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NAMPT

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Cat.No. Product Name Information Product Use Citations Product Validations
S9706 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.
Molecular Cancer, May 16, 2024, 105
Nat Commun, 2025, 16(1):2513
bioRxiv, 2025, 2025.07.28.667284
S2799 FK866 (Daporinad) FK866 (Daporinad) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. This compound triggers autophagy. Phase 1/2.
Adv Sci (Weinh), 2025, 12(33):e06599
J Neuroinflammation, 2025, 22(1):113
Cell Commun Signal, 2025, 23(1):348
Verified customer review of FK866 (Daporinad)
S8444 Padnarsertib (KPT-9274, ATG-019) Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Cell Reports Medicine, January 08 2026, 102540
Blood Advances, December 22 2025, Online ahead of print
Clinical Cancer Research, April 15 2021, 2352-2366
S8117 GMX1778 GMX1778 is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. This compound induces programmed cell death with apoptotic features. Phase 1.
Nat Commun, 2025, 16(1):2513
Nature Communications, 2025, 2513
bioRxiv, 2025, 2025.04.25.650475
Verified customer review of GMX1778
S7316 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
Nat Commun, 2025, 16(1):2513
PLoS One, 2025, 20(6):e0324443
Cell Metab, 2022, S1550-4131(22)00453-3
Verified customer review of STF-118804
S7968 P7C3 P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.
Nat Commun, 2025, 16(1):2513
Front Oncol, 2023, 13:1225220
Frontiers in Oncology, 2023, 1225220
S6629 GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
Nat Commun, 2025, 16(1):2513
Nature Communications, 2025, 2513
Molecular Cancer Research, 2024, 973-988
S8980 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. This compound turns NAMPT into a "super catalyst" that more efficiently generates nicotinamide mononucleotide.
Biotechnol Prog, 2023, e3365.