New AChR Antagonists

Catalog No.	Product Name	Information
E6729	RGH-857	RGH-857 (compound 51) is an orally active positive allosteric modulator (PAM) of the nicotinic α7 acetylcholine (α7 nACh) receptor with an EC50 of 34 nM for human α7 nAChR and demonstrating exceptional potency and efficacy in preclinical models of cognitive impairment.
S9847	Methyllycaconitine citrate (MLA)	Methyllycaconitine citrate (MLA), the citrate salt of Methyllycaconitine, is a norditerpenoid alkaloid isolated from Delphinium brownii seeds. It acts as a selective antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR) and exhibits potential as a drug candidate for Alzheimer’s disease treatment.
E6073	Solifenacin hydrochloride	Solifenacin hydrochloride (YM905 hydrochloride) is an antagonist of muscarinic receptor used for the treatment of overactive bladder. It exhibits pKi values of approximately 7.6, 6.9, and 8.0 for the M1, M2, and M3 muscarinic receptors, respectively, in radioligand binding assays.
≡ All AChR Antagonists