PGC-1α

Choose Selective PGC-1α Inhibitors

PGC-1α Products

All (5)
PGC-1α Inhibitor (1)
PGC-1α Activators (3)
PGC-1α Agonist (1)
New PGC-1α Products

Catalog No.	Product Name	Information	Product Use Citations
S8528	SR-18292	SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α.	Front Pharmacol, 2021, 12:624402 Cancers (Basel), 2020, 12(9)E2397
S1168	Valproic Acid (NSC 93819) sodium salt	Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	Sci Total Environ, 2022, 838(Pt 2):155825 Transl Psychiatry, 2022, 12(1):130 Acta Pharmacol Sin, 2022, 10.1038/s41401-022-00932-4
S3944	Valproic acid (VPA)	Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.	Cell Stem Cell, 2022, 29(7):1031-1050.e12 Cell Res, 2022, 10.1038/s41422-022-00668-0 Cell Rep, 2022, 39(12):110994
S7447	ZLN005	ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.	Biomed Pharmacother, 2021, 144:112331 J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6 Stem Cell Reports, 2020, S2213-6711(20)30418-5
E3343^New	Gynostemma pentaphyllum Extract	Gynostemma Pentaphyllum Extract, isolated from the herb of Gynostemma pentaphyllum, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.
S8528	SR-18292	SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α.	Front Pharmacol, 2021, 12:624402 Cancers (Basel), 2020, 12(9)E2397
S1168	Valproic Acid (NSC 93819) sodium salt	Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	Sci Total Environ, 2022, 838(Pt 2):155825 Transl Psychiatry, 2022, 12(1):130 Acta Pharmacol Sin, 2022, 10.1038/s41401-022-00932-4
S3944	Valproic acid (VPA)	Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.	Cell Stem Cell, 2022, 29(7):1031-1050.e12 Cell Res, 2022, 10.1038/s41422-022-00668-0 Cell Rep, 2022, 39(12):110994
S7447	ZLN005	ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.	Biomed Pharmacother, 2021, 144:112331 J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6 Stem Cell Reports, 2020, S2213-6711(20)30418-5
E3343^New	Gynostemma pentaphyllum Extract	Gynostemma Pentaphyllum Extract, isolated from the herb of Gynostemma pentaphyllum, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.
E3343^New	Gynostemma pentaphyllum Extract	Gynostemma Pentaphyllum Extract, isolated from the herb of Gynostemma pentaphyllum, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.