Autophagy Modulators

Catalog No.	Product Name	Information
E5898	SKLB-D18	SKLB-D18 is a first-in-class, potent, and selective inhibitor of ERK1/2 and ERK5 with an IC50's of 38.69 nM, 40.12 nM, and 59.72 nM, respectively, that also acts as an agonist of autophagy. It modulates mTOR/p70S6K and NCOA4-mediated ferroptosis, showing strong anti-tumor activity and offering a promising monotherapy strategy to overcome resistance in ERK1/2-targeted therapy for triple-negative breast cancer (TNBC).
F2724	SNAP29 Rabbit mAb
F2531	SQSTM1/p62 mAb	p62 (Sequestosome-1),p62 Ick ligand,p62/SQSTM1,SQSTM1,SQSTM1 / p62,SQSTM1/p62
F1488	TMEM49/VMP1 Rabbit mAb
E4692	THZ-P1-2	THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.
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