New AChR Antagonists

Catalog No.	Product Name	Information
S9847	Methyllycaconitine citrate (MLA)	Methyllycaconitine citrate (MLA), the citrate salt of Methyllycaconitine, is a norditerpenoid alkaloid isolated from Delphinium brownii seeds. It acts as a selective antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR) and exhibits potential as a drug candidate for Alzheimer’s disease treatment.
E6073	Solifenacin hydrochloride	Solifenacin hydrochloride (YM905 hydrochloride) is an antagonist of muscarinic receptor used for the treatment of overactive bladder. It exhibits pKi values of approximately 7.6, 6.9, and 8.0 for the M1, M2, and M3 muscarinic receptors, respectively, in radioligand binding assays.
E5792	BAY 2413555	BAY 2413555 is a first selective positive allosteric modulator of the muscarinic acetylcholine receptor (M2R) to restore cardiac autonomic balance. It also inhibits CYP2C8 and CYP2C9 with IC50 values of 17 µM and 13 µM, respectively.
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