

Flumethasone is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.

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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Flumethasone is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Targets
glucocorticoid receptor [1]
()
In vivo Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. [1] Flumethasone combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. [2] Flumethasone (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. Flumethasone (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. [3] The Flumethasone level in the treated animals is generally above the detection limit although, in most cases, the concentration of Flumethasone is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. Flumethasone is also detectable in the accompanying urine samples in calves. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. [4]

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.78 mM)
Ethanol 6 mg/mL (14.61 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.45
Formula

C22H28F2O5

CAS No. 2135-17-3
Storage powder
in solvent
Synonyms RS-2177, NSC-54702

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID