Home DNA Damage/DNA Repair MTH1 inhibitor - NUDIX inhibitor TH287 For research use only.

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

TH287 Chemical Structure

TH287 Chemical Structure

CAS: 1609960-30-6

Selleck's TH287 has been cited by 5 publications

Purity & Quality Control

Batch: S763101 DMSO] 53 mg/mL] false] Ethanol] 10 mg/mL] false] Water] Insoluble] false Purity: 99.15%
99.15

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Biological Activity

Description TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Targets
NUDIX1 [1] MTH1 [1]
0.8 nM
In vitro
In vitro TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]
In Vivo
In vivo In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82μM. [2]
Animal Research Animal Models C57Bl/6 mice
Dosages 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 269.13 Formula

C11H10Cl2N4
CAS No. 1609960-30-6 SDF Download TH287 SDF
Smiles CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (196.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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