FTase

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Catalog No. Product Name Information Product Use Citations Product Validations
S0404 Tipifarnib S enantiomer Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
S1453 Tipifarnib (R115777) Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
Cancers (Basel), 2022, 14(4)903
Front Microbiol, 2021, 12:628283
Int Immunopharmacol, 2020, 3;83:106462
S7465 FTI 277 HCl FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.
PLoS Biol, 2021, 19(4):e3001134
Cell Struct Funct, 2021, 46(1):1-9
Nat Commun, 2019, 10(1):273
S7467 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
S0404 Tipifarnib S enantiomer Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
S1453 Tipifarnib (R115777) Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
Cancers (Basel), 2022, 14(4)903
Front Microbiol, 2021, 12:628283
Int Immunopharmacol, 2020, 3;83:106462
S7465 FTI 277 HCl FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.
PLoS Biol, 2021, 19(4):e3001134
Cell Struct Funct, 2021, 46(1):1-9
Nat Commun, 2019, 10(1):273
S7467 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
Tags: FTase inhibitor|FTase agonist|FTase activator|FTase inducer|FTase antagonist|FTase signaling pathway|FTase assay kit