For research use only.

Catalog No.S6676 Synonyms: DR 3305, SPI-1005, PZ-51

1 publication

Ebselen Chemical Structure

CAS No. 60940-34-3

Ebselen (DR 3305, SPI-1005, PZ-51) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.

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Selleck's Ebselen has been cited by 1 publication

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Biological Activity

Description Ebselen (DR 3305, SPI-1005, PZ-51) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.
HIV-1 [1]
(Cell-free assay)
46.1 nM
In vitro

Ebselen acts on the early postentry step of the HIV-1 viral cycle prior to reverse transcription by stabilizing the incoming viral capsid.[1]


Cell Research:


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  • Cell lines: HeLa-CD4 cells
  • Concentrations: 0-100µM
  • Incubation Time: 72 h
  • Method:

    HeLa-CD4-LTR-LacZ cells are infected with NL4.3 replicative virus in the presence of increasing concentrations of ebselen for 72 h.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 55 mg/mL (200.59 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 274.18


CAS No. 60940-34-3
Storage powder
in solvent
Synonyms DR 3305, SPI-1005, PZ-51
Smiles C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03013400 Completed Drug: Ebselen|Drug: Placebo oral capsule Bipolar Disorder|Bipolar Disorder Manic University of Oxford|Stanley Medical Research Institute|Sound Pharmaceuticals Incorporated October 1 2017 Phase 2
NCT02603081 Completed Drug: SPI-1005 Meniere''s Disease Sound Pharmaceuticals Incorporated December 2015 Phase 1|Phase 2
NCT01452607 Completed Drug: SPI-1005|Drug: Placebo Hearing Loss|Cancer Sound Pharmaceuticals Incorporated May 2006 Phase 1
NCT00762671 Completed Drug: Ebselen|Drug: Placebo Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus Brigham and Women''s Hospital May 1999 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID