Venlafaxine HCl

Catalog No.S1441

Venlafaxine HCl Chemical Structure

Molecular Weight(MW): 313.86

Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
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Biological Activity

Description Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Targets
5-HT [1]
In vitro

Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. [1] Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively. [2]

In vivo Venlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. [3] Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb. [4]

Protocol

Solubility (25°C)

In vitro DMSO 55.5 mg/mL (176.83 mM)
Water 55.5 mg/mL (176.83 mM)
Ethanol 55.5 mg/mL (176.83 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 313.86
Formula

C17H27NO2·HCl

CAS No. 99300-78-4
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03588572 Recruiting Subcortical Aphasia|Ischemic Stroke Guangzhou General Hospital of Guangzhou Military Command August 1 2018 Not Applicable
NCT03588572 Recruiting Subcortical Aphasia|Ischemic Stroke Guangzhou General Hospital of Guangzhou Military Command August 1 2018 Not Applicable
NCT03538691 Recruiting Major Depressive Disorder Otsuka Pharmaceutical Development & Commercialization Inc. July 13 2018 Phase 3
NCT03538691 Recruiting Major Depressive Disorder Otsuka Pharmaceutical Development & Commercialization Inc. July 13 2018 Phase 3
NCT03434041 Recruiting Depressive Disorder Treatment-Resistant Janssen Research & Development LLC May 25 2018 Phase 3
NCT03574792 Recruiting Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Roswell Park Cancer Institute|National Cancer Institute (NCI) May 3 2018 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID