NQDI-1

For research use only.

Catalog No.S8289

3 publications

NQDI-1 Chemical Structure

Molecular Weight(MW): 319.31

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

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Biological Activity

Description NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
Targets
ASK1 [3]
(Cell-free assay)
3 μM
In vivo NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1[1].

Protocol

Animal Research:

[1]

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  • Animal Models: Female Sprague-Dawley rats
  • Dosages: 250 nmol
  • Administration: intracerebroventricularly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (65.76 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%dmso+40%PEG300+5%tween-80+ddH2O
For best results, use promptly after mixing.
0.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 319.31
Formula

C19H13NO4

CAS No. 175026-96-7
Storage powder
in solvent
Synonyms N/A
Smiles CCOC(=O)C1=C2C3=C(C=CC=C3)C(=O)C4=C2C(=CC=C4)NC1=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID