For research use only.
CAS No. 76-25-5
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
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|Description||Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.|
Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations.  Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba2+ (1 mM), H2O2 (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM).  Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants. 
|In vivo||Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos.  Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone. |
-  Penfold PL, et al. Clin Exp Immunol,?000, 121(3), 458-465.
-  Uckermann O, et al. J Pharmacol Exp Ther,?005, 315(3), 1036-1045.
-  Dechant JE, et al. Equine燰et J,?003, 35(5), 444-450.
|In vitro||DMSO||87 mg/mL (200.23 mM)|
|Ethanol||13 mg/mL (29.91 mM)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03378076||Completed||Drug: FX006 32 mg|Drug: TAcs 40 mg||Bilateral Knee Osteoarthritis||Flexion Therapeutics Inc.||December 6 2017||Phase 2|
|NCT03382262||Completed||Drug: FX006 32 mg|Drug: TAcs 40 mg||Osteoarthritis of the Shoulder|Osteoarthritis of the Hip||Flexion Therapeutics Inc.||December 18 2017||Phase 2|
|NCT02877485||Completed||Drug: Triamcinolone Acetonide|Drug: Ayr saline nasal mist||Nasal Obstruction||Stanford University||August 2016||Phase 4|
|NCT02221453||Completed||Drug: Triamcinolone Acetonide||Diabetic Macular Edema||St. Michael''s Hospital Toronto||September 2015||Phase 2|
|NCT02294656||Completed||Drug: Ranibizumab|Drug: Triamcinolone acetonide||CYSTOID MACULAR EDEMA||Soll Eye|Genentech Inc.||November 2014||Phase 1|
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