Ebselen

Catalog No.S6676 Synonyms: DR 3305, SPI-1005, PZ-51, CCG-39161

For research use only.

Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.

Ebselen Chemical Structure

CAS No. 60940-34-3

Selleck's Ebselen has been cited by 3 Publications

Purity & Quality Control

Choose Selective HIV Inhibitors

Biological Activity

Description Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.
Targets
HIV-1 [1]
(Cell-free assay)
46.1 nM
In vitro

Ebselen acts on the early postentry step of the HIV-1 viral cycle prior to reverse transcription by stabilizing the incoming viral capsid.[1]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: HeLa-CD4 cells
  • Concentrations: 0-100µM
  • Incubation Time: 72 h
  • Method:

    HeLa-CD4-LTR-LacZ cells are infected with NL4.3 replicative virus in the presence of increasing concentrations of ebselen for 72 h.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 274.18
Formula

C13H9NOSe

CAS No. 60940-34-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03013400 Completed Drug: Ebselen|Drug: Placebo oral capsule Bipolar Disorder|Bipolar Disorder Manic University of Oxford|Stanley Medical Research Institute|Sound Pharmaceuticals Incorporated October 1 2017 Phase 2
NCT02603081 Completed Drug: SPI-1005 Meniere''s Disease Sound Pharmaceuticals Incorporated December 2015 Phase 1|Phase 2
NCT01452607 Completed Drug: SPI-1005|Drug: Placebo Hearing Loss|Cancer Sound Pharmaceuticals Incorporated May 2006 Phase 1
NCT00762671 Completed Drug: Ebselen|Drug: Placebo Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus Brigham and Women''s Hospital May 1999 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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