PGC-1α

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations
S7447	ZLN005	ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator. This compound is a potent and tissue-specific PGC-1α transcriptional activator.	bioRxiv, 2025, 2025.01.10.632395 Nephrology (Carlton), 2024, 29(12):858-872 Front Immunol, 2023, 14:1089905
S8528	SR-18292	SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α.	PLoS One, 2025, 20(2):e0310908 Cell Chem Biol, 2024, 31(10):1772-1786.e5 JCI Insight, 2023, 8(17)e170513
E3343	Gynostemma pentaphyllum Extract	Gynostemma Pentaphyllum Extract, isolated from the herb of Gynostemma pentaphyllum, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.
S3944	VPA (Valproic acid)	Valproic acid (VPA) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. This compound induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Additionally, it activates Notch-1 signaling.	Cell, 2025, S0092-8674(25)00406-4 Nat Commun, 2025, 16(1):8267 Stem Cell Res Ther, 2025, 16(1):426
S1168	Valproic Acid sodium	Valproic Acid sodium is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	J Exp Clin Cancer Res, 2024, 43(1):152 J Immunother Cancer, 2024, 12(11)e009805 Front Pharmacol, 2024, 15:1534772