Catalog No.S1506 Synonyms: S9490-3
Molecular Weight(MW): 441.6
Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.
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|Description||Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.|
Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykinin/angiotensin I selectivity ratio of 1.44.  Perindopril Erbumine inhibits the angiotensin- and Aβ42-to-Aβ40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 μM, and 0.01-0.03 μM, respectively.  Perindopril Erbumine (~2 μM) displays no significant cytotoxicity towards SCC-VII and KB cells, but can significantly reduce the production of angiotensin II and the transcription of VEGF in KB cells in a concentration-dependent manner. 
|In vivo||Oral administration of Perindopril Erbumine at 2 mg/kg/day has a significant inhibitory effect on SCC-VII tumor growth, and reduces blood vessel formation surrounding the tumors in vivo due to the suppression of VEGF-induced angiogenesis.  Administration of Perindopril Erbumine at 2 mg/kg/day displays a strong inhibitory effect of the BNL-HCC tumor growth in rats similar to that of 20 mg/kg/day and in contrast to the AT1-R antagonist candesartan or losartan which at the dose of 20 mg/kg/day has no inhibitory effect.  Administration of Perindopril Erbumine at 3 mg/kg/day significantly inhibits LPS-induced apoptosis by 6.4% in RAECs in vivo than that of ramipril by 3.2%.  Administration of Perindopril Erbumine (1 mg/kg/day) significantly suppresses the hippocampal ACE activity, and prevents cognitive impairment and brain injury in rats with Alzheimer's disease (AD). |
-  Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.
-  Zou K, et al. J Biol Chem, 2009, 284(46), 31914-31920.
-  Yasumatsu R, et al. J Cancer Res Clin Oncol, 2004, 130(10), 567-573.
|In vitro||Water||88 mg/mL (199.27 mM)|
|Ethanol||88 mg/mL (199.27 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
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