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ACSS2

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Cat.No. Product Name Information Product Use Citations Product Validations
S8588 Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
Nat Commun, 2025, 16(1):2071
Cell Death Dis, 2025, 16(1):650
Cell Rep, 2025, 44(7):115947
E1147 VY-3-135 VY-3-135, a potent ACSS2 inhibitor with IC50 of 44 ± 3.85 nM, potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors.
Cancers (Basel), 2024, 16(5)1035
E1931 AD-5584 AD-5584 is a specific inhibitor of human acyl-CoA synthetase short chain family member 2 (ACSS2). It significantly reduces lipid storage, decreases colony formation, and increases cell death in vitro, while also confirming blood-brain barrier (BBB) permeability.
E1930 AD-8007 AD-8007 is a selective and brain-penetrant inhibitor of acetyl CoA synthase 2 (ACSS2). This compound significantly reduces lipid storage, cell colony formation, acetyl-CoA levels and cell survival in vitro models, and increases tumor cell death, tumor burden and increases survival in in-vivo models. It exhibits anti-cancer activity.
E1211 MTB-9655 MTB-9655 is a novel, potent and selective Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor, which is currently in Phase I clinical investigation on patients with tumors with high levels of ACSS2.