New P450 (e.g. CYP17) Inhibitors

Catalog No.	Product Name	Information
E5926	K777	K777 is an orally active, irreversible cysteine-protease inhibitor that covalently inactivates cruzain and cathepsins B and L. It also inhibits CYP3A4 with an IC50 of approximately 60 nM.
E5929	Oteseconazole	Oteseconazole(VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity with a of Kd ≤39 nM, shows no obvious effect on human CYP51.
E6915	Tienilic acid	Tienilic acid (ticrynafen; ANP-3624) is a withdrawn uricosuric diuretic and antihypertensive drug that undergoes CYP2C9-mediated bioactivation to reactive electrophilic metabolites. These metabolites covalently modify hepatic proteins and contribute to its characteristic idiosyncratic and immunoallergic hepatotoxicity.
≡ All P450 (e.g. CYP17) Inhibitors