Triamcinolone Acetonide

Catalog No.S1628

Triamcinolone Acetonide Chemical Structure

Molecular Weight(MW): 434.5

Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
Targets
Glucocorticoid receptor [1]
()
In vitro

Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. [1] Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba2+ (1 mM), H2O2 (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). [2] Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants. [3]

In vivo Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. [4] Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 87 mg/mL (200.23 mM)
Ethanol 13 mg/mL (29.91 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.5
Formula

C24H31FO6

CAS No. 76-25-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03378076 Completed Drug: FX006 32 mg|Drug: TAcs 40 mg Bilateral Knee Osteoarthritis Flexion Therapeutics Inc. December 6 2017 Phase 2
NCT03382262 Completed Drug: FX006 32 mg|Drug: TAcs 40 mg Osteoarthritis of the Shoulder|Osteoarthritis of the Hip Flexion Therapeutics Inc. December 18 2017 Phase 2
NCT02877485 Unknown status Drug: Triamcinolone Acetonide|Drug: Ayr saline nasal mist Nasal Obstruction Stanford University August 2016 Phase 4
NCT02221453 Completed Drug: Triamcinolone Acetonide Diabetic Macular Edema St. Michael''s Hospital Toronto September 2015 Phase 2
NCT02294656 Completed Drug: Ranibizumab|Drug: Triamcinolone acetonide CYSTOID MACULAR EDEMA Soll Eye|Genentech Inc. November 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID