For research use only.
Catalog No.S1888 Synonyms: MDL 458
Molecular Weight(MW): 441.52
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
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|Description||Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.|
|In vivo||Deflazacort results in a significant and equal decrease of thymus weight, indicating a marked reduction in total immunogenic tissue in rats.  Deflazacort reduces thymus weight and Daily weight gain in rats. Deflazacort lowers liver IFG-I and GHR mRNA in rats.  Deflazacort (DFC) is a heterocyclic glucocorticoid with anti-inflammatory activity but with decreased side effects. Deflazacort and [3H]dexamethasone (DEX) similarly induce in vivo ornithine decarboxylase activity in hippocampus and liver, although body weight loss after chronic treatment is significantly less for DFC.  Deflazacort induces dose-dependent decreases in osteocalcin (OC) plasma production rate (PPR). Deflazacort and prednisolone increase both postabsorptive plasma glucose and plasma calcium levels in sheep, but there are no significant differences between their effects.  Deflazacort, especially combined with L-arginine, spares quadriceps muscle from injury-induced regeneration (myf5 expression) compared with placebo treatment, despite an increase in membrane permeability immediately after exercise. Deflazacort alone prevents the typical progressive loss of function (measured as voluntary distance run over 24 hours) that is observed 3 months later in placebo-treated mice.  Deflazacort causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted. |
-  Jeong I, et al. Neuropharmacology,?012, 62(7), 2261-2266.
-  Latta K, et al. Eur J Endocrinol,?994, 131(6), 652-657.
-  Coirini H, et al. J Steroid Biochem Mol Biol, 1994, 49(1), 43-49.
|In vitro||DMSO||88 mg/mL (199.31 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03783923||Active not recruiting||Drug: Deflazacort||Limb-Girdle Muscular Dystrophy||PTC Therapeutics||May 15 2019||Phase 3|
|NCT03642145||Withdrawn||Drug: Deflazacort||Duchenne Muscular Dystrophy||PTC Therapeutics||October 31 2018||Phase 3|
|NCT02251600||Completed||Drug: Deflazacort||Duchenne Muscular Dystrophy||PTC Therapeutics||December 2014||Phase 1|
|NCT02286622||Completed||Drug: Deflazacort||Renal Impairment||PTC Therapeutics||December 2014||Phase 1|
|NCT02286609||Completed||Drug: Deflazacort||Hepatic Impairment||PTC Therapeutics||December 2014||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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