New Sodium Channel Chemicals

HomeNew Sodium Channel Chemicals
Catalog No. Product Name Information
E6460 Phenamil methanesulfonate Phenamil methanesulfonate, is a potent and less reversible inhibitor of epithelial sodium channel (ENaC) with an IC50 of 400 nM. Phenamil methanesulfonate is also a competitive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease.
E8150 Amiloride Amiloride (MK-870) is the first potent inhibitor of epithelial sodium channel (ENaC), inhibiting δβγ ENaC with an IC50 of 2.6 μM. It is also a typical blocker of PC2(TRPP2) channels and can be used in the research to study Autosomal dominant polycystic kidney disease (ADPKD).
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