AChR Antagonists

Catalog No.	Product Name	Information
E6073	Solifenacin hydrochloride	Solifenacin hydrochloride (YM905 hydrochloride) is an antagonist of muscarinic receptor used for the treatment of overactive bladder. It exhibits pKi values of approximately 7.6, 6.9, and 8.0 for the M1, M2, and M3 muscarinic receptors, respectively, in radioligand binding assays.
E5792	BAY 2413555	BAY 2413555 is a first selective positive allosteric modulator of the muscarinic acetylcholine receptor (M2R) to restore cardiac autonomic balance. It also inhibits CYP2C8 and CYP2C9 with IC50 values of 17 µM and 13 µM, respectively.
E5819	Clozapine N-oxide dihydrochloride	Clozapine N-oxide dihydrochloride is a primary metabolite of clozapine. It acts as an agonist for human muscarinic designer receptors DREADD, with a pEC50 of 8.31 for the M1 DREADD.
E6020	(±)-Darifenacin	Darifenacin [(±)-UK-88525] is a potent, specific and competitive M3 selective receptor antagonist (M3 SRA) that has been shown to have high affinity and selectivity for the M3 receptor. It significantly improves major overactive bladder (OAB) symptoms with proven efficacy, tolerability, and safety.
F2910	Muscarinic Acetylcholine Receptor 2/CM2 Rabbit mAb	Muscarinic Acetylcholine Receptor 2/CM2,Muscarinic Acetylcholine Receptor m2
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