New TLR Inhibitors

Catalog No.	Product Name	Information
P1292	ODN 2088	ODN 2088 is a potent inhibitory oligonucleotide (INH-ODN) that antagonizes TLR7 and TLR9 signaling by competitively binding the C-terminal fragment of TLR9. ODN 2088 inhibits the release of IFN-α from PBMCs stimulated with TLR7 or TLR9 ligands, and inhibits IL-6 release from TLR7-stimulated cells.
E1270	Afimetoran( BMS-986256)	Afimetoran (BMS-986256) is an orally active and selective antagonist of TLR7/8 that potently inhibits NF-κB activation and reverses TLR7-mediated steroid resistance in pDCs.
S8827	Diprovocim	Diprovocim is a potent synthetic agonist that activates the human TLR1/TLR2 heterodimer with an EC50 of 110 pM in THP-1 cells. It also exhibits significant potential as an immune adjuvant.
E2758	Robinin	Robinin is a flavonoid that acts by inhibiting TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin reduces oxidized-LDL-induced TLR2 and TLR4 expression at the mRNA level and prevents NF-κB p65 nuclear translocation by regulating TLR-NF-κB signaling. Robinin exhibits anti-inflammatory and anti-tumor effects.
≡ All TLR Inhibitors