Fluocinonide

Synonyms: Vanos,nsc 101791

Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

Fluocinonide  Chemical Structure

Fluocinonide Chemical Structure

CAS: 356-12-7

Purity & Quality Control

Batch: Purity: 100%
100

Fluocinonide Related Products

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro

Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. [1]

In Vivo
In vivo

Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed. [2]

Chemical Information & Solubility

Molecular Weight 494.52 Formula

C26H32F2O7

CAS No. 356-12-7 SDF Download Fluocinonide SDF
Smiles CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 99 mg/mL ( (200.19 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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