CAR

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations
S6895	TCPOBOP	TCPOBOP is a constitutive androstane receptor (CAR) agonist. This compound attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
S9914	CITCO	CITCO is a potent and selective constitutive androstane receptor (CAR) agonist with EC50 of 49 nM. This compound displays >50-fold selectivity for CAR over PXR in the transient transfection assay.
S1986	Meclizine 2HCl	Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.	Anticancer Res, 2019, 39(7):3767-3775 Front Pharmacol, 2017, 8:693

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6895

TCPOBOP

TCPOBOP is a constitutive androstane receptor (CAR) agonist. This compound attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

S9914

CITCO

CITCO is a potent and selective constitutive androstane receptor (CAR) agonist with EC50 of 49 nM. This compound displays >50-fold selectivity for CAR over PXR in the transient transfection assay.

S1986

Meclizine 2HCl

Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.

Anticancer Res, 2019, 39(7):3767-3775

Front Pharmacol, 2017, 8:693