Molecular Weight(MW): 319.31
NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
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|Description||NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.|
|In vivo||NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1.|
|In vitro||DMSO||21 mg/mL (65.76 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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