Home Metabolism NAMPT

NAMPT

Other Metabolism Related Inhibitors

MEK p38 MAPK Raf JNK S6 Kinase MNK TOPK Mixed Lineage Kinase TAK1 KLF MAPKAPK2
Cat.No. Product Name Information Product Use Citations Product Validations
S9706 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.
Nat Commun, 2025, 16(1):2513
bioRxiv, 2025, 2025.07.28.667284
Sci Rep, 2023, 13(1):3334
S2799 FK866 (Daporinad) FK866 (Daporinad) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. This compound triggers autophagy. Phase 1/2.
Adv Sci (Weinh), 2025, 12(33):e06599
J Neuroinflammation, 2025, 22(1):113
Cell Commun Signal, 2025, 23(1):348
Verified customer review of FK866 (Daporinad)
S8117 GMX1778 GMX1778 is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. This compound induces programmed cell death with apoptotic features. Phase 1.
Nat Commun, 2025, 16(1):2513
bioRxiv, 2025, 2025.04.25.650475
Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z
Verified customer review of GMX1778
S8444 Padnarsertib (KPT-9274) Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Signal Transduct Target Ther, 2025, 10(1):222
Cell Rep Med, 2024, 5(2):101416
Sci Rep, 2023, 13(1):3334
S7316 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
Nat Commun, 2025, 16(1):2513
PLoS One, 2025, 20(6):e0324443
Cell Metab, 2022, S1550-4131(22)00453-3
Verified customer review of STF-118804
S7968 P7C3 P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.
Nat Commun, 2025, 16(1):2513
Front Oncol, 2023, 13:1225220
Front Bioeng Biotechnol, 2022, 10:855755
S8980 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. This compound turns NAMPT into a "super catalyst" that more efficiently generates nicotinamide mononucleotide.
Biotechnol Prog, 2023, e3365.
S6629 GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
Nat Commun, 2025, 16(1):2513