NAMPT

NAMPT Products

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  • NAMPT Inhibitors (6)
  • NAMPT Activators (2)
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Catalog No. Product Name Information Product Use Citations Product Validations
S2799 Daporinad (FK866) Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.
Nat Commun, 2023, 14(1):6246
Nat Commun, 2023, 14(1):6246
Endocrinology, 2023, 164(6)bqad073
S8117 GMX1778 (CHS828) GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.
Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z
Cancers (Basel), 2023, 15(5)1415
Cancer Res Commun, 2023, 10.1158/2767-9764.CRC-22-0521
S8444 KPT 9274 (ATG-019) KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Cell Rep Med, 2024, 5(2):101416
Sci Rep, 2023, 13(1):3334
Sci Adv, 2023, 9(15):eadf8522
S7316 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
Cell Metab, 2022, S1550-4131(22)00453-3
Cell Rep, 2021, 36(6):109516
Cell Metab, 2020, 31(3):564-579
S7968 P7C3 P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.
Front Oncol, 2023, 13:1225220
Front Bioeng Biotechnol, 2022, 10:855755
Front Cell Dev Biol, 2022, 10:1032360
S8980 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates nicotinamide mononucleotide.
Biotechnol Prog, 2023, e3365.
S9706 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.
Sci Rep, 2023, 13(1):3334
S6629 GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
S2799 Daporinad (FK866) Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.
Nat Commun, 2023, 14(1):6246
Nat Commun, 2023, 14(1):6246
Endocrinology, 2023, 164(6)bqad073
S8117 GMX1778 (CHS828) GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.
Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z
Cancers (Basel), 2023, 15(5)1415
Cancer Res Commun, 2023, 10.1158/2767-9764.CRC-22-0521
S8444 KPT 9274 (ATG-019) KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Cell Rep Med, 2024, 5(2):101416
Sci Rep, 2023, 13(1):3334
Sci Adv, 2023, 9(15):eadf8522
S7316 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
Cell Metab, 2022, S1550-4131(22)00453-3
Cell Rep, 2021, 36(6):109516
Cell Metab, 2020, 31(3):564-579
S9706 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.
Sci Rep, 2023, 13(1):3334
S6629 GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
S7968 P7C3 P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.
Front Oncol, 2023, 13:1225220
Front Bioeng Biotechnol, 2022, 10:855755
Front Cell Dev Biol, 2022, 10:1032360
S8980 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates nicotinamide mononucleotide.
Biotechnol Prog, 2023, e3365.

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