NAMPT

Inhibitory Selectivity

NAMPT Products

Catalog No. Information Product Use Citations Product Validations
S2799

Daporinad (FK866, APO866)

Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.

S7316

STF-118804

STF-118804 is a highly specific NAMPT inhibitor.

S6629New

GNE-617

GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.

S8444

KPT 9274( ATG-019)

KPT-9274 is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

S8117

GMX1778 (CHS828)

GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. Phase 1.

S7968

P7C3

P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.

S8980New

SBI-797812

SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.

Catalog No. Information Product Use Citations Product Validations
S2799

Daporinad (FK866, APO866)

Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.

S7316

STF-118804

STF-118804 is a highly specific NAMPT inhibitor.

S6629New

GNE-617

GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.

S8444

KPT 9274( ATG-019)

KPT-9274 is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

S8117

GMX1778 (CHS828)

GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. Phase 1.

Catalog No. Information Product Use Citations Product Validations
S7968

P7C3

P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.

S8980New

SBI-797812

SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.