New AChR Antagonists

Catalog No.	Product Name	Information
E6021	Aceclidine	Aceclidine(Quinuclidin-3-yl acetate) is a quinuclidine-based cholinergic agonist that acts on muscarinic acetylcholine receptors M1-M5, stimulating phosphoinositide hydrolysis at M1, M3, and M5 and inhibiting cyclic AMP accumulation at M2 and M4. It also acts as a pupil-selective miotic, contracting the iris sphincter to produce a pinhole pupil that extends depth of focus and improves near vision with minimal ciliary muscle stimulation. Aceclidine (Quinuclidin-3-yl acetate) is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC50: 40 μM).
E6729	RGH-857	RGH-857 (compound 51) is an orally active positive allosteric modulator (PAM) of the nicotinic α7 acetylcholine (α7 nACh) receptor with an EC50 of 34 nM for human α7 nAChR and demonstrating exceptional potency and efficacy in preclinical models of cognitive impairment.
S9847	Methyllycaconitine citrate (MLA)	Methyllycaconitine citrate (MLA), the citrate salt of Methyllycaconitine, is a norditerpenoid alkaloid isolated from Delphinium brownii seeds. It acts as a selective antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR) and exhibits potential as a drug candidate for Alzheimer’s disease treatment.
≡ All AChR Antagonists