For research use only.
Catalog No.S1888 Synonyms: MDL 458
CAS No. 14484-47-0
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
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|Description||Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.|
|In vivo||Deflazacort results in a significant and equal decrease of thymus weight, indicating a marked reduction in total immunogenic tissue in rats.  Deflazacort reduces thymus weight and Daily weight gain in rats. Deflazacort lowers liver IFG-I and GHR mRNA in rats.  Deflazacort (DFC) is a heterocyclic glucocorticoid with anti-inflammatory activity but with decreased side effects. Deflazacort and [3H]dexamethasone (DEX) similarly induce in vivo ornithine decarboxylase activity in hippocampus and liver, although body weight loss after chronic treatment is significantly less for DFC.  Deflazacort induces dose-dependent decreases in osteocalcin (OC) plasma production rate (PPR). Deflazacort and prednisolone increase both postabsorptive plasma glucose and plasma calcium levels in sheep, but there are no significant differences between their effects.  Deflazacort, especially combined with L-arginine, spares quadriceps muscle from injury-induced regeneration (myf5 expression) compared with placebo treatment, despite an increase in membrane permeability immediately after exercise. Deflazacort alone prevents the typical progressive loss of function (measured as voluntary distance run over 24 hours) that is observed 3 months later in placebo-treated mice.  Deflazacort causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted. |
-  Jeong I, et al. Neuropharmacology,?012, 62(7), 2261-2266.
-  Latta K, et al. Eur J Endocrinol,?994, 131(6), 652-657.
-  Coirini H, et al. J Steroid Biochem Mol Biol, 1994, 49(1), 43-49.
|In vitro||DMSO||88 mg/mL (199.31 mM)|
|Ethanol||12 mg/mL (27.17 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04791345||Recruiting||Drug: Methylprednisone|Drug: Deflazacort|Drug: Dexamethasone||Healthy Volunteers||Parc de Salut Mar||February 26 2021||Phase 1|
|NCT03783923||Completed||Drug: Deflazacort||Limb-Girdle Muscular Dystrophy||PTC Therapeutics||May 15 2019||Phase 3|
|NCT03642145||Withdrawn||Drug: Deflazacort||Duchenne Muscular Dystrophy||PTC Therapeutics||October 31 2018||Phase 3|
|NCT02251600||Completed||Drug: Deflazacort||Duchenne Muscular Dystrophy||PTC Therapeutics||December 2014||Phase 1|
|NCT02286622||Completed||Drug: Deflazacort||Renal Impairment||PTC Therapeutics||December 2014||Phase 1|
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