| Cat.No. |
Product Name |
Information |
|
S0462
|
NS-1619 |
NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels. |
|
S6653
|
Nigericin sodium salt |
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
|
S4353
|
Terfenadine |
Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. |
|
S6627
|
E-4031 dihydrochloride |
E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type. |
|
S6572
|
ML335 |
ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively. |
| ≡ All Potassium Channel Chemicals |
