Sodium Channel Chemicals

Catalog No.	Product Name	Information
E6460	Phenamil methanesulfonate	Phenamil methanesulfonate, is a potent and less reversible inhibitor of epithelial sodium channel (ENaC) with an IC50 of 400 nM. Phenamil methanesulfonate is also a competitive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease.
E8150	Amiloride	Amiloride (MK-870) is the first potent inhibitor of epithelial sodium channel (ENaC), inhibiting δβγ ENaC with an IC50 of 2.6 μM. It is also a typical blocker of PC2(TRPP2) channels and can be used in the research to study Autosomal dominant polycystic kidney disease (ADPKD).
E4893	Flecainide hydrochloride	Flecainide hydrochloride, an antiarrhythmic drug, is a blocker of hydrophilic sodium channels with a pKa of 9.3. At pH 7.4. It also inhibits the ryanodine receptor (RyR2), reducing spontaneous calcium release from the sarcoplasmic reticulum.
E4949	Eslicarbazepine	Eslicarbazepine (BIA 2-194), an active metabolite of the prodrug eslicarbazepine acetate is an inhibitor of voltage-gated sodium channel (Nav). It acts by enhancing the slow activation of voltage-gated sodium channels, reducing their availability.
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