Home Metabolism FTase

FTase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S7465 FTI 277 HCl FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. This compound inhibits cell growth and induces apoptosis. This chemical is effective in clearing HDV viremia.
EMBO J, 2025, 44(4):1185-1219
BMC Biol, 2025, 23(1):233
PLoS One, 2025, 20(9):e0331440
Verified customer review of FTI 277 HCl
S1453 Tipifarnib (IND 58359) Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
Sci Rep, 2025, 15(1):6832
PLoS One, 2025, 20(9):e0331440
Cell Rep, 2023, 42(9):113098
Verified customer review of Tipifarnib (IND 58359)
S2797 Lonafarnib (SCH66336) Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.
PLoS Pathog, 2025, 21(10):e1013558
iScience, 2025, 28(2):111864
Sci Rep, 2025, 15(1):34331
Verified customer review of Lonafarnib (SCH66336)
S7467 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221