BCRP

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT

Cat.No.	Product Name	Information	Product Use Citations
S7043	Ko143	KO143 is a potent and relatively selective ATP-binding cassette sub-family G member 2 (ABCG2/BCRP) inhibitor. KO143 decreases the ATPase activity of ABCG2 with IC50 of 9.7 nM.	DSpace, 2023, 10.33540/2012 Front Oncol, 2021, 11:620907
E5985^New	CP-100356 hydrochloride	CP-100356 hydrochloride is an orally active dual inhibitor of MDR1 (P-gp) and BCRP, with IC50 of ∼0.5 µM for MDR1-mediated calcein-AM transport inhibition and ∼1.5 µM for BCRP-mediated prazosin transport inhibition. It is also a weak inhibitor of OATP1B1 (IC50 ∼ 66 µM).
S0140	KS176	KS176 (compound 9) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP, ABCG2) multidrug transporter with IC50 of 1.39 μM and 0.59 μM in Hoechst 33342 assay and Pheo A assay, respectively.
S6715	YHO-13177	YHO-13177, a novel acrylonitrile derivative, is a potent BCRP/ABCG2 inhibitor.
S6523	RG14620	RG14620 (Tyrphostin RG14620), an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2/BCRP.
S3227	5,7-Dimethoxyflavone	5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. This compound is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. It is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.