NAMPT
Inhibitory Selectivity
NAMPT Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2799 |
Daporinad (FK866, APO866)Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2. |
Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
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| S7316 |
STF-118804STF-118804 is a highly specific NAMPT inhibitor. |
RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed by
treatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
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| S6629 |
GNE-617GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM. |
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| S8444 |
KPT 9274 ( ATG-019)KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay. |
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| S8117 |
GMX1778 (CHS828)GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1. |
(d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). *P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). **P<0.01.
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| S7968 |
P7C3P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme. |
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| S8980New |
SBI-797812SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2799 |
Daporinad (FK866, APO866)Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2. |
Effect of metabolic inhibitors on SRC-1 protein levels. A549 cells grown in glucose-containing medium were treated with NAM or FK866 at the indicated concentration.
|
|
| S7316 |
STF-118804STF-118804 is a highly specific NAMPT inhibitor. |
RSV-induced SIRT1 expression is PARP1-dependent in PC12 cells. a, PC12 cells were pretreated with STF-118804 (100 nM) for 1 h prior to treatment with RSV (20 lM) for another 2 h, followed by
treatment with or without of Ab25–35 (30 lM) for an additional 24 h. SIRT1 expression was determined by western blot analysis. b, The bar graph shows the quantification of endogenous SIRT1. c, Cells were treated with various concentrations (1, 5, 10, and 20 lM) of RSV for 24 h. PARP1 expression was detected by western blot analysis.
|
|
| S6629 |
GNE-617GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM. |
||
| S8444 |
KPT 9274 ( ATG-019)KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay. |
||
| S8117 |
GMX1778 (CHS828)GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1. |
(d) Representative images of haematoxylin and eosin staining from young colons treated with or without specific Nampt inhibitor GMX1778. Bar=100 μm. (e) Colonic NAD+/NADH ratio was analysed in young mice treated with or without Nampt inhibitor GMX1778 (n=5). *P<0.05. (f) Daily faecal number of young mice treated with or without specific Nampt inhibitor GMX1778 (n=6). **P<0.01.
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7968 |
P7C3P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme. |
||
| S8980New |
SBI-797812SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN. |
