New STING Inhibitors

Cat.No. Product Name Information
S8954 STING agonist-1 (G10) STING agonist-1 (G10) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
S7904 2',3'-cGAMP 2',3'-cGAMP is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). The binding affinity of 2 ’, 3’-cGAMP to STING is 3.79 nM (Kd value).
S7905 3',3'-cGAMP 3',3'-cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
S6652 H-151 H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
All STING Inhibitors