HomeNew Potassium Channel Chemicals

New Potassium Channel Chemicals

Catalog No. Product Name Information
E5975 Ebio1 Ebio1 is a subtype-selective activator of the voltage-gated potassium channel KCNQ2 that enhances conductance through a unique twist-to-open mechanism. It induces conformational changes in the S6 helix, increasing channel activity at a saturating voltage (+50 mV).
E4642 CVN293 CVN293 is a potent, selective, and brain permeable small-molecule inhibitor of potassium (K+) ion channel KCNK13 with an IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13, respectively. It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer’s disease research.
E4788 Nigericin Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.
F2192 Sodium Potassium ATPase Rabbit mAb alpha 1 Sodium Potassium ATPase,alpha 1 Sodium Potassium ATPase/ATP1A1,Na,K-ATPase,Na,K-ATPase α1,Na+/K+ ATPase (alpha Subunit),Na+/K+ ATPase alpha-1,Sodium Potassium ATPase,Sodium Potassium ATPase Alpha 1
E4828 Cloperastine fendizoate Cloperastine fendizoate (Hustazol) is a sedative used to relieve cough and also has a peripheral action that desensitizes the afferent nerves in the tracheobronchial region. It inhibits the hERG K+ currents in a concentration-dependent manner, with an IC50 value of 0.027 μM.
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