Perindopril Erbumine

For research use only.

Catalog No.S1506 Synonyms: S9490-3

Perindopril Erbumine Chemical Structure

Molecular Weight(MW): 441.6

Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.

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Biological Activity

Description Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.
ACE [1]
1.05 nM
In vitro

Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykinin/angiotensin I selectivity ratio of 1.44. [1] Perindopril Erbumine inhibits the angiotensin- and Aβ42-to-Aβ40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 μM, and 0.01-0.03 μM, respectively. [2] Perindopril Erbumine (~2 μM) displays no significant cytotoxicity towards SCC-VII and KB cells, but can significantly reduce the production of angiotensin II and the transcription of VEGF in KB cells in a concentration-dependent manner. [3]

In vivo Oral administration of Perindopril Erbumine at 2 mg/kg/day has a significant inhibitory effect on SCC-VII tumor growth, and reduces blood vessel formation surrounding the tumors in vivo due to the suppression of VEGF-induced angiogenesis. [3] Administration of Perindopril Erbumine at 2 mg/kg/day displays a strong inhibitory effect of the BNL-HCC tumor growth in rats similar to that of 20 mg/kg/day and in contrast to the AT1-R antagonist candesartan or losartan which at the dose of 20 mg/kg/day has no inhibitory effect. [4] Administration of Perindopril Erbumine at 3 mg/kg/day significantly inhibits LPS-induced apoptosis by 6.4% in RAECs in vivo than that of ramipril by 3.2%. [5] Administration of Perindopril Erbumine (1 mg/kg/day) significantly suppresses the hippocampal ACE activity, and prevents cognitive impairment and brain injury in rats with Alzheimer's disease (AD). [6]


Animal Research:[3]
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  • Animal Models: Female BALB/c nude mice injected with SCC-VII cells
  • Dosages: 1 or 2 mg/kg/day
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro Water 88 mg/mL (199.27 mM)
Ethanol 88 mg/mL (199.27 mM)
DMSO Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 441.6


CAS No. 107133-36-8
Storage powder
in solvent
Synonyms S9490-3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID